All About (NK Cell-Mediated) Death in Two Acts and an Unexpected Encore: Initiation, Execution and Activation of Adaptive Immunity

Intracellular and Extracellular Roles of Granzyme K

(2021) Annemieke C. Bouwman et al.   Frontiers in Immunology

Inflammatory cell death induced by cytotoxic lymphocytes: a dangerous but necessary liaison

(2021) Diego Miguel et al.   FEBS Journal

Degranulation enhances presynaptic membrane packing, which protects NK cells from perforin-mediated autolysis

(2021) Yu Li et al.   PLOS BIOLOGY

Use of CAR-Transduced Natural Killer Cells in CD19-Positive Lymphoid Tumors

(2020) Enli Liu et al.   NEW ENGLAND JOURNAL OF MEDICINE

Recalling the Biological Significance of Immune Checkpoints on NK Cells: A Chance to Overcome LAG3, PD1, and CTLA4 Inhibitory Pathways by Adoptive NK Cell Transfer?

(2020) Pilar M. Lanuza et al.   Frontiers in Immunology

Gasdermin E–mediated target cell pyroptosis by CAR T cells triggers cytokine release syndrome

(2020) Yuying Liu et al.   Science Immunology

Potently Cytotoxic Natural Killer Cells Initially Emerge from Erythro-Myeloid Progenitors during Mammalian Development

(2020) Carissa Dege et al.   DEVELOPMENTAL CELL

Mechanisms of Apoptosis Resistance to NK Cell-Mediated Cytotoxicity in Cancer

(2020) Christian Sordo-Bahamonde et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Gasdermin E suppresses tumour growth by activating anti-tumour immunity

(2020) Zhibin Zhang et al.   NATURE

Supramolecular attack particles are autonomous killing entities released from cytotoxic T cells

(2020) Š. Bálint et al.   SCIENCE

Granzyme A from cytotoxic lymphocytes cleaves GSDMB to trigger pyroptosis in target cells

(2020) Zhiwei Zhou et al.   SCIENCE

Cell death induced by cytotoxic CD8+T cells is immunogenic and primes caspase-3–dependent spread immunity against endogenous tumor antigens

(2020) Paula Jaime-Sanchez et al.   Journal for ImmunoTherapy of Cancer

Cellular cytotoxicity is a form of immunogenic cell death

(2020) Luna Minute et al.   Journal for ImmunoTherapy of Cancer

NK cells and ILCs in tumor immunotherapy

(2020) Simona Sivori et al.   MOLECULAR ASPECTS OF MEDICINE

The Multifaceted Function of Granzymes in Sepsis: Some Facts and a Lot to Discover

(2020) Marcela Garzón-Tituaña et al.   Frontiers in Immunology

Synaptic secretion from human natural killer cells is diverse and includes supramolecular attack particles

(2020) Ashley R. Ambrose et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

NK cell recognition of hematopoietic cells by SLAM-SAP families

(2019) Shasha Chen et al.   Cellular & Molecular Immunology

Human NK cells: surface receptors, inhibitory checkpoints, and translational applications

(2019) Simona Sivori et al.   Cellular & Molecular Immunology

Mechanisms of natural killer cell‐mediated cellular cytotoxicity

(2019) Isabel Prager et al.   JOURNAL OF LEUKOCYTE BIOLOGY

NK cells switch from granzyme B to death receptor–mediated cytotoxicity during serial killing

(2019) Isabel Prager et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Sensitization to immune checkpoint blockade through activation of a STAT1/NK axis in the tumor microenvironment

(2019) Rachael M. Zemek et al.   Science Translational Medicine

Inhibition of the NKp44-PCNA Immune Checkpoint Using a mAb to PCNA

(2019) Kiran Kundu et al.   Cancer Immunology Research

Lipid order and charge protect killer T cells from accidental death

(2019) Jesse A. Rudd-Schmidt et al.   Nature Communications

NK Cells Stimulate Recruitment of cDC1 into the Tumor Microenvironment Promoting Cancer Immune Control

(2018) Jan P. Böttcher et al.   CELL

Antigen-specific primed cytotoxic T cells eliminate tumour cells in vivo and prevent tumour development, regardless of the presence of anti-apoptotic mutations conferring drug resistance

(2018) Paula Jaime-Sánchez et al.   CELL DEATH AND DIFFERENTIATION

Deep immune profiling by mass cytometry links human T and NK cell differentiation and cytotoxic molecule expression patterns

(2018) Bertram Bengsch et al.   JOURNAL OF IMMUNOLOGICAL METHODS

Single Degranulations in NK Cells Can Mediate Target Cell Killing

(2018) Lavesh A. Gwalani et al.   JOURNAL OF IMMUNOLOGY

A natural killer–dendritic cell axis defines checkpoint therapy–responsive tumor microenvironments

(2018) Kevin C. Barry et al.   NATURE MEDICINE

Structural principles of tumor necrosis factor superfamily signaling

(2018) Éva S. Vanamee et al.   Science Signaling

Beyond Cell Death: New Functions for TNF Family Cytokines in Autoimmunity and Tumor Immunotherapy

(2018) Fei Yi et al.   TRENDS IN MOLECULAR MEDICINE

Structural principles of tumor necrosis factor superfamily signaling

(2018) Éva S. Vanamee et al.   Science Signaling

Nidogen-1 is a novel extracellular ligand for the NKp44 activating receptor

(2018) Silvia Gaggero et al.   OncoImmunology

Natural killer cells induce distinct modes of cancer cell death: Discrimination, quantification and modulation of apoptosis, necrosis and mixed forms

(2018) Christian S Backes et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Gene Regulatory Programs Conferring Phenotypic Identities to Human NK Cells

(2018) Patrick L. Collins et al.   CELL

Integrated molecular and immunophenotypic analysis of NK cells in anti-PD-1 treated metastatic melanoma patients

(2018) Hansol Lee et al.   OncoImmunology

LFA-1 Activation in NK Cells and Their Subsets: Influence of Receptors, Maturation, and Cytokine Stimulation

(2017) Doris Urlaub et al.   JOURNAL OF IMMUNOLOGY

Granzyme B in skin inflammation and disease

(2017) Christopher T. Turner et al.   MATRIX BIOLOGY

CD56 + /CD16 − Natural Killer cells expressing the inflammatory protease granzyme A are enriched in synovial fluid from patients with osteoarthritis

(2017) P. Jaime et al.   OSTEOARTHRITIS AND CARTILAGE

Natural killer cell-mediated immunosurveillance of human cancer

(2017) Karl-Johan Malmberg et al.   SEMINARS IN IMMUNOLOGY

Serglycin determines secretory granule repertoire and regulates natural killer cell and cytotoxic T lymphocyte cytotoxicity

(2016) Vivien R. Sutton et al.   FEBS Journal

In Vivo Killing Capacity of Cytotoxic T Cells Is Limited and Involves Dynamic Interactions and T Cell Cooperativity

(2016) Stephan Halle et al.   IMMUNITY

Targeting natural killer cells in cancer immunotherapy

(2016) Camille Guillerey et al.   NATURE IMMUNOLOGY

How Do Cytotoxic Lymphocytes Kill Cancer Cells?

(2015) L. Martinez-Lostao et al.   CLINICAL CANCER RESEARCH

Mouse Cytotoxic T Cell-derived Granzyme B Activates the Mitochondrial Cell Death Pathway in a Bim-dependent Fashion

(2015) Elena Catalán et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Granzymes Regulate Proinflammatory Cytokine Responses

(2015) Annette C. Wensink et al.   JOURNAL OF IMMUNOLOGY

Necroptosis and its role in inflammation

(2015) Manolis Pasparakis et al.   NATURE

Human NK cells activated by EBV+lymphoblastoid cells overcome anti-apoptotic mechanisms of drug resistance in haematological cancer cells

(2015) Diego Sánchez-Martínez et al.   OncoImmunology

Trailing TRAIL Resistance: Novel Targets for TRAIL Sensitization in Cancer Cells

(2015) Rachana Trivedi et al.   Frontiers in Oncology

Cytotoxic and non-cytotoxic roles of the CTL/NK protease granzyme B

(2015) Inna S. Afonina et al.   IMMUNOLOGICAL REVIEWS

Perforin oligomers form arcs in cellular membranes: a locus for intracellular delivery of granzymes

(2014) S S Metkar et al.   CELL DEATH AND DIFFERENTIATION

RIP kinases: key decision makers in cell death and innate immunity

(2014) F Humphries et al.   CELL DEATH AND DIFFERENTIATION

All-trans retinoic acid (ATRA) induces miR-23a expression, decreases CTSC expression and granzyme B activity leading to impaired NK cell cytotoxicity

(2014) Diego Sanchez-Martínez et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Cysteine Cathepsins as Regulators of the Cytotoxicity of NK and T Cells

(2014) Milica PeriÅ¡ić Nanut et al.   Frontiers in Immunology

Are all granzymes cytotoxic in vivo?

(2013) Lars T. Joeckel et al.   BIOLOGICAL CHEMISTRY

Classification of human natural killer cells based on migration behavior and cytotoxic response

(2013) B. Vanherberghen et al.   BLOOD

Surface CD107a/LAMP-1 protects natural killer cells from degranulation-associated damage

(2013) A. Cohnen et al.   BLOOD

Perforin forms transient pores on the target cell plasma membrane to facilitate rapid access of granzymes during killer cell attack

(2013) J. A. Lopez et al.   BLOOD

Oncology Meets Immunology: The Cancer-Immunity Cycle

(2013) Daniel S. Chen et al.   IMMUNITY

Imaging burst kinetics and spatial coordination during serial killing by single natural killer cells

(2013) P. J. Choi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Death Receptor-Ligand Systems in Cancer, Cell Death, and Inflammation

(2013) H. Walczak   Cold Spring Harbor Perspectives in Biology

Granzyme B in injury, inflammation, and repair

(2012) Paul R. Hiebert et al.   TRENDS IN MOLECULAR MEDICINE

Human NK cell lytic granules and regulation of their exocytosis

(2012) Konrad Krzewski et al.   Frontiers in Immunology

A quarter century of granzymes

(2011) C L Ewen et al.   CELL DEATH AND DIFFERENTIATION

Molecular definitions of cell death subroutines: recommendations of the Nomenclature Committee on Cell Death 2012

(2011) L Galluzzi et al.   CELL DEATH AND DIFFERENTIATION

Natural killer cell-produced IFN-γ and TNF-α induce target cell cytolysis through up-regulation of ICAM-1

(2011) Ruipeng Wang et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Perforin pores in the endosomal membrane trigger the release of endocytosed granzyme B into the cytosol of target cells

(2011) Jerome Thiery et al.   NATURE IMMUNOLOGY

Cancer Immunoediting: Integrating Immunity's Roles in Cancer Suppression and Promotion

(2011) R. D. Schreiber et al.   SCIENCE

Granzymes in disease: bench to bedside

(2010) D J Granville   CELL DEATH AND DIFFERENTIATION

Granzymes in cancer and immunity

(2010) S P Cullen et al.   CELL DEATH AND DIFFERENTIATION

Intravital Imaging Reveals Distinct Dynamics for Natural Killer and CD8+ T Cells during Tumor Regression

(2010) Jacques Deguine et al.   IMMUNITY

Functional dissection of the granzyme family: cell death and inflammation

(2010) Desiree A. Anthony et al.   IMMUNOLOGICAL REVIEWS

Cathepsin H Is an Additional Convertase of Pro-granzyme B

(2010) Michael E. D'Angelo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Transmembrane TNF- : structure, function and interaction with anti-TNF agents

(2010) T. Horiuchi et al.   RHEUMATOLOGY

The Molecular Basis for Perforin Oligomerization and Transmembrane Pore Assembly

(2009) Katherine Baran et al.   IMMUNITY

Proteolytic Activation of the Cytotoxic Phenotype during Human NK Cell Development

(2009) J. L. Meade et al.   JOURNAL OF IMMUNOLOGY

Death by a Thousand Cuts: Granzyme Pathways of Programmed Cell Death

(2008) Dipanjan Chowdhury et al.   Annual Review of Immunology

TRAIL-R deficiency in mice enhances lymph node metastasis without affecting primary tumor development

(2008) Anne Grosse-Wilde et al.   JOURNAL OF CLINICAL INVESTIGATION