The Wheel of p53 Helps to Drive the Immune System

Coping With Stress: The Mitokine GDF-15 as a Biomarker of COVID-19 Severity

(2022) Darakhshan Sohail Ahmed et al.   Frontiers in Immunology

Signaling Pathway Reporter Screen with SARS-CoV-2 Proteins Identifies nsp5 as a Repressor of p53 Activity

(2022) Abhishek Kumar et al.   Viruses-Basel

All About (NK Cell-Mediated) Death in Two Acts and an Unexpected Encore: Initiation, Execution and Activation of Adaptive Immunity

(2022) Ariel Ramírez-Labrada et al.   Frontiers in Immunology

Schlafen 5 suppresses human immunodeficiency virus type 1 transcription by commandeering cellular epigenetic machinery

(2022) Jiwei Ding et al.   NUCLEIC ACIDS RESEARCH

To Be or Not to Be: The Case of Endoplasmic Reticulum Aminopeptidase 2

(2022) Piotr Kuśnierczyk   Frontiers in Immunology

Regulation of autoimmune disease progression by Pik3ip1 through metabolic reprogramming in T cells and therapeutic implications

(2022) Wenqiang Xie et al.   Science Advances

B cell linker protein (BLNK) is a regulator of Met receptor signaling and trafficking in non-small cell lung cancer

(2022) Shivanthy Pathmanathan et al.   iScience

ISG15 driven cellular responses to virus infection

(2022) Deeksha Munnur et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Coiled-coil domain containing 3 suppresses breast cancer growth by protecting p53 from proteasome-mediated degradation

(2022) Caiyue Li et al.   ONCOGENE

The cGAS–STING pathway and cancer

(2022) Natasha Samson et al.   Nature Cancer

Novel modulators of p53-signaling encoded by unknown genes of emerging viruses

(2021) Dina Alzhanova et al.   PLoS Pathogens

Comparative proteomics identifies Schlafen 5 (SLFN5) as a herpes simplex virus restriction factor that suppresses viral transcription

(2021) Eui Tae Kim et al.   Nature Microbiology

IL-12 Family Cytokines in Cancer and Immunotherapy

(2021) Bhalchandra Mirlekar et al.   Cancers

LACC1 deficiency links juvenile arthritis with autophagy and metabolism in macrophages

(2021) Ommar Omarjee et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The EphB6 Receptor: Kinase-Dead but Very Much Alive

(2021) Timothy G. Strozen et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Playing hide and seek: Tumor cells in control of MHC class I antigen presentation

(2021) M.L.M. Jongsma et al.   MOLECULAR IMMUNOLOGY

Transcription factor RFX7 governs a tumor suppressor network in response to p53 and stress

(2021) Luis Coronel et al.   NUCLEIC ACIDS RESEARCH

TREM2: Keeping Pace With Immune Checkpoint Inhibitors in Cancer Immunotherapy

(2021) Hui Qiu et al.   Frontiers in Immunology

TRIM22. A Multitasking Antiviral Factor

(2021) Isabel Pagani et al.   Cells

Non-Structural Protein 5 of Zika Virus Interacts with p53 in Human Neural Progenitor Cells and Induces p53-Mediated Apoptosis

(2021) Ping Li et al.   VIROLOGICA SINICA

The Positive and Negative Immunoregulatory Role of B7 Family: Promising Novel Targets in Gastric Cancer Treatment

(2021) Nadia Bolandi et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Transcriptome Analysis of Cells Exposed to Actinomycin D and Nutlin-3a Reveals New Candidate p53-Target Genes and Indicates That CHIR-98014 Is an Important Inhibitor of p53 Activity

(2021) Barbara Łasut-Szyszka et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

A Different Facet of p53 Function: Regulation of Immunity and Inflammation During Tumor Development

(2021) Di Shi et al.   Frontiers in Cell and Developmental Biology

P53 and The Immune Response: 40 Years of Exploration—A Plan for the Future

(2020) Arnold J. Levine   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

p53, cancer and the immune response

(2020) Julianna Blagih et al.   JOURNAL OF CELL SCIENCE

Synergistic activation of p53 by actinomycin D and nutlin-3a is associated with the upregulation of crucial regulators and effectors of innate immunity

(2020) Małgorzata Krześniak et al.   CELLULAR SIGNALLING

P53: A Guardian of Immunity Becomes Its Saboteur through Mutation

(2020) Arjelle Decasa Agupitan et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Characterization of BAY 1905254, an Immune Checkpoint Inhibitor Targeting the Immunoglobulin-Like Domain Containing Receptor 2 (ILDR2)

(2020) Julia Huetter et al.   Cancer Immunology Research

Myeloid Cell Expression of LACC1 is Required for Bacterial Clearance and Control of Intestinal Inflammation

(2020) Jung-Woo Kang et al.   GASTROENTEROLOGY

Adaptor proteins: Flexible and dynamic modulators of immune cell signaling

(2020) Paweł Borowicz et al.   SCANDINAVIAN JOURNAL OF IMMUNOLOGY

Human NLRP1 is a sensor for double-stranded RNA

(2020) Stefan Bauernfried et al.   SCIENCE

Imbalance of Microglial TLR4/TREM2 in LPS-Treated APP/PS1 Transgenic Mice: A Potential Link Between Alzheimer’s Disease and Systemic Inflammation

(2019) Jian Zhou et al.   NEUROCHEMICAL RESEARCH

Pik3ip1 Is a Negative Immune Regulator that Inhibits Antitumor T cell Immunity

(2019) Yichen Chen et al.   CLINICAL CANCER RESEARCH

Liver and Steroid Hormones—Can a Touch of p53 Make a Difference?

(2019) Meital Charni-Natan et al.   Frontiers in Endocrinology

GDF15 Is an Inflammation-Induced Central Mediator of Tissue Tolerance

(2019) Harding H. Luan et al.   CELL

The TWIK2 Potassium Efflux Channel in Macrophages Mediates NLRP3 Inflammasome-Induced Inflammation

(2018) Anke Di et al.   IMMUNITY

ILDR2-Fc Is a Novel Regulator of Immune Homeostasis and Inducer of Antigen-Specific Immune Tolerance

(2018) Joseph R. Podojil et al.   JOURNAL OF IMMUNOLOGY

ILDR2 Is a Novel B7-like Protein That Negatively Regulates T Cell Responses

(2018) Iris Hecht et al.   JOURNAL OF IMMUNOLOGY

The Alzheimer's disease-associated TREM2 gene is regulated by p53 tumor suppressor protein

(2018) Artur Zajkowicz et al.   NEUROSCIENCE LETTERS

Influenza A Virus Facilitates Its Infectivity by Activating p53 to Inhibit the Expression of Interferon-Induced Transmembrane Proteins

(2018) Bei Wang et al.   Frontiers in Immunology

Revealing a human p53 universe

(2018) Thuy-Ai T Nguyen et al.   NUCLEIC ACIDS RESEARCH

Inflammasome activation and assembly at a glance

(2017) Ankit Malik et al.   JOURNAL OF CELL SCIENCE

Zika virus: History, epidemiology, transmission, and clinical presentation

(2017) Byung-Hak Song et al.   JOURNAL OF NEUROIMMUNOLOGY

Human Antiviral Protein IFIX Suppresses Viral Gene Expression during Herpes Simplex Virus 1 (HSV-1) Infection and Is Counteracted by Virus-induced Proteasomal Degradation

(2017) Marni S. Crow et al.   MOLECULAR & CELLULAR PROTEOMICS

Human SLFN5 is a transcriptional co-repressor of STAT1-mediated interferon responses and promotes the malignant phenotype in glioblastoma

(2017) A D Arslan et al.   ONCOGENE

Crosstalk between Cytoplasmic RIG-I and STING Sensing Pathways

(2017) Alessandra Zevini et al.   TRENDS IN IMMUNOLOGY

Negative auto-regulators trap p53 in their web

(2017) Xiang Zhou et al.   Journal of Molecular Cell Biology

Ribosomal stress and Tp53-mediated neuronal apoptosis in response to capsid protein of the Zika virus

(2017) Lukasz P. Slomnicki et al.   Scientific Reports

InheritedTP53Mutations and the Li–Fraumeni Syndrome

(2017) Tanya Guha et al.   Cold Spring Harbor Perspectives in Medicine

Dendritic Cell Migration and Antigen Presentation Are Coordinated by the Opposing Functions of the Tetraspanins CD82 and CD37

(2016) Eleanor L. Jones et al.   JOURNAL OF IMMUNOLOGY

p53 Is a Host Cell Regulator during Herpes Simplex Encephalitis

(2016) Yuhei Maruzuru et al.   JOURNAL OF VIROLOGY

C13orf31 (FAMIN) is a central regulator of immunometabolic function

(2016) M Zaeem Cader et al.   NATURE IMMUNOLOGY

ZIKA virus elicits P53 activation and genotoxic stress in human neural progenitors similar to mutations involved in severe forms of genetic microcephaly and p53

(2016) Vincent El Ghouzzi et al.   Cell Death & Disease

p53 elevation in human cells halt SV40 infection by inhibiting T-ag expression

(2016) Nir Drayman et al.   Oncotarget

The Transactivation Domains of the p53 Protein

(2016) Nitin Raj et al.   Cold Spring Harbor Perspectives in Medicine

Whole-genome cartography of p53 response elements ranked on transactivation potential

(2015) Toma Tebaldi et al.   BMC GENOMICS

Transcriptional analysis of immune-related gene expression in p53-deficient mice with increased susceptibility to influenza A virus infection

(2015) Wenjun Yan et al.   BMC Medical Genomics

Actinomycin D and nutlin-3a synergistically promote phosphorylation of p53 on serine 46 in cancer cell lines of different origin

(2015) Artur Zajkowicz et al.   CELLULAR SIGNALLING

The Golgi-Associated Plant Pathogenesis-Related Protein GAPR-1 Enhances Type I Interferon Signaling Pathway in Response to Toll-Like Receptor 4

(2015) Qing Zhou et al.   INFLAMMATION

Differential outcome of TRIF-mediated signaling in TLR4 and TLR3 induced DC maturation

(2015) Wei Hu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Lipid-Modifying Enzyme SMPDL3B Negatively Regulates Innate Immunity

(2015) Leonhard X. Heinz et al.   Cell Reports

Interferon-Stimulated Genes: A Complex Web of Host Defenses

(2014) William M. Schneider et al.   Annual Review of Immunology

Type I interferon-mediated immune response against influenza A virus is attenuated in the absence of p53

(2014) Zixiang Zhu et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Coiled-coil domain containing 3 (CCDC3) represses tumor necrosis factor-α/nuclear factor κB-induced endothelial inflammation

(2014) Abul Kalam Azad et al.   CELLULAR SIGNALLING

p53 and ribosome biogenesis stress: The essentials

(2014) Lior Golomb et al.   FEBS LETTERS

p53 Degradation by a Coronavirus Papain-like Protease Suppresses Type I Interferon Signaling

(2014) Lin Yuan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mechanistic determinants of the directionality and energetics of active export by a heterodimeric ABC transporter

(2014) Nina Grossmann et al.   Nature Communications

CEACAM1 on activated NK cells inhibits NKG2D-mediated cytolytic function and signaling

(2013) Shuhei Hosomi et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Modulation of inflammation by interleukin-27

(2013) Markus Bosmann et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Extensive Post-translational Modification of Active and Inactivated Forms of Endogenous p53

(2013) Caroline J. DeHart et al.   MOLECULAR & CELLULAR PROTEOMICS

p53 increases MHC class I expression by upregulating the endoplasmic reticulum aminopeptidase ERAP1

(2013) Bei Wang et al.   Nature Communications

A novel feedback mechanism by Ephrin-B1/B2 in T-cell activation involves a concentration-dependent switch from costimulation to inhibition

(2012) Hiroki Kawano et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Stabilization of p53 in Influenza A Virus-infected Cells Is Associated with Compromised MDM2-mediated Ubiquitination of p53

(2012) Xiaodu Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Expression and function of interleukin-7 in secondary and tertiary lymphoid organs

(2012) Hsin-Ying Huang et al.   SEMINARS IN IMMUNOLOGY

The CEACAM1 tumor suppressor is an ATM and p53-regulated gene required for the induction of cellular senescence by DNA damage

(2012) A-P Sappino et al.   Oncogenesis

Human NK Cells Are Alerted to Induction of p53 in Cancer Cells by Upregulation of the NKG2D Ligands ULBP1 and ULBP2

(2011) S. Textor et al.   CANCER RESEARCH

Pharmacological activation of p53 triggers anticancer innate immune response through induction of ULBP2

(2011) Hai Li et al.   CELL CYCLE

IFI16 Acts as a Nuclear Pathogen Sensor to Induce the Inflammasome in Response to Kaposi Sarcoma-Associated Herpesvirus Infection

(2011) Nagaraj Kerur et al.   Cell Host & Microbe

A mutation in the immunoproteasome subunit PSMB8 causes autoinflammation and lipodystrophy in humans

(2011) Akiko Kitamura et al.   JOURNAL OF CLINICAL INVESTIGATION

CEACAM1 dampens antitumor immunity by down-regulating NKG2D ligand expression on tumor cells

(2011) Zhangguo Chen et al.   JOURNAL OF EXPERIMENTAL MEDICINE

IFN-Induced TPR Protein IFIT3 Potentiates Antiviral Signaling by Bridging MAVS and TBK1

(2011) X.-Y. Liu et al.   JOURNAL OF IMMUNOLOGY

Camptothecin-induced downregulation of MLL5 contributes to the activation of tumor suppressor p53

(2011) F Cheng et al.   ONCOGENE

Role of Interferon α (IFNα)-inducible Schlafen-5 in Regulation of Anchorage-independent Growth and Invasion of Malignant Melanoma Cells

(2010) Efstratios Katsoulidis et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Absence of SHIP-1 Results in Constitutive Phosphorylation of Tank-Binding Kinase 1 and Enhanced TLR3-Dependent IFN-β Production

(2010) Joan Ní Gabhann et al.   JOURNAL OF IMMUNOLOGY

Roles of Heparin-Binding Protein in Bacterial Infections

(2010) Adam Linder et al.   Journal of Innate Immunity

DNA Binding Cooperativity of p53 Modulates the Decision between Cell-Cycle Arrest and Apoptosis

(2010) Katharina Schlereth et al.   MOLECULAR CELL

Dual Role of p53 in Innate Antiviral Immunity

(2010) Carmen Rivas et al.   Viruses-Basel

Recruitment of Sprouty1 to Immune Synapse Regulates T Cell Receptor Signaling

(2009) J. S. Lee et al.   JOURNAL OF IMMUNOLOGY

Gene expression profiling by microarray analysis reveals an important role for caspase-1 in dengue virus-induced p53-mediated apoptosis

(2009) A.M.A. Nasirudeen et al.   JOURNAL OF MEDICAL VIROLOGY

Lack of Bax Prevents Influenza A Virus-Induced Apoptosis and Causes Diminished Viral Replication

(2009) J. E. McLean et al.   JOURNAL OF VIROLOGY

B-cell linker protein prevents aneuploidy by inhibiting cytokinesis

(2008) Hiroki Kamino et al.   CANCER SCIENCE

Transcriptional role of p53 in interferon-mediated antiviral immunity

(2008) César Muñoz-Fontela et al.   JOURNAL OF EXPERIMENTAL MEDICINE

p53 Regulates Toll-Like Receptor 3 Expression and Function in Human Epithelial Cell Lines

(2008) M. Taura et al.   MOLECULAR AND CELLULAR BIOLOGY

Expression of an IFN-Inducible Cellular Senescence Gene, IFI16, Is Up-Regulated by p53

(2008) L. L. Song et al.   MOLECULAR CANCER RESEARCH