The Positive and Negative Immunoregulatory Role of B7 Family: Promising Novel Targets in Gastric Cancer Treatment
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Title
The Positive and Negative Immunoregulatory Role of B7 Family: Promising Novel Targets in Gastric Cancer Treatment
Authors
Keywords
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Journal
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Volume 22, Issue 19, Pages 10719
Publisher
MDPI AG
Online
2021-10-04
DOI
10.3390/ijms221910719
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Note: Only part of the references are listed.- Gastric Carcinomas with Stromal B7-H3 Expression Have Lower Intratumoural CD8+ T Cell Density
- (2021) Dita Ulase et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Granulocyte-Macrophage Colony-Stimulating Factor-Activated Neutrophils Express B7-H4 That Correlates with Gastric Cancer Progression and Poor Patient Survival
- (2021) Zhi-guo Shan et al. Journal of Immunology Research
- Expression, regulation and clinical significance of B7-H3 on neutrophils in human gastric cancer
- (2021) Zheng-Yan Li et al. CLINICAL IMMUNOLOGY
- Immunological role and underlying mechanisms of B7‐H6 in tumorigenesis
- (2020) Yuxuan Hu et al. CLINICA CHIMICA ACTA
- VISTA: Coming of age as a multi‐lineage immune checkpoint
- (2020) M. A. ElTanbouly et al. CLINICAL AND EXPERIMENTAL IMMUNOLOGY
- Resistance to Checkpoint Inhibition in Cancer Immunotherapy
- (2020) Luisa Barrueto et al. Translational Oncology
- Overexpression of B7-H3 in α-SMA-Positive Fibroblasts Is Associated With Cancer Progression and Survival in Gastric Adenocarcinomas
- (2020) Shenghua Zhan et al. Frontiers in Oncology
- Immunotherapy in gastrointestinal cancer: the current scenario and future perspectives
- (2020) Mohammed Abdul-Latif et al. CANCER TREATMENT REVIEWS
- Immune suppression caused by PD-L2 expression on tumor cells in gastric cancer
- (2020) Yuko Nakayama et al. Gastric Cancer
- Characterization of BAY 1905254, an Immune Checkpoint Inhibitor Targeting the Immunoglobulin-Like Domain Containing Receptor 2 (ILDR2)
- (2020) Julia Huetter et al. Cancer Immunology Research
- ERMAP is a B7 family-related molecule that negatively regulates T cell and macrophage responses
- (2020) Min Su et al. Cellular & Molecular Immunology
- VISTA: an immune regulatory protein checking tumor and immune cells in cancer immunotherapy
- (2020) Xing Huang et al. Journal of Hematology & Oncology
- Interferon‑γ induced PD‑L1 expression and soluble PD‑L1 production in gastric cancer
- (2020) Yushi Imai et al. Oncology Letters
- Role of Immune Checkpoint Inhibitors in Gastrointestinal Malignancies
- (2020) Anita Mazloom et al. Journal of Clinical Medicine
- Mutations Defining Patient Cohorts With Elevated PD-L1 Expression in Gastric Cancer
- (2019) Otília Menyhárt et al. Frontiers in Pharmacology
- Efficacy and safety of immune checkpoint inhibitors in advanced gastric or gastroesophageal junction cancer: a systematic review and meta-analysis
- (2019) Cong Chen et al. OncoImmunology
- Overexpression of HHLA2 in human clear cell renal cell carcinoma is significantly associated with poor survival of the patients
- (2019) Lujun Chen et al. Cancer Cell International
- Hypoxia-induced VISTA promotes the suppressive function of myeloid- derived suppressor cells in the tumor microenvironment
- (2019) Jie Deng et al. Cancer Immunology Research
- Pembrolizumab with or without chemotherapy versus chemotherapy for advanced gastric or gastroesophageal junction (G/GEJ) adenocarcinoma: The phase III KEYNOTE-062 study.
- (2019) Josep Tabernero et al. JOURNAL OF CLINICAL ONCOLOGY
- HHLA2 overexpression is a novel biomarker of malignant status and poor prognosis in gastric cancer
- (2019) Li Wei et al. Human Cell
- Role of Inducible Co-Stimulator (ICOS) in cancer immunotherapy
- (2019) Florent Amatore et al. EXPERT OPINION ON BIOLOGICAL THERAPY
- VISTA is an acidic pH-selective ligand for PSGL-1
- (2019) Robert J. Johnston et al. NATURE
- Immune Checkpoints of the B7 Family. Part 2. Representatives of the B7 Family B7-H3, B7-H4, B7-H5, B7-H6, B7-H7, and ILDR2 and Their Receptors
- (2019) A. I. Chapoval et al. RUSSIAN JOURNAL OF BIOORGANIC CHEMISTRY
- Targeting Negative and Positive Immune Checkpoints with Monoclonal Antibodies in Therapy of Cancer
- (2019) Katsiaryna Marhelava et al. Cancers
- B7H4 expression in tumor cells impairs CD8 T cell responses and tumor immunity
- (2019) Linlin Zhou et al. CANCER IMMUNOLOGY IMMUNOTHERAPY
- Overexpression of B7H5/CD28H is associated with worse survival in human gastric cancer
- (2019) Can Hu et al. JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
- Chimeric antigen receptors with human scFvs preferentially induce T cell anti-tumor activity against tumors with high B7H6 expression
- (2018) Albert T. Gacerez et al. CANCER IMMUNOLOGY IMMUNOTHERAPY
- Evolving Roles for Targeting CTLA-4 in Cancer Immunotherapy
- (2018) Yinghao Zhao et al. CELLULAR PHYSIOLOGY AND BIOCHEMISTRY
- B7-H6 expression is induced by lipopolysaccharide and facilitates cancer invasion and metastasis in human gliomas
- (2018) Fengyuan Che et al. INTERNATIONAL IMMUNOPHARMACOLOGY
- Silencing of B7-H4 suppresses the tumorigenicity of the MGC-803 human gastric cancer cell line and promotes cell apoptosis via the mitochondrial signaling pathway
- (2018) Donghui Zhou et al. INTERNATIONAL JOURNAL OF ONCOLOGY
- ILDR2-Fc Is a Novel Regulator of Immune Homeostasis and Inducer of Antigen-Specific Immune Tolerance
- (2018) Joseph R. Podojil et al. JOURNAL OF IMMUNOLOGY
- ILDR2 Is a Novel B7-like Protein That Negatively Regulates T Cell Responses
- (2018) Iris Hecht et al. JOURNAL OF IMMUNOLOGY
- The association of human endogenous retrovirus-H long terminal repeat-associating protein 2 (HHLA2) expression with gastric cancer prognosis
- (2018) Masataka Shimonosono et al. Oncotarget
- Safety and Efficacy of Pembrolizumab Monotherapy in Patients With Previously Treated Advanced Gastric and Gastroesophageal Junction Cancer
- (2018) Charles S. Fuchs et al. JAMA Oncology
- Phase III, randomised trial of avelumab versus physician’s choice of chemotherapy as third-line treatment of patients with advanced gastric or gastro-oesophageal junction cancer: primary analysis of JAVELIN Gastric 300
- (2018) Y -J Bang et al. ANNALS OF ONCOLOGY
- Abstract CT111: Avelumab (anti-PD-L1) as first-line maintenance (1L mn) or second-line (2L) therapy in patients with advanced gastric or gastroesophageal junction cancer (GC/GEJC): updated phase Ib results from the JAVELIN Solid Tumor trial
- (2018) Hyun Cheol Chung et al. CANCER RESEARCH
- Effects of Combination of Anti-CTLA-4 and Anti-PD-1 on Gastric Cancer Cells Proliferation, Apoptosis and Metastasis
- (2018) Bin Wang et al. CELLULAR PHYSIOLOGY AND BIOCHEMISTRY
- VSIG-3 as a ligand of VISTA inhibits human T cell function
- (2018) Jinghua Wang et al. IMMUNOLOGY
- MiR-21 Participates in the PD-1/PD-L1 Pathway-Mediated Imbalance of Th17/Treg Cells in Patients After Gastric Cancer Resection
- (2018) Xiaoyu Zheng et al. ANNALS OF SURGICAL ONCOLOGY
- VISTA expression by microglia decreases during inflammation and is differentially regulated in CNS diseases
- (2018) Malte Borggrewe et al. GLIA
- Estimating the global cancer incidence and mortality in 2018: GLOBOCAN sources and methods
- (2018) J. Ferlay et al. INTERNATIONAL JOURNAL OF CANCER
- Immune checkpoint blockade opens a new way to cancer immunotherapy
- (2018) Sanam Sadreddini et al. JOURNAL OF CELLULAR PHYSIOLOGY
- Hedgehog signaling induces PD-L1 expression and tumor cell proliferation in gastric cancer
- (2018) Jayati Chakrabarti et al. Oncotarget
- HDAC is indispensable for IFN-γ-induced B7-H1 expression in gastric cancer
- (2018) Rui Deng et al. Clinical Epigenetics
- Immunoregulatory functions of VISTA
- (2017) Elizabeth C. Nowak et al. IMMUNOLOGICAL REVIEWS
- New checkpoints in cancer immunotherapy
- (2017) Ling Ni et al. IMMUNOLOGICAL REVIEWS
- Nivolumab in patients with advanced gastric or gastro-oesophageal junction cancer refractory to, or intolerant of, at least two previous chemotherapy regimens (ONO-4538-12, ATTRACTION-2): a randomised, double-blind, placebo-controlled, phase 3 trial
- (2017) Yoon-Koo Kang et al. LANCET
- New B7 Family Checkpoints in Human Cancers
- (2017) Ling Ni et al. MOLECULAR CANCER THERAPEUTICS
- Protein Expression of Programmed Death 1 Ligand 1 and HER2 in Gastric Carcinoma
- (2017) Eiji Oki et al. ONCOLOGY
- B7-H3 promotes gastric cancer cell migration and invasion
- (2017) Yecheng Li et al. Oncotarget
- The novel negative checkpoint regulator VISTA is expressed in gastric carcinoma and associated with PD-L1/PD-1: A future perspective for a combined gastric cancer therapy?
- (2017) Christine Böger et al. OncoImmunology
- CTLA-4 and PD-1 Pathways
- (2016) Elizabeth I. Buchbinder et al. AMERICAN JOURNAL OF CLINICAL ONCOLOGY-CANCER CLINICAL TRIALS
- Patterns of PD-L1 expression and CD8 T cell infiltration in gastric adenocarcinomas and associated immune stroma
- (2016) Elizabeth D Thompson et al. GUT
- Expression and prognostic roles of PIK3CA, JAK2, PD-L1, and PD-L2 in Epstein-Barr virus–associated gastric carcinoma
- (2016) Min Dong et al. HUMAN PATHOLOGY
- CD28 Costimulation: From Mechanism to Therapy
- (2016) Jonathan H. Esensten et al. IMMUNITY
- ICOS+Foxp3+TILs in gastric cancer are prognostic markers and effector regulatory T cells associated withHelicobacter pylori
- (2016) Hirotsugu Nagase et al. INTERNATIONAL JOURNAL OF CANCER
- Knockdown of B7-H6 inhibits tumor progression and enhances chemosensitivity in B-cell non-Hodgkin lymphoma
- (2016) FEIFEI WU et al. INTERNATIONAL JOURNAL OF ONCOLOGY
- Pembrolizumab (MK-3475) versus paclitaxel as second-line therapy for advanced gastric or gastroesophageal junction (GEJ) adenocarcinoma: Phase 3 KEYNOTE-061 study.
- (2016) Atsushi Ohtsu et al. JOURNAL OF CLINICAL ONCOLOGY
- Structural Insights into the Inhibitory Mechanism of an Antibody against B7-H6, a Stress-Induced Cellular Ligand for the Natural Killer Cell Receptor NKp30
- (2016) Xiaoping Xu et al. JOURNAL OF MOLECULAR BIOLOGY
- Pembrolizumab for patients with PD-L1-positive advanced gastric cancer (KEYNOTE-012): a multicentre, open-label, phase 1b trial
- (2016) Kei Muro et al. LANCET ONCOLOGY
- Immunotherapy for Gastric Cancer: A Focus on Immune Checkpoints
- (2016) Maria Alsina et al. Targeted Oncology
- Programmed death-ligand 1 expression in gastric adenocarcinoma is a poor prognostic factor in a high CD8+ tumor infiltrating lymphocytes group
- (2016) Hyeyoon Chang et al. Oncotarget
- B7-H4 is Predictive of Poor Prognosis in Patients with Gastric Cancer
- (2016) YongHui Cui et al. MEDICAL SCIENCE MONITOR
- Antagonizing programmed death-1 and programmed death ligand-1 as a therapeutic approach for gastric cancer
- (2016) Xiaojun Liu et al. Therapeutic Advances in Gastroenterology
- ICOS Co-Stimulation: Friend or Foe?
- (2016) Daniel J. Wikenheiser et al. Frontiers in Immunology
- Treatment of the Immune-Related Adverse Effects of Immune Checkpoint Inhibitors
- (2016) Claire F. Friedman et al. JAMA Oncology
- A New VISTA on combination therapy for negative checkpoint regulator blockade
- (2016) Jie Deng et al. Journal for ImmunoTherapy of Cancer
- Dies1/VISTA expression loss is a recurrent event in gastric cancer due to epigenetic regulation
- (2016) Patrícia Oliveira et al. Scientific Reports
- B7-H3 expression in donor T cells and host cells negatively regulates acute graft-versus-host disease lethality
- (2015) R. G. Veenstra et al. BLOOD
- Downregulation of myeloma-induced ICOS-L and regulatory T cell generation by lenalidomide and dexamethasone therapy
- (2015) Gina B. Scott et al. CELLULAR IMMUNOLOGY
- A New B7:CD28 Family Checkpoint Target for Cancer Immunotherapy: HHLA2
- (2015) Y. Xiao et al. CLINICAL CANCER RESEARCH
- Humanized Affinity-matured Monoclonal Antibody 8H9 Has Potent Antitumor Activity and Binds to FG Loop of Tumor Antigen B7-H3
- (2015) Mahiuddin Ahmed et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Tumor Therapeutics Work as Stress Inducers to Enhance Tumor Sensitivity to Natural Killer (NK) Cell Cytolysis by Up-regulating NKp30 Ligand B7-H6
- (2015) Guoshuai Cao et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Human PD-1 binds differently to its human ligands: A comprehensive modeling study
- (2015) Clement Viricel et al. JOURNAL OF MOLECULAR GRAPHICS & MODELLING
- Immune-checkpoint proteins VISTA and PD-1 nonredundantly regulate murine T-cell responses
- (2015) Jun Liu et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Control of signaling-mediated clearance of apoptotic cells by the tumor suppressor p53
- (2015) K. W. Yoon et al. SCIENCE
- HHLA2 and TMIGD2: new immunotherapeutic targets of the B7 and CD28 families
- (2015) Murali Janakiram et al. OncoImmunology
- VISTA Regulates the Development of Protective Antitumor Immunity
- (2014) I. Le Mercier et al. CANCER RESEARCH
- Expression, Clinical Significance, and Receptor Identification of the Newest B7 Family Member HHLA2 Protein
- (2014) M. Janakiram et al. CLINICAL CANCER RESEARCH
- Expression of costimulatory molecules B7-H1, B7-H4 and Foxp3+ Tregs in gastric cancer and its clinical significance
- (2014) Yiting Geng et al. International Journal of Clinical Oncology
- Coinhibitory receptor PD-1H preferentially suppresses CD4+ T cell–mediated immunity
- (2014) Dallas B. Flies et al. JOURNAL OF CLINICAL INVESTIGATION
- ICOS Controls the Pool Size of Effector-Memory and Regulatory T Cells
- (2014) Y. Burmeister et al. JOURNAL OF IMMUNOLOGY
- Aberrant expression of B7-H3 in gastric adenocarcinoma promotes cancer cell metastasis
- (2014) WEI DAI et al. ONCOLOGY REPORTS
- Impact of neoadjuvant chemotherapy on lymphocytes and co-inhibitory B7-H4 molecule in gastric cancer: low B7-H4 expression associates with favorable prognosis
- (2014) Ninu Maskey et al. TUMOR BIOLOGY
- B7-H4 Expression by Nonhematopoietic Cells in the Tumor Microenvironment Promotes Antitumor Immunity
- (2014) R. Rahbar et al. Cancer Immunology Research
- The Immunological Synapse
- (2014) M. L. Dustin Cancer Immunology Research
- Induction of B7-H6, a ligand for the natural killer cell-activating receptor NKp30, in inflammatory conditions
- (2013) J. Matta et al. BLOOD
- Novel Recombinant Human B7-H4 Antibodies Overcome Tumoral Immune Escape to Potentiate T-Cell Antitumor Responses
- (2013) D. Dangaj et al. CANCER RESEARCH
- Role of plasmacytoid dendritic cells and inducible costimulator-positive regulatory T cells in the immunosuppression microenvironment of gastric cancer
- (2013) Xiao-Mei Huang et al. CANCER SCIENCE
- Analysis of the 'angulin' proteins LSR, ILDR1 and ILDR2 - tricellulin recruitment, epithelial barrier function and implication in deafness pathogenesis
- (2013) T. Higashi et al. JOURNAL OF CELL SCIENCE
- A functional variant at miR-24 binding site in B7-H2 alters susceptibility to gastric cancer in a Chinese Han population
- (2013) Panpan Yang et al. MOLECULAR IMMUNOLOGY
- B7-H6 Protein Expression has no Prognostic Significance in Human Gastric Carcinoma
- (2013) Xiao-Juan Chen et al. PATHOLOGY & ONCOLOGY RESEARCH
- HHLA2 is a member of the B7 family and inhibits human CD4 and CD8 T-cell function
- (2013) R. Zhao et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Structure and T Cell Inhibition Properties of B7 Family Member, B7-H3
- (2013) Vladimir Vigdorovich et al. STRUCTURE
- B7-H5 costimulates human T cells via CD28H
- (2013) Yuwen Zhu et al. Nature Communications
- The role of B7 family molecules in hematologic malignancy
- (2012) P. Greaves et al. BLOOD
- Development of an Fc-Enhanced Anti-B7-H3 Monoclonal Antibody with Potent Antitumor Activity
- (2012) D. Loo et al. CLINICAL CANCER RESEARCH
- Evolution of the B7 family: co-evolution of B7H6 and NKp30, identification of a new B7 family member, B7H7, and of B7's historical relationship with the MHC
- (2012) Martin F. Flajnik et al. IMMUNOGENETICS
- Programmed cell death 1 forms negative costimulatory microclusters that directly inhibit T cell receptor signaling by recruiting phosphatase SHP2
- (2012) Tadashi Yokosuka et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Increased PD-1 expression on CD4+ and CD8+ T cells is involved in immune evasion in gastric cancer
- (2012) Hiroaki Saito et al. JOURNAL OF SURGICAL ONCOLOGY
- Colocalization of Inflammatory Response with B7-H1 Expression in Human Melanocytic Lesions Supports an Adaptive Resistance Mechanism of Immune Escape
- (2012) J. M. Taube et al. Science Translational Medicine
- Essential Role of PDL1 Expression on Nonhematopoietic Donor Cells in Acquired Tolerance to Vascularized Cardiac Allografts
- (2011) L. V. Riella et al. AMERICAN JOURNAL OF TRANSPLANTATION
- B7-H6/NKp30 interaction: a mechanism of alerting NK cells against tumors
- (2011) Tomonori Kaifu et al. CELLULAR AND MOLECULAR LIFE SCIENCES
- Ipilimumab: An Anti-CTLA-4 Antibody for Metastatic Melanoma
- (2011) E. J. Lipson et al. CLINICAL CANCER RESEARCH
- A frequent somatic mutation in CD274 3′-UTR leads to protein over-expression in gastric cancer by disrupting miR-570 binding
- (2011) Weipeng Wang et al. HUMAN MUTATION
- B7-H2 Is a Costimulatory Ligand for CD28 in Human
- (2011) Sheng Yao et al. IMMUNITY
- ICOS Receptor Instructs T Follicular Helper Cell versus Effector Cell Differentiation via Induction of the Transcriptional Repressor Bcl6
- (2011) Youn Soo Choi et al. IMMUNITY
- Structure of the human activating natural cytotoxicity receptor NKp30 bound to its tumor cell ligand B7-H6
- (2011) Yili Li et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Sustained antibody responses depend on CD28 function in bone marrow–resident plasma cells
- (2011) Cheryl H. Rozanski et al. JOURNAL OF EXPERIMENTAL MEDICINE
- B7-H3 Silencing Increases Paclitaxel Sensitivity by Abrogating Jak2/Stat3 Phosphorylation
- (2011) H. Liu et al. MOLECULAR CANCER THERAPEUTICS
- Clinical Significance of the B7-H4 Coregulatory Molecule as a Novel Prognostic Marker in Gastric Cancer
- (2011) Takaaki Arigami et al. WORLD JOURNAL OF SURGERY
- Tumor expression of B7-H4 predicts poor survival of patients suffering from gastric cancer
- (2010) Jingting Jiang et al. CANCER IMMUNOLOGY IMMUNOTHERAPY
- MicroRNA-375 Is Downregulated in Gastric Carcinomas and Regulates Cell Survival by Targeting PDK1 and 14-3-3
- (2010) Y. Tsukamoto et al. CANCER RESEARCH
- Modulation of Lymphocyte Regulation for Cancer Therapy: A Phase II Trial of Tremelimumab in Advanced Gastric and Esophageal Adenocarcinoma
- (2010) C. Ralph et al. CLINICAL CANCER RESEARCH
- CTLA-4 is expressed by human monocyte—derived dendritic cells and regulates their functions
- (2010) Stefania Laurent et al. HUMAN IMMUNOLOGY
- Expression of B7-H4 in blood of patients with gastric cancer predicts tumor progression and prognosis
- (2010) Takaaki Arigami et al. JOURNAL OF SURGICAL ONCOLOGY
- IL-10/TGF- -Modified Macrophages Induce Regulatory T Cells and Protect against Adriamycin Nephrosis
- (2010) Q. Cao et al. JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
- MicroRNA miR-29 Modulates Expression of Immunoinhibitory Molecule B7-H3: Potential Implications for Immune Based Therapy of Human Solid Tumors
- (2009) H. Xu et al. CANCER RESEARCH
- B7-H3 is a potent inhibitor of human T-cell activation: No evidence for B7-H3 and TREML2 interaction
- (2009) Judith Leitner et al. EUROPEAN JOURNAL OF IMMUNOLOGY
- Roquin Differentiates the Specialized Functions of Duplicated T Cell Costimulatory Receptor Genes Cd28 and Icos
- (2009) Michelle A. Linterman et al. IMMUNITY
- The B7 family member B7-H6 is a tumor cell ligand for the activating natural killer cell receptor NKp30 in humans
- (2009) Cameron S. Brandt et al. JOURNAL OF EXPERIMENTAL MEDICINE
- MiR-24 Tumor Suppressor Activity Is Regulated Independent of p53 and through a Target Site Polymorphism
- (2009) Prasun J. Mishra et al. PLoS One
- Effector Functions of Donor-Reactive CD8 Memory T Cells Are Dependent on ICOS Induced During Division in Cardiac Grafts
- (2008) A. D. Schenk et al. AMERICAN JOURNAL OF TRANSPLANTATION
- PD-1 and Its Ligands in Tolerance and Immunity
- (2008) Mary E. Keir et al. Annual Review of Immunology
- PI(3) kinase is associated with a mechanism of immunoresistance in breast and prostate cancer
- (2008) C A Crane et al. ONCOGENE
- The contrasting role of B7-H3
- (2008) K. A. Hofmeyer et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Triggering receptor expressed on myeloid cell-like transcript 2 (TLT-2) is a counter-receptor for B7-H3 and enhances T cell responses
- (2008) M. Hashiguchi et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Anti-CTLA4 Monoclonal Antibody Ipilimumab in the Treatment of Metastatic Melanoma: Recent Findings
- (2008) Marko Lens et al. Recent Patents on Anti-Cancer Drug Discovery
- Positional Cloning of “Lisch-like”, a Candidate Modifier of Susceptibility to Type 2 Diabetes in Mice
- (2008) Marija Dokmanovic-Chouinard et al. PLoS Genetics
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