Neuroprotective effects of indole-3-carbinol on the rotenone rat model of Parkinson's disease: Impact of the SIRT1-AMPK signaling pathway

Microglial activation contributes to cognitive impairments in rotenone-induced mouse Parkinson’s disease model

(2021) Dongdong Zhang et al.   Journal of Neuroinflammation

Ndfip1 Prevents Rotenone-Induced Neurotoxicity and Upregulation of α-Synuclein in SH-SY5Y Cells

(2021) Xin Liu et al.   Frontiers in Molecular Neuroscience

Artemisiae Iwayomogii Herba inhibits lipopolysaccharide-induced neuroinflammation by regulating NF-κB and MAPK signaling pathways

(2021) In Gyoung Ju et al.   PHYTOMEDICINE

Vitamin D and rosuvastatin obliterate peripheral neuropathy in a type-2 diabetes model through modulating Notch1, Wnt-10α, TGF-β and NRF-1 crosstalk

(2021) Engie S. El-Sawaf et al.   LIFE SCIENCES

FGF21 Protects Dopaminergic Neurons in Parkinson’s Disease Models Via Repression of Neuroinflammation

(2020) Xingxing Fang et al.   NEUROTOXICITY RESEARCH

Protective effect of Indole-3-carbinol, an NF-κB inhibitor in experimental paradigm of Parkinson’s disease: In silico and in vivo studies

(2020) Neerja Saini et al.   BRAIN BEHAVIOR AND IMMUNITY

AMPK-SIRT1-PGC1α Signal Pathway Influences the Cognitive Function of Aged Rats in Sevoflurane-Induced Anesthesia

(2020) Xiao-Yu Yang et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Neuroprotective effects of Pulicaria undulata essential oil in rotenone model of parkinson's disease in rats: Insights into its anti-inflammatory and anti-oxidant effects

(2020) Marwa Y. Issa et al.   SOUTH AFRICAN JOURNAL OF BOTANY

α-Bisabolol, a Dietary Bioactive Phytochemical Attenuates Dopaminergic Neurodegeneration through Modulation of Oxidative Stress, Neuroinflammation and Apoptosis in Rotenone-Induced Rat Model of Parkinson’s Disease

(2020) Hayate Javed et al.   Biomolecules

Inhibition of PDE4 by FCPR16 induces AMPK-dependent autophagy and confers neuroprotection in SH-SY5Y cells and neurons exposed to MPP+-induced oxidative insult

(2019) Jiahong Zhong et al.   FREE RADICAL BIOLOGY AND MEDICINE

Purinergic Signalling in Parkinson’s Disease: A Multi-target System to Combat Neurodegeneration

(2019) Adrián Tóth et al.   NEUROCHEMICAL RESEARCH

miR-9-5p modulates the progression of Parkinson’s disease by targeting SIRT1

(2019) Zuobo Wang et al.   NEUROSCIENCE LETTERS

Loss of Non-Apoptotic Role of Caspase-3 in the PINK1 Mouse Model of Parkinson’s Disease

(2019) Paola Imbriani et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Methyl jasmonate ameliorates rotenone-induced motor deficits in rats through its neuroprotective activity and increased expression of tyrosine hydroxylase immunopositive cells

(2019) Akinyinka O. Alabi et al.   METABOLIC BRAIN DISEASE

Neuroprotective effect of crocin against rotenone-induced Parkinson's disease in rats: Interplay between PI3K/Akt/mTOR signaling pathway and enhanced expression of miRNA-7 and miRNA-221

(2019) Rania M. Salama et al.   NEUROPHARMACOLOGY

Protective Effect of (−)Epigallocatechin-3-gallate on Rotenone-Induced Parkinsonism-like Symptoms in Rats

(2019) Hsiang-Chien Tseng et al.   NEUROTOXICITY RESEARCH

Resveratrol Suppresses Rotenone-induced Neurotoxicity Through Activation of SIRT1/Akt1 Signaling Pathway

(2018) Hui Wang et al.   Anatomical Record-Advances in Integrative Anatomy and Evolutionary Biology

Cellular phenotypes as inflammatory mediators in Parkinson’s disease: Interventional targets and role of natural products

(2018) Xu Jiang et al.   BIOMEDICINE & PHARMACOTHERAPY

Rotenone induces gastrointestinal pathology and microbiota alterations in a rat model of Parkinson’s disease

(2018) Michaela E. Johnson et al.   NEUROTOXICOLOGY

Tyrosine hydroxylase as a sentinel for central and peripheral tissue responses in Parkinson’s progression: Evidence from clinical studies and neurotoxin models

(2018) M.E. Johnson et al.   PROGRESS IN NEUROBIOLOGY

Echinacoside protects against MPTP/MPP+-induced neurotoxicity via regulating autophagy pathway mediated by Sirt1

(2018) Chang Chen et al.   METABOLIC BRAIN DISEASE

Next generation sequencing of RNA reveals novel targets of resveratrol with possible implications for Canavan disease

(2018) Maja Dembic et al.   MOLECULAR GENETICS AND METABOLISM

Indole-3-Carbinol Induces Apoptosis in Human Osteosarcoma MG-63 and U2OS Cells

(2018) Chang Min Lee et al.   Biomed Research International

SIRT1 and AMPK pathways are essential for the proliferation and survival of primary effusion lymphoma cells

(2017) Meilan He et al.   JOURNAL OF PATHOLOGY

AMPK: Mechanisms of Cellular Energy Sensing and Restoration of Metabolic Balance

(2017) Daniel Garcia et al.   MOLECULAR CELL

Selective A 2A receptors blockade reduces degeneration of substantia nigra dopamine neurons in a rotenone-induced rat model of Parkinson’s disease: A histological study

(2017) Ahmed M. Fathalla et al.   NEUROSCIENCE LETTERS

Treadmill Exercise Attenuates α-Synuclein Levels by Promoting Mitochondrial Function and Autophagy Possibly via SIRT1 in the Chronic MPTP/P-Induced Mouse Model of Parkinson’s Disease

(2017) Jung-Hoon Koo et al.   NEUROTOXICITY RESEARCH

The Synucleinopathies: Twenty Years On

(2017) Michel Goedert et al.   Journal of Parkinsons Disease

Redox imbalance and mitochondrial abnormalities in the diabetic lung

(2017) Jinzi Wu et al.   Redox Biology

ATP Maintenance via Two Types of ATP Regulators Mitigates Pathological Phenotypes in Mouse Models of Parkinson's Disease

(2017) Masaki Nakano et al.   EBioMedicine

Neuroprotective effect of nerolidol against neuroinflammation and oxidative stress induced by rotenone

(2016) Hayate Javed et al.   BMC NEUROSCIENCE

Harnessing the Power of Cruciferous Vegetables: Developing a Biomarker for Brassica Vegetable Consumption Using Urinary 3,3'-Diindolylmethane

(2016) N. Fujioka et al.   Cancer Prevention Research

Targeting the Autophagy/Lysosomal Degradation Pathway in Parkinsons Disease

(2016) Pilar Rivero-Ríos et al.   Current Neuropharmacology

p53 and mitochondrial dysfunction: novel insight of neurodegenerative diseases

(2016) Chun-Qiu Dai et al.   JOURNAL OF BIOENERGETICS AND BIOMEMBRANES

Tetramethylpyrazine Ameliorates Rotenone-Induced Parkinson’s Disease in Rats: Involvement of Its Anti-Inflammatory and Anti-Apoptotic Actions

(2016) Haidy E. Michel et al.   MOLECULAR NEUROBIOLOGY

Resveratrol alleviates MPTP-induced motor impairments and pathological changes by autophagic degradation of α-synuclein via SIRT1-deacetylated LC3

(2016) Yan-Jie Guo et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Ibuprofen or piroxicam protects nigral neurons and delays the development of l -dopa induced dyskinesia in rats with experimental Parkinsonism: Influence on angiogenesis

(2016) Asmaa M. Teema et al.   NEUROPHARMACOLOGY

Indole-3-carbinol protects against cisplatin-induced acute nephrotoxicity: role of calcitonin gene-related peptide and insulin-like growth factor-1

(2016) Reem N. El-Naga et al.   Scientific Reports

Pomegranate extract decreases oxidative stress and alleviates mitochondrial impairment by activating AMPK-Nrf2 in hypothalamic paraventricular nucleus of spontaneously hypertensive rats

(2016) Wenyan Sun et al.   Scientific Reports

AMPK Activation Inhibits Expression of Proinflammatory Mediators Through Downregulation of PI3K/p38 MAPK and NF-κB Signaling in Murine Macrophages

(2015) Bee-Piao Huang et al.   DNA AND CELL BIOLOGY

Protective Effects of Indole-3-Carbinol-Loaded Poly(lactic-co-glycolic acid) Nanoparticles Against Glutamate-Induced Neurotoxicity

(2015) Ji Heun Jeong et al.   JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY

The activation of the Nrf2/ARE pathway in HepG2 hepatoma cells by phytochemicals and subsequent modulation of phase II and antioxidant enzyme expression

(2015) Violetta Krajka-Kuźniak et al.   JOURNAL OF PHYSIOLOGY AND BIOCHEMISTRY

Sestrin2 Protects Dopaminergic Cells against Rotenone Toxicity through AMPK-Dependent Autophagy Activation

(2015) Yi-Sheng Hou et al.   MOLECULAR AND CELLULAR BIOLOGY

Glycyrrhizic acid Attenuates Neuroinflammation and Oxidative Stress in Rotenone Model of Parkinson’s Disease

(2015) Shreesh Ojha et al.   NEUROTOXICITY RESEARCH

Protection by genistein on cortical neurons against oxidative stress injury via inhibition of NF-kappaB, JNK and ERK signaling pathway

(2015) Yisong Qian et al.   PHARMACEUTICAL BIOLOGY

Indole-3-carbinol, a vegetable phytochemical, inhibits adipogenesis by regulating cell cycle and AMPKα signaling

(2014) Hyeon-Son Choi et al.   BIOCHIMIE

Effects of indole-3-carbinol on clonidine-induced neurotoxicity in rats: Impact on oxidative stress, inflammation, apoptosis and monoamine levels

(2014) Reem N. El-Naga et al.   NEUROTOXICOLOGY

Involvement of SIRT1–AMPK signaling in the protective action of indole-3-carbinol against hepatic steatosis in mice fed a high-fat diet

(2013) Youngshim Choi et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Indole-3-carbinol protects against pressure overload induced cardiac remodeling via activating AMPK-α

(2013) Wei Deng et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Beneficial Effect of Vitamin E in Rotenone Induced Model of PD: Behavioural, Neurochemical and Biochemical Study

(2013) Neha Sharma et al.   Experimental Neurobiology

Indole-3-carbinol directly targets SIRT1 to inhibit adipocyte differentiation

(2012) Y Choi et al.   INTERNATIONAL JOURNAL OF OBESITY

Indole-3-carbinol prevents diet-induced obesity through modulation of multiple genes related to adipogenesis, thermogenesis or inflammation in the visceral adipose tissue of mice

(2012) Youngshim Choi et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Autophagy induced by the class III histone deacetylase Sirt1 prevents prion peptide neurotoxicity

(2012) Jae-Kyo Jeong et al.   NEUROBIOLOGY OF AGING

Epidemiology and etiology of Parkinson’s disease: a review of the evidence

(2011) Karin Wirdefeldt et al.   EUROPEAN JOURNAL OF EPIDEMIOLOGY

Resveratrol-Activated AMPK/SIRT1/Autophagy in Cellular Models of Parkinson’s Disease

(2011) Yuncheng Wu et al.   NEUROSIGNALS

Current strategies to target p53 in cancer

(2010) Fang Chen et al.   BIOCHEMICAL PHARMACOLOGY