Playing hide and seek: Tumor cells in control of MHC class I antigen presentation

Healthy cells functionally present TAP-independent SSR1 peptides: implications for selection of clinically relevant antigens

(2021) Antonius A. de Waard et al.   iScience

MHC Class I Downregulation in Cancer: Underlying Mechanisms and Potential Targets for Cancer Immunotherapy

(2020) Annelisa M. Cornel et al.   Cancers

Identification of microRNAs Targeting the Transporter Associated with Antigen Processing TAP1 in Melanoma

(2020) Maria-Filothei Lazaridou et al.   Journal of Clinical Medicine

PAKC: A novel Panel of HLA class I Antigen presentation machinery Knockout Cells from the same genetic origin

(2020) Antonius A. Waard et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

The SPPL3-Defined Glycosphingolipid Repertoire Orchestrates HLA Class I-Mediated Immune Responses

(2020) Marlieke L.M. Jongsma et al.   IMMUNITY

Genome-wide Screens Identify Lineage- and Tumor-Specific Genes Modulating MHC-I- and MHC-II-Restricted Immunosurveillance of Human Lymphomas

(2020) Devin Dersh et al.   IMMUNITY

T cells specific for an unconventional natural antigen fail to recognize leukemic cells

(2019) Margot J. Pont et al.   Cancer Immunology Research

Immune signature drives leukemia escape and relapse after hematopoietic cell transplantation

(2019) Cristina Toffalori et al.   NATURE MEDICINE

Transforming Growth Factor-β Signaling in Immunity and Cancer

(2019) Eduard Batlle et al.   IMMUNITY

DUX4 Suppresses MHC Class I to Promote Cancer Immune Evasion and Resistance to Checkpoint Blockade

(2019) Guo-Liang Chew et al.   DEVELOPMENTAL CELL

An Evolutionarily Conserved Function of Polycomb Silences the MHC Class I Antigen Presentation Pathway and Enables Immune Evasion in Cancer

(2019) Marian L. Burr et al.   CANCER CELL

Tumor-induced escape mechanisms and their association with resistance to checkpoint inhibitor therapy

(2019) Michael Friedrich et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Frequent Loss of IRF2 in Cancers Leads to Immune Evasion through Decreased MHC Class I Antigen Presentation and Increased PD-L1 Expression

(2019) Barry A. Kriegsman et al.   JOURNAL OF IMMUNOLOGY

Deubiquitinating Enzyme UCH-L1 Promotes Dendritic Cell Antigen Cross-Presentation by Favoring Recycling of MHC Class I Molecules

(2019) Anna T. Reinicke et al.   JOURNAL OF IMMUNOLOGY

Phosphoinositide 3-kinase signaling can modulate MHC class I and II expression

(2019) Sanjay Chandrasekaran et al.   MOLECULAR CANCER RESEARCH

MHC class I dysfunction of glioma stem cells escapes from CTL-mediated immune response via activation of Wnt/β-catenin signaling pathway

(2019) Wei Yang et al.   ONCOGENE

Basis of PD1/PD-L1 Therapies

(2019) Barbara Seliger   Journal of Clinical Medicine

The RNA-binding Protein MEX3B Mediates Resistance to Cancer Immunotherapy by Downregulating HLA-A Expression

(2018) Lu Huang et al.   CLINICAL CANCER RESEARCH

Tumor-associated calreticulin variants functionally compromise the peptide loading complex and impair its recruitment of MHC-I

(2018) Najla Arshad et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

DNA methyltransferase inhibition upregulates MHC-I to potentiate cytotoxic T lymphocyte responses in breast cancer

(2018) Na Luo et al.   Nature Communications

Complex pattern of immune evasion in MSI colorectal cancer

(2018) Mine Ozcan et al.   OncoImmunology

Nedd4 Binding Protein 1 (N4BP1) and TNFAIP3 Interacting Protein 1 (TNIP1) control MHC-1 display in neuroblastoma

(2018) Lotte Spel et al.   CANCER RESEARCH

STAT3 associates with vacuolar H+-ATPase and regulates cytosolic and lysosomal pH

(2018) Bin Liu et al.   CELL RESEARCH

Identification of non-mutated neoantigens presented by TAP-deficient tumors

(2018) Koen A. Marijt et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Prolyl isomerase Pin1: a promoter of cancer and a target for therapy

(2018) Yang Chen et al.   Cell Death & Disease

Evolutionary Pressure against MHC Class II Binding Cancer Mutations

(2018) Rachel Marty Pyke et al.   CELL

Biological Consequences of Major Histocompatibility Class-II Expression by Tumor Cells in Cancer

(2018) Margaret L Axelrod et al.   CLINICAL CANCER RESEARCH

The regulatory roles of glycosphingolipid‐enriched lipid rafts in immune systems

(2018) Hitoshi Nakayama et al.   FEBS LETTERS

Immune Escape of Relapsed AML Cells after Allogeneic Transplantation

(2018) Matthew J. Christopher et al.   NEW ENGLAND JOURNAL OF MEDICINE

MARCH9-mediated ubiquitination regulates MHC I export from the TGN

(2017) Francesca De Angelis Rigotti et al.   IMMUNOLOGY AND CELL BIOLOGY

The MEK Inhibitors Trametinib and Cobimetinib Induce a Type I Interferon Response in Human Keratinocytes

(2017) Daniela Lulli et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The regulatory network behind MHC class I expression

(2017) Marlieke L.M. Jongsma et al.   MOLECULAR IMMUNOLOGY

Patient HLA class I genotype influences cancer response to checkpoint blockade immunotherapy

(2017) Diego Chowell et al.   SCIENCE

Resistance to checkpoint blockade therapy through inactivation of antigen presentation

(2017) Moshe Sade-Feldman et al.   Nature Communications

Impaired HLA Class I Antigen Processing and Presentation as a Mechanism of Acquired Resistance to Immune Checkpoint Inhibitors in Lung Cancer

(2017) Scott Gettinger et al.   Cancer Discovery

Inhibition of hepatocellular carcinoma growth by blockade of glycosphingolipid synthesis

(2017) Richard Jennemann et al.   Oncotarget

Tuning cancer fate: the unremitting role of host immunity

(2017) B. Calì et al.   Open Biology

Epigenetic priming restores the HLA class-I antigen processing machinery expression in Merkel cell carcinoma

(2017) Cathrin Ritter et al.   Scientific Reports

TAP-independent self-peptides enhance T cell recognition of immune-escaped tumors

(2016) Elien M. Doorduijn et al.   JOURNAL OF CLINICAL INVESTIGATION

HNRNPR Regulates the Expression of Classical and Nonclassical MHC Class I Proteins

(2016) Adi Reches et al.   JOURNAL OF IMMUNOLOGY

Mutations Associated with Acquired Resistance to PD-1 Blockade in Melanoma

(2016) Jesse M. Zaretsky et al.   NEW ENGLAND JOURNAL OF MEDICINE

NLRC5/MHC class I transactivator is a target for immune evasion in cancer

(2016) Sayuri Yoshihama et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Primary Resistance to PD-1 Blockade Mediated by JAK1/2 Mutations

(2016) Daniel Sanghoon Shin et al.   Cancer Discovery

Role of the Polycomb Repressive Complex 2 (PRC2) in Transcriptional Regulation and Cancer

(2016) Anne Laugesen et al.   Cold Spring Harbor Perspectives in Medicine

Kinase Regulation of Human MHC Class I Molecule Expression on Cancer Cells

(2016) E. J. Brea et al.   Cancer Immunology Research

Comprehensive analysis of cancer-associated somatic mutations in class I HLA genes

(2015) Sachet A Shukla et al.   NATURE BIOTECHNOLOGY

BioGPS: building your own mash-up of gene annotations and expression profiles

(2015) Chunlei Wu et al.   NUCLEIC ACIDS RESEARCH

Comprehensive Glycomics of a Multistep Human Brain Tumor Model Reveals Specific Glycosylation Patterns Related to Malignancy

(2015) Jun-ichi Furukawa et al.   PLoS One

The first step of peptide selection in antigen presentation by MHC class I molecules

(2015) Malgorzata A. Garstka et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Immunogenicity of somatic mutations in human gastrointestinal cancers

(2015) E. Tran et al.   SCIENCE

A non-proteolytic role for ubiquitin in deadenylation of MHC-I mRNA by the RNA-binding E3-ligase MEX-3C

(2015) Florencia Cano et al.   Nature Communications

Division of labor between IRF1 and IRF2 in regulating different stages of transcriptional activation in cellular antiviral activities

(2015) Gang Ren et al.   Cell and Bioscience

BRAFV600E Co-opts a Conserved MHC Class I Internalization Pathway to Diminish Antigen Presentation and CD8+ T-cell Recognition of Melanoma

(2015) S. D. Bradley et al.   Cancer Immunology Research

Epigenetic regulations in the IFNγ signalling pathway: IFNγ-mediated MHC class I upregulation on tumour cells is associated with DNA demethylation of antigen-presenting machinery genes

(2015) Veronika Vlková et al.   Oncotarget

Generation of MHC class I diversity in primary tumors and selection of the malignant phenotype

(2014) Federico Garrido et al.   INTERNATIONAL JOURNAL OF CANCER

Distinct Assembly Profiles of HLA-B Molecules

(2014) S. M. Rizvi et al.   JOURNAL OF IMMUNOLOGY

Translating DRiPs: MHC class I immunosurveillance of pathogens and tumors

(2014) L. C. Anton et al.   JOURNAL OF LEUKOCYTE BIOLOGY

High-throughput epitope discovery reveals frequent recognition of neo-antigens by CD4+ T cells in human melanoma

(2014) Carsten Linnemann et al.   NATURE MEDICINE

MHC Class I-Related Antigen-Processing Machinery Component Defects in Feline Mammary Carcinoma

(2014) Alessandra Favole et al.   Translational Oncology

Cytokeratin 8-MHC class I interactions: A potential novel immune escape phenotype by a lymph node metastatic carcinoma cell line

(2013) Ming-Syue Wu et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Immunogenetics of HIV disease

(2013) Maureen P. Martin et al.   IMMUNOLOGICAL REVIEWS

Immune escape of cancer cells with beta2-microglobulin loss over the course of metastatic melanoma

(2013) Ana B. del Campo et al.   INTERNATIONAL JOURNAL OF CANCER

The MAPK Pathway Is a Predominant Regulator of HLA-A Expression in Esophageal and Gastric Cancer

(2013) K. Mimura et al.   JOURNAL OF IMMUNOLOGY

MHC Class I Antigen Processing and Presenting Machinery: Organization, Function, and Defects in Tumor Cells

(2013) P. Leone et al.   JNCI-Journal of the National Cancer Institute

Implication of the β2-microglobulin gene in the generation of tumor escape phenotypes

(2012) Monica Bernal et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

The RNA-binding E3 ubiquitin ligase MEX-3C links ubiquitination with MHC-I mRNA degradation

(2012) Florencia Cano et al.   EMBO JOURNAL

High expression of lactotriaosylceramide, a differentiation-associated glycosphingolipid, in the bone marrow of acute myeloid leukemia patients

(2012) Zheng Wang et al.   GLYCOBIOLOGY

The cBio Cancer Genomics Portal: An Open Platform for Exploring Multidimensional Cancer Genomics Data: Figure 1.

(2012) Ethan Cerami et al.   Cancer Discovery

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

MARCH ubiquitin ligases alter the itinerary of clathrin-independent cargo from recycling to degradation

(2011) Craig A. Eyster et al.   MOLECULAR BIOLOGY OF THE CELL

Interaction between ERAP1 and HLA-B27 in ankylosing spondylitis implicates peptide handling in the mechanism for HLA-B27 in disease susceptibility

(2011) David M Evans et al.   NATURE GENETICS

A role for UDP-glucose glycoprotein glucosyltransferase in expression and quality control of MHC class I molecules

(2011) W. Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Essential glycan-dependent interactions optimize MHC class I peptide loading

(2011) P. A. Wearsch et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Regulation of human EGF receptor by lipids

(2011) U. Coskun et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Inverse correlation of HER2 with MHC class I expression on oesophageal squamous cell carcinoma

(2010) T Maruyama et al.   BRITISH JOURNAL OF CANCER

Frequent loss of heterozygosity in the β2-microglobulin region of chromosome 15 in primary human tumors

(2010) Isabel Maleno et al.   IMMUNOGENETICS

Class I MHC molecules as probes of membrane patchiness: from biophysical measurements to modulation of immune responses

(2010) Michael Edidin   IMMUNOLOGIC RESEARCH

ABC proteins in antigen translocation and viral inhibition

(2010) David Parcej et al.   Nature Chemical Biology

Relationship between HLA class I antigen processing machinery component expression and the clinicopathologic characteristics of bladder carcinomas

(2009) Helen P. Cathro et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Calreticulin-dependent recycling in the early secretory pathway mediates optimal peptide loading of MHC class I molecules

(2009) Christopher Howe et al.   EMBO JOURNAL

Hypermethylation of HLA class I gene is associated with HLA class I down-regulation in human gastric cancer

(2009) Q. Ye et al.   TISSUE ANTIGENS

HER-2/neu mediated down-regulation of MHC class I antigen processing prevents CTL-mediated tumor recognition upon DNA vaccination in HLA-A2 transgenic mice

(2008) Simona Vertuani et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Viral and cellular MARCH ubiquitin ligases and cancer

(2008) Xiaoli Wang et al.   SEMINARS IN CANCER BIOLOGY