Hepatocellular carcinoma-derived high mobility group box 1 triggers M2 macrophage polarization via a TLR2/NOX2/autophagy axis

Tumor-derived exosomal HMGB1 promotes esophageal squamous cell carcinoma progression through inducing PD1+ TAM expansion

(2019) Bin Li et al.   Oncogenesis

How the phagocyte NADPH oxidase regulates innate immunity

(2018) David C. Thomas   FREE RADICAL BIOLOGY AND MEDICINE

Radiotherapy-induced cell death activates paracrine HMGB1-TLR2 signaling and accelerates pancreatic carcinoma metastasis

(2018) Xuelian Chen et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Rage induces hepatocellular carcinoma proliferation and sorafenib resistance by modulating autophagy

(2018) Jun Li et al.   Cell Death & Disease

Mitochondrial ROS-derived PTEN oxidation activates PI3K pathway for mTOR-induced myogenic autophagy

(2018) Jin-Hwan Kim et al.   CELL DEATH AND DIFFERENTIATION

INT-HA induces M2-like macrophage differentiation of human monocytes via TLR4-miR-935 pathway

(2018) Boke Zhang et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

NADPH oxidase NOX2 mediates TLR2/6-dependent release of GM-CSF from endothelial cells

(2017) Jutta Schuett et al.   FASEB JOURNAL

High-mobility group box 1 protein orchestrates responses to tissue damage via inflammation, innate and adaptive immunity, and tissue repair

(2017) Marco E. Bianchi et al.   IMMUNOLOGICAL REVIEWS

Mitochondrial ROS Production Protects the Intestine from Inflammation through Functional M2 Macrophage Polarization

(2017) Laura Formentini et al.   Cell Reports

NADPH Oxidases Are Essential for Macrophage Differentiation

(2016) Qing Xu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

An interaction between Scribble and the NADPH oxidase complex controls M1 macrophage polarization and function

(2016) Weiyue Zheng et al.   NATURE CELL BIOLOGY

Tumour hypoxia promotes melanoma growth and metastasis via High Mobility Group Box-1 and M2-like macrophages

(2016) Roman Huber et al.   Scientific Reports

Reactive oxygen species in the tumor niche triggers altered activation of macrophages and immunosuppression: Role of fluoxetine

(2015) Sayan Ghosh et al.   CELLULAR SIGNALLING

The Role of HMGB1 Signaling Pathway in the Development and Progression of Hepatocellular Carcinoma: A Review

(2015) Xuanbin Wang et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Autophagy-mediated HMGB1 release promotes gastric cancer cell survival via RAGE activation of extracellular signal-regulated kinases 1/2

(2015) QIU-YU ZHANG et al.   ONCOLOGY REPORTS

Lipoteichoic Acid Induces HO-1 Expression via the TLR2/MyD88/c-Src/NADPH Oxidase Pathway and Nrf2 in Human Tracheal Smooth Muscle Cells

(2014) I.-T. Lee et al.   JOURNAL OF IMMUNOLOGY

Heat Shock Protein 70, Released from Heat-Stressed Tumor Cells, Initiates Antitumor Immunity by Inducing Tumor Cell Chemokine Production and Activating Dendritic Cells via TLR4 Pathway

(2014) T. Chen et al.   JOURNAL OF IMMUNOLOGY

TLR9 Signaling in the Tumor Microenvironment Initiates Cancer Recurrence after Radiotherapy

(2013) C. Gao et al.   CANCER RESEARCH

ROS play a critical role in the differentiation of alternatively activated macrophages and the occurrence of tumor-associated macrophages

(2013) Yan Zhang et al.   CELL RESEARCH

Toll-like Receptor 2 Mediates Peripheral Nerve Injury-induced NADPH Oxidase 2 Expression in Spinal Cord Microglia

(2013) Hyoungsub Lim et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The many faces of HMGB1: molecular structure-functional activity in inflammation, apoptosis, and chemotaxis

(2013) Huan Yang et al.   JOURNAL OF LEUKOCYTE BIOLOGY

CLEC4F Is an Inducible C-Type Lectin in F4/80-Positive Cells and Is Involved in Alpha-Galactosylceramide Presentation in Liver

(2013) Chih-Ya Yang et al.   PLoS One

TLR2-dependent selective autophagy regulates NF-κB lysosomal degradation in hepatoma-derived M2 macrophage differentiation

(2012) C-P Chang et al.   CELL DEATH AND DIFFERENTIATION

Metabolic regulation by HMGB1-mediated autophagy and mitophagy

(2011) Rui Kang et al.   Autophagy

High-Mobility Group Box 1 Is Essential for Mitochondrial Quality Control

(2011) Daolin Tang et al.   Cell Metabolism

High-mobility Group Box 1 is Associated with Clinicopathologic Features in Patients with Hepatocellular Carcinoma

(2011) Wei Jiang et al.   PATHOLOGY & ONCOLOGY RESEARCH

Different Tumor Microenvironments Contain Functionally Distinct Subsets of Macrophages Derived from Ly6C(high) Monocytes

(2010) K. Movahedi et al.   CANCER RESEARCH

Endogenous HMGB1 regulates autophagy

(2010) Daolin Tang et al.   JOURNAL OF CELL BIOLOGY

Membrane-associated Hsp72 from tumor-derived exosomes mediates STAT3-dependent immunosuppressive function of mouse and human myeloid-derived suppressor cells

(2010) Fanny Chalmin et al.   JOURNAL OF CLINICAL INVESTIGATION

Increased intratumoral regulatory T cells are related to intratumoral macrophages and poor prognosis in hepatocellular carcinoma patients

(2009) Jia Zhou et al.   INTERNATIONAL JOURNAL OF CANCER

NADPH Oxidase 2 Interaction with TLR2 Is Required for Efficient Innate Immune Responses to Mycobacteria via Cathelicidin Expression

(2009) C.-S. Yang et al.   JOURNAL OF IMMUNOLOGY

Mechanism Regulating Reactive Oxygen Species in Tumor-Induced Myeloid-Derived Suppressor Cells

(2009) C. A. Corzo et al.   JOURNAL OF IMMUNOLOGY

Tumor-associated macrophages (TAM) as major players of the cancer-related inflammation

(2009) G. Solinas et al.   JOURNAL OF LEUKOCYTE BIOLOGY

The expression of HMGB1 protein and its receptor RAGE in human malignant tumors

(2009) Nora Kostova et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Carcinoma-produced factors activate myeloid cells through TLR2 to stimulate metastasis

(2009) Sunhwa Kim et al.   NATURE

Serum high mobility group box chromosomal protein 1 is associated with clinicopathologic features in patients with hepatocellular carcinoma

(2008) B.-Q. Cheng et al.   DIGESTIVE AND LIVER DISEASE

Cancer-related inflammation

(2008) Alberto Mantovani et al.   NATURE