Indole-3-Carbinol: Occurrence, Health-Beneficial Properties, and Cellular/Molecular Mechanisms

Anti-inflammatory, antioxidant, antihypertensive, and antiarrhythmic effect of indole-3-carbinol, a phytochemical derived from cruciferous vegetables

(2022) Natalia Jorgelina Prado et al.   Heliyon

Cancer Statistics, 2021

(2021) Rebecca L. Siegel et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Indole-3-carbinol ameliorates necroptosis and inflammation of intestinal epithelial cells in mice with ulcerative colitis by activating Aryl Hydrocarbon Receptor

(2021) Chunting Peng et al.   EXPERIMENTAL CELL RESEARCH

3,3′-Diindolylmethane Suppresses the Growth of Hepatocellular Carcinoma by Regulating Its Invasion, Migration, and ER Stress-Mediated Mitochondrial Apoptosis

(2021) Suvesh Munakarmi et al.   Cells

Neuroprotective effects of indole-3-carbinol on the rotenone rat model of Parkinson's disease: Impact of the SIRT1-AMPK signaling pathway

(2021) Khalid A. Mohamad et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Glucosinolates From Cruciferous Vegetables and Their Potential Role in Chronic Disease: Investigating the Preclinical and Clinical Evidence

(2021) Emma L. Connolly et al.   Frontiers in Pharmacology

Indoles Derived From Glucobrassicin: Cancer Chemoprevention by Indole-3-Carbinol and 3,3'-Diindolylmethane

(2021) David E. Williams   Frontiers in Nutrition

Modulatory Effect of Indoles on the Expression of miRNAs Regulating G1/S Cell Cycle Phase in Breast Cancer Cells

(2020) Sherien M. El-Daly et al.   APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY

Protective effect of Indole-3-carbinol, an NF-κB inhibitor in experimental paradigm of Parkinson’s disease: In silico and in vivo studies

(2020) Neerja Saini et al.   BRAIN BEHAVIOR AND IMMUNITY

3,3′-Diindolylmethane modulates aryl hydrocarbon receptor of esophageal squamous cell carcinoma to reverse epithelial-mesenchymal transition through repressing RhoA/ROCK1-mediated COX2/PGE2 pathway

(2020) Peiyao Zhu et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Changes in Mortality in Top 10 Causes of Death from 2011 to 2018

(2020) Jamal S. Rana et al.   JOURNAL OF GENERAL INTERNAL MEDICINE

Dietary Indole-3-Carbinol Alleviated Spleen Enlargement, Enhanced IgG Response in C3H/HeN Mice Infected with Citrobacter rodentium

(2020) Yanbei Wu et al.   Nutrients

PTEN/Akt Signaling-Mediated Activation of the Mitochondrial Pathway Contributes to the 3,3′-Diindolylmethane-Mediated Antitumor Effect in Malignant Melanoma Cells

(2020) Xiaoli Wang et al.   JOURNAL OF MEDICINAL FOOD

3,3'-Diindolylmethane inhibits patient-derived xenograft colon tumor growth by targeting COX1/2 and ERK1/2

(2019) Xueli Tian et al.   CANCER LETTERS

Indole-3-carbinol inhibits lipid deposition and promotes autophagy in hyperlipidemia zebrafish larvae

(2019) Yonghong Jiang et al.   ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY

Amelioration of Hyperglycemia-Induced Nephropathy by 3,3′-Diindolylmethane in Diabetic Mice

(2019) Kyeong-Mi Choi et al.   MOLECULES

Indole-3-Carbinol (I3C) enhances the sensitivity of murine breast adenocarcinoma cells to doxorubicin (DOX) through inhibition of NF-κβ, blocking angiogenesis and regulation of mitochondrial apoptotic pathway

(2018) Subhadip Hajra et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Anticarcinogenic effect of indole-3-carbinol (I3C) on human hepatocellular carcinoma SNU449 cells

(2018) CM Lee et al.   HUMAN & EXPERIMENTAL TOXICOLOGY

Preventive effects of indole-3-carbinol against alcohol-induced liver injury in mice via antioxidant, anti-inflammatory, and anti-apoptotic mechanisms: Role of gut-liver-adipose tissue axis

(2018) Youngshim Choi et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Targeting the Microcirculation by Indole-3-carbinol and Its Main Derivate 3,3,'-diindolylmethane: Effects on Angiogenesis, Thrombosis and Inflammation

(2018) Emmanuel Ampofo et al.   MINI-REVIEWS IN MEDICINAL CHEMISTRY

3,3′-Diindolylmethane Enhances Glucose Uptake Through Activation of Insulin Signaling in 3T3-L1 Adipocytes

(2018) Kyeong-Mi Choi et al.   Obesity

Breeding Characteristics and Dose-dependent Blood Pressure Responses of Transgenic Cyp1a1–Ren2 Rats

(2018) Catherine J Leader et al.   COMPARATIVE MEDICINE

3,3′-Diindolylmethane Suppresses the Inflammatory Response to Lipopolysaccharide in Murine Macrophages

(2018) Han Jin Cho et al.   JOURNAL OF NUTRITION

3,3′-Diindolylmethane Suppresses Adipogenesis Using AMPKα-Dependent Mechanism in 3T3-L1 Adipocytes and Caenorhabditis elegans

(2017) Jihye Lee et al.   JOURNAL OF MEDICINAL FOOD

Indole-3-carbinol is a potent inhibitor of ischemia–reperfusion–induced inflammation

(2017) Emmanuel Ampofo et al.   JOURNAL OF SURGICAL RESEARCH

3,3′-Diindolylmethane attenuates cardiomyocyte hypoxia by modulating autophagy in H9c2 cells

(2017) Kai Liang et al.   Molecular Medicine Reports

3,3’-Diindolylmethane suppresses high-fat diet-induced obesity through inhibiting adipogenesis of pre-adipocytes by targeting USP2 activity

(2017) Hee Yang et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Effect of Oral Administration of 3,3′-Diindolylmethane on Dextran Sodium Sulfate-Induced Acute Colitis in Mice

(2016) Eun-Joo Jeon et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Indole-3-carbinol induces tumor cell death: function follows form

(2016) Bryant W. Megna et al.   JOURNAL OF SURGICAL RESEARCH

Indole-3-carbinol protects against cisplatin-induced acute nephrotoxicity: role of calcitonin gene-related peptide and insulin-like growth factor-1

(2016) Reem N. El-Naga et al.   Scientific Reports

Indole-3-carbinol as inhibitors of glucocorticoid-induced apoptosis in osteoblastic cells through blocking ROS-mediated Nrf2 pathway

(2015) Hao Lin et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

3,3′-Diindolylmethane increases bone mass by suppressing osteoclastic bone resorption in mice

(2015) Tai-yong Yu et al.   JOURNAL OF PHARMACOLOGICAL SCIENCES

Pro-apoptotic and anti-proliferative effects of 3,3′-diindolylmethane in nasopharyngeal carcinoma cells via downregulation of telomerase activity

(2015) FEN LI et al.   Molecular Medicine Reports

3'3-Diindolylmethane inhibits migration, invasion and metastasis of hepatocellular carcinoma by suppressing FAK signaling

(2015) Wen-Xue Li et al.   Oncotarget

Reactivity and Stability of Glucosinolates and Their Breakdown Products in Foods

(2014) Franziska S. Hanschen et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Indole-3-carbinol and its N-alkoxy derivatives preferentially target ERα-positive breast cancer cells

(2014) Joseph A Caruso et al.   CELL CYCLE

Attenuation of hyperglycemia-mediated oxidative stress by indole-3-carbinol and its metabolite 3, 3′- diindolylmethane in C57BL/6J mice

(2014) Poornima Jayakumar et al.   JOURNAL OF PHYSIOLOGY AND BIOCHEMISTRY

Renal Nitric Oxide Synthase and Antioxidant Preservation in Cyp1a1-Ren-2 Transgenic Rats With Inducible Malignant Hypertension

(2013) Mark W. Cunningham et al.   AMERICAN JOURNAL OF HYPERTENSION

Indole-3-Carbinol and 3',3'-Diindolylmethane Modulate Androgen's Effect on C-C Chemokine Ligand 2 and Monocyte Attraction to Prostate Cancer Cells

(2013) E.-K. Kim et al.   Cancer Prevention Research

Indole-3-carbinol inhibits LPS-induced inflammatory response by blocking TRIF-dependent signaling pathway in macrophages

(2013) Jun Jiang et al.   FOOD AND CHEMICAL TOXICOLOGY

Regulation of carbohydrate metabolism by indole-3-carbinol and its metabolite 3,3′-diindolylmethane in high-fat diet-induced C57BL/6J mice

(2013) Jayakumar Poornima et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Indole-3-carbinol inhibits cell proliferation and induces apoptosis in Hep-2 laryngeal cancer cells

(2013) YA-QIU WANG et al.   ONCOLOGY REPORTS

Indole-3-carbinol attenuates the deleterious gestational effects of bisphenol A exposure on the prostate gland of male F1 rats

(2013) Joyce Zalotti Brandt et al.   REPRODUCTIVE TOXICOLOGY

3,3'-Diindolylmethane Inhibits Lipopolysaccharide-Induced Microglial Hyperactivation and Attenuates Brain Inflammation

(2013) H. W. Kim et al.   TOXICOLOGICAL SCIENCES

Antiangiogenic activity of indole-3-carbinol in endothelial cells stimulated with activated macrophages

(2012) Mei-Lin Wang et al.   FOOD CHEMISTRY

Indole-3-carbinol directly targets SIRT1 to inhibit adipocyte differentiation

(2012) Y Choi et al.   INTERNATIONAL JOURNAL OF OBESITY

Indole-3-carbinol prevents diet-induced obesity through modulation of multiple genes related to adipogenesis, thermogenesis or inflammation in the visceral adipose tissue of mice

(2012) Youngshim Choi et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

3,3′-Diindolylmethane induces activating transcription factor 3 (ATF3) via ATF4 in human colorectal cancer cells

(2012) Seong-Ho Lee et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Glucosinolate structures in evolution

(2012) Niels Agerbirk et al.   PHYTOCHEMISTRY

Water Stress and Aphid Feeding Differentially Influence Metabolite Composition in Arabidopsis thaliana (L.)

(2012) Inga Mewis et al.   PLoS One

Anticancer effects of 3,3′-diindolylmethane are associated with G1 arrest and mitochondria-dependent apoptosis in human nasopharyngeal carcinoma cells

(2012) YU XU et al.   Oncology Letters

Indole-3-carbinol downregulation of telomerase gene expression requires the inhibition of estrogen receptor-alpha and Sp1 transcription factor interactions within the hTERT promoter and mediates the G1 cell cycle arrest of human breast cancer cells

(2011) C. N. Marconett et al.   CARCINOGENESIS

Suppression of inflammation-associated factors by indole-3-carbinol in mice fed high-fat diets and in isolated, co-cultured macrophages and adipocytes

(2011) H-P Chang et al.   INTERNATIONAL JOURNAL OF OBESITY

In vivo pharmacodynamics of indole-3-carbinol in the inhibition of prostate cancer in transgenic adenocarcinoma of mouse prostate (TRAMP) mice: Involvement of Nrf2 and cell cycle/apoptosis signaling pathways

(2011) Tien-Yuan Wu et al.   MOLECULAR CARCINOGENESIS

Antiobesity activities of indole-3-carbinol in high-fat-diet–induced obese mice

(2011) Hsiao-Pei Chang et al.   NUTRITION

Key Role of Fe2+in Epithiospecifier Protein Activity

(2010) David J. Williams et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

3,3′-diindolylmethane suppresses 12-O-tetradecanoylphorbol-13-acetate-induced inflammation and tumor promotion in mouse skin via the downregulation of inflammatory mediators

(2010) Eun Ji Kim et al.   MOLECULAR CARCINOGENESIS

Activation of Checkpoint Kinase 2 by 3,3'-Diindolylmethane Is Required for Causing G2/M Cell Cycle Arrest in Human Ovarian Cancer Cells

(2010) P. K. Kandala et al.   MOLECULAR PHARMACOLOGY

Induction of G1 and G2/M cell cycle arrests by the dietary compound 3,3'-diindolylmethane in HT-29 human colon cancer cells

(2009) Hyun Ju Choi et al.   BMC GASTROENTEROLOGY

3,3′-diindolylmethane attenuates colonic inflammation and tumorigenesis in mice

(2009) Yoon Hee Kim et al.   INFLAMMATORY BOWEL DISEASES

Effect of Boiling on the Content of Ascorbigen, Indole-3-carbinol, Indole-3-acetonitrile, and 3,3′-Diindolylmethane in Fermented Cabbage

(2009) Ewa Ciska et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Dose-dependent titration of prorenin and blood pressure in Cyp1a1ren-2 transgenic rats: absence of prorenin-induced glomerulosclerosis

(2009) Barbara Peters et al.   JOURNAL OF HYPERTENSION

Oral Administration of 3,3′-Diindolylmethane Inhibits Lung Metastasis of 4T1 Murine Mammary Carcinoma Cells in BALB/c Mice

(2009) Eun Ji Kim et al.   JOURNAL OF NUTRITION

Effects of different cooking methods on health-promoting compounds of broccoli

(2009) Gao-feng Yuan et al.   Journal of Zhejiang University-SCIENCE B

3,3′-Diindolylmethane reduces levels of HIF-1α and HIF-1 activity in hypoxic cultured human cancer cells

(2008) Jacques E. Riby et al.   BIOCHEMICAL PHARMACOLOGY

Mammalian Target of Rapamycin Repression by 3,3'-Diindolylmethane Inhibits Invasion and Angiogenesis in Platelet-Derived Growth Factor-D-Overexpressing PC3 Cells

(2008) D. Kong et al.   CANCER RESEARCH

Indole-3-carbinol inhibits MDA-MB-231 breast cancer cell motility and induces stress fibers and focal adhesion formation by activation of Rho kinase activity

(2008) Christine T. Brew et al.   INTERNATIONAL JOURNAL OF CANCER

Indole glucosinolate breakdown and its biological effects

(2008) Niels Agerbirk et al.   PHYTOCHEMISTRY REVIEWS

The Genetic Basis of Constitutive and Herbivore-Induced ESP-Independent Nitrile Formation in Arabidopsis

(2008) M. Burow et al.   PLANT PHYSIOLOGY

N-Alkoxy derivatization of indole-3-carbinol increases the efficacy of the G1 cell cycle arrest and of I3C-specific regulation of cell cycle gene transcription and activity in human breast cancer cells

(2007) Sarah M. Jump et al.   BIOCHEMICAL PHARMACOLOGY

Seasonal variation in glucosinolate content in Brassica oleracea crops grown in northwestern Spain

(2007) María Elena Cartea et al.   PHYTOCHEMISTRY