Therapy-resistant breast cancer in focus: Clinically relevant mitigation by flavonoids targeting cancer stem cells

Plant flavonoids: Classification, distribution, biosynthesis, and antioxidant activity

(2022) Nan Shen et al.   FOOD CHEMISTRY

Kaempferol and Apigenin suppresses the stemness properties of TNBC cells by modulating Sirtuins

(2022) Abhilasha Sharma et al.   MOLECULAR DIVERSITY

Deregulation of the CD44-NANOG-MDR1 associated chemoresistance pathways of breast cancer stem cells potentiates the anti-cancer effect of Kaempferol in synergism with Verapamil

(2022) Sourav Kumar Nandi et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Anti-breast cancer effects of phytochemicals: primary, secondary, and tertiary care

(2022) Alena Mazurakova et al.   EPMA Journal

Mitochondrial health quality control: measurements and interpretation in the framework of predictive, preventive, and personalized medicine

(2022) Lenka Koklesova et al.   EPMA Journal

Flavonoids exert potential in the management of hypertensive disorders in pregnancy

(2022) Alena Mazurakova et al.   Pregnancy Hypertension-An International Journal of Womens Cardiovascular Health

Anti-prostate cancer protection and therapy in the framework of predictive, preventive and personalised medicine — comprehensive effects of phytochemicals in primary, secondary and tertiary care

(2022) Alena Mazurakova et al.   EPMA Journal

Kaempferol attenuates viability of ex-vivo cultured post-NACT breast tumor explants through downregulation of p53 induced stemness, inflammation and apoptosis evasion pathways

(2022) Sourav Kumar Nandi et al.   PATHOLOGY RESEARCH AND PRACTICE

Evaluation of Wound Healing and Anti-Inflammatory Activity of Hydroalcoholic Leaf Extract of Clematis simensis Fresen (Ranunculaceae)

(2022) Nathnael Teshome et al.   Clinical Cosmetic and Investigational Dermatology

Soy isoflavones decrease fibroglandular breast tissue measured by magnetic resonance imaging in premenopausal women: a 2-year randomized double-blind placebo controlled clinical trial

(2022) Lee-Jane W. Lu et al.   Clinical Nutrition ESPEN

SOX2-high cancer cells exhibit an aggressive phenotype, with increases in stemness, proliferation and invasion, as well as higher metabolic activity and ATP production

(2022) Marta Mauro-Lizcano et al.   Aging-US

Current and future burden of breast cancer: Global statistics for 2020 and 2040

(2022) Melina Arnold et al.   BREAST

Epidemiology of Triple-Negative Breast Cancer

(2021) Frederick M. Howard et al.   CANCER JOURNAL

Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries

(2021) Hyuna Sung et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Lipid tethering of breast tumor cells reduces cell aggregation during mammosphere formation

(2021) Lekhana Bhandary et al.   Scientific Reports

Ampelopsin Inhibits Cell Proliferation and Induces Apoptosis in HL60 and K562 Leukemia Cells by Downregulating AKT and NF-κB Signaling Pathways

(2021) Jang Mi Han et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Xanthohumol for Human Malignancies: Chemistry, Pharmacokinetics and Molecular Targets

(2021) Vancha Harish et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Flavonoids as an effective sensitizer for anti-cancer therapy: insights into multi-faceted mechanisms and applicability towards individualized patient profiles

(2021) Alena Liskova et al.   EPMA Journal

Nrf2 inhibition sensitizes breast cancer stem cells to ionizing radiation via suppressing DNA repair

(2021) Shenghui Qin et al.   FREE RADICAL BIOLOGY AND MEDICINE

Protective Effects of Flavonoids Against Mitochondriopathies and Associated Pathologies: Focus on the Predictive Approach and Personalized Prevention

(2021) Lenka Koklesova et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Cripto-1 as a Key Factor in Tumor Progression, Epithelial to Mesenchymal Transition and Cancer Stem Cells

(2021) Hilal Arnouk et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Genistein: An Integrative Overview of Its Mode of Action, Pharmacological Properties, and Health Benefits

(2021) Javad Sharifi-Rad et al.   Oxidative Medicine and Cellular Longevity

Mammospheres of letrozole-resistant breast cancer cells enhance breast cancer aggressiveness

(2021) Jankiben Patel et al.   Oncology Letters

Caution, “normal” BMI: health risks associated with potentially masked individual underweight—EPMA Position Paper 2021

(2021) Olga Golubnitschaja et al.   EPMA Journal

Chalcone Derivatives: Role in Anticancer Therapy

(2021) Yang Ouyang et al.   Biomolecules

Ampelopsin Suppresses Stem Cell Properties Accompanied by Attenuation of Oxidative Phosphorylation in Chemo- and Radio-Resistant MDA-MB-231 Breast Cancer Cells

(2021) Vi Nguyen-Phuong Truong et al.   Pharmaceuticals

Luteolin Inhibits Breast Cancer Stemness and Enhances Chemosensitivity through the Nrf2-Mediated Pathway

(2021) Kuen-Jang Tsai et al.   MOLECULES

Flavonoids against non-physiologic inflammation attributed to cancer initiation, development, and progression—3PM pathways

(2021) Peter Kubatka et al.   EPMA Journal

Suppressive role of Viola odorata extract on malignant characters of mammosphere-derived breast cancer stem cells

(2020) S. Yousefnia et al.   Clinical & Translational Oncology

Dietary phytochemicals as the potential protectors against carcinogenesis and their role in cancer chemoprevention

(2020) Alena Liskova et al.   CLINICAL AND EXPERIMENTAL MEDICINE

Polyphenols Extracted from Artemisia annua L. Exhibit Anti-Cancer Effects on Radio-Resistant MDA-MB-231 Human Breast Cancer Cells by Suppressing Stem Cell Phenotype, β-Catenin, and MMP-9

(2020) Young Shin Ko et al.   MOLECULES

Hexane Extract of Garcinia quaesita Fruits Induces Apoptosis in Breast Cancer Stem Cells Isolated from Triple Negative Breast Cancer Cell Line MDA-MB-231

(2020) Varuni Colamba Pathiranage et al.   NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL

Advanced High-Content-Screening Applications of Clonogenicity in Cancer

(2020) Hector Esquer et al.   SLAS Discovery

Therapeutic Potential of Quercetin: New Insights and Perspectives for Human Health

(2020) Bahare Salehi et al.   ACS Omega

Cardamonin: A new player to fight cancer via multiple cancer signaling pathways

(2020) Javaria Nawaz et al.   LIFE SCIENCES

Chalcone hybrids as potential anticancer agents: Current development, mechanism of action, and structure‐activity relationship

(2020) Feng Gao et al.   MEDICINAL RESEARCH REVIEWS

Flavonoids in Cancer Metastasis

(2020) Alena Liskova et al.   Cancers

Optimal multiparametric set-up modelled for best survival outcomes in palliative treatment of liver malignancies: unsupervised machine learning and 3 PM recommendations

(2020) Elisha Goldstein et al.   EPMA Journal

Implications of flavonoids as potential modulators of cancer neovascularity

(2020) Alena Liskova et al.   JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY

Rhus coriaria L. (Sumac) Demonstrates Oncostatic Activity in the Therapeutic and Preventive Model of Breast Carcinoma

(2020) Peter Kubatka et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Identification of potential therapeutic target of naringenin in breast cancer stem cells inhibition by bioinformatics and in vitro studies

(2020) Adam Hermawan et al.   SAUDI PHARMACEUTICAL JOURNAL

Breast Cancer Stem Cells: Biomarkers, Identification and Isolation Methods, Regulating Mechanisms, Cellular Origin, and Beyond

(2020) Xiaoli Zhang et al.   Cancers

EGCG-Derivative G28 Shows High Efficacy Inhibiting the Mammosphere-Forming Capacity of Sensitive and Resistant TNBC Models

(2019) Ariadna Giró-Perafita et al.   MOLECULES

Dietary Phytochemicals Targeting Cancer Stem Cells

(2019) Alena Liskova et al.   MOLECULES

Controlling metastatic cancer: the role of phytochemicals in cell signaling

(2019) Andrea Kapinova et al.   JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY

Luteolin, a flavonoid, as an anticancer agent: A review

(2019) Muhammad Imran et al.   BIOMEDICINE & PHARMACOTHERAPY

The Triple-negative Breast Cancer Cell Line MDA-MB 231 Is Specifically Inhibited by the Ionophore Salinomycin

(2019) THOMAS HERO et al.   ANTICANCER RESEARCH

DNA Methylation Status in Cancer Disease: Modulations by Plant-Derived Natural Compounds and Dietary Interventions

(2019) Karin Jasek et al.   Biomolecules

SOX2 in development and cancer biology

(2019) Daniel Novak et al.   SEMINARS IN CANCER BIOLOGY

Characterization of the stemness potency of mammospheres isolated from the breast cancer cell lines

(2019) Saghar Yousefnia et al.   TUMOR BIOLOGY

Improvement strategies for the oral bioavailability of poorly water-soluble flavonoids: An overview

(2019) Juanjuan Zhao et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Chrysin: Pharmacological and therapeutic properties

(2019) Saima Naz et al.   LIFE SCIENCES

Breast Cancer in Young Women: Status Quo and Advanced Disease Management by a Predictive, Preventive, and Personalized Approach

(2019) Erik Kudela et al.   Cancers

Molecular Mechanisms of Action of Genistein in Cancer: Recent Advances

(2019) Hardeep Singh Tuli et al.   Frontiers in Pharmacology

Flavonoid metabolism: the interaction of metabolites and gut microbiota

(2018) Kaeko Murota et al.   BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY

STAT3, stem cells, cancer stem cells and p63

(2018) Michaela Galoczova et al.   CELLULAR & MOLECULAR BIOLOGY LETTERS

Molecular understanding of Epigallocatechin gallate (EGCG) in cardiovascular and metabolic diseases

(2018) Qian Yi Eng et al.   JOURNAL OF ETHNOPHARMACOLOGY

Quercetin reversed MDR in breast cancer cells through down-regulating P-gp expression and eliminating cancer stem cells mediated by YB-1 nuclear translocation

(2018) Shizheng Li et al.   PHYTOTHERAPY RESEARCH

Quercetin Inhibits Breast Cancer Stem Cells via Downregulation of Aldehyde Dehydrogenase 1A1 (ALDH1A1), Chemokine Receptor Type 4 (CXCR4), Mucin 1 (MUC1), and Epithelial Cell Adhesion Molecule (EpCAM)

(2018) Rong Wang et al.   MEDICAL SCIENCE MONITOR

Premenopausal breast cancer: potential clinical utility of a multi-omics based machine learning approach for patient stratification

(2018) Holger Fröhlich et al.   EPMA Journal

Topical silymarin administration for prevention of acute radiodermatitis in breast cancer patients: A randomized, double-blind, placebo-controlled clinical trial

(2018) Hedyieh Karbasforooshan et al.   PHYTOTHERAPY RESEARCH

Flavonoids in Cancer and Apoptosis

(2018) Mariam Abotaleb et al.   Cancers

Cardamonin (2′,4′-dihydroxy-6′-methoxychalcone) isolated from Boesenbergia rotunda (L.) Mansf. inhibits CFA-induced rheumatoid arthritis in rats

(2017) Fui-Ling Voon et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

The Versatile Effects of Dihydromyricetin in Health

(2017) Hongliang Li et al.   Evidence-based Complementary and Alternative Medicine

Inhibiting epidermal growth factor receptor signalling potentiates mesenchymal-epithelial transition of breast cancer stem cells and their responsiveness to anticancer drugs

(2017) Kanakaraju Manupati et al.   FEBS Journal

Ampelopsin attenuates lipopolysaccharide-induced inflammatory response through the inhibition of the NF-κB and JAK2/STAT3 signaling pathways in microglia

(2017) Leihua Weng et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Antineoplastic effects of clove buds (Syzygium aromaticum L.) in the model of breast carcinoma

(2017) Peter Kubatka et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Pomegranate Extract Alters Breast Cancer Stem Cell Properties in Association with Inhibition of Epithelial-to-Mesenchymal Transition

(2017) Sameera Nallanthighal et al.   NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL

Factors Associated with Early Mortality Among Patients with De Novo Metastatic Breast Cancer: A Population‐Based Study

(2017) Ines Vaz‐Luis et al.   ONCOLOGIST

Packaging and transfer of mitochondrial DNA via exosomes regulate escape from dormancy in hormonal therapy-resistant breast cancer

(2017) Pasquale Sansone et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Suppression of Nrf2 Activity by Chestnut Leaf Extract Increases Chemosensitivity of Breast Cancer Stem Cells to Paclitaxel

(2017) Yaejin Woo et al.   Nutrients

Fatty acid synthase expression and its association with clinico-histopathological features in triple-negative breast cancer

(2017) Ariadna Giró-Perafita et al.   Oncotarget

Feeling cold and other underestimated symptoms in breast cancer: anecdotes or individual profiles for advanced patient stratification?

(2017) Olga Golubnitschaja   EPMA Journal

“Pre-metastatic niches” in breast cancer: are they created by or prior to the tumour onset? “Flammer Syndrome” relevance to address the question

(2017) Rostyslav Bubnov et al.   EPMA Journal

Long-term soy consumption and tumor tissue MicroRNA and gene expression in triple-negative breast cancer

(2016) Xingyi Guo et al.   CANCER

Xanthohumol, a Prenylated Chalcone from Hops, Inhibits the Viability and Stemness of Doxorubicin-Resistant MCF-7/ADR Cells

(2016) Ming Liu et al.   MOLECULES

Hypoxia induces the breast cancer stem cell phenotype by HIF-dependent and ALKBH5-mediated m6A-demethylation of NANOG mRNA

(2016) Chuanzhao Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Epigallocatechin-3-gallate ameliorates radiation-induced acute skin damage in breast cancer patients undergoing adjuvant radiotherapy

(2016) Wanqi Zhu et al.   Oncotarget

Epithelial-Mesenchymal Plasticity of Breast Cancer Stem Cells: Implications for Metastasis and Therapeutic Resistance

(2015) Ming Luo et al.   CURRENT PHARMACEUTICAL DESIGN

Fruit peel polyphenols demonstrate substantial anti-tumour effects in the model of breast cancer

(2015) Peter Kubatka et al.   EUROPEAN JOURNAL OF NUTRITION

Side population cells and drug resistance in breast cancer

(2015) MEIJIAN WANG et al.   Molecular Medicine Reports

Antineoplastic effects of Chlorella pyrenoidosa in the breast cancer model

(2015) Peter Kubatka et al.   NUTRITION

The role of Nanog expression in tamoxifen-resistant breast cancer cells

(2015) Mohamed El-Sheemy et al.   OncoTargets and Therapy

Cardamonin reduces chemotherapy-enriched breast cancer stem-like cells in vitro and in vivo

(2015) Deyong Jia et al.   Oncotarget

Activation of NRF2 by p62 and proteasome reduction in sphere-forming breast carcinoma cells

(2015) In-geun Ryoo et al.   Oncotarget

Blocking the formation of radiation–induced breast cancer stem cells

(2015) Yangyang Wang et al.   Oncotarget

Breast cancer stem cells, EMT and therapeutic targets

(2014) Srishti Kotiyal et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Effects of a green tea extract, Polyphenon E, on systemic biomarkers of growth factor signalling in women with hormone receptor-negative breast cancer

(2014) K. D. Crew et al.   JOURNAL OF HUMAN NUTRITION AND DIETETICS

The Effects of Soy Supplementation on Gene Expression in Breast Cancer: A Randomized Placebo-Controlled Study

(2014) M. Shike et al.   JNCI-Journal of the National Cancer Institute

Oxidative stress, mammospheres and Nrf2-new implication for breast cancer therapy?

(2014) Tongde Wu et al.   MOLECULAR CARCINOGENESIS

Ampelopsin Induces Cell Growth Inhibition and Apoptosis in Breast Cancer Cells through ROS Generation and Endoplasmic Reticulum Stress Pathway

(2014) Yong Zhou et al.   PLoS One

Dietary intake and breast cancer among carriers and noncarriers of BRCA mutations in the Korean Hereditary Breast Cancer Study

(2013) Kwang-Pil Ko et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Flavonoid Bioavailability and Attempts for Bioavailability Enhancement

(2013) Surangi Thilakarathna et al.   Nutrients

Genistein decreases the breast cancer stem-like cell population through Hedgehog pathway

(2013) Panhong Fan et al.   Stem Cell Research & Therapy

Soy Isoflavone Supplementation for Breast Cancer Risk Reduction: A Randomized Phase II Trial

(2012) S. A. Khan et al.   Cancer Prevention Research

Anti-Cancer Activities of Tea Epigallocatechin-3-Gallate in Breast Cancer Patients under Radiotherapy

(2012) G. Zhang et al.   CURRENT MOLECULAR MEDICINE

Radiation-Induced Reprogramming of Breast Cancer Cells

(2012) Chann Lagadec et al.   STEM CELLS

Mammary Development and Breast Cancer: The Role of Stem Cells

(2011) C. Ercan et al.   CURRENT MOLECULAR MEDICINE

Differentiation of breast cancer stem cells by knockdown of CD44: promising differentiation therapy

(2011) Phuc V Pham et al.   Journal of Translational Medicine

A Review on the Dietary Flavonoid Kaempferol

(2011) J. M. Calderon-Montano et al.   MINI-REVIEWS IN MEDICINAL CHEMISTRY

Kruppel-like factor 4 (KLF4) is required for maintenance of breast cancer stem cells and for cell migration and invasion

(2011) F Yu et al.   ONCOGENE

Cancer Stem Cells and Side Population Cells in Breast Cancer and Metastasis

(2011) Kelly M. Britton et al.   Cancers

Green tea improves metabolic biomarkers, not weight or body composition: a pilot study in overweight breast cancer survivors

(2010) N. R. Stendell-Hollis et al.   JOURNAL OF HUMAN NUTRITION AND DIETETICS

Dietary intake of selected flavonols, flavones, and flavonoid-rich foods and risk of cancer in middle-aged and older women

(2009) Lu Wang et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Hyaluronan-CD44 Interaction Activates Stem Cell Marker Nanog, Stat-3-mediated MDR1 Gene Expression, and Ankyrin-regulated Multidrug Efflux in Breast and Ovarian Tumor Cells

(2008) Lilly Y. W. Bourguignon et al.   JOURNAL OF BIOLOGICAL CHEMISTRY