Mitochondrial protein hyperacetylation underpins heart failure with preserved ejection fraction in mice

Nicotinamide for the treatment of heart failure with preserved ejection fraction

(2021) Mahmoud Abdellatif et al.   Science Translational Medicine

Hypoxic acclimation improves cardiac redox homeostasis and protects heart against ischemia-reperfusion injury through upregulation of O-GlcNAcylation

(2021) Wei Ou et al.   Redox Biology

Extreme Acetylation of the Cardiac Mitochondrial Proteome Does Not Promote Heart Failure

(2020) Michael Thomas Davidson et al.   CIRCULATION RESEARCH

Targeting Mitochondria-Inflammation Circuit by β-Hydroxybutyrate Mitigates HFpEF

(2020) Yan Deng et al.   CIRCULATION RESEARCH

SUCLA2 mutations cause global protein succinylation contributing to the pathomechanism of a hereditary mitochondrial disease

(2020) Philipp Gut et al.   Nature Communications

Crosstalk between mitochondrial hyperacetylation and oxidative stress in vascular dysfunction and hypertension

(2019) Sergey I Dikalov et al.   ANTIOXIDANTS & REDOX SIGNALING

Nitrosative stress drives heart failure with preserved ejection fraction

(2019) Gabriele G. Schiattarella et al.   NATURE

Lysine acetyltransferases and lysine deacetylases as targets for cardiovascular disease

(2019) Peng Li et al.   Nature Reviews Cardiology

Mitochondria in the signaling pathways that control longevity and health span

(2019) Mansour Akbari et al.   AGEING RESEARCH REVIEWS

Unlocking the Secrets of Mitochondria in the Cardiovascular System

(2019) Rong Tian et al.   CIRCULATION

Disruption of Acetyl-Lysine Turnover in Muscle Mitochondria Promotes Insulin Resistance and Redox Stress without Overt Respiratory Dysfunction

(2019) Ashley S. Williams et al.   Cell Metabolism

Cardiovascular Metabolomics

(2018) Robert W. McGarrah et al.   CIRCULATION RESEARCH

Metabolic remodelling in heart failure

(2018) Edoardo Bertero et al.   Nature Reviews Cardiology

Sirtuins and NAD + in the Development and Treatment of Metabolic and Cardiovascular Diseases

(2018) Alice E. Kane et al.   CIRCULATION RESEARCH

Mitochondrial dysfunction in pathophysiology of heart failure

(2018) Bo Zhou et al.   JOURNAL OF CLINICAL INVESTIGATION

Heart Failure With Preserved Ejection Fraction in the Young

(2018) Jasper Tromp et al.   CIRCULATION

Functions and mechanisms of non-histone protein acetylation

(2018) Takeo Narita et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

STRING v11: protein–protein association networks with increased coverage, supporting functional discovery in genome-wide experimental datasets

(2018) Damian Szklarczyk et al.   NUCLEIC ACIDS RESEARCH

The Aging Cardiovascular System

(2017) Francesco Paneni et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Epidemiology of heart failure with preserved ejection fraction

(2017) Shannon M. Dunlay et al.   Nature Reviews Cardiology

Normalization of NAD+Redox Balance as a Therapy for Heart FailureClinical Perspective

(2016) Chi Fung Lee et al.   CIRCULATION

Nicotinamide riboside is uniquely and orally bioavailable in mice and humans

(2016) Samuel A. J. Trammell et al.   Nature Communications

NAD+ Metabolism and the Control of Energy Homeostasis: A Balancing Act between Mitochondria and the Nucleus

(2015) Carles Cantó et al.   Cell Metabolism

SIRT3 Mediates Multi-Tissue Coupling for Metabolic Fuel Switching

(2015) Kristin E. Dittenhafer-Reed et al.   Cell Metabolism

cytoHubba: identifying hub objects and sub-networks from complex interactome

(2014) Chia-Hao Chin et al.   BMC Systems Biology

Obesity-induced lysine acetylation increases cardiac fatty acid oxidation and impairs insulin signalling

(2014) Osama Abo Alrob et al.   CARDIOVASCULAR RESEARCH

Heart Failure With Preserved Ejection Fraction

(2014) Kavita Sharma et al.   CIRCULATION RESEARCH

Atrogin-1 deficiency promotes cardiomyopathy and premature death via impaired autophagy

(2014) Tania Zaglia et al.   JOURNAL OF CLINICAL INVESTIGATION

The pathophysiology of heart failure with preserved ejection fraction

(2014) Barry A. Borlaug   Nature Reviews Cardiology

50 years of protein acetylation: from gene regulation to epigenetics, metabolism and beyond

(2014) Eric Verdin et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Growth Differentiation Factor 11 Is a Circulating Factor that Reverses Age-Related Cardiac Hypertrophy

(2013) Francesco S. Loffredo et al.   CELL

Mitochondrial Complex I Deficiency Increases Protein Acetylation and Accelerates Heart Failure

(2013) Georgios Karamanlidis et al.   Cell Metabolism

Sca-1 Knockout Impairs Myocardial and Cardiac Progenitor Cell Function

(2012) Brandi Bailey et al.   CIRCULATION RESEARCH

Predictors of New-Onset Heart Failure

(2012) Jennifer E. Ho et al.   Circulation-Heart Failure

 40 Isoform of p53 Controls  -Cell Proliferation and Glucose Homeostasis in Mice

(2011) C. Hinault et al.   DIABETES