Disrupted BRCA1‐PALB2 interaction induces tumor immunosuppression and T ‐lymphocyte infiltration in HCC through cGAS‐STING pathway

Hepatocellular carcinoma

(2021) Josep M. Llovet et al.   Nature Reviews Disease Primers

Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries

(2021) Hyuna Sung et al.   CA-A CANCER JOURNAL FOR CLINICIANS

TBK1 recruitment to STING activates both IRF3 and NF-κB that mediate immune defense against tumors and viral infections

(2021) Seoyun Yum et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Immunotherapy Updates in Advanced Hepatocellular Carcinoma

(2021) Amisha Singh et al.   Cancers

New insights into M1/M2 macrophages: key modulators in cancer progression

(2021) Jiuyang Liu et al.   Cancer Cell International

Microbiota triggers STING-type I IFN-dependent monocyte reprogramming of the tumor microenvironment

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Comprehensive elaboration of the cGAS-STING signaling axis in cancer development and immunotherapy

(2020) Juyan Zheng et al.   Molecular Cancer

MLH1 Deficiency-Triggered DNA Hyperexcision by Exonuclease 1 Activates the cGAS-STING Pathway

(2020) Junhong Guan et al.   CANCER CELL

The BRUCE-ATR Signaling Axis Is Required for Accurate DNA Replication and Suppression of Liver Cancer Development

(2019) Chunmin Ge et al.   HEPATOLOGY

Integrated Proteogenomic Characterization of HBV-Related Hepatocellular Carcinoma

(2019) Qiang Gao et al.   CELL

The cGAS-STING pathway is a therapeutic target in a preclinical model of hepatocellular carcinoma

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Pembrolizumab As Second-Line Therapy in Patients With Advanced Hepatocellular Carcinoma in KEYNOTE-240: A Randomized, Double-Blind, Phase III Trial

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The Cytosolic DNA-Sensing cGAS–STING Pathway in Cancer

(2019) John Kwon et al.   Cancer Discovery

Evidence of Intertissue Differences in the DNA Damage Response and the Pro-oncogenic Role of NF-κB in Mice with Disengaged BRCA1–PALB2 Interaction

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Immune checkpoint blockade therapy for cancer: An overview of FDA-approved immune checkpoint inhibitors

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The cGAS–cGAMP–STING pathway connects DNA damage to inflammation, senescence, and cancer

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Mechanisms of Oncogene-Induced Replication Stress: Jigsaw Falling into Place

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Oxidative DNA damage induced by ROS-modulating agents with the ability to target DNA: A comparison of the biological characteristics of citrus pectin and apple pectin

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ROS and the DNA damage response in cancer

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Impact of germline and somatic BRCA1/2 mutations: tumor spectrum and detection platforms

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Immune oncology in hepatocellular carcinoma—hype and hope

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Nivolumab in patients with advanced hepatocellular carcinoma (CheckMate 040): an open-label, non-comparative, phase 1/2 dose escalation and expansion trial

(2017) Anthony B El-Khoueiry et al.   LANCET

Lack of immunological DNA sensing in hepatocytes facilitates hepatitis B virus infection

(2016) Martin K. Thomsen et al.   HEPATOLOGY

Combination cancer immunotherapies tailored to the tumour microenvironment

(2015) Mark J. Smyth et al.   Nature Reviews Clinical Oncology

Genome-Derived Cytosolic DNA Mediates Type I Interferon-Dependent Rejection of B Cell Lymphoma Cells

(2015) Yu J. Shen et al.   Cell Reports

STAT1 Drives Tumor Progression in Serous Papillary Endometrial Cancer

(2014) B. Kharma et al.   CANCER RESEARCH

Male Fertility Defect Associated with Disrupted BRCA1-PALB2 Interaction in Mice

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Involvement of DNA Damage Response Pathways in Hepatocellular Carcinoma

(2014) Sheau-Fang Yang et al.   Biomed Research International

The degree of liver injury determines the role of p21 in liver regeneration and hepatocarcinogenesis in mice

(2013) Laura Elisa Buitrago-Molina et al.   HEPATOLOGY

Cyclic GMP-AMP Synthase Is a Cytosolic DNA Sensor That Activates the Type I Interferon Pathway

(2012) L. Sun et al.   SCIENCE

DNA damage induces reactive oxygen species generation through the H2AX-Nox1/Rac1 pathway

(2012) M A Kang et al.   Cell Death & Disease

PALB2 Links BRCA1 and BRCA2 in the DNA-Damage Response

(2009) Feng Zhang et al.   CURRENT BIOLOGY

PALB2 is an integral component of the BRCA complex required for homologous recombination repair

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