Gut dysbiosis induced by cardiac pressure overload enhances adverse cardiac remodeling in a T cell-dependent manner

Heart Disease and Stroke Statistics—2020 Update: A Report From the American Heart Association

(2020) Salim S. Virani et al.   CIRCULATION

Loss of Gut Microbiota Alters Immune System Composition and Cripples Post-Infarction Cardiac Repair

(2019) Tony WH Tang et al.   CIRCULATION

Control of tumor-associated macrophages and T cells in glioblastoma via AHR and CD39

(2019) Maisa C. Takenaka et al.   NATURE NEUROSCIENCE

Can intestinal microbiota and circulating microbial products contribute to pulmonary arterial hypertension?

(2019) Thenappan Thenappan et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

The MetaCyc database of metabolic pathways and enzymes - a 2019 update

(2019) Ron Caspi et al.   NUCLEIC ACIDS RESEARCH

Microbiota-derived peptide mimics drive lethal inflammatory cardiomyopathy

(2019) Cristina Gil-Cruz et al.   SCIENCE

Non-Ischemic Heart Failure With Reduced Ejection Fraction Is Associated With Altered Intestinal Microbiota

(2018) Themistoklis Katsimichas et al.   CIRCULATION JOURNAL

Adaptive immune education by gut microbiota antigens

(2018) Qing Zhao et al.   IMMUNOLOGY

Metagenomic and metabolomic analyses unveil dysbiosis of gut microbiota in chronic heart failure patients

(2018) Xiao Cui et al.   Scientific Reports

Gut microbe-derived metabolite trimethylamine N-oxide induces cardiac hypertrophy and fibrosis

(2018) Zehua Li et al.   LABORATORY INVESTIGATION

Dietary metabolism, the gut microbiome, and heart failure

(2018) W. H. Wilson Tang et al.   Nature Reviews Cardiology

Th1 effector T cells selectively orchestrate cardiac fibrosis in nonischemic heart failure

(2017) Tania Nevers et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Gut dysbiosis and neuroimmune responses to brain infection with Theiler’s murine encephalomyelitis virus

(2017) F. J. Carrillo-Salinas et al.   Scientific Reports

Dysbiosis and compositional alterations with aging in the gut microbiota of patients with heart failure

(2017) Takehiro Kamo et al.   PLoS One

Type I interferons and microbial metabolites of tryptophan modulate astrocyte activity and central nervous system inflammation via the aryl hydrocarbon receptor

(2016) Veit Rothhammer et al.   NATURE MEDICINE

Microbial short chain fatty acid metabolites lower blood pressure via endothelial G protein-coupled receptor 41

(2016) Niranjana Natarajan et al.   PHYSIOLOGICAL GENOMICS

Isolation and Flow Cytometric Characterization of Murine Small Intestinal Lymphocytes

(2016) Cheryn J. Couter et al.   Jove-Journal of Visualized Experiments

Pathogenic Gut Flora in Patients With Chronic Heart Failure

(2016) Evasio Pasini et al.   JACC-Heart Failure

Left Ventricular T-Cell Recruitment Contributes to the Pathogenesis of Heart FailureCLINICAL PERSPECTIVE

(2015) Tania Nevers et al.   Circulation-Heart Failure

Choline Diet and Its Gut Microbe–Derived Metabolite, Trimethylamine N-Oxide, Exacerbate Pressure Overload–Induced Heart FailureCLINICAL PERSPECTIVE

(2015) Chelsea L. Organ et al.   Circulation-Heart Failure

STAMP: statistical analysis of taxonomic and functional profiles

(2014) Donovan H. Parks et al.   BIOINFORMATICS

CD4 + T Cells Promote the Transition From Hypertrophy to Heart Failure During Chronic Pressure Overload

(2014) Fanny Laroumanie et al.   CIRCULATION

The contributory role of gut microbiota in cardiovascular disease

(2014) W.H. Wilson Tang et al.   JOURNAL OF CLINICAL INVESTIGATION

Cardiac-specific ablation of ARNT leads to lipotoxicity and cardiomyopathy

(2014) Rongxue Wu et al.   JOURNAL OF CLINICAL INVESTIGATION

Intestinal Blood Flow in Patients With Chronic Heart Failure

(2014) Anja Sandek et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Tryptophan Catabolites from Microbiota Engage Aryl Hydrocarbon Receptor and Balance Mucosal Reactivity via Interleukin-22

(2013) Teresa Zelante et al.   IMMUNITY

Protein Kinase G Iα Inhibits Pressure Overload–Induced Cardiac Remodeling and Is Required for the Cardioprotective Effect of Sildenafil In Vivo

(2013) Robert M. Blanton et al.   Journal of the American Heart Association

Activation of CD4 + T Lymphocytes Improves Wound Healing and Survival After Experimental Myocardial Infarction in Mice

(2012) Ulrich Hofmann et al.   CIRCULATION

Functional interactions between the gut microbiota and host metabolism

(2012) Valentina Tremaroli et al.   NATURE

Host-Gut Microbiota Metabolic Interactions

(2012) J. K. Nicholson et al.   SCIENCE

Microbiota regulates immune defense against respiratory tract influenza A virus infection

(2011) T. Ichinohe et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Studies on bacterial endotoxin and intestinal absorption function in patients with chronic heart failure

(2010) Anja Sandek et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

Cardiomyocyte PDGFR-β signaling is an essential component of the mouse cardiac response to load-induced stress

(2010) Vishnu Chintalgattu et al.   JOURNAL OF CLINICAL INVESTIGATION

Induction of Intestinal Th17 Cells by Segmented Filamentous Bacteria

(2009) Ivaylo I. Ivanov et al.   CELL

Role of Gut Commensal Microflora in the Development of Experimental Autoimmune Encephalomyelitis

(2009) J. Ochoa-Reparaz et al.   JOURNAL OF IMMUNOLOGY

Specific Microbiota Direct the Differentiation of IL-17-Producing T-Helper Cells in the Mucosa of the Small Intestine

(2008) Ivaylo I. Ivanov et al.   Cell Host & Microbe

17 Beta-Estradiol Differentially Affects Left Ventricular and Cardiomyocyte Hypertrophy Following Myocardial Infarction and Pressure Overload

(2008) Richard D. Patten et al.   JOURNAL OF CARDIAC FAILURE