R-Loops and R-Loop-Binding Proteins in Cancer Progression and Drug Resistance
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Title
R-Loops and R-Loop-Binding Proteins in Cancer Progression and Drug Resistance
Authors
Keywords
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Journal
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Volume 24, Issue 8, Pages 7064
Publisher
MDPI AG
Online
2023-04-12
DOI
10.3390/ijms24087064
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Note: Only part of the references are listed.- Proximity labeling identifies a repertoire of site-specific R-loop modulators
- (2022) Qingqing Yan et al. Nature Communications
- p53 at the crossroad of DNA replication and ribosome biogenesis stress pathways
- (2022) Mikael S. Lindström et al. CELL DEATH AND DIFFERENTIATION
- DNA repair defects in cancer and therapeutic opportunities
- (2022) Jessica L. Hopkins et al. GENES & DEVELOPMENT
- Depletion of RNASEH2 Activity Leads to Accumulation of DNA Double-strand Breaks and Reduced Cellular Survivability in T Cell Leukemia
- (2022) Dipayan Ghosh et al. JOURNAL OF MOLECULAR BIOLOGY
- Walking a tightrope: The complex balancing act of R-loops in genome stability
- (2022) Joshua R. Brickner et al. MOLECULAR CELL
- Sources, resolution and physiological relevance of R-loops and RNA–DNA hybrids
- (2022) Eva Petermann et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- MUS81 Inhibition Enhances the Anticancer Efficacy of Talazoparib by Impairing ATR/CHK1 Signaling Pathway in Gastric Cancer
- (2022) Tao Wang et al. Frontiers in Oncology
- Phase II study of ceralasertib (AZD6738) in combination with durvalumab in patients with advanced gastric cancer
- (2022) Minsuk Kwon et al. Journal for ImmunoTherapy of Cancer
- DDX17 is required for efficient DSB repair at DNA:RNA hybrid deficient loci
- (2022) Aldo S Bader et al. NUCLEIC ACIDS RESEARCH
- R-loop-derived cytoplasmic RNA–DNA hybrids activate an immune response
- (2022) Magdalena P. Crossley et al. NATURE
- Pathophysiological Role and Diagnostic Potential of R-Loops in Cancer and Beyond
- (2022) Essak S. Khan et al. Genes
- RNF168 regulates R-loop resolution and genomic stability in BRCA1/2-deficient tumors
- (2021) Parasvi S. Patel et al. JOURNAL OF CLINICAL INVESTIGATION
- G-quadruplexes: a promising target for cancer therapy
- (2021) Nils Kosiol et al. Molecular Cancer
- ADAR1 RNA editing enzyme regulates R-loop formation and genome stability at telomeres in cancer cells
- (2021) Yusuke Shiromoto et al. Nature Communications
- PBRM1 Deficiency Confers Synthetic Lethality to DNA Repair Inhibitors in Cancer
- (2021) Roman M. Chabanon et al. CANCER RESEARCH
- PARP1-mediated PARylation of TonEBP prevents R-loop–associated DNA damage
- (2021) Byeong Jin Ye et al. DNA REPAIR
- Untangling the crosstalk between BRCA1 and R-loops during DNA repair
- (2021) Marta San Martin Alonso et al. NUCLEIC ACIDS RESEARCH
- Phase 1 study of the ATR inhibitor berzosertib (formerly M6620, VX-970) combined with gemcitabine ± cisplatin in patients with advanced solid tumours
- (2021) Mark R. Middleton et al. BRITISH JOURNAL OF CANCER
- MRE11 as a molecular signature and therapeutic target for cancer treatment with radiotherapy
- (2021) Yen-Yun Wang et al. CANCER LETTERS
- R-Loop–Mediated ssDNA Breaks Accumulate Following Short-Term Exposure to the HDAC Inhibitor Romidepsin
- (2021) Maryam Safari et al. MOLECULAR CANCER RESEARCH
- Novel and highly potent ATR inhibitor M4344 kills cancer cells with replication stress and enhances the chemotherapeutic activity of widely used DNA damaging agents
- (2021) Ukhyun Jo et al. MOLECULAR CANCER THERAPEUTICS
- Hypoxia-induced SETX links replication stress with the unfolded protein response
- (2021) Shaliny Ramachandran et al. Nature Communications
- RNF168-mediated localization of BARD1 recruits the BRCA1-PALB2 complex to DNA damage
- (2021) John J. Krais et al. Nature Communications
- BRCA1 binds TERRA RNA and suppresses R-Loop-based telomeric DNA damage
- (2021) Jekaterina Vohhodina et al. Nature Communications
- BRCA2 deficiency reveals that oxidative stress impairs RNaseH1 function to cripple mitochondrial DNA maintenance
- (2021) Xavier Renaudin et al. Cell Reports
- The exon-junction complex helicase eIF4A3 controls cell fate via coordinated regulation of ribosome biogenesis and translational output
- (2021) Dimitris C. Kanellis et al. Science Advances
- Transcription-Replication Collisions—A Series of Unfortunate Events
- (2021) Commodore St Germain et al. Biomolecules
- A phase 1b study evaluating the safety and preliminary efficacy of berzosertib in combination with gemcitabine in patients with advanced non-small cell lung cancer
- (2021) Ruth Plummer et al. LUNG CANCER
- BRCA1 prevents R-loop-associated centromeric instability
- (2021) Carine Racca et al. Cell Death & Disease
- The Effect of Atypical Nucleic Acids Structures in DNA Double Strand Break Repair: A Tale of R-loops and G-Quadruplexes
- (2021) Rosa Camarillo et al. Frontiers in Genetics
- Mono-hydrazone based G-quadruplex selective ligands induce DNA damage and genome instability in human cancer cells
- (2020) Jussara Amato et al. JOURNAL OF MEDICINAL CHEMISTRY
- Regulatory R-loops as facilitators of gene expression and genome stability
- (2020) Christof Niehrs et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- A P53-Independent DNA Damage Response Suppresses Oncogenic Proliferation and Genome Instability
- (2020) Katerina D. Fagan-Solis et al. Cell Reports
- Mechanisms of Multidrug Resistance in Cancer Chemotherapy
- (2020) Karol Bukowski et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- DNA interference is controlled by R-loop length in a type I-F1 CRISPR-Cas system
- (2020) Donata Tuminauskaite et al. BMC BIOLOGY
- Nucleolar RNA polymerase II drives ribosome biogenesis
- (2020) Karan J. Abraham et al. NATURE
- Landscape of G-quadruplex DNA structural regions in breast cancer
- (2020) Robert Hänsel-Hertsch et al. NATURE GENETICS
- Topoisomerase 1 prevents replication stress at R-loop-enriched transcription termination sites
- (2020) Alexy Promonet et al. Nature Communications
- RAD51-dependent recruitment of TERRA lncRNA to telomeres through R-loops
- (2020) Marianna Feretzaki et al. NATURE
- BRD4 prevents the accumulation of R-loops and protects against transcription–replication collision events and DNA damage
- (2020) Fred C. Lam et al. Nature Communications
- BRD4 Prevents R-Loop Formation and Transcription-Replication Conflicts by Ensuring Efficient Transcription Elongation
- (2020) Drake S. Edwards et al. Cell Reports
- Triple-negative breast cancer therapeutic resistance: Where is the Achilles' heel?
- (2020) Xupeng Bai et al. CANCER LETTERS
- R-Loops as Cellular Regulators and Genomic Threats
- (2019) Madzia P. Crossley et al. MOLECULAR CELL
- BRCA1-associated R-loop affects transcription and differentiation in breast luminal epithelial cells
- (2019) Huai-Chin Chiang et al. NUCLEIC ACIDS RESEARCH
- Multiple cancer pathways regulate telomere protection
- (2019) Leire Bejarano et al. EMBO Molecular Medicine
- BRCA2 Deletion Induces Alternative Lengthening of Telomeres in Telomerase Positive Colon Cancer Cells
- (2019) Luca Pompili et al. Genes
- ATR Protects the Genome against R Loops through a MUS81-Triggered Feedback Loop
- (2019) Dominick A. Matos et al. MOLECULAR CELL
- RNase H1 and H2 Are Differentially Regulated to Process RNA-DNA Hybrids
- (2019) Arianna Lockhart et al. Cell Reports
- The molecular landscape of ETMR at diagnosis and relapse
- (2019) Sander Lambo et al. NATURE
- CPSF3-dependent pre-mRNA processing as a druggable node in AML and Ewing’s sarcoma
- (2019) Nathan T. Ross et al. Nature Chemical Biology
- N6-methyladenosine regulates the stability of RNA:DNA hybrids in human cells
- (2019) Abdulkadir Abakir et al. NATURE GENETICS
- Regulation of RNA Polymerase I TranscriptioninDevelopment, Disease, and Aging
- (2018) Samim Sharifi et al. Annual Review of Biochemistry
- The Augmented R-Loop Is a Unifying Mechanism for Myelodysplastic Syndromes Induced by High-Risk Splicing Factor Mutations
- (2018) Liang Chen et al. MOLECULAR CELL
- RPA and RAD51: fork reversal, fork protection, and genome stability
- (2018) Kamakoti P. Bhat et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- SLAM-seq defines direct gene-regulatory functions of the BRD4-MYC axis
- (2018) Matthias Muhar et al. SCIENCE
- Drosha drives the formation of DNA:RNA hybrids around DNA break sites to facilitate DNA repair
- (2018) Wei-Ting Lu et al. Nature Communications
- RPA and RAD51: fork reversal, fork protection, and genome stability
- (2018) Kamakoti P. Bhat et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- BRCA2 Regulates Transcription Elongation by RNA Polymerase II to Prevent R-Loop Accumulation
- (2018) Mahmud K.K. Shivji et al. Cell Reports
- Multifaceted Impact of MicroRNA 493-5p on Genome-Stabilizing Pathways Induces Platinum and PARP Inhibitor Resistance in BRCA2 -Mutated Carcinomas
- (2018) Khyati Meghani et al. Cell Reports
- Telomere Maintenance Mechanisms in Cancer
- (2018) Tiago Bordeira Gaspar et al. Genes
- Spliceosome Mutations Induce R Loop-Associated Sensitivity to ATR Inhibition in Myelodysplastic Syndromes
- (2018) Hai Dang Nguyen et al. CANCER RESEARCH
- ATR inhibition is a promising radiosensitizing strategy for triple negative breast cancer
- (2018) Xinyi Tu et al. MOLECULAR CANCER THERAPEUTICS
- R-Loops in Motor Neuron Diseases
- (2018) Martina G. L. Perego et al. MOLECULAR NEUROBIOLOGY
- EWS–FLI1 increases transcription to cause R-loops and block BRCA1 repair in Ewing sarcoma
- (2018) Aparna Gorthi et al. NATURE
- Human mitochondrial degradosome prevents harmful mitochondrial R loops and mitochondrial genome instability
- (2018) Sonia Silva et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- DNA damage and genome instability by G-quadruplex ligands are mediated by R loops in human cancer cells
- (2018) Alessio De Magis et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Risks of Breast, Ovarian, and Contralateral Breast Cancer for BRCA1 and BRCA2 Mutation Carriers
- (2017) Karoline B. Kuchenbaecker et al. JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
- R Loops and Links to Human Disease
- (2017) Patricia Richard et al. JOURNAL OF MOLECULAR BIOLOGY
- R-ChIP Using Inactive RNase H Reveals Dynamic Coupling of R-loops with Transcriptional Pausing at Gene Promoters
- (2017) Liang Chen et al. MOLECULAR CELL
- A mitosis-specific and R loop–driven ATR pathway promotes faithful chromosome segregation
- (2017) Lilian Kabeche et al. SCIENCE
- Attenuation of RNA polymerase II pausing mitigates BRCA1-associated R-loop accumulation and tumorigenesis
- (2017) Xiaowen Zhang et al. Nature Communications
- Camptothecin resistance is determined by the regulation of topoisomerase I degradation mediated by ubiquitin proteasome pathway
- (2017) Koji Ando et al. Oncotarget
- The 2016 WHO Classification of Tumours of the Urinary System and Male Genital Organs—Part A: Renal, Penile, and Testicular Tumours
- (2016) Holger Moch et al. EUROPEAN UROLOGY
- S1-DRIP-seq identifies high expression and polyA tracts as major contributors to R-loop formation
- (2016) Lamia Wahba et al. GENES & DEVELOPMENT
- Nascent Connections: R-Loops and Chromatin Patterning
- (2016) Frédéric Chédin TRENDS IN GENETICS
- Co-transcriptional R-loops are the main cause of estrogen-induced DNA damage
- (2016) Caroline Townsend Stork et al. eLife
- BRCA1 Recruitment to Transcriptional Pause Sites Is Required for R-Loop-Driven DNA Damage Repair
- (2015) Elodie Hatchi et al. MOLECULAR CELL
- R loops: new modulators of genome dynamics and function
- (2015) José M. Santos-Pereira et al. NATURE REVIEWS GENETICS
- The molecular basis for centromere identity and function
- (2015) Kara L. McKinley et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- Primer retention owing to the absence of RNase H1 is catastrophic for mitochondrial DNA replication
- (2015) J. Bradley Holmes et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Breaking bad: R-loops and genome integrity
- (2015) Julie Sollier et al. TRENDS IN CELL BIOLOGY
- Homologous Recombination and Human Health: The Roles of BRCA1, BRCA2, and Associated Proteins
- (2015) Rohit Prakash et al. Cold Spring Harbor Perspectives in Biology
- Directional R-Loop Formation by the CRISPR-Cas Surveillance Complex Cascade Provides Efficient Off-Target Site Rejection
- (2015) Marius Rutkauskas et al. Cell Reports
- The Meaning, Measurement and Modification of Hypoxia in the Laboratory and the Clinic
- (2014) E.M. Hammond et al. CLINICAL ONCOLOGY
- A double-edged sword: R loops as threats to genome integrity and powerful regulators of gene expression
- (2014) K. Skourti-Stathaki et al. GENES & DEVELOPMENT
- BRCA2 prevents R-loop accumulation and associates with TREX-2 mRNA export factor PCID2
- (2014) Vaibhav Bhatia et al. NATURE
- Brd4 activates P-TEFb for RNA polymerase II CTD phosphorylation
- (2014) Friederike Itzen et al. NUCLEIC ACIDS RESEARCH
- RNaseH1 regulates TERRA-telomeric DNA hybrids and telomere maintenance in ALT tumour cells
- (2014) Rajika Arora et al. Nature Communications
- BAF180 Promotes Cohesion and Prevents Genome Instability and Aneuploidy
- (2014) Peter M. Brownlee et al. Cell Reports
- Genome-Wide Distribution of RNA-DNA Hybrids Identifies RNase H Targets in tRNA Genes, Retrotransposons and Mitochondria
- (2014) Aziz El Hage et al. PLoS Genetics
- BRCA1 and Oxidative Stress
- (2014) Yong Yi et al. Cancers
- Detection of Single Nucleotide Polymorphism by RNase H-Cleavage Mediated Allele-Specific Extension Method
- (2013) Jingli Hou et al. BIOTECHNOLOGY & BIOTECHNOLOGICAL EQUIPMENT
- GC skew at the 5' and 3' ends of human genes links R-loop formation to epigenetic regulation and transcription termination
- (2013) P. A. Ginno et al. GENOME RESEARCH
- BRCA1 is a key regulator of breast differentiation through activation of Notch signalling with implications for anti-endocrine treatment of breast cancers
- (2013) N. E. Buckley et al. NUCLEIC ACIDS RESEARCH
- Mitochondrial Dysfunction in Cancer
- (2013) Michelle L. Boland et al. Frontiers in Oncology
- RNA Polymerase II Elongation Control
- (2012) Qiang Zhou et al. Annual Review of Biochemistry
- Topoisomerase 1 Inhibitors and Cancer Therapy
- (2012) Julia Moukharskaya et al. HEMATOLOGY-ONCOLOGY CLINICS OF NORTH AMERICA
- Promoter-proximal pausing of RNA polymerase II: emerging roles in metazoans
- (2012) Karen Adelman et al. NATURE REVIEWS GENETICS
- RNA Degradation in Yeast and Human Mitochondria
- (2011) Roman J. Szczesny et al. Biochimica et Biophysica Acta-Gene Regulatory Mechanisms
- Double-Strand Break Repair-Independent Role for BRCA2 in Blocking Stalled Replication Fork Degradation by MRE11
- (2011) Katharina Schlacher et al. CELL
- Human Senataxin Resolves RNA/DNA Hybrids Formed at Transcriptional Pause Sites to Promote Xrn2-Dependent Termination
- (2011) Konstantina Skourti-Stathaki et al. MOLECULAR CELL
- Inhibition of BET recruitment to chromatin as an effective treatment for MLL-fusion leukaemia
- (2011) Mark A. Dawson et al. NATURE
- Transcription by RNA polymerase III: more complex than we thought
- (2011) Robert J. White NATURE REVIEWS GENETICS
- Suppression of inflammation by a synthetic histone mimic
- (2010) Edwige Nicodeme et al. NATURE
- Selective inhibition of BET bromodomains
- (2010) Panagis Filippakopoulos et al. NATURE
- JTE-607, a multiple cytokine production inhibitor, induces apoptosis accompanied by an increase in p21waf1/cip1in acute myelogenous leukemia cells
- (2009) Nobuyuki Tajima et al. CANCER SCIENCE
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