Journal
MATRIX BIOLOGY
Volume 91-92, Issue -, Pages 167-175Publisher
ELSEVIER
DOI: 10.1016/j.matbio.2020.04.001
Keywords
Fibrosis; Myocardial infarction; Inflammation; T-cell; Sex; Age
Categories
Funding
- National Institute of Health (NIDA) [U54DA016511]
- Biomedical Laboratory Research and Development Service of the Veterans Affairs Office of Research and Development Award [IK2BX003922, I01CX001608]
- American Physiological Society
- 2019 S&R Foundation Ryuji Ueno Award
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Inflammation contributes to the development of heart failure (HF) through multiple mechanisms including regulating extracellular matrix (ECM) degradation and deposition. Interactions between cells in the myocardium orchestrates the magnitude and duration of inflammatory cell recruitment and ECM remodeling events associated with HF. More recently, studies have shown T-cells have signficant roles in post-MI wound healing. T-cell biology in HF illustrates the complexity of cross-talk between inflammatory cell types and resident fibroblasts. This review will focus on T-cell recruitment to the myocardium and T-cell specific factors that might influence cardiac wound healing and fibrosis in the heart with consideration of age and sex as important factors in T-cell activity. (c) 2020 Elsevier B.V. All rights reserved.
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