Pattern recognition receptors in the development of nonalcoholic fatty liver disease and progression to hepatocellular carcinoma: An emerging therapeutic strategy

Disrupted BRCA1‐PALB2 interaction induces tumor immunosuppression and T ‐lymphocyte infiltration in HCC through cGAS‐STING pathway

(2022) Hui Ma et al.   HEPATOLOGY

The Invasive Potential of Hepatoma Cells Induced by Radiotherapy is Related to the Activation of Stellate Cells and Could be Inhibited by EGCG Through the TLR4 Signaling Pathway

(2022) Xiaoyun Shen et al.   RADIATION RESEARCH

AgNPs Aggravated Hepatic Steatosis, Inflammation, Oxidative Stress, and Epigenetic Changes in Mice With NAFLD Induced by HFD

(2022) Ling Wen et al.   Frontiers in Bioengineering and Biotechnology

Iron metabolism in non-alcoholic fatty liver disease: A promising therapeutic target

(2022) Hanqing Chen   Liver Research

Prognostic role of TLR4 and TLR2 in hepatocellular carcinoma

(2021) Valtteri Kairaluoma et al.   ACTA ONCOLOGICA

E7766, a Macrocycle‐Bridged Stimulator of Interferon Genes (STING) Agonist with Potent Pan‐Genotypic Activity

(2021) Dae‐Shik Kim et al.   ChemMedChem

Lactobacillus rhamnosus GG induces cGAS/STING- dependent type I interferon and improves response to immune checkpoint blockade

(2021) Wei Si et al.   GUT

Maintaining manganese in tumor to activate cGAS-STING pathway evokes a robust abscopal anti-tumor effect

(2021) Chao Wang et al.   JOURNAL OF CONTROLLED RELEASE

TLR9 in MAFLD and NASH: At the Intersection of Inflammation and Metabolism

(2021) Christopher R. Shepard   Frontiers in Endocrinology

Toll‐like receptor 5 and 8 in hepatocellular carcinoma

(2021) Valtteri Kairaluoma et al.   APMIS

Iron oxide nanoparticles aggravate hepatic steatosis and liver injury in nonalcoholic fatty liver disease through BMP-SMAD-mediated hepatic iron overload

(2021) Meilin Zhu et al.   Nanotoxicology

Toll-like receptor 1 as a possible target in non-alcoholic fatty liver disease

(2021) Anja Baumann et al.   Scientific Reports

Endotoxins and Non-Alcoholic Fatty Liver Disease

(2021) Takaomi Kessoku et al.   Frontiers in Endocrinology

MAFLD: A consensus-driven proposed nomenclature for metabolic associated fatty liver disease

(2020) Mohammed Eslam et al.   GASTROENTEROLOGY

TLR5 agonist entolimod reduces the adverse toxicity of TNF while preserving its antitumor effects

(2020) Gary J. Haderski et al.   PLoS One

Remdesivir attenuates high fat diet (HFD)-induced NAFLD by regulating hepatocyte dyslipidemia and inflammation via the suppression of STING

(2020) Yan-Ni Li et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

DNA sensing and associated type 1 interferon signaling contributes to progression of radiation-induced liver injury

(2020) Shisuo Du et al.   Cellular & Molecular Immunology

From NAFLD to MAFLD: when pathophysiology succeeds

(2020) Herbert Tilg et al.   Nature Reviews Gastroenterology & Hepatology

Hepatocyte mitochondria-derived danger signals directly activate hepatic stellate cells and drive progression of liver fibrosis

(2020) Ping An et al.   Nature Communications

Rapamycin-Loaded mPEG-PLGA Nanoparticles Ameliorate Hepatic Steatosis and Liver Injury in Non-alcoholic Fatty Liver Disease

(2020) Ruifang Zhao et al.   Frontiers in Chemistry

cGAS-STING, an important pathway in cancer immunotherapy

(2020) Minlin Jiang et al.   Journal of Hematology & Oncology

Hepatocellular carcinoma-derived high mobility group box 1 triggers M2 macrophage polarization via a TLR2/NOX2/autophagy axis

(2020) Dong-Jer Shiau et al.   Scientific Reports

Identification of prognostic biomarkers and correlations with immune infiltrates among cGAS-STING in hepatocellular carcinoma

(2020) Zhenhua Qi et al.   BIOSCIENCE REPORTS

cGAS-STING pathway in cancer biotherapy

(2020) Yang Wang et al.   Molecular Cancer

Hepatic stellate cells specific liposomes with the Toll‐like receptor 4 shRNA attenuates liver fibrosis

(2020) Yuwei Zhang et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Nanoparticle delivery improves the pharmacokinetic properties of cyclic dinucleotide STING agonists to open a therapeutic window for intravenous administration

(2020) Mohamed Wehbe et al.   JOURNAL OF CONTROLLED RELEASE

Autophagy induction via STING trafficking is a primordial function of the cGAS pathway

(2019) Xiang Gui et al.   NATURE

The cGAS-cGAMP-STING Pathway: A Molecular Link Between Immunity and Metabolism

(2019) Juli Bai et al.   DIABETES

From NASH to HCC: current concepts and future challenges

(2019) Quentin M. Anstee et al.   Nature Reviews Gastroenterology & Hepatology

TLR 4 increases the stemness and is highly expressed in relapsed human hepatocellular carcinoma

(2019) Shuang Zhou et al.   Cancer Medicine

The role of senescence in the development of non-alcoholic fatty liver disease and progression to non-alcoholic steatohepatitis

(2019) Alkistis-Maria Papatheodoridi et al.   HEPATOLOGY

Toll-like receptor 3 downregulation is an escape mechanism from apoptosis during hepatocarcinogenesis

(2019) Marc Bonnin et al.   JOURNAL OF HEPATOLOGY

DNA sensing by the cGAS–STING pathway in health and disease

(2019) Mona Motwani et al.   NATURE REVIEWS GENETICS

Prevalence, incidence, and outcome of non-alcoholic fatty liver disease in Asia, 1999–2019: a systematic review and meta-analysis

(2019) Jie Li et al.   Lancet Gastroenterology & Hepatology

Activation of the Toll‑like receptor 2 signaling pathway inhibits the proliferation of HCC cells in vitro

(2019) Yi Chen et al.   ONCOLOGY REPORTS

STING expression in monocyte-derived macrophages is associated with the progression of liver inflammation and fibrosis in patients with nonalcoholic fatty liver disease

(2019) Xiaoxiao Wang et al.   LABORATORY INVESTIGATION

The cGAS-STING pathway is a therapeutic target in a preclinical model of hepatocellular carcinoma

(2019) Martin K. Thomsen et al.   ONCOGENE

Interferon Receptor Signaling Pathways Regulating PD-L1 and PD-L2 Expression

(2019) Angel Garcia-Diaz et al.   Cell Reports

cGAS-mediated autophagy protects the liver from ischemia-reperfusion injury independently of STING

(2018) Zhao Lei et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

TBK1 at the Crossroads of Inflammation and Energy Homeostasis in Adipose Tissue

(2018) Peng Zhao et al.   CELL

Recent developments with immunotherapy for hepatocellular carcinoma

(2018) Oliver Waidmann   EXPERT OPINION ON BIOLOGICAL THERAPY

DEP domain-containing mTOR-interacting protein suppresses lipogenesis and ameliorates hepatic steatosis and acute-on-chronic liver injury in alcoholic liver disease

(2018) Hanqing Chen et al.   HEPATOLOGY

The cGAS–cGAMP–STING pathway connects DNA damage to inflammation, senescence, and cancer

(2018) Tuo Li et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Pharmacotherapy for NASH: Current and emerging

(2018) Monica A. Konerman et al.   JOURNAL OF HEPATOLOGY

Activation of the STING-IRF3 pathway promotes hepatocyte inflammation, apoptosis and induces metabolic disorders in nonalcoholic fatty liver disease

(2018) J.T. Qiao et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Triggering and resolution of inflammation in NASH

(2018) Susanne Schuster et al.   Nature Reviews Gastroenterology & Hepatology

Toll-Like Receptor-7 Signaling Promotes Nonalcoholic Steatohepatitis by Inhibiting Regulatory T Cells in Mice

(2018) Yoon Seok Roh et al.   AMERICAN JOURNAL OF PATHOLOGY

Mitochondrial inner membrane permeabilisation enables mtDNA release during apoptosis

(2018) Joel S Riley et al.   EMBO JOURNAL

Global Perspectives on Non-alcoholic Fatty Liver Disease and Non-alcoholic Steatohepatitis

(2018) Zobair Younossi et al.   HEPATOLOGY

Interferon-β signal may up-regulate PD-L1 expression through IRF9-dependent and independent pathways in lung cancer cells

(2018) Yoshie Morimoto et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Molecular pathways of nonalcoholic fatty liver disease development and progression

(2018) Fernando Bessone et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Expression of STING Is Increased in Liver Tissues From Patients With NAFLD and Promotes Macrophage-Mediated Hepatic Inflammation and Fibrosis in Mice

(2018) Xianjun Luo et al.   GASTROENTEROLOGY

STING-mediated inflammation in Kupffer cells contributes to progression of nonalcoholic steatohepatitis

(2018) Yongsheng Yu et al.   JOURNAL OF CLINICAL INVESTIGATION

Nonalcoholic Fatty Liver Disease

(2018) Irene Pierantonelli et al.   TRANSPLANTATION

The contribution of toll-like receptor signaling to the development of liver fibrosis and cancer in hepatocyte-specific TAK1-deleted mice

(2017) Isabelle Jingyi Song et al.   INTERNATIONAL JOURNAL OF CANCER

Cytoplasmic chromatin triggers inflammation in senescence and cancer

(2017) Zhixun Dou et al.   NATURE

Innate immune sensing of cytosolic chromatin fragments through cGAS promotes senescence

(2017) Selene Glück et al.   NATURE CELL BIOLOGY

Small molecule inhibition of cGAS reduces interferon expression in primary macrophages from autoimmune mice

(2017) Jessica Vincent et al.   Nature Communications

Progression and Natural History of Nonalcoholic Fatty Liver Disease in Adults

(2016) Andrea Marengo et al.   Clinics in Liver Disease

Innate Immunity and Inflammation in NAFLD/NASH

(2016) Marco Arrese et al.   DIGESTIVE DISEASES AND SCIENCES

Lack of immunological DNA sensing in hepatocytes facilitates hepatitis B virus infection

(2016) Martin K. Thomsen et al.   HEPATOLOGY

Global epidemiology of nonalcoholic fatty liver disease-Meta-analytic assessment of prevalence, incidence, and outcomes

(2016) Zobair M. Younossi et al.   HEPATOLOGY

Toll-like Receptor 4 on Macrophage Promotes the Development of Steatohepatitis-related Hepatocellular Carcinoma in Mice

(2016) Kouichi Miura et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Hepatocyte mitochondrial DNA drives nonalcoholic steatohepatitis by activation of TLR9

(2016) Irma Garcia-Martinez et al.   JOURNAL OF CLINICAL INVESTIGATION

Nucleic Acid-Targeting Pathways Promote Inflammation in Obesity-Related Insulin Resistance

(2016) Xavier S. Revelo et al.   Cell Reports

Mitochondrial DNA stress primes the antiviral innate immune response

(2015) A. Phillip West et al.   NATURE

TLR4 signaling promotes a COX-2/PGE2/STAT3 positive feedback loop in hepatocellular carcinoma (HCC) cells

(2015) Ang Lin et al.   OncoImmunology

Apoptotic Caspases Suppress mtDNA-Induced STING-Mediated Type I IFN Production

(2014) Michael J. White et al.   CELL

Cyclic [G(2′,5′)pA(3′,5′)p] Is the Metazoan Second Messenger Produced by DNA-Activated Cyclic GMP-AMP Synthase

(2013) Pu Gao et al.   CELL

Toll-like receptors and liver disease

(2013) Vivek Kesar et al.   LIVER INTERNATIONAL

Expression of toll-like receptors 1-5 but not TLR 6-10 is elevated in livers of patients with non-alcoholic fatty liver disease

(2013) Giridhar Kanuri et al.   LIVER INTERNATIONAL

cGAS produces a 2′-5′-linked cyclic dinucleotide second messenger that activates STING

(2013) Andrea Ablasser et al.   NATURE

The global NAFLD epidemic

(2013) Rohit Loomba et al.   Nature Reviews Gastroenterology & Hepatology

NAFLD, NASH and liver cancer

(2013) Gregory A. Michelotti et al.   Nature Reviews Gastroenterology & Hepatology

The association between Toll-like receptor 2 single-nucleotide polymorphisms and hepatocellular carcinoma susceptibility

(2012) Xie Junjie et al.   BMC CANCER

Toll-like receptor 2 and palmitic acid cooperatively contribute to the development of nonalcoholic steatohepatitis through inflammasome activation in mice

(2012) Kouichi Miura et al.   HEPATOLOGY

Increased hepatic expression of TLR2 and TLR4 in the hepatic inflammation-fibrosis-carcinoma sequence

(2012) João-Bruno Soares et al.   Innate Immunity

Cyclic GMP-AMP Synthase Is a Cytosolic DNA Sensor That Activates the Type I Interferon Pathway

(2012) L. Sun et al.   SCIENCE

Toll-like receptor-2 deficiency enhances non-alcoholic steatohepatitis

(2010) Chantal A Rivera et al.   BMC GASTROENTEROLOGY

Pattern Recognition Receptors and Inflammation

(2010) Osamu Takeuchi et al.   CELL

The incidence and risk factors of hepatocellular carcinoma in patients with nonalcoholic steatohepatitis

(2010) Mustafa S. Ascha et al.   HEPATOLOGY

Susceptibility to gut leakiness: a possible mechanism for endotoxaemia in non-alcoholic steatohepatitis

(2010) Ashkan Farhadi et al.   LIVER INTERNATIONAL

The Protein Kinase IKKɛ Regulates Energy Balance in Obese Mice

(2009) Shian-Huey Chiang et al.   CELL

Sensing pathogens and danger signals by the inflammasome

(2009) Joao HF Pedra et al.   CURRENT OPINION IN IMMUNOLOGY

Increased intestinal permeability and tight junction alterations in nonalcoholic fatty liver disease

(2009) Luca Miele et al.   HEPATOLOGY

Toll‐like receptors and adaptor molecules in liver disease: Update

(2008) Ekihiro Seki et al.   HEPATOLOGY

STING is an endoplasmic reticulum adaptor that facilitates innate immune signalling

(2008) Hiroki Ishikawa et al.   NATURE