Reactive oxygen species formation and its effect on CD4+ T cell-mediated inflammation

Microbiota imbalance induced by dietary sugar disrupts immune-mediated protection from metabolic syndrome

(2022) Yoshinaga Kawano et al.   CELL

Metabolic Disturbance and Th17/Treg Imbalance Are Associated With Progression of Gingivitis

(2021) Weijie Wang et al.   Frontiers in Immunology

Treg Heterogeneity, Function, and Homeostasis

(2020) Daniil Shevyrev et al.   Frontiers in Immunology

In Vivo CD4+ T Cell Differentiation and Function: Revisiting the Th1/Th2 Paradigm

(2020) Mikel Ruterbusch et al.   Annual Review of Immunology

Reactive oxygen species (ROS) as pleiotropic physiological signalling agents

(2020) Helmut Sies et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Mitochondrial complex III is essential for suppressive function of regulatory T cells

(2019) Samuel E. Weinberg et al.   NATURE

Oxidative Insults and Mitochondrial DNA Mutation Promote Enhanced Autophagy and Mitophagy Compromising Cell Viability in Pluripotent Cell Model of Mitochondrial Disease

(2019) Dar-Shong Lin et al.   Cells

Human FOXP3+ Regulatory T Cell Heterogeneity and Function in Autoimmunity and Cancer

(2019) James B. Wing et al.   IMMUNITY

The pathogenicity of Th17 cells in autoimmune diseases

(2019) Keiko Yasuda et al.   Seminars in Immunopathology

Treg cells in autoimmunity: from identification to Treg-based therapies

(2019) Lisa Göschl et al.   Seminars in Immunopathology

High Glucose Intake Exacerbates Autoimmunity through Reactive-Oxygen-Species-Mediated TGF-β Cytokine Activation

(2019) Dunfang Zhang et al.   IMMUNITY

Glycerol phosphate shuttle enzyme GPD2 regulates macrophage inflammatory responses

(2019) P. Kent Langston et al.   NATURE IMMUNOLOGY

The Metabolic Requirements of Th2 Cell Differentiation

(2019) Julian M. Stark et al.   Frontiers in Immunology

Biochemical basis and metabolic interplay of redox regulation

(2019) Lixiao Zhang et al.   Redox Biology

Detection, identification, and quantification of oxidative protein modifications

(2019) Clare L. Hawkins et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Metabolic Control of Treg Cell Stability, Plasticity, and Tissue-Specific Heterogeneity

(2019) Hao Shi et al.   Frontiers in Immunology

Biological Production, Detection, and Fate of Hydrogen Peroxide

(2018) Christine C. Winterbourn   ANTIOXIDANTS & REDOX SIGNALING

Reactive Oxygen Species in Metabolic and Inflammatory Signaling

(2018) Steven J. Forrester et al.   CIRCULATION RESEARCH

Redox Regulation Beyond ROS

(2018) Ralf P. Brandes et al.   CIRCULATION RESEARCH

Cytochrome P450 Structure, Function and Clinical Significance: A Review

(2018) Palrasu Manikandan et al.   CURRENT DRUG TARGETS

Proanthocyanidins: novel treatment for psoriasis that reduces oxidative stress and modulates Th17 and Treg cells

(2018) Rui Lai et al.   REDOX REPORT

Long-term antigen exposure irreversibly modifies metabolic requirements for T cell function

(2018) Marie Bettonville et al.   eLife

Metabolic Reprogramming in Modulating T Cell Reactive Oxygen Species Generation and Antioxidant Capacity

(2018) Josephin N. Rashida Gnanaprakasam et al.   Frontiers in Immunology

Foxp3+ T Regulatory Cells: Still Many Unanswered Questions—A Perspective After 20 Years of Study

(2018) Ethan M. Shevach   Frontiers in Immunology

Structure of the insulin receptor–insulin complex by single-particle cryo-EM analysis

(2018) Giovanna Scapin et al.   NATURE

Unexpected function of the phagocyte NADPH oxidase in supporting hyperglycolysis in stimulated neutrophils: key role of 6-phosphofructo-2-kinase

(2017) Athan Baillet et al.   FASEB JOURNAL

Pharmacological modulation of reactive oxygen species (ROS) improves the airway hyperresponsiveness by shifting the Th1 response in allergic inflammation induced by ovalbumin

(2017) Renata Tiscoski Nesi et al.   FREE RADICAL RESEARCH

Increased lipid and protein oxidation and lowered anti-oxidant defenses in systemic lupus erythematosus are associated with severity of illness, autoimmunity, increased adhesion molecules, and Th1 and Th17 immune shift

(2017) Bruna Miglioranza Scavuzzi et al.   IMMUNOLOGIC RESEARCH

Suppression of Th17 cell differentiation by misshapen/NIK-related kinase MINK1

(2017) Guotong Fu et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Therapeutic Potential of Targeting the Th17/Treg Axis in Autoimmune Disorders

(2017) Patrizia Fasching et al.   MOLECULES

Oxidative stress and male infertility

(2017) Shilpa Bisht et al.   Nature Reviews Urology

Metabolic pathways as possible therapeutic targets for progressive multiple sclerosis

(2017) StevenM LeVine et al.   Neural Regeneration Research

Reactive oxygen species-driven HIF1α triggers accelerated glycolysis in endothelial cells exposed to low oxygen tension

(2017) Jin-Young Paik et al.   NUCLEAR MEDICINE AND BIOLOGY

Cellular and Molecular Dynamics of Th17 Differentiation and its Developmental Plasticity in the Intestinal Immune Response

(2017) Suniti Bhaumik et al.   Frontiers in Immunology

T Cell-Mediated Beta Cell Destruction: Autoimmunity and Alloimmunity in the Context of Type 1 Diabetes

(2017) Adam L. Burrack et al.   Frontiers in Endocrinology

Succinate Dehydrogenase Supports Metabolic Repurposing of Mitochondria to Drive Inflammatory Macrophages

(2016) Evanna L. Mills et al.   CELL

2-Oxoglutarate dehydrogenase is a more significant source of O 2 ·− /H 2 O 2 than pyruvate dehydrogenase in cardiac and liver tissue

(2016) Ryan J. Mailloux et al.   FREE RADICAL BIOLOGY AND MEDICINE

MicroRNA-23a Curbs Necrosis during Early T Cell Activation by Enforcing Intracellular Reactive Oxygen Species Equilibrium

(2016) Baojun Zhang et al.   IMMUNITY

Role of ROS and RNS Sources in Physiological and Pathological Conditions

(2016) Sergio Di Meo et al.   Oxidative Medicine and Cellular Longevity

Aerobic glycolysis promotes T helper 1 cell differentiation through an epigenetic mechanism

(2016) M. Peng et al.   SCIENCE

Mast cells and IgE in defense against venoms: Possible “good side” of allergy?

(2016) Stephen J. Galli et al.   ALLERGOLOGY INTERNATIONAL

CD4 T cell differentiation in type 1 diabetes

(2015) L. S. K. Walker et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

ROS-dependent signal transduction

(2015) Colleen R Reczek et al.   CURRENT OPINION IN CELL BIOLOGY

ATM functions at the peroxisome to induce pexophagy in response to ROS

(2015) Jiangwei Zhang et al.   NATURE CELL BIOLOGY

The immunology of asthma

(2015) Bart N Lambrecht et al.   NATURE IMMUNOLOGY

Endoplasmic Reticulum Stress and Oxidative Stress in Cell Fate Decision and Human Disease

(2014) Stewart Siyan Cao et al.   ANTIOXIDANTS & REDOX SIGNALING

TCR-triggered extracellular superoxide production is not required for T-cell activation

(2014) Aleksey V Belikov et al.   Cell Communication and Signaling

The Glucose Transporter Glut1 Is Selectively Essential for CD4 T Cell Activation and Effector Function

(2014) Andrew N. Macintyre et al.   Cell Metabolism

NADPH oxidases: an overview from structure to innate immunity-associated pathologies

(2014) Arvind Panday et al.   Cellular & Molecular Immunology

Regulatory T Cells Control Antigen-Specific Expansion of Tfh Cell Number and Humoral Immune Responses via the Coreceptor CTLA-4

(2014) James Badger Wing et al.   IMMUNITY

Role of Metabolic H2O2Generation

(2014) Helmut Sies   JOURNAL OF BIOLOGICAL CHEMISTRY

The 2-Oxoacid Dehydrogenase Complexes in Mitochondria Can Produce Superoxide/Hydrogen Peroxide at Much Higher Rates Than Complex I

(2014) Casey L. Quinlan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Follicular helper T cell signature in type 1 diabetes

(2014) Rupert Kenefeck et al.   JOURNAL OF CLINICAL INVESTIGATION

Transplantation Survival Is Maintained by Granzyme B+ Regulatory Cells and Adaptive Regulatory T Cells

(2014) D. C. Gondek et al.   JOURNAL OF IMMUNOLOGY

The Glutathione System: A New Drug Target in Neuroimmune Disorders

(2014) Gerwyn Morris et al.   MOLECULAR NEUROBIOLOGY

Ischaemic accumulation of succinate controls reperfusion injury through mitochondrial ROS

(2014) Edward T. Chouchani et al.   NATURE

De novo fatty acid synthesis controls the fate between regulatory T and T helper 17 cells

(2014) Luciana Berod et al.   NATURE MEDICINE

Cellular mechanisms and physiological consequences of redox-dependent signalling

(2014) Kira M. Holmström et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

T cell responses: naïve to memory and everything in between

(2013) Nathan D. Pennock et al.   ADVANCES IN PHYSIOLOGY EDUCATION

Metabolic Regulation of T Lymphocytes

(2013) Nancie J. MacIver et al.   Annual Review of Immunology

Mitochondria as Oxidative Signaling Organelles in T-cell Activation: Physiological Role and Pathological Implications

(2013) Marcin M. Kamiński et al.   ARCHIVUM IMMUNOLOGIAE ET THERAPIAE EXPERIMENTALIS

Posttranscriptional Control of T Cell Effector Function by Aerobic Glycolysis

(2013) Chih-Hao Chang et al.   CELL

Inhibitors of ROS production by the ubiquinone-binding site of mitochondrial complex I identified by chemical screening

(2013) Adam L. Orr et al.   FREE RADICAL BIOLOGY AND MEDICINE

Mitochondria Are Required for Antigen-Specific T Cell Activation through Reactive Oxygen Species Signaling

(2013) Laura A. Sena et al.   IMMUNITY

Mitochondrial ROS Fire Up T Cell Activation

(2013) Michael P. Murphy et al.   IMMUNITY

Treg and CTLA-4: Two intertwining pathways to immune tolerance

(2013) Lucy S.K. Walker   JOURNAL OF AUTOIMMUNITY

Peroxynitrite, a Stealthy Biological Oxidant

(2013) Rafael Radi   JOURNAL OF BIOLOGICAL CHEMISTRY

Sodium chloride drives autoimmune disease by the induction of pathogenic TH17 cells

(2013) Markus Kleinewietfeld et al.   NATURE

Control of amino-acid transport by antigen receptors coordinates the metabolic reprogramming essential for T cell differentiation

(2013) Linda V Sinclair et al.   NATURE IMMUNOLOGY

Physiological Phenotype and Vulnerability in Parkinson's Disease

(2013) D. J. Surmeier et al.   Cold Spring Harbor Perspectives in Medicine

Sites of reactive oxygen species generation by mitochondria oxidizing different substrates

(2013) Casey L. Quinlan et al.   Redox Biology

Superoxide generation by complex III: From mechanistic rationales to functional consequences

(2012) Lea Bleier et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

CD4+T Cells: Differentiation and Functions

(2012) Rishi Vishal Luckheeram et al.   Clinical & Developmental Immunology

Hyperactivity of the Ero1α Oxidase Elicits Endoplasmic Reticulum Stress but No Broad Antioxidant Response

(2012) Henning Gram Hansen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mitochondrial Complex II Can Generate Reactive Oxygen Species at High Rates in Both the Forward and Reverse Reactions

(2012) Casey L. Quinlan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Enhanced Th17 Differentiation and Aggravated Arthritis in IEX-1-Deficient Mice by Mitochondrial Reactive Oxygen Species-Mediated Signaling

(2012) L. Zhi et al.   JOURNAL OF IMMUNOLOGY

T cell populations in the pancreatic lymph node naturally and consistently expand and contract in NOD mice as disease progresses

(2012) Idania Marrero et al.   MOLECULAR IMMUNOLOGY

A multiply redundant genetic switch 'locks in' the transcriptional signature of regulatory T cells

(2012) Wenxian Fu et al.   NATURE IMMUNOLOGY

Transcription factor Foxp3 and its protein partners form a complex regulatory network

(2012) Dipayan Rudra et al.   NATURE IMMUNOLOGY

Experimental autoimmune encephalomyelitis (EAE) as a model for multiple sclerosis (MS)

(2011) Cris S Constantinescu et al.   BRITISH JOURNAL OF PHARMACOLOGY

Redox regulation of calcium ion channels: Chemical and physiological aspects

(2011) Ivan Bogeski et al.   CELL CALCIUM

Unraveling the Biological Roles of Reactive Oxygen Species

(2011) Michael P. Murphy et al.   Cell Metabolism

Mitochondrial Complex III ROS Regulate Adipocyte Differentiation

(2011) Kathryn V. Tormos et al.   Cell Metabolism

The Transcription Factor Myc Controls Metabolic Reprogramming upon T Lymphocyte Activation

(2011) Ruoning Wang et al.   IMMUNITY

Peroxiredoxin Functions as a Peroxidase and a Regulator and Sensor of Local Peroxides

(2011) Sue Goo Rhee et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

HIF1α–dependent glycolytic pathway orchestrates a metabolic checkpoint for the differentiation of TH17 and Tregcells

(2011) Lewis Z. Shi et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Cutting Edge: Distinct Glycolytic and Lipid Oxidative Metabolic Programs Are Essential for Effector and Regulatory CD4+ T Cell Subsets

(2011) R. D. Michalek et al.   JOURNAL OF IMMUNOLOGY

Estrogen-related receptor-  is a metabolic regulator of effector T-cell activation and differentiation

(2011) R. D. Michalek et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Two modes of immune suppression by Foxp3+ regulatory T cells under inflammatory or non-inflammatory conditions

(2011) Tomoyuki Yamaguchi et al.   SEMINARS IN IMMUNOLOGY

Differentiation of Effector CD4 T Cell Populations

(2010) Jinfang Zhu et al.   Annual Review of Immunology

Signaling Functions of Reactive Oxygen Species

(2010) Henry Jay Forman et al.   BIOCHEMISTRY

Th17 and Regulatory T Cells in Mediating and Restraining Inflammation

(2010) Dan R. Littman et al.   CELL

Metabolism in T cell activation and differentiation

(2010) Erika L Pearce   CURRENT OPINION IN IMMUNOLOGY

Recycling of peroxiredoxin IV provides a novel pathway for disulphide formation in the endoplasmic reticulum

(2010) Timothy J Tavender et al.   EMBO JOURNAL

Mammalian Target of Rapamycin Protein Complex 2 Regulates Differentiation of Th1 and Th2 Cell Subsets via Distinct Signaling Pathways

(2010) Keunwook Lee et al.   IMMUNITY

Mitochondrial Reactive Oxygen Species Control T Cell Activation by Regulating IL-2 and IL-4 Expression: Mechanism of Ciprofloxacin-Mediated Immunosuppression

(2010) M. M. Kaminski et al.   JOURNAL OF IMMUNOLOGY

Glutamine Uptake and Metabolism Are Coordinately Regulated by ERK/MAPK during T Lymphocyte Activation

(2010) E. L. Carr et al.   JOURNAL OF IMMUNOLOGY

Mitochondrial metabolism and ROS generation are essential for Kras-mediated tumorigenicity

(2010) F. Weinberg et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Nonphagocytic NADPH Oxidase Duox1 Mediates a Positive Feedback Loop During T Cell Receptor Signaling

(2010) J. Kwon et al.   Science Signaling

Role of Hydrogen Peroxide in NF-κB Activation: From Inducer to Modulator

(2009) Virgínia Oliveira-Marques et al.   ANTIOXIDANTS & REDOX SIGNALING

Reactive oxygen species and peroxisomes: Struggling for balance

(2009) Nina A. Bonekamp et al.   BIOFACTORS

The roles of IL-17A in inflammatory immune responses and host defense against pathogens

(2009) Yoichiro Iwakura et al.   IMMUNOLOGICAL REVIEWS

ORAI1 and STIM1 deficiency in human and mice: roles of store-operated Ca2+entry in the immune system and beyond

(2009) Stefan Feske   IMMUNOLOGICAL REVIEWS

Enhancing CD8 T-cell memory by modulating fatty acid metabolism

(2009) Erika L. Pearce et al.   NATURE

High efficiency of ROS production by glycerophosphate dehydrogenase in mammalian mitochondria

(2008) Tomáš Mráček et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

How mitochondria produce reactive oxygen species

(2008) Michael P. Murphy   BIOCHEMICAL JOURNAL

The Biology of Cancer: Metabolic Reprogramming Fuels Cell Growth and Proliferation

(2008) Ralph J. DeBerardinis et al.   Cell Metabolism

CTLA-4 Control over Foxp3+ Regulatory T Cell Function

(2008) K. Wing et al.   SCIENCE

New drugs targeting Th2 lymphocytes in asthma

(2008) Gaetano Caramori et al.   Journal of Occupational Medicine and Toxicology

Oxidative microenvironment exerts an opposite regulatory effect on cytokine production by Th1 and Th2 cells

(2007) Barbara Frossi et al.   MOLECULAR IMMUNOLOGY