BRCA1 and Oxidative Stress

Nrf2 is associated with the regulation of basal transcription activity of the BRCA1 gene

(2013) Qiaoqiao Wang et al.   ACTA BIOCHIMICA ET BIOPHYSICA SINICA

Role of Nrf2 in Oxidative Stress and Toxicity

(2013) Qiang Ma   Annual Review of Pharmacology and Toxicology

Redox Imbalance and Biochemical Changes in Cancer

(2013) T. C. Jorgenson et al.   CANCER RESEARCH

Nrf2 Prevents Initiation but Accelerates Progression through the Kras Signaling Pathway during Lung Carcinogenesis

(2013) Hironori Satoh et al.   CANCER RESEARCH

Cysteine-Mediated Redox Signaling: Chemistry, Biology, and Tools for Discovery

(2013) Candice E. Paulsen et al.   CHEMICAL REVIEWS

Molecular Pathways: Reactive Oxygen Species Homeostasis in Cancer Cells and Implications for Cancer Therapy

(2013) V. Nogueira et al.   CLINICAL CANCER RESEARCH

Redox regulation of protein kinases

(2013) Aoife Corcoran et al.   FEBS Journal

Regulation of Nrf2—an update

(2013) Suryakant K. Niture et al.   FREE RADICAL BIOLOGY AND MEDICINE

BRCA1 interacts with Nrf2 to regulate antioxidant signaling and cell survival

(2013) Chiara Gorrini et al.   JOURNAL OF EXPERIMENTAL MEDICINE

BRCA1 shields vascular smooth muscle cells from oxidative stress

(2013) Fina Lovren et al.   JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY

The correlations between BRCA1 defect and environmental factors in the risk of breast cancer

(2013) Hyo Jin Kang et al.   JOURNAL OF TOXICOLOGICAL SCIENCES

Functional interplay between the DNA-damage-response kinase ATM and ARF tumour suppressor protein in human cancer

(2013) Georgia Velimezi et al.   NATURE CELL BIOLOGY

A tuberous sclerosis complex signalling node at the peroxisome regulates mTORC1 and autophagy in response to ROS

(2013) Jiangwei Zhang et al.   NATURE CELL BIOLOGY

Modulation of oxidative stress as an anticancer strategy

(2013) Chiara Gorrini et al.   NATURE REVIEWS DRUG DISCOVERY

APE2 is required for ATR-Chk1 checkpoint activation in response to oxidative stress

(2013) J. Willis et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Stabilization of mutant BRCA1 protein confers PARP inhibitor and platinum resistance

(2013) N. Johnson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Antioxidants: Friends or foe in prevention or treatment of cancer: The debate of the century

(2013) Soodabeh Saeidnia et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Oxidants, antioxidants and the current incurability of metastatic cancers

(2013) J. Watson   Open Biology

BRCA1 in the DNA damage response and at telomeres

(2013) Eliot M. Rosen   Frontiers in Genetics

Oxidative Stress in the Carcinogenicity of Chemical Carcinogens

(2013) Anna Kakehashi et al.   Cancers

Redox Molecular Machines Involved in Tumor Progression

(2012) Matteo Parri et al.   ANTIOXIDANTS & REDOX SIGNALING

Redox Environment, Free Radical, and Oxidative DNA Damage

(2012) Sarah J. Storr et al.   ANTIOXIDANTS & REDOX SIGNALING

An overview of transcriptional regulation in response to toxicological insult

(2012) Paul Jennings et al.   ARCHIVES OF TOXICOLOGY

Redox modulation of the DNA damage response

(2012) Fanny Caputo et al.   BIOCHEMICAL PHARMACOLOGY

The Nrf2 cell defence pathway: Keap1-dependent and -independent mechanisms of regulation

(2012) Holly K. Bryan et al.   BIOCHEMICAL PHARMACOLOGY

The incidence of pancreatic cancer in BRCA1 and BRCA2 mutation carriers

(2012) J Iqbal et al.   BRITISH JOURNAL OF CANCER

Germline BRCA1 mutations increase prostate cancer risk

(2012) D Leongamornlert et al.   BRITISH JOURNAL OF CANCER

Making sense of cell surface nucleolin: Implications for respiratory syncytial virus prophylaxis and therapy

(2012) Richard G. Hegele   CELL CYCLE

BRCA1 mutations drive oxidative stress and glycolysis in the tumor microenvironment

(2012) Ubaldo E. Martinez-Outschoorn et al.   CELL CYCLE

Reactive oxygen species (ROS) homeostasis and redox regulation in cellular signaling

(2012) Paul D. Ray et al.   CELLULAR SIGNALLING

The role of BRCA1 in DNA double-strand repair: Past and present

(2012) Kevin W. Caestecker et al.   EXPERIMENTAL CELL RESEARCH

Regulation of intracellular signalling through cysteine oxidation by reactive oxygen species

(2012) H. Miki et al.   JOURNAL OF BIOCHEMISTRY

BRCA1 targets G2/M cell cycle proteins for ubiquitination and proteasomal degradation

(2012) S Shabbeer et al.   ONCOGENE

The Bad, the Good, and the Ugly about Oxidative Stress

(2012) Marlene Jimenez-Del-Rio et al.   Oxidative Medicine and Cellular Longevity

BRCA1 negatively regulates IGF-1 expression through an estrogen-responsive element-like site

(2012) H J Kang et al.   Cell Death & Disease

Mechanisms of BRCA1 Tumor Suppression: Figure 1.

(2012) Daniel P. Silver et al.   Cancer Discovery

Prevalence ofBRCA1andBRCA2mutations in Ashkenazi Jewish families with breast and pancreatic cancer

(2011) Zsofia K. Stadler et al.   CANCER

BRCA1 RING Function Is Essential for Tumor Suppression but Dispensable for Therapy Resistance

(2011) Rinske Drost et al.   CANCER CELL

New insights into the roles of ATM and DNA-PKcs in the cellular response to oxidative stress

(2011) Benjamin P.C. Chen et al.   CANCER LETTERS

ATM activation in the presence of oxidative stress 

(2011) Zhi Guo et al.   CELL CYCLE

The BRCA1 ubiquitin ligase and homologous recombination repair

(2011) Tomohiko Ohta et al.   FEBS LETTERS

Tumor suppressor genes and ROS: complex networks of interactions

(2011) Beyza Vurusaner et al.   FREE RADICAL BIOLOGY AND MEDICINE

IRF7: activation, regulation, modification and function

(2011) S Ning et al.   GENES AND IMMUNITY

Signal transduction by reactive oxygen species

(2011) Toren Finkel   JOURNAL OF CELL BIOLOGY

Role of oxidative stress and DNA damage in human carcinogenesis

(2011) Thomas B. Kryston et al.   MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS

BRCA1 tumour suppression occurs via heterochromatin-mediated silencing

(2011) Quan Zhu et al.   NATURE

Selective killing of cancer cells by a small molecule targeting the stress response to ROS

(2011) Lakshmi Raj et al.   NATURE

NF-κB regulates DNA double-strand break repair in conjunction with BRCA1–CtIP complexes

(2011) Meta Volcic et al.   NUCLEIC ACIDS RESEARCH

BRCA1 Tumor Suppression Depends on BRCT Phosphoprotein Binding, But Not Its E3 Ligase Activity

(2011) R. Shakya et al.   SCIENCE

Detoxification: A Novel Function of BRCA1 in Tumor Suppression?

(2011) Hyo Jin Kang et al.   TOXICOLOGICAL SCIENCES

Bioactive food components prevent carcinogenic stress via Nrf2 activation in BRCA1 deficient breast epithelial cells

(2011) Hyo Jin Kang et al.   TOXICOLOGY LETTERS

Novel aspect of chemophototherapy in treatment of cancer

(2011) Sandesh Chibber et al.   TUMOR BIOLOGY

BRCA1 role in the mitigation of radiotoxicity and chromosomal instability through repair of clustered DNA lesions

(2010) Jessica M. Hair et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Transcriptional Regulation of the Base Excision Repair Pathway by BRCA1

(2010) Tapas Saha et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Ubiquitin-like protein conjugation and the ubiquitin–proteasome system as drug targets

(2010) Lynn Bedford et al.   NATURE REVIEWS DRUG DISCOVERY

Redox Regulation in Cancer: A Double-edged Sword with Therapeutic Potential

(2010) Asha Acharya et al.   Oxidative Medicine and Cellular Longevity

ATM Activation by Oxidative Stress

(2010) Z. Guo et al.   SCIENCE

Breast cancer arising in a BRCA-mutated background: therapeutic implications from an animal model and drug development

(2009) J. Fasano et al.   ANNALS OF ONCOLOGY

Understanding the functions of BRCA1 in the DNA-damage response

(2009) Maximina H. Yun et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

BRCA1 down-regulates cellular levels of reactive oxygen species

(2009) Tapas Saha et al.   FEBS LETTERS

Elevated level of 8-oxo-7,8-dihydro-2′-deoxyguanosine in leukocytes ofBRCA1mutation carriers compared to healthy controls

(2009) Tomasz Dziaman et al.   INTERNATIONAL JOURNAL OF CANCER

Derepression of HMGA2 via Removal of ZBRK1/BRCA1/CtIP Complex Enhances Mammary Tumorigenesis

(2009) Kazi Mokim Ahmed et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Premature senescence is a major response to DNA cross-linking agents in BRCA1-defective cells: implication for tailored treatments of BRCA1 mutation carriers

(2009) M. Santarosa et al.   MOLECULAR CANCER THERAPEUTICS

Direct Interaction between Nrf2 and p21Cip1/WAF1 Upregulates the Nrf2-Mediated Antioxidant Response

(2009) Weimin Chen et al.   MOLECULAR CELL

Transcriptional responses to oxidative stress: Pathological and toxicological implications

(2009) Qiang Ma   PHARMACOLOGY & THERAPEUTICS

BRCA1 transcriptional activity is enhanced by interactions between its AD1 domain and AhR

(2008) Hyo Jin Kang et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

Phosphorylated Insulin-Like Growth Factor-I/Insulin Receptor Is Present in All Breast Cancer Subtypes and Is Related to Poor Survival

(2008) J. H. Law et al.   CANCER RESEARCH

Prevalence and characteristics of pancreatic cancer in families with BRCA1 and BRCA2 mutations

(2008) Daniel H. Kim et al.   Familial Cancer

Germline BRCA1 mutations predispose to pancreatic adenocarcinoma

(2008) Wigdan Al-Sukhni et al.   HUMAN GENETICS

Reactive oxygen species: Current knowledge and applications in cancer research and therapeutic

(2008) Andy T.Y. Lau et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Crosstalk Between IGF1R and Estrogen Receptor Signaling in Breast Cancer

(2008) Dedra H. Fagan et al.   JOURNAL OF MAMMARY GLAND BIOLOGY AND NEOPLASIA

Molecular mechanisms of Nrf2-mediated antioxidant response

(2008) Wenge Li et al.   MOLECULAR CARCINOGENESIS

The ubiquitin E3 ligase activity of BRCA1 and its biological functions

(2008) Wenwen Wu et al.   Cell Division

Induction and processing of complex DNA damage in human breast cancer cells MCF-7 and nonmalignant MCF-10A cells

(2007) Dave C. Francisco et al.   FREE RADICAL BIOLOGY AND MEDICINE