Oxidative Insults and Mitochondrial DNA Mutation Promote Enhanced Autophagy and Mitophagy Compromising Cell Viability in Pluripotent Cell Model of Mitochondrial Disease

Mitochondrial Stasis Reveals p62-Mediated Ubiquitination in Parkin-Independent Mitophagy and Mitigates Nonalcoholic Fatty Liver Disease

(2018) Tatsuya Yamada et al.   Cell Metabolism

Cytochrome c oxidase deficiency, oxidative stress, possible antioxidant therapy and link to nuclear DNA damage

(2018) Liza Douiev et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

Emerging molecular mechanisms in chemotherapy: Ca2+ signaling at the mitochondria-associated endoplasmic reticulum membranes

(2018) Martijn Kerkhofs et al.   Cell Death & Disease

HUWE1 E3 ligase promotes PINK1/PARKIN-independent mitophagy by regulating AMBRA1 activation via IKKα

(2018) Anthea Di Rita et al.   Nature Communications

Calcium/calmodulin-dependent protein kinase regulates the PINK1/Parkin and DJ-1 pathways of mitophagy during sepsis

(2017) Xianghong Zhang et al.   FASEB JOURNAL

Cell Biology of the Mitochondrion

(2017) Alexander M. van der Bliek et al.   GENETICS

Monitoring and Measuring Autophagy

(2017) Saori R. Yoshii et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Accumulation of autophagosomes confers cytotoxicity

(2017) Robert W. Button et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Inflexibility of AMPK-mediated metabolic reprogramming in mitochondrial disease

(2017) Dar-Shong Lin et al.   Oncotarget

Cell Biology of the Mitochondrion

(2017) Alexander M. van der Bliek et al.   GENETICS

Mitochondrial quality control: Cell-type-dependent responses to pathological mutant mitochondrial DNA

(2016) Adriana Malena et al.   Autophagy

Intracellular pH Modulates Autophagy and Mitophagy

(2016) Alexey V. Berezhnov et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Clinical Phenotype and Segregation of Mitochondrial 3243A>G Mutation in 2 Pairs of Monozygotic Twins

(2016) Kengo Maeda et al.   JAMA Neurology

Critical role of AMP-activated protein kinase in the balance between mitophagy and mitochondrial biogenesis in MELAS disease

(2015) Juan Garrido-Maraver et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Membrane dynamics in autophagosome biogenesis

(2015) S. R. Carlsson et al.   JOURNAL OF CELL SCIENCE

Metabolic rescue in pluripotent cells from patients with mtDNA disease

(2015) Hong Ma et al.   NATURE

Impaired respiratory function in MELAS-induced pluripotent stem cells with high heteroplasmy levels

(2015) Masaki Kodaira et al.   FEBS Open Bio

Bulk autophagy, but not mitophagy, is increased in cellular model of mitochondrial disease

(2014) María Morán et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Mitochondrial Staining Allows Robust Elimination of Apoptotic and Damaged Cells during Cell Sorting

(2014) Natasha S. Barteneva et al.   JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY

Progressive increase in mtDNA 3243A>G heteroplasmy causes abrupt transcriptional reprogramming

(2014) M. Picard et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The m.3243A>G mitochondrial DNA mutation and related phenotypes. A matter of gender?

(2013) Michelangelo Mancuso et al.   JOURNAL OF NEUROLOGY

A novel image-based cytometry method for autophagy detection in living cells

(2012) Leo Li-Ying Chan et al.   Autophagy

Screening of effective pharmacological treatments for MELAS syndrome using yeasts, fibroblasts and cybrid models of the disease

(2012) Juan Garrido-Maraver et al.   BRITISH JOURNAL OF PHARMACOLOGY

Mutant Twinkle increases dopaminergic neurodegeneration, mtDNA deletions and modulates Parkin expression

(2012) Lanying Song et al.   HUMAN MOLECULAR GENETICS

Autophagy, mitochondria and oxidative stress: cross-talk and redox signalling

(2011) Jisun Lee et al.   BIOCHEMICAL JOURNAL

Secondary coenzyme Q10 deficiency triggers mitochondria degradation by mitophagy in MELAS fibroblasts

(2011) David Cotán et al.   FASEB JOURNAL

Mitochondrial autophagy in cells with mtDNA mutations results from synergistic loss of transmembrane potential and mTORC1 inhibition

(2011) Robert W. Gilkerson et al.   HUMAN MOLECULAR GENETICS

The AMPK signalling pathway coordinates cell growth, autophagy and metabolism

(2011) Maria M. Mihaylova et al.   NATURE CELL BIOLOGY

Mitochondrial bioenergetics and dynamics interplay in complex I-deficient fibroblasts

(2010) M. Morán et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Bioenergetics of neurons inhibit the translocation response of Parkin following rapid mitochondrial depolarization

(2010) Victor S. Van Laar et al.   HUMAN MOLECULAR GENETICS

Cellular pathophysiological consequences of BCS1L mutations in mitochondrial complex III enzyme deficiency

(2010) María Morán et al.   HUMAN MUTATION

Parkin overexpression selects against a deleterious mtDNA mutation in heteroplasmic cybrid cells

(2010) D.-F. Suen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Genetic background influences mitochondrial function: modeling mitochondrial disease for therapeutic development

(2010) Paule Bénit et al.   TRENDS IN MOLECULAR MEDICINE

The A3243G tRNALeu(UUR) MELAS mutation causes amino acid misincorporation and a combined respiratory chain assembly defect partially suppressed by overexpression of EFTu and EFG2

(2008) F. Sasarman et al.   HUMAN MOLECULAR GENETICS