Journal
JOURNAL OF VIROLOGY
Volume 85, Issue 17, Pages 9243-9246Publisher
AMER SOC MICROBIOLOGY
DOI: 10.1128/JVI.00457-11
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Funding
- NIAID [AI048407, AI41356, AI077454, T32 AI07419]
- National Natural Science Foundation of China [30872365]
- Ministry of Science and Technology [2006CB910901, KSCX2-YW-R-150]
- Ministry of Health [2009ZX10604, 2008ZX10002-011]
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Persistent induction of type 1 interferon (IFN) is associated with human immunodeficiency virus type 1 (HIV-1) infection. We report here that the pathogenic HIV strain R3A (HIV-R3A) induced high levels of type 1 IFN, while the nonpathogenic HIV-R3B showed no significant induction in human fetal thymus organ culture (HFTOC). We found that IFN contributed to the depletion of human T cells by HIV-R3A in a fusion-independent fashion. The R3B recombinant with the R3A Env V1V2 domain (R3B/A-V1V2) was able to induce type 1 IFN, which contributed to the increased depletion of T cells. Therefore, type 1 IFN induction plays a significant role in HIV-induced T cell depletion in the human thymus.
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