Indole-3-Carbinol: Occurrence, Health-Beneficial Properties, and Cellular/Molecular Mechanisms
出版年份 2023 全文链接
标题
Indole-3-Carbinol: Occurrence, Health-Beneficial Properties, and Cellular/Molecular Mechanisms
作者
关键词
-
出版物
Annual Review of Food Science and Technology
Volume 14, Issue 1, Pages 347-366
出版商
Annual Reviews
发表日期
2023-03-28
DOI
10.1146/annurev-food-060721-025531
参考文献
相关参考文献
注意：仅列出部分参考文献，下载原文获取全部文献信息。- Anti-inflammatory, antioxidant, antihypertensive, and antiarrhythmic effect of indole-3-carbinol, a phytochemical derived from cruciferous vegetables
- (2022) Natalia Jorgelina Prado et al. Heliyon
- Cancer Statistics, 2021
- (2021) Rebecca L. Siegel et al. CA-A CANCER JOURNAL FOR CLINICIANS
- Indole-3-carbinol ameliorates necroptosis and inflammation of intestinal epithelial cells in mice with ulcerative colitis by activating Aryl Hydrocarbon Receptor
- (2021) Chunting Peng et al. EXPERIMENTAL CELL RESEARCH
- 3,3′-Diindolylmethane Suppresses the Growth of Hepatocellular Carcinoma by Regulating Its Invasion, Migration, and ER Stress-Mediated Mitochondrial Apoptosis
- (2021) Suvesh Munakarmi et al. Cells
- Neuroprotective effects of indole-3-carbinol on the rotenone rat model of Parkinson's disease: Impact of the SIRT1-AMPK signaling pathway
- (2021) Khalid A. Mohamad et al. TOXICOLOGY AND APPLIED PHARMACOLOGY
- Glucosinolates From Cruciferous Vegetables and Their Potential Role in Chronic Disease: Investigating the Preclinical and Clinical Evidence
- (2021) Emma L. Connolly et al. Frontiers in Pharmacology
- Indoles Derived From Glucobrassicin: Cancer Chemoprevention by Indole-3-Carbinol and 3,3'-Diindolylmethane
- (2021) David E. Williams Frontiers in Nutrition
- Modulatory Effect of Indoles on the Expression of miRNAs Regulating G1/S Cell Cycle Phase in Breast Cancer Cells
- (2020) Sherien M. El-Daly et al. APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY
- Protective effect of Indole-3-carbinol, an NF-κB inhibitor in experimental paradigm of Parkinson’s disease: In silico and in vivo studies
- (2020) Neerja Saini et al. BRAIN BEHAVIOR AND IMMUNITY
- 3,3′-Diindolylmethane modulates aryl hydrocarbon receptor of esophageal squamous cell carcinoma to reverse epithelial-mesenchymal transition through repressing RhoA/ROCK1-mediated COX2/PGE2 pathway
- (2020) Peiyao Zhu et al. JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
- Changes in Mortality in Top 10 Causes of Death from 2011 to 2018
- (2020) Jamal S. Rana et al. JOURNAL OF GENERAL INTERNAL MEDICINE
- Dietary Indole-3-Carbinol Alleviated Spleen Enlargement, Enhanced IgG Response in C3H/HeN Mice Infected with Citrobacter rodentium
- (2020) Yanbei Wu et al. Nutrients
- PTEN/Akt Signaling-Mediated Activation of the Mitochondrial Pathway Contributes to the 3,3′-Diindolylmethane-Mediated Antitumor Effect in Malignant Melanoma Cells
- (2020) Xiaoli Wang et al. JOURNAL OF MEDICINAL FOOD
- 3,3'-Diindolylmethane inhibits patient-derived xenograft colon tumor growth by targeting COX1/2 and ERK1/2
- (2019) Xueli Tian et al. CANCER LETTERS
- Indole-3-carbinol inhibits lipid deposition and promotes autophagy in hyperlipidemia zebrafish larvae
- (2019) Yonghong Jiang et al. ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY
- Amelioration of Hyperglycemia-Induced Nephropathy by 3,3′-Diindolylmethane in Diabetic Mice
- (2019) Kyeong-Mi Choi et al. MOLECULES
- Indole-3-Carbinol (I3C) enhances the sensitivity of murine breast adenocarcinoma cells to doxorubicin (DOX) through inhibition of NF-κβ, blocking angiogenesis and regulation of mitochondrial apoptotic pathway
- (2018) Subhadip Hajra et al. CHEMICO-BIOLOGICAL INTERACTIONS
- Anticarcinogenic effect of indole-3-carbinol (I3C) on human hepatocellular carcinoma SNU449 cells
- (2018) CM Lee et al. HUMAN & EXPERIMENTAL TOXICOLOGY
- Preventive effects of indole-3-carbinol against alcohol-induced liver injury in mice via antioxidant, anti-inflammatory, and anti-apoptotic mechanisms: Role of gut-liver-adipose tissue axis
- (2018) Youngshim Choi et al. JOURNAL OF NUTRITIONAL BIOCHEMISTRY
- Targeting the Microcirculation by Indole-3-carbinol and Its Main Derivate 3,3,'-diindolylmethane: Effects on Angiogenesis, Thrombosis and Inflammation
- (2018) Emmanuel Ampofo et al. MINI-REVIEWS IN MEDICINAL CHEMISTRY
- 3,3′-Diindolylmethane Enhances Glucose Uptake Through Activation of Insulin Signaling in 3T3-L1 Adipocytes
- (2018) Kyeong-Mi Choi et al. Obesity
- Breeding Characteristics and Dose-dependent Blood Pressure Responses of Transgenic Cyp1a1–Ren2 Rats
- (2018) Catherine J Leader et al. COMPARATIVE MEDICINE
- 3,3′-Diindolylmethane Suppresses the Inflammatory Response to Lipopolysaccharide in Murine Macrophages
- (2018) Han Jin Cho et al. JOURNAL OF NUTRITION
- 3,3′-Diindolylmethane Suppresses Adipogenesis Using AMPKα-Dependent Mechanism in 3T3-L1 Adipocytes and Caenorhabditis elegans
- (2017) Jihye Lee et al. JOURNAL OF MEDICINAL FOOD
- Indole-3-carbinol is a potent inhibitor of ischemia–reperfusion–induced inflammation
- (2017) Emmanuel Ampofo et al. JOURNAL OF SURGICAL RESEARCH
- 3,3′-Diindolylmethane attenuates cardiomyocyte hypoxia by modulating autophagy in H9c2 cells
- (2017) Kai Liang et al. Molecular Medicine Reports
- 3,3’-Diindolylmethane suppresses high-fat diet-induced obesity through inhibiting adipogenesis of pre-adipocytes by targeting USP2 activity
- (2017) Hee Yang et al. MOLECULAR NUTRITION & FOOD RESEARCH
- Effect of Oral Administration of 3,3′-Diindolylmethane on Dextran Sodium Sulfate-Induced Acute Colitis in Mice
- (2016) Eun-Joo Jeon et al. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
- Indole-3-carbinol induces tumor cell death: function follows form
- (2016) Bryant W. Megna et al. JOURNAL OF SURGICAL RESEARCH
- Indole-3-carbinol protects against cisplatin-induced acute nephrotoxicity: role of calcitonin gene-related peptide and insulin-like growth factor-1
- (2016) Reem N. El-Naga et al. Scientific Reports
- Indole-3-carbinol as inhibitors of glucocorticoid-induced apoptosis in osteoblastic cells through blocking ROS-mediated Nrf2 pathway
- (2015) Hao Lin et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- 3,3′-Diindolylmethane increases bone mass by suppressing osteoclastic bone resorption in mice
- (2015) Tai-yong Yu et al. JOURNAL OF PHARMACOLOGICAL SCIENCES
- Pro-apoptotic and anti-proliferative effects of 3,3′-diindolylmethane in nasopharyngeal carcinoma cells via downregulation of telomerase activity
- (2015) FEN LI et al. Molecular Medicine Reports
- 3'3-Diindolylmethane inhibits migration, invasion and metastasis of hepatocellular carcinoma by suppressing FAK signaling
- (2015) Wen-Xue Li et al. Oncotarget
- Reactivity and Stability of Glucosinolates and Their Breakdown Products in Foods
- (2014) Franziska S. Hanschen et al. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
- Indole-3-carbinol and its N-alkoxy derivatives preferentially target ERα-positive breast cancer cells
- (2014) Joseph A Caruso et al. CELL CYCLE
- Attenuation of hyperglycemia-mediated oxidative stress by indole-3-carbinol and its metabolite 3, 3′- diindolylmethane in C57BL/6J mice
- (2014) Poornima Jayakumar et al. JOURNAL OF PHYSIOLOGY AND BIOCHEMISTRY
- Renal Nitric Oxide Synthase and Antioxidant Preservation in Cyp1a1-Ren-2 Transgenic Rats With Inducible Malignant Hypertension
- (2013) Mark W. Cunningham et al. AMERICAN JOURNAL OF HYPERTENSION
- Indole-3-Carbinol and 3',3'-Diindolylmethane Modulate Androgen's Effect on C-C Chemokine Ligand 2 and Monocyte Attraction to Prostate Cancer Cells
- (2013) E.-K. Kim et al. Cancer Prevention Research
- Indole-3-carbinol inhibits LPS-induced inflammatory response by blocking TRIF-dependent signaling pathway in macrophages
- (2013) Jun Jiang et al. FOOD AND CHEMICAL TOXICOLOGY
- Regulation of carbohydrate metabolism by indole-3-carbinol and its metabolite 3,3′-diindolylmethane in high-fat diet-induced C57BL/6J mice
- (2013) Jayakumar Poornima et al. MOLECULAR AND CELLULAR BIOCHEMISTRY
- Indole-3-carbinol inhibits cell proliferation and induces apoptosis in Hep-2 laryngeal cancer cells
- (2013) YA-QIU WANG et al. ONCOLOGY REPORTS
- Indole-3-carbinol attenuates the deleterious gestational effects of bisphenol A exposure on the prostate gland of male F1 rats
- (2013) Joyce Zalotti Brandt et al. REPRODUCTIVE TOXICOLOGY
- 3,3'-Diindolylmethane Inhibits Lipopolysaccharide-Induced Microglial Hyperactivation and Attenuates Brain Inflammation
- (2013) H. W. Kim et al. TOXICOLOGICAL SCIENCES
- Antiangiogenic activity of indole-3-carbinol in endothelial cells stimulated with activated macrophages
- (2012) Mei-Lin Wang et al. FOOD CHEMISTRY
- Indole-3-carbinol directly targets SIRT1 to inhibit adipocyte differentiation
- (2012) Y Choi et al. INTERNATIONAL JOURNAL OF OBESITY
- Indole-3-carbinol prevents diet-induced obesity through modulation of multiple genes related to adipogenesis, thermogenesis or inflammation in the visceral adipose tissue of mice
- (2012) Youngshim Choi et al. JOURNAL OF NUTRITIONAL BIOCHEMISTRY
- 3,3′-Diindolylmethane induces activating transcription factor 3 (ATF3) via ATF4 in human colorectal cancer cells
- (2012) Seong-Ho Lee et al. JOURNAL OF NUTRITIONAL BIOCHEMISTRY
- Glucosinolate structures in evolution
- (2012) Niels Agerbirk et al. PHYTOCHEMISTRY
- Water Stress and Aphid Feeding Differentially Influence Metabolite Composition in Arabidopsis thaliana (L.)
- (2012) Inga Mewis et al. PLoS One
- Anticancer effects of 3,3′-diindolylmethane are associated with G1 arrest and mitochondria-dependent apoptosis in human nasopharyngeal carcinoma cells
- (2012) YU XU et al. Oncology Letters
- Indole-3-carbinol downregulation of telomerase gene expression requires the inhibition of estrogen receptor-alpha and Sp1 transcription factor interactions within the hTERT promoter and mediates the G1 cell cycle arrest of human breast cancer cells
- (2011) C. N. Marconett et al. CARCINOGENESIS
- Suppression of inflammation-associated factors by indole-3-carbinol in mice fed high-fat diets and in isolated, co-cultured macrophages and adipocytes
- (2011) H-P Chang et al. INTERNATIONAL JOURNAL OF OBESITY
- In vivo pharmacodynamics of indole-3-carbinol in the inhibition of prostate cancer in transgenic adenocarcinoma of mouse prostate (TRAMP) mice: Involvement of Nrf2 and cell cycle/apoptosis signaling pathways
- (2011) Tien-Yuan Wu et al. MOLECULAR CARCINOGENESIS
- Antiobesity activities of indole-3-carbinol in high-fat-diet–induced obese mice
- (2011) Hsiao-Pei Chang et al. NUTRITION
- Key Role of Fe2+in Epithiospecifier Protein Activity
- (2010) David J. Williams et al. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
- 3,3′-diindolylmethane suppresses 12-O-tetradecanoylphorbol-13-acetate-induced inflammation and tumor promotion in mouse skin via the downregulation of inflammatory mediators
- (2010) Eun Ji Kim et al. MOLECULAR CARCINOGENESIS
- Activation of Checkpoint Kinase 2 by 3,3'-Diindolylmethane Is Required for Causing G2/M Cell Cycle Arrest in Human Ovarian Cancer Cells
- (2010) P. K. Kandala et al. MOLECULAR PHARMACOLOGY
- Induction of G1 and G2/M cell cycle arrests by the dietary compound 3,3'-diindolylmethane in HT-29 human colon cancer cells
- (2009) Hyun Ju Choi et al. BMC GASTROENTEROLOGY
- 3,3′-diindolylmethane attenuates colonic inflammation and tumorigenesis in mice
- (2009) Yoon Hee Kim et al. INFLAMMATORY BOWEL DISEASES
- Effect of Boiling on the Content of Ascorbigen, Indole-3-carbinol, Indole-3-acetonitrile, and 3,3′-Diindolylmethane in Fermented Cabbage
- (2009) Ewa Ciska et al. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
- Dose-dependent titration of prorenin and blood pressure in Cyp1a1ren-2 transgenic rats: absence of prorenin-induced glomerulosclerosis
- (2009) Barbara Peters et al. JOURNAL OF HYPERTENSION
- Oral Administration of 3,3′-Diindolylmethane Inhibits Lung Metastasis of 4T1 Murine Mammary Carcinoma Cells in BALB/c Mice
- (2009) Eun Ji Kim et al. JOURNAL OF NUTRITION
- Effects of different cooking methods on health-promoting compounds of broccoli
- (2009) Gao-feng Yuan et al. Journal of Zhejiang University-SCIENCE B
- 3,3′-Diindolylmethane reduces levels of HIF-1α and HIF-1 activity in hypoxic cultured human cancer cells
- (2008) Jacques E. Riby et al. BIOCHEMICAL PHARMACOLOGY
- Mammalian Target of Rapamycin Repression by 3,3'-Diindolylmethane Inhibits Invasion and Angiogenesis in Platelet-Derived Growth Factor-D-Overexpressing PC3 Cells
- (2008) D. Kong et al. CANCER RESEARCH
- Indole-3-carbinol inhibits MDA-MB-231 breast cancer cell motility and induces stress fibers and focal adhesion formation by activation of Rho kinase activity
- (2008) Christine T. Brew et al. INTERNATIONAL JOURNAL OF CANCER
- Indole glucosinolate breakdown and its biological effects
- (2008) Niels Agerbirk et al. PHYTOCHEMISTRY REVIEWS
- The Genetic Basis of Constitutive and Herbivore-Induced ESP-Independent Nitrile Formation in Arabidopsis
- (2008) M. Burow et al. PLANT PHYSIOLOGY
- N-Alkoxy derivatization of indole-3-carbinol increases the efficacy of the G1 cell cycle arrest and of I3C-specific regulation of cell cycle gene transcription and activity in human breast cancer cells
- (2007) Sarah M. Jump et al. BIOCHEMICAL PHARMACOLOGY
- Seasonal variation in glucosinolate content in Brassica oleracea crops grown in northwestern Spain
- (2007) María Elena Cartea et al. PHYTOCHEMISTRY
Add your recorded webinar
Do you already have a recorded webinar? Grow your audience and get more views by easily listing your recording on Peeref.
Upload NowCreate your own webinar
Interested in hosting your own webinar? Check the schedule and propose your idea to the Peeref Content Team.
Create Now