Identification of potential therapeutic target of naringenin in breast cancer stem cells inhibition by bioinformatics and in vitro studies

Eriodictyol Inhibits Proliferation, Metastasis and Induces Apoptosis of Glioma Cells via PI3K/Akt/NF-κB Signaling Pathway

(2020) Wenjun Li et al.   Frontiers in Pharmacology

Pharmacokinetics and Metabolism of Naringin and Active Metabolite Naringenin in Rats, Dogs, Humans, and the Differences Between Species

(2020) Yang Bai et al.   Frontiers in Pharmacology

p53 Loss in Breast Cancer Leads to Myc Activation, Increased Cell Plasticity, and Expression of a Mitotic Signature with Prognostic Value

(2019) Angela Santoro et al.   Cell Reports

The citrus flavanone naringenin attenuates zymosan-induced mouse joint inflammation: induction of Nrf2 expression in recruited CD45+ hematopoietic cells

(2019) Allan J. C. Bussmann et al.   INFLAMMOPHARMACOLOGY

Identification of gene-phenotype connectivity associated with flavanone naringenin by functional network analysis

(2019) Suhong Fu et al.   PeerJ

Pharmacokinetics, Tissue Distribution, Metabolism, and Excretion of Naringin in Aged Rats

(2019) Xuan Zeng et al.   Frontiers in Pharmacology

Safety and pharmacokinetics of naringenin: A randomized, controlled, single‐ascending‐dose clinical trial

(2019) Candida J. Rebello et al.   DIABETES OBESITY & METABOLISM

Quercetin and naringenin abate diethylnitrosamine/acetylaminofluorene-induced hepatocarcinogenesis in Wistar rats: the roles of oxidative stress, inflammation and cell apoptosis

(2019) Osama M. Ahmed et al.   DRUG AND CHEMICAL TOXICOLOGY

Role of Reactive Oxygen Species in Cancer Progression: Molecular Mechanisms and Recent Advancements

(2019) Vaishali Aggarwal et al.   Biomolecules

Naringenin, a common flavanone, inhibits the formation of AGEs in bread and attenuates AGEs-induced oxidative stress and inflammation in RAW264.7 cells

(2018) Jing Teng et al.   FOOD CHEMISTRY

ADMETlab: a platform for systematic ADMET evaluation based on a comprehensively collected ADMET database

(2018) Jie Dong et al.   Journal of Cheminformatics

Combinatorial anti-proliferative effects of tamoxifen and naringenin: The role of four estrogen receptor subtypes

(2018) Zhixiang Xu et al.   TOXICOLOGY

In vitro-to-in vivo extrapolation (IVIVE) by PBTK modeling for animal-free risk assessment approaches of potential endocrine-disrupting compounds

(2018) Eric Fabian et al.   ARCHIVES OF TOXICOLOGY

Naringenin inhibited migration and invasion of glioblastoma cells through multiple mechanisms

(2018) Yen-Yu Chen et al.   ENVIRONMENTAL TOXICOLOGY

Naringenin causes ASK1-induced apoptosis via reactive oxygen species in human pancreatic cancer cells

(2017) Hyun Jin Park et al.   FOOD AND CHEMICAL TOXICOLOGY

Naringenin-Induced Apoptotic Cell Death in Prostate Cancer Cells Is Mediated via the PI3K/AKT and MAPK Signaling Pathways

(2017) Whasun Lim et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

In Vitro – In Vivo Extrapolation of Metabolism- and Transporter-Mediated Drug–Drug Interactions—Overview of Basic Prediction Methods

(2017) Kenta Yoshida et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

DrugBank 5.0: a major update to the DrugBank database for 2018

(2017) David S Wishart et al.   NUCLEIC ACIDS RESEARCH

Cancer stem cells: The root of tumor recurrence and metastases

(2017) Claudia Peitzsch et al.   SEMINARS IN CANCER BIOLOGY

SwissADME: a free web tool to evaluate pharmacokinetics, drug-likeness and medicinal chemistry friendliness of small molecules

(2017) Antoine Daina et al.   Scientific Reports

Biochemical and Molecular Mechanisms of Radioprotective Effects of Naringenin, a Phytochemical from Citrus Fruits

(2016) Sumit Kumar et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Hesperetin and Naringenin sensitize HER2 positive cancer cells to death by serving as HER2 Tyrosine Kinase inhibitors

(2016) Bhavya Balan Chandrika et al.   LIFE SCIENCES

The flavonoid apigenin reduces prostate cancer CD44 + stem cell survival and migration through PI3K/Akt/NF-κB signaling

(2016) Suat Erdogan et al.   LIFE SCIENCES

p53 deficiency induces cancer stem cell pool expansion in a mouse model of triple-negative breast tumors

(2016) A Chiche et al.   ONCOGENE

CD44hiCD24lo mammosphere-forming cells from primary breast cancer display resistance to multiple chemotherapeutic drugs

(2016) PING JI et al.   ONCOLOGY REPORTS

Apigenin Inhibits Cancer Stem Cell-Like Phenotypes in Human Glioblastoma Cells via Suppression of c-Met Signaling

(2016) Boram Kim et al.   PHYTOTHERAPY RESEARCH

Naringenin inhibits proliferation, migration, and invasion as well as induces apoptosis of gastric cancer SGC7901 cell line by downregulation of AKT pathway

(2016) Lei Bao et al.   TUMOR BIOLOGY

Naringenin inhibits migration of lung cancer cells via the inhibition of matrix metalloproteinases-2 and −9

(2016) Huai-Lu Chang et al.   Experimental and Therapeutic Medicine

Spheres from cervical cancer cells display stemness and cancer drug resistance

(2016) Huan Liu et al.   Oncology Letters

Mutational Profile of Metastatic Breast Cancers: A Retrospective Analysis

(2016) Celine Lefebvre et al.   PLOS MEDICINE

Wnt5a Signaling in Cancer

(2016) Marwa Asem et al.   Cancers

TGF-β induces p53/Smads complex formation in the PAI-1 promoter to activate transcription

(2016) Yuki Kawarada et al.   Scientific Reports

Growth inhibitory and chemo-sensitization effects of naringenin, a natural flavanone purified from Thymus vulgaris, on human breast and colorectal cancer

(2015) Mohamed Salah I Abaza et al.   Cancer Cell International

The Epithelial-Mesenchymal Transition and Cancer Stem Cells: Functional and Mechanistic Links

(2015) Xiangqiang Liu et al.   CURRENT PHARMACEUTICAL DESIGN

Cytotoxicity of natural products and derivatives toward MCF-7 cell monolayers and cancer stem-like mammospheres

(2015) Ean-Jeong Seo et al.   PHYTOMEDICINE

Enhanced anticancer effect of ABT-737 in combination with naringenin on gastric cancer cells

(2015) HAIYANG ZHANG et al.   Experimental and Therapeutic Medicine

Overcoming Multidrug Resistance in Cancer Stem Cells

(2015) Karobi Moitra   Biomed Research International

cytoHubba: identifying hub objects and sub-networks from complex interactome

(2014) Chia-Hao Chin et al.   BMC Systems Biology

STRING v10: protein–protein interaction networks, integrated over the tree of life

(2014) Damian Szklarczyk et al.   NUCLEIC ACIDS RESEARCH

ColonyArea: An ImageJ Plugin to Automatically Quantify Colony Formation in Clonogenic Assays

(2014) Camilo Guzmán et al.   PLoS One

ALDH1A1 Maintains Ovarian Cancer Stem Cell-Like Properties by Altered Regulation of Cell Cycle Checkpoint and DNA Repair Network Signaling

(2014) Erhong Meng et al.   PLoS One

Copper (II) and 2,2′-Bipyridine Complexation Improves Chemopreventive Effects of Naringenin against Breast Tumor Cells

(2014) Júlio César Conceição Filho et al.   PLoS One

Integrative Analysis of Complex Cancer Genomics and Clinical Profiles Using the cBioPortal

(2013) J. Gao et al.   Science Signaling

Naringin inhibits growth potential of human triple-negative breast cancer cells by targeting β-catenin signaling pathway

(2013) Hongzhong Li et al.   TOXICOLOGY LETTERS

Combinatorial treatment of mammospheres with trastuzumab and salinomycin efficiently targets HER2-positive cancer cells and cancer stem cells

(2012) Prajakta S. Oak et al.   INTERNATIONAL JOURNAL OF CANCER

Breast-cancer stem cells—beyond semantics

(2012) Sunil Badve et al.   LANCET ONCOLOGY

Naringenin Decreases Invasiveness and Metastasis by Inhibiting TGF-β-Induced Epithelial to Mesenchymal Transition in Pancreatic Cancer Cells

(2012) Changjie Lou et al.   PLoS One

Transforming growth factor-β transiently induces vimentin expression and invasive capacity in a canine mammary gland tumor cell line

(2012) K. Yoshida et al.   RESEARCH IN VETERINARY SCIENCE

The cBio Cancer Genomics Portal: An Open Platform for Exploring Multidimensional Cancer Genomics Data: Figure 1.

(2012) Ethan Cerami et al.   Cancer Discovery

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

Naringenin reduces lung metastasis in a breast cancer resection model

(2011) Lei Qin et al.   Protein & Cell

β-Catenin Is a Positive Regulator of Estrogen Receptor-α Function in Breast Cancer Cells

(2011) Nibedita Gupta et al.   Cancers

Phase 2 trial of primary systemic therapy with doxorubicin and docetaxel followed by surgery, radiotherapy, and adjuvant chemotherapy with cyclophosphamide, methotrexate, and 5-fluorouracil based on clinical and pathologic response in patients with stage IIB to III breast cancer

(2010) Ricardo H. Alvarez et al.   CANCER

Naringenin up-regulates the expression of death receptor 5 and enhances TRAIL-induced apoptosis in human lung cancer A549 cells

(2010) Cheng-Yun Jin et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Estrogen receptor α attenuates transforming growth factor-β signaling in breast cancer cells independent from agonistic and antagonistic ligands

(2009) Matthias B. Stope et al.   BREAST CANCER RESEARCH AND TREATMENT

Metformin Selectively Targets Cancer Stem Cells, and Acts Together with Chemotherapy to Block Tumor Growth and Prolong Remission

(2009) H. A. Hirsch et al.   CANCER RESEARCH

Stem cell marker aldehyde dehydrogenase 1-positive breast cancers are characterized by negative estrogen receptor, positive human epidermal growth factor receptor type 2, and high Ki67 expression

(2009) Koji Morimoto et al.   CANCER SCIENCE

Mechanisms of Chemotherapeutic Drug Resistance in Cancer Therapy—A Quick Review

(2009) Fu-Shing Liu   Taiwanese Journal of Obstetrics & Gynecology

Bioinformatics enrichment tools: paths toward the comprehensive functional analysis of large gene lists

(2008) Da Wei Huang et al.   NUCLEIC ACIDS RESEARCH

Comparison of 3D and 2D tumor models reveals enhanced HER2 activation in 3D associated with an increased response to trastuzumab

(2008) M Pickl et al.   ONCOGENE

Naringenin-Loaded Nanoparticles Improve the Physicochemical Properties and the Hepatoprotective Effects of Naringenin in Orally-Administered Rats with CCl4-Induced Acute Liver Failure

(2008) Feng-Lin Yen et al.   PHARMACEUTICAL RESEARCH