Cholic acid exposure during late pregnancy causes placental dysfunction and fetal growth restriction by reactive oxygen species‐mediated activation of placental GCN2/eIF2α pathway

Gestational cholestasis induced intrauterine growth restriction through triggering IRE1α‐mediated apoptosis of placental trophoblast cells

(2022) Xing‐Xing Gao et al.   FASEB JOURNAL

Pregnancy-Associated Liver Diseases

(2022) Norah A. Terrault et al.   GASTROENTEROLOGY

Differential expression of placental 11β-HSD2 induced by high maternal glucocorticoid exposure mediates sex differences in placental and fetal development

(2022) Pengxia Yu et al.   SCIENCE OF THE TOTAL ENVIRONMENT

Substance P Hinders Bile Acid-Induced Hepatocellular Injury by Modulating Oxidative Stress and Inflammation

(2022) Dahyeon Lee et al.   Antioxidants

Predictive Value of Serum Cholic Acid and Lithocholic Acid for the Diagnosis in an Intrahepatic Cholestasis of Pregnancy Population with High Levels of Total Bile Acids and the Correlation with Placental Hypoxia-Inducible Factor-1α

(2022) Chu-Yun Cheng et al.   International Journal of Womens Health

Beyond stillbirth: association of intrahepatic cholestasis of pregnancy severity and adverse outcomes

(2022) Minhazur Sarker et al.   AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY

Mitochondrial ROS-mediated ribosome stalling and GCN2 activation are partially involved in 1-nitropyrene-induced steroidogenic inhibition in testes

(2022) Jian Li et al.   ENVIRONMENT INTERNATIONAL

Impact of N-Acetyl Cysteine (NAC) on Tuberculosis (TB) Patients—A Systematic Review

(2022) Daniel Adon Mapamba et al.   Antioxidants

Rhythm of fetoplacental 11β-hydroxysteroid dehydrogenase type 2 – fetal protection from morning maternal glucocorticoids

(2021) Eva Kathrin Lamadé et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Dexamethasone-induced intrauterine growth restriction modulates expression of placental vascular growth factors and fetal and placental growth

(2021) A Arias et al.   MOLECULAR HUMAN REPRODUCTION

Melatonin protects against environmental stress-induced fetal growth restriction via suppressing ROS-mediated GCN2/ATF4/BNIP3-dependent mitophagy in placental trophoblasts

(2021) Hua-Long Zhu et al.   Redox Biology

Microcystin-LR inhibits testosterone synthesis via reactive oxygen species-mediated GCN2/eIF2α pathway in mouse testes

(2021) Lan Gao et al.   SCIENCE OF THE TOTAL ENVIRONMENT

Association of Elevated Maternal Serum Total Bile Acids With Low Birth Weight and Intrauterine Fetal Growth Restriction

(2021) Fuzhen Song et al.   JAMA Network Open

P-gp expression inhibition mediates placental glucocorticoid barrier opening and fetal weight loss

(2021) Caiyun Ge et al.   BMC Medicine

The eIF2 kinase GCN2 directs keratinocyte collective cell migration during wound healing via coordination of reactive oxygen species and amino acids

(2021) Rebecca R. Miles et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Inhibition of GCN2 alleviates hepatic steatosis and oxidative stress in obese mice: Involvement of NRF2 regulation

(2021) Juntao Yuan et al.   Redox Biology

Dysregulation of bile acids increases the risk for preterm birth in pregnant women

(2020) Sangmin You et al.   Nature Communications

Gestational Vitamin D Deficiency Causes Placental Insufficiency and Fetal Intrauterine Growth Restriction Partially through Inducing Placental Inflammation

(2020) Yuan Hua Chen et al.   JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY

Tracking placental development in health and disease

(2020) John D. Aplin et al.   Nature Reviews Endocrinology

The placenta in fetal growth restriction: What is going wrong?

(2020) Cherry Sun et al.   PLACENTA

Continuous association of total bile acid levels with the risk of small for gestational age infants

(2020) Li Li et al.   Scientific Reports

Cholestasis: A Prospective Study of Perinatal Outcomes and Time to Symptom Improvement

(2020) Casey S. Yule et al.   AMERICAN JOURNAL OF PERINATOLOGY

Cadmium down-regulates 11β-HSD2 expression and elevates active glucocorticoid level via PERK/p-eIF2α pathway in placental trophoblasts

(2020) Xue-Ting Shi et al.   CHEMOSPHERE

Environmental exposure to cadmium impairs fetal growth and placental angiogenesis via GCN-2-mediated mitochondrial stress

(2020) Yong-Wei Xiong et al.   JOURNAL OF HAZARDOUS MATERIALS

Fetal cardiac dysfunction in intrahepatic cholestasis of pregnancy is associated with elevated serum bile acid concentrations

(2020) Tharni Vasavan et al.   JOURNAL OF HEPATOLOGY

Cost-effectiveness of Antenatal Corticosteroid Therapy vs No Therapy in Women at Risk of Late Preterm Delivery

(2019) Cynthia Gyamfi-Bannerman et al.   JAMA Pediatrics

Placental weight and size in relation to fetal growth restriction: a case-control study

(2019) Hong-Jiao Liu et al.   Journal of Maternal-Fetal & Neonatal Medicine

Enzymatic quantification of total serum bile acids as a monitoring strategy for women with intrahepatic cholestasis of pregnancy receiving ursodeoxycholic acid treatment: a cohort study

(2019) LB Manna et al.   BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY

Glucocorticoid exposure during hippocampal neurogenesis primes future stress response by inducing changes in DNA methylation

(2019) Nadine Provençal et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Obeticholic Acid Protects against Gestational Cholestasis-Induced Fetal Intrauterine Growth Restriction in Mice

(2019) Wei Chen et al.   Oxidative Medicine and Cellular Longevity

Role of eIF2α Kinases in Translational Control and Adaptation to Cellular Stress

(2018) Ronald C. Wek   Cold Spring Harbor Perspectives in Biology

Mechanisms for establishment of the placental glucocorticoid barrier, a guard for life

(2018) Ping Zhu et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Programming of central and peripheral insulin resistance by low birthweight and postnatal catch-up growth in male mice

(2018) Lindsey M. Berends et al.   DIABETOLOGIA

From population reference to national standard: new and improved birthweight charts

(2018) Liset Hoftiezer et al.   AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY

Early Second-Trimester Fetal Growth Restriction and Adverse Perinatal Outcomes

(2017) Lorene A. Temming et al.   OBSTETRICS AND GYNECOLOGY

Pregnancy Suppresses the Daily Rhythmicity of Core Body Temperature and Adipose Metabolic Gene Expression in the Mouse

(2016) Michaela D. Wharfe et al.   ENDOCRINOLOGY

Obeticholic Acid Protects against Lipopolysaccharide-Induced Fetal Death and Intrauterine Growth Restriction through Its Anti-Inflammatory Activity

(2016) Yuan-Hua Chen et al.   JOURNAL OF IMMUNOLOGY

Pravastatin ameliorates placental vascular defects, fetal growth, and cardiac function in a model of glucocorticoid excess

(2016) Caitlin S. Wyrwoll et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Maternal bile acid transporter deficiency promotes neonatal demise

(2015) Yuanyuan Zhang et al.   Nature Communications

Inflammation in rat pregnancy inhibits spiral artery remodeling leading to fetal growth restriction and features of preeclampsia

(2014) Tiziana Cotechini et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The eIF2α kinases: their structures and functions

(2013) Neysan Donnelly et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Intrahepatic cholestasis of pregnancy and associated hepatobiliary disease: A population-based cohort study

(2013) Hanns-Ulrich Marschall et al.   HEPATOLOGY

Maternal cholestasis during pregnancy programs metabolic disease in offspring

(2013) Georgia Papacleovoulou et al.   JOURNAL OF CLINICAL INVESTIGATION

The eIF2α/ATF4 pathway is essential for stress-induced autophagy gene expression

(2013) Wafa B’chir et al.   NUCLEIC ACIDS RESEARCH

Infection-Induced Host Translational Blockage Inhibits Immune Responses and Epithelial Renewal in the Drosophila Gut

(2012) Sveta Chakrabarti et al.   Cell Host & Microbe

Evidence of endoplasmic reticulum stress and protein synthesis inhibition in the placenta of non-native women at high altitude

(2012) Hong Wa Yung et al.   FASEB JOURNAL