Type I Interferon: Understanding Its Role in HIV Pathogenesis and Therapy

Innate DNA sensing is impaired in HIV patients and IFI16 expression correlates with chronic immune activation

(2014) S. K. Nissen et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Assessment of chloroquine as a modulator of immune activation to improve CD4 recovery in immune nonresponding HIV-infected patients receiving antiretroviral therapy

(2014) J-P Routy et al.   HIV MEDICINE

Type I Interferon Protects Antiviral CD8+ T Cells from NK Cell Cytotoxicity

(2014) Haifeng C. Xu et al.   IMMUNITY

Type I Interferons Protect T Cells against NK Cell Attack Mediated by the Activating Receptor NCR1

(2014) Josh Crouse et al.   IMMUNITY

Molecular and Transcriptional Basis of CD4+ T Cell Dysfunction during Chronic Infection

(2014) Alison Crawford et al.   IMMUNITY

Interferon γ-inducible Protein (IFI) 16 Transcriptionally Regulates Type I Interferons and Other Interferon-stimulated Genes and Controls the Interferon Response to both DNA and RNA Viruses

(2014) Mikayla R. Thompson et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Evolutionary Analysis Identifies an MX2 Haplotype Associated with Natural Resistance to HIV-1 Infection

(2014) Manuela Sironi et al.   MOLECULAR BIOLOGY AND EVOLUTION

Type I interferon responses in rhesus macaques prevent SIV infection and slow disease progression

(2014) Netanya G. Sandler et al.   NATURE

SAMHD1 Restricts HIV-1 Replication and Regulates Interferon Production in Mouse Myeloid Cells

(2014) Ruonan Zhang et al.   PLoS One

Innate Immune Responses and Rapid Control of Inflammation in African Green Monkeys Treated or Not with Interferon-Alpha during Primary SIVagm Infection

(2014) Béatrice Jacquelin et al.   PLoS Pathogens

Plasmacytoid Dendritic Cells Suppress HIV-1 Replication but Contribute to HIV-1 Induced Immunopathogenesis in Humanized Mice

(2014) Guangming Li et al.   PLoS Pathogens

Plasmacytoid Dendritic Cell Dynamics Tune Interferon-Alfa Production in SIV-Infected Cynomolgus Macaques

(2014) Timothée Bruel et al.   PLoS Pathogens

Transient Increase of Interferon-Stimulated Genes and No Clinical Benefit by Chloroquine Treatment During Acute Simian Immunodeficiency Virus Infection of Macaques

(2013) Monica Vaccari et al.   AIDS RESEARCH AND HUMAN RETROVIRUSES

Type I interferon regulation of natural killer cell function in primary and secondary infections

(2013) Michele L Stackaruk et al.   Expert Review of Vaccines

Multi-functional plasmacytoid dendritic cells redistribute to gut tissues during simian immunodeficiency virus infection

(2013) Haiying Li et al.   IMMUNOLOGY

Longitudinal Analysis of Distribution and Function of Plasmacytoid Dendritic Cells in Peripheral Blood and Gut Mucosa of HIV Infected Patients

(2013) C. Lehmann et al.   JOURNAL OF INFECTIOUS DISEASES

Hepatitis C Therapy With Interferon-α and Ribavirin Reduces CD4 T-Cell–Associated HIV-1 DNA in HIV-1/Hepatitis C Virus–Coinfected Patients

(2013) Hong Sun et al.   JOURNAL OF INFECTIOUS DISEASES

Therapeutic Depletion of Natural Killer Cells Controls Persistent Infection

(2013) S. N. Waggoner et al.   JOURNAL OF VIROLOGY

Human MX2 is an interferon-induced post-entry inhibitor of HIV-1 infection

(2013) Caroline Goujon et al.   NATURE

MX2 is an interferon-induced inhibitor of HIV-1 infection

(2013) Melissa Kane et al.   NATURE

Pan-viral specificity of IFN-induced genes reveals new roles for cGAS in innate immunity

(2013) John W. Schoggins et al.   NATURE

Cell death by pyroptosis drives CD4 T-cell depletion in HIV-1 infection

(2013) Gilad Doitsh et al.   NATURE

PD-1 Blockade in Chronically HIV-1-Infected Humanized Mice Suppresses Viral Loads

(2013) Edward Seung et al.   PLoS One

Expression profile of host restriction factors in HIV-1 elite controllers

(2013) Mohamed Abdel-Mohsen et al.   Retrovirology

Blockade of Chronic Type I Interferon Signaling to Control Persistent LCMV Infection

(2013) E. B. Wilson et al.   SCIENCE

Persistent LCMV Infection Is Controlled by Blockade of Type I Interferon Signaling

(2013) J. R. Teijaro et al.   SCIENCE

IFI16 DNA Sensor Is Required for Death of Lymphoid CD4 T Cells Abortively Infected with HIV

(2013) K. M. Monroe et al.   SCIENCE

Cyclic GMP-AMP Synthase Is an Innate Immune Sensor of HIV and Other Retroviruses

(2013) D. Gao et al.   SCIENCE

IL-15 cis Presentation Is Required for Optimal NK Cell Activation in Lipopolysaccharide-Mediated Inflammatory Conditions

(2013) Ivan Zanoni et al.   Cell Reports

Intact Type I Interferon Production and IRF7 Function in Sooty Mangabeys

(2013) Steven E. Bosinger et al.   PLoS Pathogens

Blocking TLR7- and TLR9-mediated IFN-α Production by Plasmacytoid Dendritic Cells Does Not Diminish Immune Activation in Early SIV Infection

(2013) Muhamuda Kader et al.   PLoS Pathogens

Plasmacytoid Dendritic Cells Contribute to Systemic but Not Local Antiviral Responses to HSV Infections

(2013) Melissa Swiecki et al.   PLoS Pathogens

Continuous versus intermittent treatment strategies during primary HIV-1 infection

(2012) Cécile Goujard et al.   AIDS

Treatment of SIV-infected sooty mangabeys with a type-I IFN agonist results in decreased virus replication without inducing hyperimmune activation

(2012) T. H. Vanderford et al.   BLOOD

Pathogenic Simian Immunodeficiency Virus Infection Is Associated with Expansion of the Enteric Virome

(2012) Scott A. Handley et al.   CELL

Effects of Hydroxychloroquine on Immune Activation and Disease Progression Among HIV-Infected Patients Not Receiving Antiretroviral Therapy

(2012) Nicholas I. Paton et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

The Depletion of NK Cells Prevents T Cell Exhaustion to Efficiently Control Disseminating Virus Infection

(2012) K. D. Cook et al.   JOURNAL OF IMMUNOLOGY

Innate Immune Activation Enhances HIV Acquisition in Women, Diminishing the Effectiveness of Tenofovir Microbicide Gel

(2012) Vivek Naranbhai et al.   JOURNAL OF INFECTIOUS DISEASES

SIV Infection Induces Accumulation of Plasmacytoid Dendritic Cells in the Gut Mucosa

(2012) R. K. Reeves et al.   JOURNAL OF INFECTIOUS DISEASES

A FOXO3–IRF7 gene regulatory circuit limits inflammatory sequelae of antiviral responses

(2012) Vladimir Litvak et al.   NATURE

Codon-usage-based inhibition of HIV protein synthesis by human schlafen 11

(2012) Manqing Li et al.   NATURE

SAMHD1 restricts HIV-1 infection in resting CD4+ T cells

(2012) Hanna-Mari Baldauf et al.   NATURE MEDICINE

Microbial translocation in HIV infection: causes, consequences and treatment opportunities

(2012) Netanya G. Sandler et al.   NATURE REVIEWS MICROBIOLOGY

Interferon-Alpha Administration Enhances CD8+ T Cell Activation in HIV Infection

(2012) Maura Manion et al.   PLoS One

Cyclic GMP-AMP Synthase Is a Cytosolic DNA Sensor That Activates the Type I Interferon Pathway

(2012) L. Sun et al.   SCIENCE

Polymorphisms in interferon regulatory factor 7 reduce interferon-α responses of plasmacytoid dendritic cells to HIV-1

(2011) Judy Chang et al.   AIDS

Hydroxychloroquine drastically reduces immune activation in HIV-infected, antiretroviral therapy-treated immunologic nonresponders

(2011) S. Piconi et al.   BLOOD

Plasmacytoid dendritic cells are recruited to the colorectum and contribute to immune activation during pathogenic SIV infection in rhesus macaques

(2011) S. Kwa et al.   BLOOD

Spatiotemporal trafficking of HIV in human plasmacytoid dendritic cells defines a persistently IFN-α–producing and partially matured phenotype

(2011) Meagan O’Brien et al.   JOURNAL OF CLINICAL INVESTIGATION

TRIM5 is an innate immune sensor for the retrovirus capsid lattice

(2011) Thomas Pertel et al.   NATURE

A diverse range of gene products are effectors of the type I interferon antiviral response

(2011) John W. Schoggins et al.   NATURE

Alpha interferon administration during structured interruptions of combination antiretroviral therapy in patients with chronic HIV-1 infection: INTERVAC ANRS 105 trial

(2010) François Boué et al.   AIDS

Evidence of dysregulation of dendritic cells in primary HIV infection

(2010) R. L. Sabado et al.   BLOOD

Safety, Tolerability, and Mechanisms of Antiretroviral Activity of Pegylated Interferon Alfa‐2a in HIV‐1–Monoinfected Participants: A Phase II Clinical Trial

(2010) David M. Asmuth et al.   JOURNAL OF INFECTIOUS DISEASES

Interferon-α Produces Significant Decreases in HIV Load

(2010) Jorge A. Tavel et al.   JOURNAL OF INTERFERON AND CYTOKINE RESEARCH

Plasmacytoid dendritic cells in HIV infection: striking a delicate balance

(2010) Patricia Fitzgerald-Bocarsly et al.   JOURNAL OF LEUKOCYTE BIOLOGY

In acute pathogenic SIV infection plasmacytoid dendritic cells are depleted from blood and lymph nodes despite mobilization

(2010) Simon M. Barratt-Boyes et al.   JOURNAL OF MEDICAL PRIMATOLOGY

Reduction of Immune Activation with Chloroquine Therapy during Chronic HIV Infection

(2010) S. M. Murray et al.   JOURNAL OF VIROLOGY

The Interferon-Induced Gene ISG15 Blocks Retrovirus Release from Cells Late in the Budding Process

(2010) A. Pincetic et al.   JOURNAL OF VIROLOGY

Downregulation of Robust Acute Type I Interferon Responses Distinguishes Nonpathogenic Simian Immunodeficiency Virus (SIV) Infection of Natural Hosts from Pathogenic SIV Infection of Rhesus Macaques

(2010) L. D. Harris et al.   JOURNAL OF VIROLOGY

IFI16 is an innate immune sensor for intracellular DNA

(2010) Leonie Unterholzner et al.   NATURE IMMUNOLOGY

Virologic and immunologic activity of PegIntron in HIV disease

(2009) Jonathan B Angel et al.   AIDS

Tetherin Inhibits HIV-1 Release by Directly Tethering Virions to Cells

(2009) David Perez-Caballero et al.   CELL

Glycerol monolaurate prevents mucosal SIV transmission

(2009) Qingsheng Li et al.   NATURE

The Interferon-Induced Protein BST-2 Restricts HIV-1 Release and Is Downregulated from the Cell Surface by the Viral Vpu Protein

(2008) Nanette Van Damme et al.   Cell Host & Microbe

Tetherin inhibits retrovirus release and is antagonized by HIV-1 Vpu

(2008) Stuart J. D. Neil et al.   NATURE

Enhancing SIV-specific immunity in vivo by PD-1 blockade

(2008) Vijayakumar Velu et al.   NATURE