Telomere Maintenance Mechanisms in Cancer

Telomere length and genetics are independent colorectal tumour risk factors in an evaluation of biomarkers in normal bowel

(2018) Ceres Fernandez-Rozadilla et al.   BRITISH JOURNAL OF CANCER

Comprehensive screening for PD-L1 expression in thyroid cancer

(2017) Soomin Ahn et al.   ENDOCRINE-RELATED CANCER

Next-generation Sequencing of Nonmuscle Invasive Bladder Cancer Reveals Potential Biomarkers and Rational Therapeutic Targets

(2017) Eugene J. Pietzak et al.   EUROPEAN UROLOGY

TERT promoter mutation status in sarcomatoid urothelial carcinomas of the upper urinary tract

(2017) Xiaoyan Wang et al.   Future Oncology

The TERT hypermethylated oncologic region predicts recurrence and survival in pancreatic cancer

(2017) Inês Faleiro et al.   Future Oncology

Prevalence of promoter mutations in the TERT gene in oral cavity squamous cell carcinoma

(2017) Kai-Ping Chang et al.   HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK

Comparative study of TERT promoter mutation status within spatially, temporally and morphologically distinct components of urothelial carcinoma

(2017) Noah A Brown et al.   HISTOPATHOLOGY

Refining Dynamic Risk Stratification and Prognostic Groups for Differentiated Thyroid Cancer With TERT Promoter Mutations

(2017) Tae Hyuk Kim et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

TERT, BRAF, and NRAS in Primary Thyroid Cancer and Metastatic Disease

(2017) Miguel Melo et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

TERTbiology and function in cancer: beyond immortalisation

(2017) Ana Pestana et al.   JOURNAL OF MOLECULAR ENDOCRINOLOGY

Detection of the alternative lengthening of telomeres pathway in malignant gliomas for improved molecular diagnosis

(2017) Anne Fogli et al.   JOURNAL OF NEURO-ONCOLOGY

TERT-mediated and ATRX-mediated Telomere Maintenance and Neuroblastoma

(2017) Xiao-Feng Duan et al.   JOURNAL OF PEDIATRIC HEMATOLOGY ONCOLOGY

Clinicopathological characteristics of TERT promoter mutation and telomere length in hepatocellular carcinoma

(2017) Hye Won Lee et al.   MEDICINE

Characterization of melanoma susceptibility genes in high-risk patients from Central Italy

(2017) Cristina Pellegrini et al.   MELANOMA RESEARCH

Molecular alterations of coexisting thyroid papillary carcinoma and anaplastic carcinoma: identification of TERT mutation as an independent risk factor for transformation

(2017) Naoki Oishi et al.   MODERN PATHOLOGY

TERT promoter mutations in telomere biology

(2017) Barbara Heidenreich et al.   MUTATION RESEARCH-REVIEWS IN MUTATION RESEARCH

Whole-genome landscape of pancreatic neuroendocrine tumours

(2017) Aldo Scarpa et al.   NATURE

Whole-genome landscapes of major melanoma subtypes

(2017) Nicholas K. Hayward et al.   NATURE

Systematic analysis of telomere length and somatic alterations in 31 cancer types

(2017) Floris P Barthel et al.   NATURE GENETICS

TERT Promoter Mutation and Telomere Length in Salivary Gland Tumors

(2017) Heejin Kim et al.   PATHOLOGY & ONCOLOGY RESEARCH

Epigenetics in cancer: Fundamentals and Beyond

(2017) Subhankar Biswas et al.   PHARMACOLOGY & THERAPEUTICS

Mutations in the promoter of the telomerase geneTERTcontribute to tumorigenesis by a two-step mechanism

(2017) Kunitoshi Chiba et al.   SCIENCE

TERT Promoter Mutations Were Not Found in Papillary Thyroid Microcarcinomas That Showed Disease Progression on Active Surveillance

(2017) Tomonori Yabuta et al.   THYROID

Spectrum of genetic mutations in de novo PUNLMP of the urinary bladder

(2017) Maria Del Carmen Rodriguez Pena et al.   VIRCHOWS ARCHIV

Preclinical and clinical implications of TERT promoter mutation in glioblastoma multiforme

(2017) Da Eun Jeong et al.   Oncology Letters

Mutation of the TERT promoter leads to poor prognosis of patients with non-small cell lung cancer

(2017) Soo-Jung Jung et al.   Oncology Letters

Promoter mutations and cellular distribution of telomerase in non-clear cell and clear cell hepatocellular carcinoma

(2017) Wan Huang et al.   Oncotarget

Association between rs2853669 in TERT gene and the risk and prognosis of human cancer: a systematic review and meta-analysis

(2017) Na Shen et al.   Oncotarget

The TERT promoter mutation incidence is modified by germline TERT rs2736098 and rs2736100 polymorphisms in hepatocellular carcinoma

(2017) Xiaotian Yuan et al.   Oncotarget

TERT promoter status and gene copy number gains: effect on TERT expression and association with prognosis in breast cancer

(2017) Mathilde Gay-Bellile et al.   Oncotarget

Telomere Recognition and Assembly Mechanism of Mammalian Shelterin

(2017) Fabian Erdel et al.   Cell Reports

Highly Aggressive Metastatic Melanoma Cells Unable to Maintain Telomere Length

(2017) Nikenza Viceconte et al.   Cell Reports

Frequency and geographic distribution of TERT promoter mutations in primary hepatocellular carcinoma

(2017) Francesca Pezzuto et al.   Infectious Agents and Cancer

Epigenetic Regulation of Telomere Maintenance for Therapeutic Interventions in Gliomas

(2017) et al.   Genes

The frequency and prognostic effect of TERT promoter mutation in diffuse gliomas

(2017) Yujin Lee et al.   Acta Neuropathologica Communications

Frequent alternative lengthening of telomeres and ATRX loss in adult NF1-associated diffuse and high-grade astrocytomas

(2016) Fausto J. Rodriguez et al.   ACTA NEUROPATHOLOGICA

AcquiredTERTpromoter mutations stimulateTERTtranscription in mantle cell lymphoma

(2016) Julieta Panero et al.   AMERICAN JOURNAL OF HEMATOLOGY

Recurrent TERT promoter mutations in urothelial carcinoma and potential clinical applications

(2016) Boaz Kurtis et al.   Annals of Diagnostic Pathology

TERT rs2736100 genotypes are associated with differential risk of myeloproliferative neoplasms in Swedish and Chinese male patient populations

(2016) Jenny Dahlström et al.   ANNALS OF HEMATOLOGY

TERTrs2736100 A>C SNP andJAK246/1 haplotype significantly contribute to the occurrence ofJAK2V617F andCALRmutated myeloproliferative neoplasms - a multicentric study on 529 patients

(2016) Adrian P. Trifa et al.   BRITISH JOURNAL OF HAEMATOLOGY

Reactivation of telomerase in cancer

(2016) Semih Can Akincilar et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Alternative Lengthening of Telomeres in Primary Pancreatic Neuroendocrine Tumors Is Associated with Aggressive Clinical Behavior and Poor Survival

(2016) Joo Young Kim et al.   CLINICAL CANCER RESEARCH

Alternative Lengthening of Telomeres and Loss of DAXX/ATRX Expression Predicts Metastatic Disease and Poor Survival in Patients with Pancreatic Neuroendocrine Tumors

(2016) Aatur D. Singhi et al.   CLINICAL CANCER RESEARCH

TERTpromoter mutations are a major indicator of recurrence and death due to papillary thyroid carcinomas

(2016) Martyn Bullock et al.   CLINICAL ENDOCRINOLOGY

Clinical utility of TERT promoter mutations and ALK rearrangement in thyroid cancer patients with a high prevalence of the BRAF V600E mutation

(2016) Ja Seong Bae et al.   Diagnostic Pathology

Classic Architecture with Multicentricity and Local Recurrence, and Absence of TERT Promoter Mutations are Correlates of BRAF V600E Harboring Pediatric Papillary Thyroid Carcinomas

(2016) Semen Onder et al.   ENDOCRINE PATHOLOGY

TERTpromoter mutations and long-term survival in patients with thyroid cancer

(2016) Tae Hyuk Kim et al.   ENDOCRINE-RELATED CANCER

TERTpromoter mutations: a genetic signature of benign and malignant thyroid tumours occurring in the context of tinea capitis irradiation

(2016) Paula Boaventura et al.   EUROPEAN JOURNAL OF ENDOCRINOLOGY

Polymorphisms in human telomerase reverse transcriptase (h TERT ) gene and susceptibility to gastric cancer in a Turkish population: Hospital-based case–control study

(2016) Süleyman Bayram et al.   GENE

Association Between Human Telomerase Reverse Transcriptase Gene Variations and Risk of Developing Breast Cancer

(2016) Ezgi Oztas et al.   Genetic Testing and Molecular Biomarkers

Leucocyte telomere length, genetic variants at the TERT gene region and risk of pancreatic cancer

(2016) Ying Bao et al.   GUT

Detection of TERT promoter mutations in primary adenocarcinoma of the urinary bladder

(2016) Morgan L. Cowan et al.   HUMAN PATHOLOGY

The prognostic impact of TERT promoter mutations in glioblastomas is modified by the rs2853669 single nucleotide polymorphism

(2016) Rui Batista et al.   INTERNATIONAL JOURNAL OF CANCER

TERTpromoter mutations in melanoma survival

(2016) Eduardo Nagore et al.   INTERNATIONAL JOURNAL OF CANCER

Distribution of TERT promoter mutations in primary and metastatic melanomas in Austrian patients

(2016) Richard Ofner et al.   JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY

Genomic and transcriptomic hallmarks of poorly differentiated and anaplastic thyroid cancers

(2016) Iñigo Landa et al.   JOURNAL OF CLINICAL INVESTIGATION

TERT mutation in glioma: Frequency, prognosis and risk

(2016) Yang Yuan et al.   JOURNAL OF CLINICAL NEUROSCIENCE

Telomerase Expression by Aberrant Methylation of the TERT Promoter in Melanoma Arising in Giant Congenital Nevi

(2016) Yiping Fan et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Quadruplex Nucleic Acids as Novel Therapeutic Targets

(2016) Stephen Neidle   JOURNAL OF MEDICINAL CHEMISTRY

Varying Mutational Alterations in Multiple Primary Melanomas

(2016) Friederike Egberts et al.   JOURNAL OF MOLECULAR DIAGNOSTICS

Brain regions associated with telomerase reverse transcriptase promoter mutations in primary glioblastomas

(2016) Xing Fan et al.   JOURNAL OF NEURO-ONCOLOGY

TERT Promoter Mutation Predicts Radioiodine-Refractory Character in Distant Metastatic Differentiated Thyroid Cancer

(2016) Xue Yang et al.   JOURNAL OF NUCLEAR MEDICINE

Massively parallel sequencing of phyllodes tumours of the breast reveals actionable mutations, andTERTpromoter hotspot mutations andTERTgene amplification as likely drivers of progression

(2016) Salvatore Piscuoglio et al.   JOURNAL OF PATHOLOGY

Telomere biology including TERT rearrangements in neuroblastoma: a useful indicator for surgical treatments

(2016) Masumi Kawashima et al.   JOURNAL OF PEDIATRIC SURGERY

Frequency of telomerase reverse transcripter promoter mutations in desmoplastic melanoma subtypes

(2016) Shi Yang et al.   MELANOMA RESEARCH

Molecular profiling, including TERT promoter mutations, of acral lentiginous melanomas

(2016) Vinicius de Lima Vazquez et al.   MELANOMA RESEARCH

High prevalence of TERT promoter mutations in primary squamous cell carcinoma of the urinary bladder

(2016) Morgan Cowan et al.   MODERN PATHOLOGY

TERT promoter mutations and prognosis in solitary fibrous tumor

(2016) Armita Bahrami et al.   MODERN PATHOLOGY

Telomere profiles and tumor-associated macrophages with different immune signatures affect prognosis in glioblastoma

(2016) Noelyn A Hung et al.   MODERN PATHOLOGY

DNA methylation mediated up-regulation ofTERRAnon-coding RNA is coincident with elongated telomeres in the human placenta

(2016) Boris Novakovic et al.   MOLECULAR HUMAN REPRODUCTION

Break-induced telomere synthesis underlies alternative telomere maintenance

(2016) Robert L. Dilley et al.   NATURE

Classification based on mutations ofTERTpromoter andIDHcharacterizes subtypes in grade II/III gliomas

(2016) Pei Yang et al.   NEURO-ONCOLOGY

Study of hTERT and Histone 3 Mutations in Medulloblastoma

(2016) Marta Viana-Pereira et al.   PATHOBIOLOGY

Association ofTERTpromoter mutations with telomerase expression in melanoma

(2016) Seungjae Lee et al.   Pigment Cell & Melanoma Research

HighTERTpromoter mutation frequency in non-acral cutaneous metastatic melanoma

(2016) Henrik Ekedahl et al.   Pigment Cell & Melanoma Research

TERTpromoter mutations associate with fast-growing melanoma

(2016) Eduardo Nagore et al.   Pigment Cell & Melanoma Research

Clinical Characteristics and Prognostic Significance of TERT Promoter Mutations in Cancer: A Cohort Study and a Meta-Analysis

(2016) Ping Yuan et al.   PLoS One

Prognostic Significance ofTERTPromoter Mutations in Papillary Thyroid Carcinomas in aBRAFV600EMutation–Prevalent Population

(2016) Seung Eun Lee et al.   THYROID

UncommonTERTPromoter Mutations in Pediatric Thyroid Cancer

(2016) Ali S. Alzahrani et al.   THYROID

High prevalence of TERT promoter mutations in micropapillary urothelial carcinoma

(2016) Doreen Nguyen et al.   VIRCHOWS ARCHIV

Telomeric RNAs are essential to maintain telomeres

(2016) Juan José Montero et al.   Nature Communications

TERT promoter mutations in primary liver tumors

(2016) Jean-Charles Nault et al.   Clinics and Research in Hepatology and Gastroenterology

Genetic variants in TERT are associated with risk of gastric cancer in a Chinese Han population

(2016) Xianglong Duan et al.   Oncotarget

Frequent somatic TERT promoter mutations and CTNNB1 mutations in hepatocellular carcinoma

(2016) Seung Eun Lee et al.   Oncotarget

The genetic difference between Western and Chinese urothelial cell carcinomas: infrequent FGFR3 mutation in Han Chinese patients

(2016) Xiaotian Yuan et al.   Oncotarget

A cancer specific hypermethylation signature of the TERT promoter predicts biochemical relapse in prostate cancer: a retrospective cohort study

(2016) Pedro Castelo-Branco et al.   Oncotarget

The association between the TERT rs2736100 AC genotype and reduced risk of upper tract urothelial carcinomas in a Han Chinese population

(2016) Xiaotian Yuan et al.   Oncotarget

Tumor specific mutations in TERT promoter and CTNNB1 gene in hepatitis B and hepatitis C related hepatocellular carcinoma

(2016) Francesca Pezzuto et al.   Oncotarget

BRAF and TERT promoter mutations in the aggressiveness of papillary thyroid carcinoma: a study of 653 patients

(2016) Langping Jin et al.   Oncotarget

Telomerase reverse transcriptase promoter mutations in hepatitis B virus-associated hepatocellular carcinoma

(2016) Xunjun Yang et al.   Oncotarget

Functional evaluation of TERT-CLPTM1L genetic variants associated with susceptibility of papillary thyroid carcinoma

(2016) Minghua Ge et al.   Scientific Reports

TERT promoter mutations in pancreatic endocrine tumours are rare and mainly found in tumours from patients with hereditary syndromes

(2016) João Vinagre et al.   Scientific Reports

TERT Promoter Mutations and Tumor Persistence/Recurrence in Papillary Thyroid Cancer

(2016) Jae Kyung Myung et al.   Cancer Research and Treatment

Roles of telomeres and telomerase in cancer, and advances in telomerase-targeted therapies

(2016) Mohammad A. Jafri et al.   Genome Medicine

Therapeutic Targeting of Telomerase

(2016) Kathrin Jäger et al.   Genes

Lack of TERT Promoter Mutations in Human B-Cell Non-Hodgkin Lymphoma

(2016) Gary Lam et al.   Genes

Telomerase Regulation from Beginning to the End

(2016) Deanna MacNeil et al.   Genes

The Role of ATRX in the Alternative Lengthening of Telomeres (ALT) Phenotype

(2016) João Amorim et al.   Genes

Absence of TERT promoter mutations in pituitary adenomas

(2016) C. S. Martins et al.   JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION

The role of TERT-CLPTM1L SNPs, hTERT expression and telomere length in the pathogenesis of oral squamous cell carcinoma

(2016) Jelena Carkic et al.   Journal of Oral Science

Regulation of the Telomerase Reverse Transcriptase Subunit through Epigenetic Mechanisms

(2016) Kayla A. Lewis et al.   Frontiers in Genetics

A combination of TERT promoter mutation and MGMT methylation status predicts clinically relevant subgroups of newly diagnosed glioblastomas

(2016) Hideyuki Arita et al.   Acta Neuropathologica Communications

BRAF V600E and TERT Promoter Mutations in Papillary Thyroid Carcinoma in Chinese Patients

(2016) Jian Sun et al.   PLoS One

MYC and Human Telomerase Gene (TERC) Copy Number Gain in Early-stage Non–small Cell Lung Cancer

(2015) Antonella Flacco et al.   AMERICAN JOURNAL OF CLINICAL ONCOLOGY-CANCER CLINICAL TRIALS

Leiomyosarcoma With Alternative Lengthening of Telomeres Is Associated With Aggressive Histologic Features, Loss of ATRX Expression, and Poor Clinical Outcome

(2015) Jau-Yu Liau et al.   AMERICAN JOURNAL OF SURGICAL PATHOLOGY

Telomerase reverse transcriptase promoter mutations in glandular lesions of the urinary bladder

(2015) Eric Vail et al.   Annals of Diagnostic Pathology

Heterogeneity of TERT promoter mutations status in squamous cell carcinomas of different anatomical sites

(2015) Katherine A. Cheng et al.   Annals of Diagnostic Pathology

TERT promoter mutations are frequent and show association with MED12 mutations in phyllodes tumors of the breast

(2015) Masayuki Yoshida et al.   BRITISH JOURNAL OF CANCER

TERTpromoter mutations in periocular carcinomas: implications of ultraviolet light in pathogenesis

(2015) Shih-Yao Lin et al.   BRITISH JOURNAL OF OPHTHALMOLOGY

Co-occurrence of Myeloproliferative Neoplasms and Solid Tumors Is Attributed to a Synergism Between Cytoreductive Therapy and the Common TERT Polymorphism rs2736100

(2015) T. Krahling et al.   CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION

Telomere maintenance is pivotal for high-risk neuroblastoma

(2015) Falk Hertwig et al.   CELL CYCLE

TERT Polymorphism rs2736100-C Is Associated with EGFR Mutation-Positive Non-Small Cell Lung Cancer

(2015) R. Wei et al.   CLINICAL CANCER RESEARCH

TERTpromoter mutations in thyroid cancer: a report from a Middle Eastern population

(2015) Ebtesam Qasem et al.   ENDOCRINE-RELATED CANCER

Tall cell papillary thyroid carcinoma: new diagnostic criteria and mutations in BRAF and TERT

(2015) M. S Dettmer et al.   ENDOCRINE-RELATED CANCER

Recurrent TERT promoter mutations identified in a large-scale study of multiple tumour types are associated with increased TERT expression and telomerase activation

(2015) Dong-Sheng Huang et al.   EUROPEAN JOURNAL OF CANCER

TERT promoter mutations are associated with distant metastases in papillary thyroid carcinoma

(2015) G. Gandolfi et al.   EUROPEAN JOURNAL OF ENDOCRINOLOGY

Human telomerase: biogenesis, trafficking, recruitment, and activation

(2015) Jens C. Schmidt et al.   GENES & DEVELOPMENT

Telomerase Reverse Transcriptase (TERT) Gene Variations and Susceptibility of Colorectal Cancer

(2015) Ayse Tarbin Jannuzzi et al.   Genetic Testing and Molecular Biomarkers

Association of genetic polymorphisms in TERT-CLPTM1L with lung cancer in a Chinese population

(2015) S.G. Liu et al.   GENETICS AND MOLECULAR RESEARCH

Alternative lengthening of telomeres phenotype in malignant vascular tumors is highly associated with loss of ATRX expression and is frequently observed in hepatic angiosarcomas

(2015) Jau-Yu Liau et al.   HUMAN PATHOLOGY

TERTgene harbors multiple variants associated with pancreatic cancer susceptibility

(2015) Daniele Campa et al.   INTERNATIONAL JOURNAL OF CANCER

Mutations inTERTpromoter andFGFR3and telomere length in bladder cancer

(2015) Ismail Hosen et al.   INTERNATIONAL JOURNAL OF CANCER

PML induces compaction, TRF2 depletion and DNA damage signaling at telomeres and promotes their alternative lengthening

(2015) S. Osterwald et al.   JOURNAL OF CELL SCIENCE

Association of TERT Promoter Mutation, But Not BRAF Mutation, With Increased Mortality in PTC

(2015) Jonathan R. George et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Association ofTERTPromoter Mutation 1,295,228 C>T WithBRAFV600E Mutation, Older Patient Age, and Distant Metastasis in Anaplastic Thyroid Cancer

(2015) Xiaoguang Shi et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Clinical and Molecular Features of Hürthle Cell Carcinoma of the Thyroid

(2015) Ana-Maria Chindris et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Coexistence of TERT Promoter and BRAF Mutations in Papillary Thyroid Carcinoma: Added Value in Patient Prognosis?

(2015) Miguel Melo et al.   JOURNAL OF CLINICAL ONCOLOGY

TERTPolymorphism rs2853669 Influences on Lung Cancer Risk in the Korean Population

(2015) Seung Soo Yoo et al.   JOURNAL OF KOREAN MEDICAL SCIENCE

TERRA mimicking ssRNAs prevail over the DNA substrate for telomerasein vitrodue to interactions with the alternative binding site

(2015) Dulat Azhibek et al.   JOURNAL OF MOLECULAR RECOGNITION

TERT promoter mutations and rs2853669 polymorphism: prognostic impact and interactions with common alterations in glioblastomas

(2015) Umberto Nencha et al.   JOURNAL OF NEURO-ONCOLOGY

Telomerase (TERT) promoter mutations are infrequent in Merkel cell carcinomas

(2015) Hye Jin Chung et al.   JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY

TERT Promoter Mutations and Risk of Recurrence in Meningioma

(2015) Felix Sahm et al.   JNCI-Journal of the National Cancer Institute

Comprehensive screening of alternative lengthening of telomeres phenotype and loss of ATRX expression in sarcomas

(2015) Jau-Yu Liau et al.   MODERN PATHOLOGY

Alternative lengthening of telomeres and loss of ATRX are frequent events in pleomorphic and dedifferentiated liposarcomas

(2015) Jen-Chieh Lee et al.   MODERN PATHOLOGY

Telomerase in differentiated thyroid cancer: Promoter mutations, expression and localization

(2015) Marina Muzza et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Telomerase activation by genomic rearrangements in high-risk neuroblastoma

(2015) Martin Peifer et al.   NATURE

TERT rearrangements are frequent in neuroblastoma and identify aggressive tumors

(2015) Linda J Valentijn et al.   NATURE GENETICS

Exome sequencing of desmoplastic melanoma identifies recurrent NFKBIE promoter mutations and diverse activating mutations in the MAPK pathway

(2015) A Hunter Shain et al.   NATURE GENETICS

Exome sequencing of hepatocellular carcinomas identifies new mutational signatures and potential therapeutic targets

(2015) Kornelius Schulze et al.   NATURE GENETICS

TERRA and the state of the telomere

(2015) Karsten Rippe et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Complex interactions between the DNA-damage response and mammalian telomeres

(2015) Nausica Arnoult et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Prognostic quality of activating TERT promoter mutations in glioblastoma: interaction with the rs2853669 polymorphism and patient age at diagnosis

(2015) Sabine Spiegl-Kreinecker et al.   NEURO-ONCOLOGY

Glioma Groups Based on 1p/19q, IDH, and TERT Promoter Mutations in Tumors

(2015) Jeanette E. Eckel-Passow et al.   NEW ENGLAND JOURNAL OF MEDICINE

TERT Promoter Mutations and TERT mRNA but Not FGFR3 Mutations Are Urinary Biomarkers in Han Chinese Patients With Urothelial Bladder Cancer

(2015) K. Wang et al.   ONCOLOGIST

Frequency of TERT Promoter Mutations in Prostate Cancer

(2015) Robert Stoehr et al.   PATHOBIOLOGY

Association between the TERT Genetic Polymorphism rs2853676 and Cancer Risk: Meta-Analysis of 76 108 Cases and 134 215 Controls

(2015) Jin-Lin Cao et al.   PLoS One

TERTpromoter mutations and telomerase reactivation in urothelial cancer

(2015) Sumit Borah et al.   SCIENCE

Alternative lengthening of telomeres renders cancer cells hypersensitive to ATR inhibitors

(2015) R. L. Flynn et al.   SCIENCE

Human telomere biology: A contributory and interactive factor in aging, disease risks, and protection

(2015) E. H. Blackburn et al.   SCIENCE

TERTPromoter Mutations in Papillary Thyroid Microcarcinomas

(2015) Dario de Biase et al.   THYROID

TERT promoter hot spot mutations are frequent in Indian cervical and oral squamous cell carcinomas

(2015) Vilvanathan Vinothkumar et al.   TUMOR BIOLOGY

Coexistence of TERT promoter and BRAF mutations in cutaneous melanoma is associated with more clinicopathological features of aggressiveness

(2015) Elisabetta Macerola et al.   VIRCHOWS ARCHIV

Common telomerase reverse transcriptase promoter mutations in hepatocellular carcinomas from different geographical locations

(2015) Dilek Cevik   WORLD JOURNAL OF GASTROENTEROLOGY

Influence of thehTERTrs2736100 polymorphism on telomere length in gastric cancer

(2015) Byung Joon Choi   WORLD JOURNAL OF GASTROENTEROLOGY

Genetic variation at MECOM, TERT, JAK2 and HBS1L-MYB predisposes to myeloproliferative neoplasms

(2015) William Tapper et al.   Nature Communications

Whole-genome mutational landscape of liver cancers displaying biliary phenotype reveals hepatitis impact and molecular diversity

(2015) Akihiro Fujimoto et al.   Nature Communications

TERRA and the state of the telomere

(2015) Karsten Rippe et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Complex interactions between the DNA-damage response and mammalian telomeres

(2015) Nausica Arnoult et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Dyskerin and TERC expression may condition survival in lung cancer patients

(2015) Marianna Penzo et al.   Oncotarget

TERT promoter mutations and long telomere length predict poor survival and radiotherapy resistance in gliomas

(2015) Ke Gao et al.   Oncotarget

Common variations in TERT-CLPTM1L locus are reproducibly associated with the risk of nasopharyngeal carcinoma in Chinese populations

(2015) Yang Zhang et al.   Oncotarget

TERT promoter mutations and polymorphisms as prognostic factors in primary glioblastoma

(2015) Mohamed Ali Mosrati et al.   Oncotarget

Association between TERT promoter polymorphisms and acute myeloid leukemia risk and prognosis

(2015) Mohamed Ali Mosrati et al.   Oncotarget

The TERT promoter SNP rs2853669 decreases E2F1 transcription factor binding and increases mortality and recurrence risks in liver cancer

(2015) Eunkyong Ko et al.   Oncotarget

TERT promoter mutations and telomere length in adult malignant gliomas and recurrences

(2015) Barbara Heidenreich et al.   Oncotarget

TERT Promoter Mutations Are Predictive of Aggressive Clinical Behavior in Patients with Spitzoid Melanocytic Neoplasms

(2015) Seungjae Lee et al.   Scientific Reports

The asymmetry of telomere replication contributes to replicative senescence heterogeneity

(2015) Thibault Bourgeron et al.   Scientific Reports

TERT Promoter Mutations and Risk of Recurrence in Meningioma

(2015) Felix Sahm et al.   JNCI-Journal of the National Cancer Institute

Telomeric repeat-containing RNA TERRA: a noncoding RNA connecting telomere biology to genome integrity

(2015) Emilio Cusanelli et al.   Frontiers in Genetics

Association of genetic polymorphisms in the telomerase reverse transcriptase gene with prostate cancer aggressiveness

(2015) DAPENG WU et al.   Molecular Medicine Reports

Mutations in IDH1, IDH2, and in the TERT promoter define clinically distinct subgroups of adult malignant gliomas

(2015) Patrick J. Killela et al.   Oncotarget

Intratumoral diversity of telomere length in individual neuroblastoma tumors

(2015) Annalisa Pezzolo et al.   Oncotarget

TERT promoter mutations in renal cell carcinomas and upper tract urothelial carcinomas

(2015) Kun Wang et al.   Oncotarget

TERT promoter mutations and gene amplification: Promoting TERT expression in Merkel cell carcinoma

(2015) Hong Xie et al.   Oncotarget

TERT promoter mutations are associated with distant metastases in upper tract urothelial carcinomas and serve as urinary biomarkers detected by a sensitive castPCR

(2015) Kun Wang et al.   Oncotarget

Expression level of hTERT is regulated by somatic mutation and common single nucleotide polymorphism at promoter region in glioblastoma

(2015) Chul-Kee Park et al.   Oncotarget

Alternative lengthening of telomeres is enriched in, and impacts survival of TP53 mutant pediatric malignant brain tumors

(2014) Joshua Mangerel et al.   ACTA NEUROPATHOLOGICA

Common germline variation at theTERTlocus contributes to familial clustering of myeloproliferative neoplasms

(2014) Roland Jäger et al.   AMERICAN JOURNAL OF HEMATOLOGY

Polymorphisms of TERT and CLPTM1L and the Risk of Hepatocellular Carcinoma in Chinese Males

(2014) Ling-Yan Su et al.   Asian Pacific Journal of Cancer Prevention

Genetic Variations in TERT-CLPTM1L Genes and Risk of Lung Cancer in a Chinese Population

(2014) Meng-Meng Zhao et al.   Asian Pacific Journal of Cancer Prevention

Increased paired box transcription factor 8 has a survival function in Glioma

(2014) Noelyn Hung et al.   BMC CANCER

Mutation frequencies of GNAQ, GNA11, BAP1, SF3B1, EIF1AX and TERT in uveal melanoma: detection of an activating mutation in the TERT gene promoter in a single case of uveal melanoma

(2014) M Dono et al.   BRITISH JOURNAL OF CANCER

TERT promoter mutations in gliomas, genetic associations and clinico-pathological correlations

(2014) M Labussière et al.   BRITISH JOURNAL OF CANCER

TERTpromoter mutation as an early genetic event activating telomerase in follicular thyroid adenoma (FTA) and atypical FTA

(2014) Na Wang et al.   CANCER

Genome Sequencing of SHH Medulloblastoma Predicts Genotype-Related Response to Smoothened Inhibition

(2014) Marcel Kool et al.   CANCER CELL

Genomic Profiling of Hepatocellular Adenomas Reveals Recurrent FRK-Activating Mutations and the Mechanisms of Malignant Transformation

(2014) Camilla Pilati et al.   CANCER CELL

Diagnostic and prognostic TERT promoter mutations in thyroid fine-needle aspiration biopsy

(2014) R. Liu et al.   ENDOCRINE-RELATED CANCER

The activating TERT promoter mutation C228T is recurrent in subsets of adrenal tumors

(2014) Tiantian Liu et al.   ENDOCRINE-RELATED CANCER

Polymorphisms in the TERT gene are associated with lung cancer risk in the Chinese Han population

(2014) Lei Gao et al.   EUROPEAN JOURNAL OF CANCER PREVENTION

Low frequency of TERT promoter mutations in gastrointestinal stromal tumors (GISTs)

(2014) Nathália C Campanella et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

The absence of TERT promoter mutations in primary gastric cancer

(2014) Tiantian Liu et al.   GENE

Telomere position effect: regulation of gene expression with progressive telomere shortening over long distances

(2014) Jérôme D. Robin et al.   GENES & DEVELOPMENT

Telomerase reverse transcriptase promoter mutation is an early somatic genetic alteration in the transformation of premalignant nodules in hepatocellular carcinoma on cirrhosis

(2014) Jean Charles Nault et al.   HEPATOLOGY

TERTpromoter mutations in clear cell renal cell carcinoma

(2014) Ismail Hosen et al.   INTERNATIONAL JOURNAL OF CANCER

TERTpromoter mutations predict worse survival in laryngeal cancer patients

(2014) Yiping Qu et al.   INTERNATIONAL JOURNAL OF CANCER

Telomeropathies: An emerging spectrum disorder

(2014) Brody Holohan et al.   JOURNAL OF CELL BIOLOGY

Telomerase-Dependent and Independent Telomere Maintenance and its Clinical Implications in Medullary Thyroid Carcinoma

(2014) Na Wang et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

TERTPromoter Mutations and Their Association withBRAFV600E Mutation and Aggressive Clinicopathological Characteristics of Thyroid Cancer

(2014) Xiaoli Liu et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

TERT Promoter Mutations Are a Major Indicator of Poor Outcome in Differentiated Thyroid Carcinomas

(2014) Miguel Melo et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

BRAF V600E and TERT Promoter Mutations Cooperatively Identify the Most Aggressive Papillary Thyroid Cancer With Highest Recurrence

(2014) Mingzhao Xing et al.   JOURNAL OF CLINICAL ONCOLOGY

TERTpromoter mutation is uncommon in acral lentiginous melanoma

(2014) Jau-Yu Liau et al.   JOURNAL OF CUTANEOUS PATHOLOGY

TERT promoter hotspot mutations are recurrent in myxoid liposarcomas but rare in other soft tissue sarcoma entities

(2014) Christian Koelsche et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

High frequency of TERT promoter mutation in small cell carcinoma of bladder, but not in small cell carcinoma of other origins

(2014) Xiaoyong Zheng et al.   Journal of Hematology & Oncology

The genomic landscape of hepatoblastoma and their progenies with HCC-like features

(2014) Melanie Eichenmüller et al.   JOURNAL OF HEPATOLOGY

TERT promoter mutations: Gatekeeper and driver of hepatocellular carcinoma

(2014) Roser Pinyol et al.   JOURNAL OF HEPATOLOGY

TERT Promoter Mutations in Skin Cancer: The Effects of Sun Exposure and X-Irradiation

(2014) Helena Pópulo et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

TERT promoter mutations and BRAF mutations are rare in sporadic, and TERT promoter mutations are absent in NF1-related malignant peripheral nerve sheath tumors

(2014) Hendrikus J. Dubbink et al.   JOURNAL OF NEURO-ONCOLOGY

TERT gene amplification is associated with poor outcome in acral lentiginous melanoma

(2014) Alba Diaz et al.   JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY

Alternative Lengthening of Telomeres Predicts Site of Origin in Neuroendocrine Tumor Liver Metastases

(2014) Epameinondas Dogeas et al.   JOURNAL OF THE AMERICAN COLLEGE OF SURGEONS

TERT Promoter Mutation Status as an Independent Prognostic Factor in Cutaneous Melanoma

(2014) Klaus G. Griewank et al.   JNCI-Journal of the National Cancer Institute

Pleiotropic Associations of Risk Variants Identified for Other Cancers With Lung Cancer Risk: The PAGE and TRICL Consortia

(2014) S. Lani Park et al.   JNCI-Journal of the National Cancer Institute

The germline sequence variant rs2736100_C in TERT associates with myeloproliferative neoplasms

(2014) A Oddsson et al.   LEUKEMIA

Recurrent TERT promoter mutations in non-small cell lung cancers

(2014) Xiao Ma et al.   LUNG CANCER

Melanomas of unknown primary frequently harbor TERT-promoter mutations

(2014) Friederike Egberts et al.   MELANOMA RESEARCH

Molecular alterations in endometrial and ovarian clear cell carcinomas: clinical impacts of telomerase reverse transcriptase promoter mutation

(2014) Hsien-Neng Huang et al.   MODERN PATHOLOGY

Trans-ancestry mutational landscape of hepatocellular carcinoma genomes

(2014) Yasushi Totoki et al.   NATURE GENETICS

The rise of regulatory RNA

(2014) Kevin V. Morris et al.   NATURE REVIEWS GENETICS

TERT promoter mutations: a novel independent prognostic factor in primary glioblastomas

(2014) Matthias Simon et al.   NEURO-ONCOLOGY

Combined analysis of TERT, EGFR, and IDH status defines distinct prognostic glioblastoma classes

(2014) M. Labussiere et al.   NEUROLOGY

TERT Promoter Mutations Lead to High Transcriptional Activity under Hypoxia and Temozolomide Treatment and Predict Poor Prognosis in Gliomas

(2014) Chen Chen et al.   PLoS One

Prognostic Value Analysis of Mutational and Clinicopathological Factors in Non-Small Cell Lung Cancer

(2014) Chenguang Li et al.   PLoS One

Expression of Telomeres in Astrocytoma WHO Grade 2 to 4: TERRA Level Correlates with Telomere Length, Telomerase Activity, and Advanced Clinical Grade

(2014) Sandra Sampl et al.   Translational Oncology

TERT polymorphisms rs2853669 and rs7726159 influence on prostate cancer risk in Russian population

(2014) Alexandra S. Shadrina et al.   TUMOR BIOLOGY

Increased lung cancer risk associated with the TERT rs2736100 polymorphism: an updated meta-analysis

(2014) Jihua Yang et al.   TUMOR BIOLOGY

Frequency of TERT promoter mutations in primary tumors of the liver

(2014) Alexander Quaas et al.   VIRCHOWS ARCHIV

Telomerase promoter mutations in cancer: an emerging molecular biomarker?

(2014) João Vinagre et al.   VIRCHOWS ARCHIV

Telomerase reverse transcriptase promoter mutations in primary cutaneous melanoma

(2014) Barbara Heidenreich et al.   Nature Communications

Identification of TERRA locus unveils a telomere protection role through association to nearly all chromosomes

(2014) Isabel López de Silanes et al.   Nature Communications

Functional characterization of the TERRA transcriptome at damaged telomeres

(2014) Antonio Porro et al.   Nature Communications

RNaseH1 regulates TERRA-telomeric DNA hybrids and telomere maintenance in ALT tumour cells

(2014) Rajika Arora et al.   Nature Communications

TERT promoter mutation in resectable hepatocellular carcinomas: A strong association with hepatitis C infection and absence of hepatitis B infection

(2014) Yu-Ling Chen et al.   International Journal of Surgery

TERT promoter mutation and aberrant hypermethylation are associated with elevated expression in medulloblastoma and characterise the majority of non-infant SHH subgroup tumours

(2013) Janet C. Lindsey et al.   ACTA NEUROPATHOLOGICA

TERT promoter mutations rather than methylation are the main mechanism for TERT upregulation in adult gliomas

(2013) Hideyuki Arita et al.   ACTA NEUROPATHOLOGICA

TERT promoter mutations in primary and secondary glioblastomas

(2013) Naosuke Nonoguchi et al.   ACTA NEUROPATHOLOGICA

Upregulating mutations in the TERT promoter commonly occur in adult malignant gliomas and are strongly associated with total 1p19q loss

(2013) Hideyuki Arita et al.   ACTA NEUROPATHOLOGICA

Distribution of TERT promoter mutations in pediatric and adult tumors of the nervous system

(2013) Christian Koelsche et al.   ACTA NEUROPATHOLOGICA

TERT promoter mutations are highly recurrent in SHH subgroup medulloblastoma

(2013) Marc Remke et al.   ACTA NEUROPATHOLOGICA

High Incidence of ActivatingTERTPromoter Mutations in Meningiomas Undergoing Malignant Progression

(2013) Stéphane Goutagny et al.   BRAIN PATHOLOGY

TERT promoter mutations in ocular melanoma distinguish between conjunctival and uveal tumours

(2013) K G Griewank et al.   BRITISH JOURNAL OF CANCER

Joint effects between five identified risk variants, allergy, and autoimmune conditions on glioma risk

(2013) Mahboobeh Safaeian et al.   CANCER CAUSES & CONTROL

TERT Promoter Mutations Occur Early in Urothelial Neoplasia and Are Biomarkers of Early Disease and Disease Recurrence in Urine

(2013) I. Kinde et al.   CANCER RESEARCH

The Hallmarks of Aging

(2013) Carlos López-Otín et al.   CELL

The Somatic Genomic Landscape of Glioblastoma

(2013) Cameron W. Brennan et al.   CELL

Highly prevalentTERTpromoter mutations in bladder cancer and glioblastoma

(2013) Xiaoli Liu et al.   CELL CYCLE

TERT promoter mutations in cancer development

(2013) Barbara Heidenreich et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

Highly prevalent TERT promoter mutations in aggressive thyroid cancers

(2013) Xiaoli Liu et al.   ENDOCRINE-RELATED CANCER

Telomerase Reverse Transcriptase Gene Promoter Mutations Help Discern the Origin of Urogenital Tumors: A Genomic and Molecular Study

(2013) Song Wu et al.   EUROPEAN UROLOGY

Telomerase Reverse Transcriptase Promoter Mutations in Bladder Cancer: High Frequency Across Stages, Detection in Urine, and Lack of Association with Outcome

(2013) Yves Allory et al.   EUROPEAN UROLOGY

Comprehensive Mutation Analysis of the TERT Promoter in Bladder Cancer and Detection of Mutations in Voided Urine

(2013) Carolyn D. Hurst et al.   EUROPEAN UROLOGY

Significant association of 5p15.33 (TERT–CLPTM1Lgenes) with lung cancer in Chinese Han population

(2013) Zhenhong Zhao et al.   EXPERIMENTAL LUNG RESEARCH

Loss of DAXX and ATRX Are Associated With Chromosome Instability and Reduced Survival of Patients With Pancreatic Neuroendocrine Tumors

(2013) Ilaria Marinoni et al.   GASTROENTEROLOGY

Genetic variants in TERT–CLPTM1L genetic region associated with several types of cancer: A meta-analysis

(2013) Cheng Li et al.   GENE

Alternative lengthening of telomeres in normal mammalian somatic cells

(2013) A. A. Neumann et al.   GENES & DEVELOPMENT

Telomere length, telomere-related genes, and breast cancer risk: The breast cancer health disparities study

(2013) Andrew J. Pellatt et al.   GENES CHROMOSOMES & CANCER

TERT Genetic Polymorphism rs2736100 Was Associated with Lung Cancer: A Meta-Analysis Based on 14,492 Subjects

(2013) Hui-Min Wang et al.   Genetic Testing and Molecular Biomarkers

Fine-mapping identifies multiple prostate cancer risk loci at 5p15, one of which associates with TERT expression

(2013) Zsofia Kote-Jarai et al.   HUMAN MOLECULAR GENETICS

Low frequency of TERT promoter somatic mutation in 313 sporadic esophageal squamous cell carcinomas

(2013) Yuda Zhao et al.   INTERNATIONAL JOURNAL OF CANCER

Low frequency ofTERTpromoter mutations in a large cohort of gallbladder and gastric cancers

(2013) Yiping Qu et al.   INTERNATIONAL JOURNAL OF CANCER

Absence of TERT promoter mutations in esophageal adenocarcinoma

(2013) A.M.J. van Nistelrooij et al.   INTERNATIONAL JOURNAL OF CANCER

Frequent SomaticTERTPromoter Mutations in Thyroid Cancer: Higher Prevalence in Advanced Forms of the Disease

(2013) Iñigo Landa et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Frequent somatic mutations of the telomerase reverse transcriptase promoter in ovarian clear cell carcinoma but not in other major types of gynaecological malignancy

(2013) Ren-Chin Wu et al.   JOURNAL OF PATHOLOGY

Methylation of the TERT promoter and risk stratification of childhood brain tumours: an integrative genomic and molecular study

(2013) Pedro Castelo-Branco et al.   LANCET ONCOLOGY

Genetic polymorphisms of TERT and CLPTM1L and risk of lung cancer—A case–control study in a Chinese population

(2013) Ajay A. Myneni et al.   LUNG CANCER

Chromophobe hepatocellular carcinoma with abrupt anaplasia: a proposal for a new subtype of hepatocellular carcinoma with unique morphological and molecular features

(2013) Laura D Wood et al.   MODERN PATHOLOGY

Mutations of the TERT promoter are common in basal cell carcinoma and squamous cell carcinoma

(2013) Glynis A Scott et al.   MODERN PATHOLOGY

TERT promoter mutations are frequent in atypical fibroxanthomas and pleomorphic dermal sarcomas

(2013) Klaus G Griewank et al.   MODERN PATHOLOGY

The alternative lengthening of telomere phenotype is significantly associated with loss of ATRX expression in high-grade pediatric and adult astrocytomas: a multi-institutional study of 214 astrocytomas

(2013) Malak Abedalthagafi et al.   MODERN PATHOLOGY

Genetic variations inTERT-CLPTM1Llocus are associated with risk of lung cancer in chinese population

(2013) Rong Zhong et al.   MOLECULAR CARCINOGENESIS

Telomeric Noncoding RNA TERRA Is Induced by Telomere Shortening to Nucleate Telomerase Molecules at Short Telomeres

(2013) Emilio Cusanelli et al.   MOLECULAR CELL

Signatures of mutational processes in human cancer

(2013) Ludmil B. Alexandrov et al.   NATURE

Pan-cancer patterns of somatic copy number alteration

(2013) Travis I Zack et al.   NATURE GENETICS

Finding the end: recruitment of telomerase to telomeres

(2013) Jayakrishnan Nandakumar et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Overexpression and promoter mutation of the TERT gene in malignant pleural mesothelioma

(2013) A Tallet et al.   ONCOGENE

The age- and shorter telomere-dependent TERT promoter mutation in follicular thyroid cell-derived carcinomas

(2013) T Liu et al.   ONCOGENE

MLH1 Promoter Methylation Frequency in Colorectal Cancer Patients and Related Clinicopathological and Molecular Features

(2013) Xia Li et al.   PLoS One

Longer Telomere Length in Peripheral White Blood Cells Is Associated with Risk of Lung Cancer and the rs2736100 (CLPTM1L-TERT) Polymorphism in a Prospective Cohort Study among Women in China

(2013) Qing Lan et al.   PLoS One

TERT Promoter Mutations Are Frequent in Cutaneous Basal Cell Carcinoma and Squamous Cell Carcinoma

(2013) Klaus G. Griewank et al.   PLoS One

Association between the Telomerase Reverse Transcriptase (TERT) rs2736098 Polymorphism and Cancer Risk: Evidence from a Case-Control Study of Non-Small-Cell Lung Cancer and a Meta-Analysis

(2013) Haijian Wu et al.   PLoS One

TERT promoter mutations in bladder cancer affect patient survival and disease recurrence through modification by a common polymorphism

(2013) P. S. Rachakonda et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

TERT promoter mutations occur frequently in gliomas and a subset of tumors derived from cells with low rates of self-renewal

(2013) P. J. Killela et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

TERT Promoter Mutations in Familial and Sporadic Melanoma

(2013) S. Horn et al.   SCIENCE

Highly Recurrent TERT Promoter Mutations in Human Melanoma

(2013) F. W. Huang et al.   SCIENCE

Telomere biology and translational research

(2013) Philip J. Mason et al.   Translational Research

Telomerase: central regulator of all of the hallmarks of cancer

(2013) Kee Chung Low et al.   TRENDS IN BIOCHEMICAL SCIENCES

RTEL1 and TERT polymorphisms are associated with astrocytoma risk in the Chinese Han population

(2013) Tian-Bo Jin et al.   TUMOR BIOLOGY

An unbiased in vivo screen reveals multiple transcription factors that control HPV E6-regulated hTERT in keratinocytes

(2013) Mei Xu et al.   VIROLOGY

Frequency of TERT promoter mutations in human cancers

(2013) João Vinagre et al.   Nature Communications

High frequency of telomerase reverse-transcriptase promoter somatic mutations in hepatocellular carcinoma and preneoplastic lesions

(2013) Jean Charles Nault et al.   Nature Communications

The Role of Telomere Biology in Cancer

(2012) Lifeng Xu et al.   Annual Review of Pathology-Mechanisms of Disease

Telomeres and Early-Life Stress: An Overview

(2012) Lawrence H. Price et al.   BIOLOGICAL PSYCHIATRY

The TERT rs2736100 Polymorphism and Cancer Risk: A Meta-analysis Based on 25 Case-Control Studies

(2012) Peng Zou et al.   BMC CANCER

Molecular and Morphologic Correlates of the Alternative Lengthening of Telomeres Phenotype in High-Grade Astrocytomas

(2012) Doreen N. Nguyen et al.   BRAIN PATHOLOGY

The TERT variant rs2736100 is associated with colorectal cancer risk

(2012) B Kinnersley et al.   BRITISH JOURNAL OF CANCER

Selected polymorphisms of GSTP1 and TERT were associated with glioma risk in Han Chinese

(2012) Gang Li et al.   Cancer Epidemiology

Telomere Length and Genetic Variation in Telomere Maintenance Genes in Relation to Ovarian Cancer Risk

(2012) K. L. Terry et al.   CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION

TERT polymorphisms modify the risk of acute lymphoblastic leukemia in Chinese children

(2012) Xiaojing Sheng et al.   CARCINOGENESIS

Mutational Processes Molding the Genomes of 21 Breast Cancers

(2012) Serena Nik-Zainal et al.   CELL

Genomic amplification of the human telomerase gene (hTERC) associated with human papillomavirus is related to the progression of uterine cervical dysplasia to invasive cancer

(2012) Hongqian Liu et al.   Diagnostic Pathology

Genetic alterations in RAS-regulated pathway in acral lentiginous melanoma

(2012) Joan A. Puig-Butillé et al.   EXPERIMENTAL DERMATOLOGY

Multiple variants of TERT and CLPTM1L constitute risk factors for lung adenocarcinoma

(2012) X.F. Chen et al.   GENETICS AND MOLECULAR RESEARCH

Functional genomic analysis of chromosomal aberrations in a compendium of 8000 cancer genomes

(2012) T.-M. Kim et al.   GENOME RESEARCH

Prognostic Value of Alternative Lengthening of Telomeres–Associated Biomarkers in Uterine Sarcoma and Uterine Carcinosarcoma

(2012) Yoo-Kyung Lee et al.   INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER

TERT'srole in colorectal carcinogenesis

(2012) Andrew J. Pellatt et al.   MOLECULAR CARCINOGENESIS

Common genetic variants inTERTcontribute to risk of cervical cancer in a Chinese population

(2012) Sumin Wang et al.   MOLECULAR CARCINOGENESIS

Association of genetic variants of human telomerase with colorectal polyps and colorectal cancer risk

(2012) Philipp Hofer et al.   MOLECULAR CARCINOGENESIS

Driver mutations in histone H3.3 and chromatin remodelling genes in paediatric glioblastoma

(2012) Jeremy Schwartzentruber et al.   NATURE

Telomere length regulates TERRA levels through increased trimethylation of telomeric H3K9 and HP1α

(2012) Nausica Arnoult et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Telomere maintenance mechanisms in malignant peripheral nerve sheath tumors: expression and prognostic relevance

(2012) L. Venturini et al.   NEURO-ONCOLOGY

Association between glioma susceptibility loci and tumour pathology defines specific molecular etiologies

(2012) Anna Luisa Di Stefano et al.   NEURO-ONCOLOGY

Replication of results of genome-wide association studies on lung cancer susceptibility loci in a Korean population

(2012) EUN YOUNG BAE et al.   RESPIROLOGY

Removal of Shelterin Reveals the Telomere End-Protection Problem

(2012) A. Sfeir et al.   SCIENCE

Loss of ATRX, Genome Instability, and an Altered DNA Damage Response Are Hallmarks of the Alternative Lengthening of Telomeres Pathway

(2012) Courtney A. Lovejoy et al.   PLoS Genetics

Association of Sequence Variants on Chromosomes 20, 11, and 5 (20q13.33, 11q23.3, and 5p15.33) With Glioma Susceptibility in a Chinese Population

(2011) Hongyan Chen et al.   AMERICAN JOURNAL OF EPIDEMIOLOGY

Prevalence of the Alternative Lengthening of Telomeres Telomere Maintenance Mechanism in Human Cancer Subtypes

(2011) Christopher M. Heaphy et al.   AMERICAN JOURNAL OF PATHOLOGY

Telomerase: Structure, functions, and activity regulation

(2011) M. I. Zvereva et al.   BIOCHEMISTRY-MOSCOW

Lack of association between common single nucleotide polymorphisms in the TERT-CLPTM1L locus and breast cancer in women of African ancestry

(2011) Yonglan Zheng et al.   BREAST CANCER RESEARCH AND TREATMENT

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

A challenging epigenetic message: telomerase activity is associated with complex changes in lifestyle

(2011) András Falus et al.   CELL BIOLOGY INTERNATIONAL

Epigenetic Modifications

(2011) Diane E. Handy et al.   CIRCULATION

Genetic stratification of neuroblastoma for treatment tailoring

(2011) Marta Jeison et al.   Future Oncology

Telomere maintenance in wilms tumors: First evidence for the presence of alternative lengthening of telomeres mechanism

(2011) Lorenza Venturini et al.   GENES CHROMOSOMES & CANCER

Cancer susceptibility variants and the risk of adult glioma in a US case–control study

(2011) Kathleen M. Egan et al.   JOURNAL OF NEURO-ONCOLOGY

The alternative lengthening of telomeres pathway may operate in non-neoplastic human cells

(2011) Tania L Slatter et al.   JOURNAL OF PATHOLOGY

It all comes together at the ends: Telomerase structure, function, and biogenesis

(2011) Joshua D. Podlevsky et al.   MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS

Telomeres and lifestyle factors: Roles in cellular aging

(2011) Jue Lin et al.   MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS

The CDKN2A G500 Allele Is More Frequent in GBM Patients with No Defined Telomere Maintenance Mechanism Tumors and Is Associated with Poorer Survival

(2011) Janice A. Royds et al.   PLoS One

Stress exposure in intrauterine life is associated with shorter telomere length in young adulthood

(2011) S. Entringer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Architecture of human telomerase RNA

(2011) Q. Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Altered Telomeres in Tumors with ATRX and DAXX Mutations

(2011) C. M. Heaphy et al.   SCIENCE

DAXX/ATRX, MEN1, and mTOR Pathway Genes Are Frequently Altered in Pancreatic Neuroendocrine Tumors

(2011) Y. Jiao et al.   SCIENCE

Epigenetic diet: impact on the epigenome and cancer

(2011) Tabitha M Hardy et al.   Epigenomics

hTERT methylation is necessary but not sufficient for telomerase activity in colorectal cells

(2011) CRISTINA VALLS-BAUTISTA et al.   Oncology Letters

Prognostic relevance of ALT-associated markers in liposarcoma: a comparative analysis

(2010) Lorenza Venturini et al.   BMC CANCER

Telomere length and genetic analyses in population-based studies of endometrial cancer risk

(2010) Jennifer Prescott et al.   CANCER

Multiple Genetic Variants in Telomere Pathway Genes and Breast Cancer Risk

(2010) J. Shen et al.   CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION

Genetic variations in TERT-CLPTM1L genes and risk of squamous cell carcinoma of the head and neck

(2010) Z. Liu et al.   CARCINOGENESIS

Variation at the TERT locus and predisposition for cancer

(2010) Duncan M. Baird   EXPERT REVIEWS IN MOLECULAR MEDICINE

Assaying and investigating Alternative Lengthening of Telomeres activity in human cells and cancers

(2010) Jeremy D. Henson et al.   FEBS LETTERS

Genetic variants in telomere-maintaining genes and skin cancer risk

(2010) Hongmei Nan et al.   HUMAN GENETICS

Presence of Alternative Lengthening of Telomeres Mechanism in Patients With Glioblastoma Identifies a Less Aggressive Tumor Type With Longer Survival

(2010) Kerrie L. McDonald et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

The landscape of somatic copy-number alteration across human cancers

(2010) Rameen Beroukhim et al.   NATURE

Variation in TP63 is associated with lung adenocarcinoma susceptibility in Japanese and Korean populations

(2010) Daiki Miki et al.   NATURE GENETICS

Alternative lengthening of telomeres: models, mechanisms and implications

(2010) Anthony J. Cesare et al.   NATURE REVIEWS GENETICS

Telomeres: protecting chromosomes against genome instability

(2010) Roderick J. O'Sullivan et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The non-coding RNA TERRA is a natural ligand and direct inhibitor of human telomerase

(2010) Sophie Redon et al.   NUCLEIC ACIDS RESEARCH

The 5p15.33 Locus Is Associated with Risk of Lung Adenocarcinoma in Never-Smoking Females in Asia

(2010) Chao Agnes Hsiung et al.   PLoS Genetics

A Genome-wide Association Study of Lung Cancer Identifies a Region of Chromosome 5p15 Associated with Risk for Adenocarcinoma

(2009) Maria Teresa Landi et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Detection of Genomic Amplification of the Human Telomerase Gene TERC , a Potential Marker for Triage of Women with HPV-Positive, Abnormal Pap Smears

(2009) Sonia Andersson et al.   AMERICAN JOURNAL OF PATHOLOGY

Positive Regulation of Human Telomerase Reverse Transcriptase Gene Expression and Telomerase Activity by DNA Methylation in Pancreatic Cancer

(2009) Alpana Kumari et al.   ANNALS OF SURGICAL ONCOLOGY

hTERTmethylation and expression in gastric cancer

(2009) Carolina Oliveira Gigek et al.   BIOMARKERS

Polymorphisms in Telomere Maintenance Genes and Risk of Lung Cancer

(2009) J. E. Choi et al.   CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION

A functional promoter polymorphism in the TERT gene does not affect inherited susceptibility to breast cancer

(2009) Verena Varadi et al.   CANCER GENETICS AND CYTOGENETICS

Common genetic variants on 5p15.33 contribute to risk of lung adenocarcinoma in a Chinese population

(2009) Guangfu Jin et al.   CARCINOGENESIS

Role of 5p15.33 (TERT-CLPTM1L), 6p21.33 and 15q25.1 (CHRNA5-CHRNA3) variation and lung cancer risk in never-smokers

(2009) Y. Wang et al.   CARCINOGENESIS

TERRA: telomeric repeat-containing RNA

(2009) Brian Luke et al.   EMBO JOURNAL

Rearrangement of upstream sequences of thehTERTgene during cellular immortalization

(2009) Yuanjun Zhao et al.   GENES CHROMOSOMES & CANCER

Telomere-Maintenance Mechanisms in Soft-Tissue Malignant Fibrous Histiocytomas

(2009) Toshihiro Matsuo et al.   JOURNAL OF BONE AND JOINT SURGERY-AMERICAN VOLUME

Telomere biology in neuroblastoma: telomere binding proteins and alternative strengthening of telomeres

(2009) Yoshiyuki Onitake et al.   JOURNAL OF PEDIATRIC SURGERY

TERRA RNA Binding to TRF2 Facilitates Heterochromatin Formation and ORC Recruitment at Telomeres

(2009) Zhong Deng et al.   MOLECULAR CELL

Complex landscapes of somatic rearrangement in human breast cancer genomes

(2009) Philip J. Stephens et al.   NATURE

The cancer genome

(2009) Michael R. Stratton et al.   NATURE

Sequence variants at the TERT-CLPTM1L locus associate with many cancer types

(2009) Thorunn Rafnar et al.   NATURE GENETICS

Genome-wide association study identifies five susceptibility loci for glioma

(2009) Sanjay Shete et al.   NATURE GENETICS

Telomerase activity is associated with an increase in DNA methylation at the proximal subtelomere and a reduction in telomeric transcription

(2009) Laura J. Ng et al.   NUCLEIC ACIDS RESEARCH

How Telomeres Solve the End-Protection Problem

(2009) T. de Lange   SCIENCE

Increased copy number of the TERT and TERC telomerase subunit genes in cancer cells

(2008) Ying Cao et al.   CANCER SCIENCE

Understanding and exploitinghTERTpromoter regulation for diagnosis and treatment of human cancers

(2008) Satoru Kyo et al.   CANCER SCIENCE

Alternative lengthening of telomeres frequently occurs in mismatch repair system-deficient gastric carcinoma

(2008) Yasuhiro Omori et al.   CANCER SCIENCE

Multiple Mechanisms of Telomere Maintenance Exist and Differentially Affect Clinical Outcome in Diffuse Malignant Peritoneal Mesothelioma

(2008) R. Villa et al.   CLINICAL CANCER RESEARCH

Different telomere maintenance mechanisms in alveolar and embryonal rhabdomyosarcoma

(2008) Anat Ohali et al.   GENES CHROMOSOMES & CANCER

Genomic copy number alterations as predictive markers of systemic recurrence in breast cancer

(2008) Ki-Tae Hwang et al.   INTERNATIONAL JOURNAL OF CANCER

Evaluation of Telomere Length Maintenance Mechanisms in Adrenocortical Carcinoma

(2008) Tobias Else et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Lung cancer susceptibility locus at 5p15.33

(2008) James D McKay et al.   NATURE GENETICS

Unusually stable abnormal karyotype in a highly aggressive melanoma negative for telomerase activity

(2008) Sarantis Gagos et al.   Molecular Cytogenetics

Telomerase redefined: Integrated regulation of hTR and hTERT for telomere maintenance and telomerase activity

(2007) C.J. Cairney et al.   BIOCHIMIE