Human islet amyloid polypeptide (hIAPP) - a curse in type II diabetes mellitus: insights from structure and toxicity studies
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Title
Human islet amyloid polypeptide (hIAPP) - a curse in type II diabetes mellitus: insights from structure and toxicity studies
Authors
Keywords
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Journal
BIOLOGICAL CHEMISTRY
Volume -, Issue -, Pages -
Publisher
Walter de Gruyter GmbH
Online
2020-08-28
DOI
10.1515/hsz-2020-0174
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Note: Only part of the references are listed.- Vaccination Against Amyloidogenic Aggregates in Pancreatic Islets Prevents Development of Type 2 Diabetes Mellitus
- (2020) Elisa S. Roesti et al. Vaccines
- Glycated Insulin Exacerbates the Cytotoxicity of Human Islet Amyloid Polypeptides: a Vicious Cycle in Type 2 Diabetes
- (2019) Liang Ma et al. ACS Chemical Biology
- Protein glycation by glyoxal promotes amyloid formation by islet amyloid polypeptide
- (2019) Yi-Hsuan Hsu et al. BIOPHYSICAL JOURNAL
- α-synuclein in the pathophysiology of Alzheimer’s disease
- (2019) Daniel Twohig et al. Molecular Neurodegeneration
- BRICHOS domain of Bri2 inhibits islet amyloid polypeptide (IAPP) fibril formation and toxicity in human beta cells
- (2018) Marie E. Oskarsson et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Amylin – Its role in the homeostatic and hedonic control of eating and recent developments of amylin analogs to treat obesity
- (2018) Christina Neuner Boyle et al. Molecular Metabolism
- Characterisation of the Structure and Oligomerisation of Islet Amyloid Polypeptides (IAPP): A Review of Molecular Dynamics Simulation Studies
- (2018) Sandra Moore et al. MOLECULES
- Amyloid-Beta and Phosphorylated Tau Accumulations Cause Abnormalities at Synapses of Alzheimer’s disease Neurons
- (2017) Ravi Rajmohan et al. JOURNAL OF ALZHEIMERS DISEASE
- Induction of IAPP amyloid deposition and associated diabetic abnormalities by a prion-like mechanism
- (2017) Abhisek Mukherjee et al. JOURNAL OF EXPERIMENTAL MEDICINE
- The β-cell assassin: IAPP cytotoxicity
- (2017) Daniel Raleigh et al. JOURNAL OF MOLECULAR ENDOCRINOLOGY
- A Free Energy Barrier Caused by the Refolding of an Oligomeric Intermediate Controls the Lag Time of Amyloid Formation by hIAPP
- (2017) Arnaldo L. Serrano et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Stabilization and structural analysis of a membrane-associated hIAPP aggregation intermediate
- (2017) Diana C Rodriguez Camargo et al. eLife
- The redox environment triggers conformational changes and aggregation of hIAPP in Type II Diabetes
- (2017) Diana C. Rodriguez Camargo et al. Scientific Reports
- The Role of Cholesterol in Driving IAPP-Membrane Interactions
- (2016) Michele F.M. Sciacca et al. BIOPHYSICAL JOURNAL
- Coordination of Zn2+ and Cu2+ to the membrane disrupting fragment of amylin
- (2016) M. Rowińska-Żyrek DALTON TRANSACTIONS
- Pancreatic β-Cell Membrane Fluidity and Toxicity Induced by Human Islet Amyloid Polypeptide Species
- (2016) Emily H. Pilkington et al. Scientific Reports
- Amyloid Formation in Human Islets Is Enhanced by Heparin and Inhibited by Heparinase
- (2015) K. J. Potter et al. AMERICAN JOURNAL OF TRANSPLANTATION
- New Insights Into the Mechanisms of Islet Inflammation in Type 2 Diabetes: Figure 1
- (2015) Lucy Marzban DIABETES
- Islet amyloid polypeptide exerts a novel autocrine action in β-cell signaling and proliferation
- (2015) Montse Visa et al. FASEB JOURNAL
- Heparan Sulfate Proteoglycans Are Important for Islet Amyloid Formation and Islet Amyloid Polypeptide-induced Apoptosis
- (2015) Marie E. Oskarsson et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Membrane Curvature-sensing and Curvature-inducing Activity of Islet Amyloid Polypeptide and Its Implications for Membrane Disruption
- (2015) Natalie C. Kegulian et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Type 2 diabetes as a protein misfolding disease
- (2015) Abhisek Mukherjee et al. TRENDS IN MOLECULAR MEDICINE
- Differential Effect of Amylin on Endothelial-Dependent Vasodilation in Mesenteric Arteries from Control and Insulin Resistant Rats
- (2015) Mariam El Assar et al. PLoS One
- UCHL1 deficiency exacerbates human islet amyloid polypeptide toxicity in β-cells
- (2014) Safia Costes et al. Autophagy
- Stable, Metastable, and Kinetically Trapped Amyloid Aggregate Phases
- (2014) Tatiana Miti et al. BIOMACROMOLECULES
- The role of caspase-8 in amyloid-induced beta cell death in human and mouse islets
- (2014) Yoo Jin Park et al. DIABETOLOGIA
- IL-1 mediates amyloid-associated islet dysfunction and inflammation in human islet amyloid polypeptide transgenic mice
- (2014) Clara Y. Westwell-Roper et al. DIABETOLOGIA
- Islet amyloid formation is an important determinant for inducing islet inflammation in high-fat-fed human IAPP transgenic mice
- (2014) Daniel T. Meier et al. DIABETOLOGIA
- Amylin in vasodilation, energy expenditure and inflammation
- (2014) Fan Yang Frontiers in Bioscience-Landmark
- Amyloidogenic peptide oligomer accumulation in autophagy-deficient β cells induces diabetes
- (2014) Jinyoung Kim et al. JOURNAL OF CLINICAL INVESTIGATION
- Human IAPP–induced pancreatic β cell toxicity and its regulation by autophagy
- (2014) Nayumi Shigihara et al. JOURNAL OF CLINICAL INVESTIGATION
- Autophagy defends pancreatic β cells from human islet amyloid polypeptide-induced toxicity
- (2014) Jacqueline F. Rivera et al. JOURNAL OF CLINICAL INVESTIGATION
- Advanced Glycation End Products and Diabetic Complications
- (2014) Varun Parkash Singh et al. KOREAN JOURNAL OF PHYSIOLOGY & PHARMACOLOGY
- Chaperones Ameliorate Beta Cell Dysfunction Associated with Human Islet Amyloid Polypeptide Overexpression
- (2014) Lisa Cadavez et al. PLoS One
- Structural dynamics inside a functionalized metal–organic framework probed by ultrafast 2D IR spectroscopy
- (2014) Jun Nishida et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Cations as Switches of Amyloid-Mediated Membrane Disruption Mechanisms: Calcium and IAPP
- (2013) Michele F.M. Sciacca et al. BIOPHYSICAL JOURNAL
- Membrane destabilization by monomeric hIAPP observed by imaging fluorescence correlation spectroscopy
- (2013) Nirmalya Bag et al. CHEMICAL COMMUNICATIONS
- Role of Reduced -Cell Mass Versus Impaired -Cell Function in the Pathogenesis of Type 2 Diabetes
- (2013) J. J. Meier et al. DIABETES CARE
- Mechanisms of islet amyloidosis toxicity in type 2 diabetes
- (2013) Andisheh Abedini et al. FEBS LETTERS
- Adsorption and Orientation of Human Islet Amyloid Polypeptide (hIAPP) Monomer at Anionic Lipid Bilayers: Implications for Membrane-Mediated Aggregation
- (2013) Yan Jia et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Amide Proton Solvent Protection in Amylin Fibrils Probed by Quenched Hydrogen Exchange NMR
- (2013) Andrei T. Alexandrescu PLoS One
- Mechanism of IAPP amyloid fibril formation involves an intermediate with a transient -sheet
- (2013) L. E. Buchanan et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Islet amyloid polypeptide toxicity and membrane interactions
- (2013) P. Cao et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Aggregation of islet amyloid polypeptide: from physical chemistry to cell biology
- (2012) Ping Cao et al. CURRENT OPINION IN STRUCTURAL BIOLOGY
- Islet amyloid polypeptide in pancreatic islets from type 2 diabetic subjects
- (2012) Tatsuo Tomita Islets
- Membrane Disruption and Early Events in the Aggregation of the Diabetes Related Peptide IAPP from a Molecular Perspective
- (2011) Jeffrey R. Brender et al. ACCOUNTS OF CHEMICAL RESEARCH
- β-Cell Loss and β-Cell Apoptosis in Human Type 2 Diabetes Are Related to Islet Amyloid Deposition
- (2011) Catherine A. Jurgens et al. AMERICAN JOURNAL OF PATHOLOGY
- Structure and membrane orientation of IAPP in its natively amidated form at physiological pH in a membrane environment
- (2011) Ravi Prakash Reddy Nanga et al. BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES
- Control of energy homeostasis by amylin
- (2011) Thomas A. Lutz CELLULAR AND MOLECULAR LIFE SCIENCES
- Exendin-4 increases islet amyloid deposition but offsets the resultant beta cell toxicity in human islet amyloid polypeptide transgenic mouse islets
- (2011) K. Aston-Mourney et al. DIABETOLOGIA
- Concentration-dependent transitions govern the subcellular localization of islet amyloid polypeptide
- (2011) Mazin Magzoub et al. FASEB JOURNAL
- Clustering and Internalization of Toxic Amylin Oligomers in Pancreatic Cells Require Plasma Membrane Cholesterol
- (2011) Saurabh Trikha et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Fibril Structure of Human Islet Amyloid Polypeptide
- (2011) Sahar Bedrood et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Mechanism of Amylin Fibrillization Enhancement by Heparin
- (2011) Suman Jha et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- IL-1 Blockade Attenuates Islet Amyloid Polypeptide-Induced Proinflammatory Cytokine Release and Pancreatic Islet Graft Dysfunction
- (2011) C. Westwell-Roper et al. JOURNAL OF IMMUNOLOGY
- 2DIR Spectroscopy of Human Amylin Fibrils Reflects Stable β-Sheet Structure
- (2011) Lu Wang et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- The Amyloid Formation Mechanism in Human IAPP: Dimers Have β-Strand Monomer−Monomer Interfaces
- (2011) Nicholas F. Dupuis et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Islet Amyloid Polypeptide, Islet Amyloid, and Diabetes Mellitus
- (2011) Per Westermark et al. PHYSIOLOGICAL REVIEWS
- MCP-1 Upregulates Amylin Expression in Murine Pancreatic β Cells through ERK/JNK-AP1 and NF-κB Related Signaling Pathways Independent of CCR2
- (2011) Kun Cai et al. PLoS One
- Human-IAPP disrupts the autophagy/lysosomal pathway in pancreatic β-cells: protective role of p62-positive cytoplasmic inclusions
- (2010) J F Rivera et al. CELL DEATH AND DIFFERENTIATION
- -Cell Dysfunctional ERAD/Ubiquitin/Proteasome System in Type 2 Diabetes Mediated by Islet Amyloid Polypeptide-Induced UCH-L1 Deficiency
- (2010) S. Costes et al. DIABETES
- TNF-α acutely upregulates amylin expression in murine pancreatic beta cells
- (2010) K. Cai et al. DIABETOLOGIA
- Involvement of mitochondrial dysfunction in human islet amyloid polypeptide-induced apoptosis in INS-1E pancreatic beta cells: An effect attenuated by phycocyanin
- (2010) Xiao-Ling Li et al. INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
- Activation of the NLRP3 inflammasome by islet amyloid polypeptide provides a mechanism for enhanced IL-1β in type 2 diabetes
- (2010) Seth L Masters et al. NATURE IMMUNOLOGY
- Central amylin acts as an adiposity signal to control body weight and energy expenditure
- (2010) Peter Y. Wielinga et al. PHYSIOLOGY & BEHAVIOR
- Autophagy protects against human islet amyloid polypeptide-associated apoptosis
- (2010) Shuhei Morita et al. Journal of Diabetes Investigation
- β-cell mass in people with type 2 diabetes
- (2010) Jae-Hyoung Cho et al. Journal of Diabetes Investigation
- Evidence for Proteotoxicity in β Cells in Type 2 Diabetes
- (2009) Tatyana Gurlo et al. AMERICAN JOURNAL OF PATHOLOGY
- Fatty acids induce amylin expression and secretion by pancreatic β-cells
- (2009) Dongfei Qi et al. AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
- Membrane permeabilization by Islet Amyloid Polypeptide
- (2009) Maarten F.M. Engel CHEMISTRY AND PHYSICS OF LIPIDS
- Degradation of cAMP-Responsive Element-Binding Protein by the Ubiquitin-Proteasome Pathway Contributes to Glucotoxicity in -Cells and Human Pancreatic Islets
- (2009) S. Costes et al. DIABETES
- Autophagy in human type 2 diabetes pancreatic beta cells
- (2009) M. Masini et al. DIABETOLOGIA
- Helix Stabilization Precedes Aqueous and Bilayer-Catalyzed Fiber Formation in Islet Amyloid Polypeptide
- (2009) Jessica A. Williamson et al. JOURNAL OF MOLECULAR BIOLOGY
- Amyloidogenic Propensities and Conformational Properties of ProIAPP and IAPP in the Presence of Lipid Bilayer Membranes
- (2009) Suman Jha et al. JOURNAL OF MOLECULAR BIOLOGY
- IL-1β caused pancreatic β-cells apoptosis is mediated in part by endoplasmic reticulum stress via the induction of endoplasmic reticulum Ca2+ release through the c-Jun N-terminal kinase pathway
- (2009) Q. Wang et al. MOLECULAR AND CELLULAR BIOCHEMISTRY
- Atomic structures of IAPP (amylin) fusions suggest a mechanism for fibrillation and the role of insulin in the process
- (2009) Jed J. W. Wiltzius et al. PROTEIN SCIENCE
- A Single Mutation in the Nonamyloidogenic Region of Islet Amyloid Polypeptide Greatly Reduces Toxicity†
- (2008) Jeffrey R. Brender et al. BIOCHEMISTRY
- Effect of Pressure on Islet Amyloid Polypeptide Aggregation: Revealing the Polymorphic Nature of the Fibrillation Process†
- (2008) Diana Radovan et al. BIOCHEMISTRY
- Loss of Autophagy Diminishes Pancreatic β Cell Mass and Function with Resultant Hyperglycemia
- (2008) Hye Seung Jung et al. Cell Metabolism
- Autophagy Is Important in Islet Homeostasis and Compensatory Increase of Beta Cell Mass in Response to High-Fat Diet
- (2008) Chie Ebato et al. Cell Metabolism
- Calcium elevation in mouse pancreatic beta cells evoked by extracellular human islet amyloid polypeptide involves activation of the mechanosensitive ion channel TRPV4
- (2008) S. Casas et al. DIABETOLOGIA
- The Unfolded Protein Response: A Pathway That Links Insulin Demand with β-Cell Failure and Diabetes
- (2008) Donalyn Scheuner et al. ENDOCRINE REVIEWS
- Islet Amyloid in Type 2 Diabetes, and the Toxic Oligomer Hypothesis
- (2008) Leena Haataja et al. ENDOCRINE REVIEWS
- Atomic structure of the cross-β spine of islet amyloid polypeptide (amylin)
- (2008) Jed J.W. Wiltzius et al. PROTEIN SCIENCE
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