Review
Biochemistry & Molecular Biology
Tom Kretzschmar, Jasmine M. F. Wu, P. Christian Schulze
Summary: Heart failure remains the most common cause of death in the industrialized world, and despite new therapeutic interventions, complete prevention of its development and progression is still not possible, highlighting the need for further research to understand the underlying mechanisms. This review provides a detailed overview of the contribution of impaired mitochondrial dynamics and energy homeostasis during heart failure progression.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Cardiac & Cardiovascular Systems
Joohee Choi, Joshua B. Holmes, Kenneth S. Campbell, Julian E. Stelzer
Summary: OM and danicamtiv increase myocardial force output through different mechanisms, with OM significantly increasing Ca2+ sensitivity of force generation and danicamtiv having a less pronounced effect. Both drugs slow down cross-bridge kinetics, but danicamtiv has a more pronounced inhibitory effect on the OM-induced dynamic delay.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2023)
Editorial Material
Biochemistry & Molecular Biology
James Chen, Damian C. Ekiert
Summary: This paragraph describes a drug for treating multidrug-resistant tuberculosis, which targets the key enzyme ATP synthase in cellular respiration. A recent study shows that this drug, along with another inhibitor, prevents the enzymatic function by inhibiting the necessary rotational motions.
Article
Cardiac & Cardiovascular Systems
Yu-Han Chen, Albert P. Ta, Yumay Chen, Hsiao-Chen Lee, Wenjun Fan, Phang-Lang Chen, Maria C. Jordan, Kenneth P. Roos, Grant R. MacGregor, Qin Yang, Robert A. Edwards, Junfeng Li, Ping H. Wang
Summary: The study aimed to investigate the effect of mitochondrial AKT signaling on cardiac structure and function. The results showed that disrupted mitochondrial AKT signaling led to cardiomyopathy with cardiac fibrosis, left ventricular hypertrophy, and dysfunction. On the other hand, activation of mitochondrial AKT1 protected against diabetic cardiomyopathy and improved overall metabolism. These findings highlight the importance of mitochondrial AKT signaling in maintaining cardiac health.
CARDIOVASCULAR DIABETOLOGY
(2023)
Editorial Material
Endocrinology & Metabolism
Salvatore Nesci, Giovanni Romeo
Summary: A recent study by Ganetzky et al. has discovered a de novo heterozygous variant in the catalytic subunit of mitochondrial F1FO-ATPase, which is found to be the main cause of an autosomal dominant syndrome associated with defective ATP production. This article describes how the dysfunction of F1FO-ATPase in primary congenital hypothyroidism is caused by the 'rotor free-wheeling'.
TRENDS IN ENDOCRINOLOGY AND METABOLISM
(2023)
Article
Cardiac & Cardiovascular Systems
Elric Zweck, Maximilian Karschnia, Daniel Scheiber, Harald Heidecke, Ralf Dechend, Carmen Barthuber, Sina Kaufmann, Malte Kelm, Michael Roden, Ralf Westenfeld, Julia Szendroedi, Fritz Boege
Summary: GPCR autoantibodies are significantly altered in non-ischaemic heart failure (HF), but they are poorly correlated or even inversely correlated with haemodynamic, metabolic, and functional markers of disease severity, myocardial histology, and myocardial mitochondrial efficiency. These observations do not suggest a specific cardio-pathogenic role of GPCR autoantibodies in non-ischaemic HF, and further investigations are needed before specific therapies targeting GPCR autoantibodies can be clinically tested.
Article
Cardiac & Cardiovascular Systems
Kyra K. Peczkowski, Mohammed A. Mashali, Nancy S. Saad, Austin Hare, Courtney M. Campbell, Bryan A. Whitson, Nahush A. Mokadam, Paul M. L. Janssen
Summary: The study found that nonfailing hearts generally have higher EAT content compared to end-stage failing hearts, and there is no strong correlation between EAT quantity and BMI in both nonfailing and failing hearts. Atrial EAT is closely correlated with ventricular EAT in both nonfailing and failing hearts.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2022)
Article
Cardiac & Cardiovascular Systems
Vinayak Kumar, Alexander J. Ryu, Armando Manduca, Chaitanya Rao, Raymond J. Gibbons, Bernard J. Gersh, Krishnaswamy Chandrasekaran, Samuel J. Asirvatham, Philip A. Araoz, Jae K. Oh, Alexander C. Egbe, Atta Behfar, Barry A. Borlaug, Nandan S. Anavekar
Summary: This study found that healthy myocardium is compressible, while myocardium in patients with heart failure with reduced ejection fraction is incompressible. The ratio MVs/MVd may need further investigation in different populations to understand its variations.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2021)
Article
Multidisciplinary Sciences
Jan M. Hughes-Austin, Ronit Katz, Darcy S. Majka, Michael H. Criqui, William H. Robinson, Gary S. Firestein, W. Gregory Hundley, Joachim H. Ix
Summary: This study found that serum reactivity to citrullinated protein/peptide antigens was associated with altered left ventricular structure and function. Specifically, higher reactivity was linked to lower left ventricular ejection fraction, but not with left ventricular mass or incident heart failure.
Article
Medicine, General & Internal
Mauricio Rodrigues Jordao, Fernanda G. Pessoa, Keila C. B. Fonseca, Fernando Zanoni, Vera M. C. Salemi, Leandro E. Souza, Orlando N. Ribeiro, Fabio Fernandes, Maria Claudia Irigoyen, Luiz Felipe P. Moreira, Charles Mady, Felix Jose Alvarez Ramires
Summary: The study found that the bilateral sympathectomy group had higher levels of peripheral catecholamines and consequently higher heart rate, indicating that the activation of compensatory pathways may have deleterious effects. During the exercise test, the bilateral group showed basal tachycardia and increased tachycardia at peak exercise.
Article
Multidisciplinary Sciences
Leo Poelzl, Felix Naegele, Jakob Hirsch, Michael Graber, Daniela Lobenwein, Elke Kirchmair, Rosalie Huber, Christian Dorfmueller, Sophia Lechner, Georg Schaefer, Martin Hermann, Helga Fritsch, Ivan Tancevski, Michael Grimm, Johannes Holfeld, Can Gollmann-Tepekoeylue
Summary: This study demonstrates that shockwave therapy can induce regeneration of ischemic muscle in a dose-dependent manner, enhance angiogenesis, and improve limb perfusion within a therapeutic range without causing cellular damage. Provides evidence for the potential of shockwave therapy as a regenerative treatment option for ischemic cardiomyopathy.
SCIENTIFIC REPORTS
(2021)
Article
Multidisciplinary Sciences
Adewale S. Adebayo, Marius Roman, Syabira Yusoff, Melanie Gulston, Lathishia Joel-David, Bony Anthony, Florence Y. Lai, Antonio Murgia, Bryony Eagle-Hemming, Sophia Sheikh, Tracy Kumar, Hardeep Aujla, Will Dott, Julian L. Griffin, Gavin J. Murphy, Marcin J. Wozniak
Summary: This study investigated changes in myocardial gene expression and energy-related metabolites at different BMI levels in cardiac surgery patients. The analysis revealed that protein translation, muscle contraction, and lipid metabolism pathways showed distinct expression patterns at different BMI ranges. Metabolite analysis showed differences in acylcarnitines, ribose-5-phosphate, and alpha-ketoglutarate levels among different BMI groups. The molecular differences in myocardium reflected the biphasic relationship between BMI and mortality.
SCIENTIFIC REPORTS
(2022)
Article
Pharmacology & Pharmacy
Giorgio Minotti, Emanuela Salvatorelli, Giorgio Reggiardo, Fabio Mangiacapra, Massimiliano Camilli, Pierantonio Menna
Summary: Diastolic dysfunction (DD) may occur before heart failure (HF) in cancer patients treated with chemotherapy. By analyzing data from patients treated with anthracyclines, it was found that the risk of DD is lower than the risk of HF and the levels of B-type natriuretic peptide (BNP) can help identify patients with high or low risk of DD.
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS
(2022)
Article
Cardiac & Cardiovascular Systems
Elvira Forte, Bryant Perkins, Amalia Sintou, Harkaran S. Kalkat, Angelos Papanikolaou, Catherine Jenkins, Mashael Alsubaie, Rasheda A. Chowdhury, Theodore M. Duffy, Daniel A. Skelly, Jane Branca, Mohamed Bellahcene, Michael D. Schneider, Sian E. Harding, Milena B. Furtado, Fu Siong Ng, Muneer G. Hasham, Nadia Rosenthal, Susanne Sattler
Summary: After ischemic injury to the heart, cross-priming dendritic cells play a role in activating cytotoxic CD8(+) T cells by presenting self-antigens from necrotic cardiac cells. Research suggests that activation of cytotoxic CD8(+) T cells by cross-priming DC may exacerbate inflammatory damage of the myocardium and corresponding decline in cardiac function.
Article
Engineering, Biomedical
Chloe Pezzana, Audrey Cras, Fanny Simeliere, Rose Guesdon, Manon Desgres, Bruna Lima Correa, Ashley Peuffier, Valerie Bellamy, Sara Gouarderes, Antonio Alberdi, Marie-Cecile Perier, Laetitia Pidial, Florence Agnely, Amelie Bochot, Albert Hagege, Jean-Sebastien Silvestre, Philippe Menasche
Summary: Loading extracellular vesicles (EV) into hyaluronic acid (HA) biomaterial improves their delivery in the failing myocardium, preserving cardiac function, promoting angiogenesis, and reducing apoptosis and fibrosis.
Article
Cardiac & Cardiovascular Systems
Gad Cotter, Marco Metra, Beth A. Davison, Guillaume Jondeau, John G. F. Cleland, Robert C. Bourge, Olga Milo, Christopher M. O'Connor, John D. Parker, Guillermo Torre-Amione, Dirk J. van Veldhuisen, Isaac Kobrin, Maurizio Rainisio, Stefanie Senger, Christopher Edwards, John J. McMurray, John R. Teerlink
EUROPEAN JOURNAL OF HEART FAILURE
(2018)
Article
Pharmacology & Pharmacy
Victor Segura-Ibarra, Javier Amione-Guerra, Ana S. Cruz-Solbes, Francisca E. Cara, David A. Iruegas-Nunez, Suhong Wu, Keith A. Youker, Arvind Bhimaraj, Guillermo Torre-Amione, Mauro Ferrari, Harry Karmouty-Quintana, Ashrith Guha, Elvin Blanco
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2017)
Article
Engineering, Biomedical
Ashrith Guha, Duc Nguyen, Ana S. Cruz-Solbes, Javier Amione-Guerra, Robert C. Schutt, Arvind Bhimaraj, Barry H. Trachtenberg, Myung H. Park, Edward A. Graviss, Osama Gaber, Erik Suarez, Eva Montane, Guillermo Torre-Amione, Jerry D. Estep
Article
Engineering, Biomedical
Carly S. Filgueira, Giacomo Bruno, Zachary W. Smith, Corrine Ying Xuan Chua, Andrea Ballerini, Marco Folci, April L. Gilbert, Priya Jain, Jagannadha K. Sastry, Pramod N. Nehete, Kathryn A. Shelton, Lori R. Hill, Areeba Ali, Keith A. Youker, Alessandro Grattoni
BIOMEDICAL MICRODEVICES
(2018)
Article
Microbiology
Carson T. Kirkpatrick, Yongxing Wang, Miguel M. Leiva Juarez, Pooja Shivshankar, Jezreel Pantaleon Garcia, Alexandria K. Plumer, Vikram V. Kulkarni, Hayden H. Ware, Fahad Gulraiz, Miguel A. Chavez Cavasos, Gabriela Martinez Zayes, Shradha Wali, Andrew P. Rice, Hongbing Liu, James M. Tour, William K. A. Sikkema, Ana S. Cruz Solbes, Keith A. Youker, Michael J. Tuvim, Burton F. Dickey, Scott E. Evans
Article
Multidisciplinary Sciences
Vengadeshprabhu Karuppagounder, Anamika Bajpai, Shu Meng, Somasundaram Arumugam, Remya Sreedhar, Vijayasree V. Giridharan, Ashrith Guha, Arvind Bhimaraj, Keith A. Youker, Suresh S. Palaniyandi, Harry Karmouty-Quintana, Fadia Kamal, Kara L. Spiller, Kenichi Watanabe, Rajarajan A. Thandavarayan
Review
Biochemistry & Molecular Biology
David Brenes-Castro, Elena C. Castillo, Eduardo Vazquez-Garza, Guillermo Torre-Amione, Gerardo Garcia-Rivas
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2018)
Article
Medicine, General & Internal
David Rodriguez, Gerardo Garcia-Rivas, Estibalitz Laresgoiti-Servitje, Jesus Yanez, Guillermo Torre-Amione, Carlos Jerjes-Sanchez
Article
Medicine, General & Internal
Luis Sanchez-Trujillo, Carlos Jerjes-Sanchez, David Rodriguez, Jathniel Panneflek, Claudia Ortiz-Ledesma, Gerardo Garcia-Rivas, Guillermo Torre-Amione
Article
Cardiac & Cardiovascular Systems
Carsten Tschoepe, Leslie T. Cooper, Guillermo Torre-Amione, Sophie Van Linthout
CIRCULATION RESEARCH
(2019)
Correction
Microbiology
Carson T. Kirkpatrick, Yongxing Wang, Miguel M. Leiva Juarez, Pooja Shivshankar, Jezreel Pantaleon Garcia, Alexandria K. Plumer, Vikram V. Kulkarni, Hayden H. Ware, Fahad Gulraiz, Miguel A. Chavez Cavasos, Gabriela Martinez Zayas, Shradha Wali, Andrew P. Rice, Hongbing Liu, James M. Tour, William K. A. Sikkema, Ana S. Cruz Solbes, Keith A. Youker, Michael J. Tuvim, Burton F. Dickey, Scott E. Evans
Article
Engineering, Biomedical
Areeba Ali, Cesar Uribe, Raquel Araujo-Gutierrez, Ana S. Cruz-Solbes, Hernan G. Marcos-Abdala, Keith A. Youker, Ashrith Guha, Guillermo Torre-Amione, Duc T. Nguyen, Edward A. Graviss, John P. Cooke, Arvind Bhimaraj
Summary: Endothelial vasodilatory dysfunction measured by a simple test utilizing digital thermal monitoring can predict adverse bleeding events in patients with CF-LVADs. Patients with poor endothelial function may have worse survival outcomes.
Article
Genetics & Heredity
Guangyu Wang, Ana Sofia Cruz, Keith Youker, Hernan G. Marcos-Abdala, Rajarajan A. Thandavarayan, John P. Cooke, Guillermo Torre-Amione, Kaifu Chen, Arvind Bhimaraj
Summary: The transition between endothelial and mesenchymal cell types plays a key role in the pathophysiology of heart failure and subsequent recovery, as observed in both murine models and human myocardial samples.
FRONTIERS IN GENETICS
(2021)
Article
Pharmacology & Pharmacy
Zhen Yang, Feng Li, Dedipya Yelamanchili, Zihua Zeng, Corina Rosales, Keith A. Youker, Haifa Shen, Mauro Ferrari, John Mahmarian, Henry J. Pownall, Dale J. Hamilton, Zheng Li
ADVANCED THERAPEUTICS
(2019)
Article
Cardiac & Cardiovascular Systems
Renfang Mao, Shu Meng, Qilin Gu, Raquel Araujo-Gutierrez, Sandeep Kumar, Qing Yan, Felicidad Almazan, Keith A. Youker, Yingbin Fu, Henry J. Pownall, John P. Cooke, Yury I. Miller, Longhou Fang
CIRCULATION RESEARCH
(2017)