Indoles Derived From Glucobrassicin: Cancer Chemoprevention by Indole-3-Carbinol and 3,3'-Diindolylmethane

Regulation of Long Non-Coding RNAs by Plant Secondary Metabolites: A Novel Anticancer Therapeutic Approach

(2021) Mohammad Reza Kalhori et al.   Cancers

3,3′-Diindolylmethane Exhibits Significant Metabolism after Oral Dosing in Humans

(2021) Monica L. Vermillion Maier et al.   DRUG METABOLISM AND DISPOSITION

Modulatory Effect of Indoles on the Expression of miRNAs Regulating G1/S Cell Cycle Phase in Breast Cancer Cells

(2020) Sherien M. El-Daly et al.   APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY

Chemopreventive Agent 3,3′-Diindolylmethane Inhibits MDM2 in Colorectal Cancer Cells

(2020) Xiang Gao et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Mechanisms Underlying Biological Effects of Cruciferous Glucosinolate-Derived Isothiocyanates/Indoles: A Focus on Metabolic Syndrome

(2020) Montserrat Esteve   Frontiers in Nutrition

Breast cancer organoid model allowed to reveal potentially beneficial combinations of 3,3′-diindolylmethane and chemotherapy drugs

(2020) Sergey V. Nikulin et al.   BIOCHIMIE

Inhibition of Tumor Growth by Dietary Indole-3-Carbinol in a Prostate Cancer Xenograft Model May Be Associated with Disrupted Gut Microbial Interactions

(2019) Yanbei Wu et al.   Nutrients

The neuroprotective action of 3,3′-diindolylmethane against ischemia involves an inhibition of apoptosis and autophagy that depends on HDAC and AhR/CYP1A1 but not ERα/CYP19A1 signaling

(2019) J. Rzemieniec et al.   APOPTOSIS

3,3′-Diindolylmethane Inhibits TNF-α- and TGF-β-Induced Epithelial–Mesenchymal Transition in Breast Cancer Cells

(2019) Joomin Lee   NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL

Flavin-containing monooxygenase 3 (FMO3): genetic variants and their consequences for drug metabolism and disease

(2019) Ian R. Phillips et al.   XENOBIOTICA

Trimethylamine-N-Oxide (TMAO) Predicts Cardiovascular Mortality in Peripheral Artery Disease

(2019) Carmen Roncal et al.   Scientific Reports

Comparison of dienogest effects upon 3,3′–diindolylmethane supplementation in models of endometriosis and clinical cases

(2018) Diana M. Morales-Prieto et al.   Reproductive Biology

3,3′-Diindolylmethane Suppresses the Inflammatory Response to Lipopolysaccharide in Murine Macrophages

(2018) Han Jin Cho et al.   JOURNAL OF NUTRITION

The phytochemical 3,3′-diindolylmethane decreases expression of AR-controlled DNA damage repair genes through repressive chromatin modifications and is associated with DNA damage in prostate cancer cells

(2017) Zoraya Palomera-Sanchez et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Dietary tryptophan alleviates dextran sodium sulfate-induced colitis through aryl hydrocarbon receptor in mice

(2017) Jahidul Islam et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Treatment with anti-cancer agents results in profound changes in lncRNA expression in colon cancer cells

(2017) O. L. Zinovieva et al.   MOLECULAR BIOLOGY

Short Chain Fatty Acids Enhance Aryl Hydrocarbon (Ah) Responsiveness in Mouse Colonocytes and Caco-2 Human Colon Cancer Cells

(2017) Un-Ho Jin et al.   Scientific Reports

3,3′-Diindolylmethane induces anti-human gastric cancer cells by the miR-30e-ATG5 modulating autophagy

(2016) Yang Ye et al.   BIOCHEMICAL PHARMACOLOGY

Harnessing the Power of Cruciferous Vegetables: Developing a Biomarker for Brassica Vegetable Consumption Using Urinary 3,3'-Diindolylmethane

(2016) N. Fujioka et al.   Cancer Prevention Research

Indole-3-carbinol induces tumor cell death: function follows form

(2016) Bryant W. Megna et al.   JOURNAL OF SURGICAL RESEARCH

Dibenzo[def,p]chrysene transplacental carcinogenesis in wild-type,Cyp1b1knockout, andCYP1B1humanized mice

(2016) Erin P. Madeen et al.   MOLECULAR CARCINOGENESIS

Research on cruciferous vegetables, indole-3-carbinol, and cancer prevention: A tribute to Lee W. Wattenberg

(2016) Naomi Fujioka et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Chemopreventive properties of 3,3′-diindolylmethane in breast cancer: evidence from experimental and human studies

(2016) Cynthia A. Thomson et al.   NUTRITION REVIEWS

Bidirectional communication between the Aryl hydrocarbon Receptor (AhR) and the microbiome tunes host metabolism

(2016) Agata Korecka et al.   npj Biofilms and Microbiomes

First results of the double-blind randomized placebo-controlled multicenter clinical trial of DIM-based therapy designed as personalized approach to reverse prostatic intraepithelial neoplasia (PIN)

(2016) Mikhail Paltsev et al.   EPMA Journal

Regulation of PCGEM1 by p54/nrb in prostate cancer

(2016) Tsui-Ting Ho et al.   Scientific Reports

Genome-wide transcriptome analysis reveals inactivation of Wnt/β-catenin by 3,3′-diindolylmethane inhibiting proliferation of colon cancer cells

(2015) SUN-HEE LEEM et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Role of BioResponse 3,3′-Diindolylmethane in the Treatment of Human Prostate Cancer: Clinical Experience

(2015) Yiwei Li et al.   MEDICAL PRINCIPLES AND PRACTICE

3'3-Diindolylmethane inhibits migration, invasion and metastasis of hepatocellular carcinoma by suppressing FAK signaling

(2015) Wen-Xue Li et al.   Oncotarget

Double-blind randomized placebo-controlled multicenter clinical trial (phase IIa) on diindolylmethane’s efficacy and safety in the treatment of CIN: implications for cervical cancer prevention

(2015) Levon Ashrafian et al.   EPMA Journal

Adaptation of the human aryl hydrocarbon receptor to sense microbiota-derived indoles

(2015) Troy D. Hubbard et al.   Scientific Reports

Essential role of the cancer stem/progenitor cell marker nucleostemin for indole-3-carbinol anti-proliferative responsiveness in human breast cancer cells

(2014) Antony S Tin et al.   BMC BIOLOGY

Indole-3-carbinol induces cMYC and IAP-family downmodulation and promotes apoptosis of Epstein–Barr virus (EBV)-positive but not of EBV-negative Burkitt's lymphoma cell lines

(2014) Gema Perez-Chacon et al.   PHARMACOLOGICAL RESEARCH

Effects of Sulforaphane and 3,3′-Diindolylmethane on Genome-Wide Promoter Methylation in Normal Prostate Epithelial Cells and Prostate Cancer Cells

(2014) Carmen P. Wong et al.   PLoS One

Regulation of MicroRNAs by Natural Agents: New Strategies in Cancer Therapies

(2014) Neoh Hun Phuah et al.   Biomed Research International

Epigenetic Modifications of Nrf2 by 3,3′-diindolylmethane In Vitro in TRAMP C1 Cell Line and In Vivo TRAMP Prostate Tumors

(2013) Tien-Yuan Wu et al.   AAPS Journal

Phytochemicals from Cruciferous Vegetables, Epigenetics, and Prostate Cancer Prevention

(2013) Gregory W. Watson et al.   AAPS Journal

Urinary 3,3'-Diindolylmethane: A Biomarker of Glucobrassicin Exposure and Indole-3-Carbinol Uptake in Humans

(2013) N. Fujioka et al.   CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION

The Role of Estrogen Receptor   in Transplacental Cancer Prevention by Indole-3-Carbinol

(2013) A. D. Benninghoff et al.   Cancer Prevention Research

The epigenome as a potential mediator of cancer and disease prevention in prenatal development

(2013) Pushpinder Kaur et al.   NUTRITION REVIEWS

Use of natural AhR ligands as potential therapeutic modalities against inflammatory disorders

(2013) Philip B Busbee et al.   NUTRITION REVIEWS

DIM (3,3'-diindolylmethane) confers protection against ionizing radiation by a unique mechanism

(2013) S. Fan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Differential modulation of dibenzo[def,p]chrysene transplacental carcinogenesis: Maternal diets rich in indole-3-carbinol versus sulforaphane

(2013) Lyndsey E. Shorey et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Comparative preclinical pharmacokinetics study of 3,3′-diindolylmethane formulations: is personalized treatment and targeted chemoprevention in the horizon?

(2013) Mikhail Paltsev et al.   EPMA Journal

3,3′-Diindolylmethane Induces G1 Arrest and Apoptosis in Human Acute T-Cell Lymphoblastic Leukemia Cells

(2012) Lyndsey E. Shorey et al.   PLoS One

3,3′-Diindolylmethane, but not indole-3-carbinol, inhibits histone deacetylase activity in prostate cancer cells

(2012) Laura M. Beaver et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Pharmacodynamics of dietary phytochemical indoles I3C and DIM: Induction of Nrf2-mediated phase II drug metabolizing and antioxidant genes and synergism with isothiocyanates

(2011) Constance Lay-Lay Saw et al.   BIOPHARMACEUTICS & DRUG DISPOSITION

Transplacental carcinogenesis with dibenzo[def,p]chrysene (DBC): Timing of maternal exposures determines target tissue response in offspring

(2011) Lyndsey E. Shorey et al.   CANCER LETTERS

The rainbow trout liver cancer model: Response to environmental chemicals and studies on promotion and chemoprevention

(2011) David E. Williams   COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY

Antioxidant N-acetyl-L-cysteine (NAC) supplementation reduces reactive oxygen species (ROS)-mediated hepatocellular tumor promotion of indole-3-carbinol (I3C) in rats

(2011) Keisuke Shimamoto et al.   JOURNAL OF TOXICOLOGICAL SCIENCES

Attenuation of multi-targeted proliferation-linked signaling by 3,3′-diindolylmethane (DIM): From bench to clinic

(2011) Sanjeev Banerjee et al.   MUTATION RESEARCH-REVIEWS IN MUTATION RESEARCH

Inhibition of Fatty Acid Synthase and Sp1 Expression by 3,3′-Diindolylmethane in Human Breast Cancer Cells

(2011) George E. Saati et al.   NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL

Effects of 5,6-benzoflavone, indole-3-carbinol (I3C) and diindolylmethane (DIM) on chemically-induced mammary carcinogenesis: Is DIM a substitute for I3C?

(2011) Ronald Lubet   ONCOLOGY REPORTS

3,3′-Diindolylmethane Modulates Estrogen Metabolism in Patients with Thyroid Proliferative Disease: A Pilot Study

(2011) Shilpi Rajoria et al.   THYROID

Chemopreventive Agent 3,3'-Diindolylmethane Selectively Induces Proteasomal Degradation of Class I Histone Deacetylases

(2010) Y. Li et al.   CANCER RESEARCH

3,3′-Diindolylmethane decreases VCAM-1 expression and alleviates experimental colitis via a BRCA1-dependent antioxidant pathway

(2010) Zhen Huang et al.   FREE RADICAL BIOLOGY AND MEDICINE

3,3'-Diindolylmethane inhibits migration and invasion of human cancer cells through combined suppression of ERK and AKT pathways

(2010) Tiwari   ONCOLOGY REPORTS

Cruciferous Vegetable Intake and Cancer Prevention: Role of Nutrigenetics

(2009) C. B. Ambrosone et al.   Cancer Prevention Research

Nonlinear Cancer Response at Ultralow Dose: A 40800-Animal ED001Tumor and Biomarker Study

(2009) George S. Bailey et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Oral diindolylmethane (DIM): Pilot evaluation of a nonsurgical treatment for cervical dysplasia

(2009) Giuseppe Del Priore et al.   GYNECOLOGIC ONCOLOGY

3,3′-diindolylmethane attenuates colonic inflammation and tumorigenesis in mice

(2009) Yoon Hee Kim et al.   INFLAMMATORY BOWEL DISEASES

Minireview: Modulation of Hormone Receptor Signaling by Dietary Anticancer Indoles

(2009) Gary L. Firestone et al.   MOLECULAR ENDOCRINOLOGY

Aryl hydrocarbon receptor suppresses intestinal carcinogenesis in ApcMin/+ mice with natural ligands

(2009) K. Kawajiri et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Anti-adult T-cell leukemia/lymphoma effects of indole-3-carbinol

(2009) Yoshiaki Machijima et al.   Retrovirology

Modulation of Aflatoxin B1–Mediated Genotoxicity in Primary Cultures of Human Hepatocytes by Diindolylmethane, Curcumin, and Xanthohumols

(2009) Kerstin Gross-Steinmeyer et al.   TOXICOLOGICAL SCIENCES

Single-Dose Pharmacokinetics and Tolerability of Absorption-Enhanced 3,3'-Diindolylmethane in Healthy Subjects

(2008) G. A. Reed et al.   CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION

Indole-3-carbinol as a chemopreventive and anti-cancer agent

(2008) Jing-Ru Weng et al.   CANCER LETTERS

Identifying efficacious approaches to chemoprevention with chlorophyllin, purified chlorophylls and freeze-dried spinach in a mouse model of transplacental carcinogenesis

(2008) D. J. Castro et al.   CARCINOGENESIS

Chemoprevention of dibenzo[a,l]pyrene transplacental carcinogenesis in mice born to mothers administered green tea: primary role of caffeine

(2008) D. J. Castro et al.   CARCINOGENESIS

The cancer chemopreventive actions of phytochemicals derived from glucosinolates

(2008) John D. Hayes et al.   EUROPEAN JOURNAL OF NUTRITION

Inhibitory effects of a dietary phytochemical 3,3′-diindolylmethane on the phenobarbital-induced hepatic CYP mRNA expression and CYP-catalyzed reactions in female rats

(2008) Daniel R. Parkin et al.   FOOD AND CHEMICAL TOXICOLOGY

A Review of the Clinical Efficacy and Safety of Cruciferous Vegetable Phytochemicals

(2008) Deanna M. Minich et al.   NUTRITION REVIEWS

Cruciferous vegetable intake and the risk of human cancer: epidemiological evidence

(2008) Mi Kyung Kim et al.   PROCEEDINGS OF THE NUTRITION SOCIETY