Article
Biochemistry & Molecular Biology
Nikolaos Vrachnis, Savvas Argyridis, Dionysios Vrachnis, Nikolaos Antonakopoulos, Georgios Valsamakis, Christos Iavazzo, Dimitrios Zygouris, Nikolaos Salakos, Alexandros Rodolakis, Nikolaos Vlahos, George Mastorakos, Peter Drakakis, Zoi Iliodromiti
Summary: The study found that both FGF21 and insulin concentrations increased in cases of abnormal fetal growth. Higher levels of these hormones were observed in fetuses with restricted growth (SGA) or macrosomia (LGA).
Article
Medicine, General & Internal
Chiara Lubrano, Emanuela Taricco, Chiara Coco, Fiorenza Di Domenico, Chiara Mando, Irene Cetin
Summary: Alterations in intrauterine fetal growth increase the risk of adverse perinatal and neonatal outcomes. Risk factors for fetal growth alterations include advanced age, being primiparous, and a lower pregestational BMI. Prematurity, hyperlactacidemia, and hypoxemia are the main factors contributing to worse neonatal outcomes.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Obstetrics & Gynecology
Henry Tal Lesser, Christopher D'Adamo, Geralyn O'Reilly, Pedro Arrabal, Robert M. Ehsanipoor
Summary: This study aimed to evaluate the outcomes of maternal and neonatal in low-risk singleton pregnancies diagnosed with fetal growth restriction (EFW < 10th%) during the mid-second trimester (between 17 and 22 weeks and 6 days' gestation). The results showed a high proportion of small for gestational age neonates and several adverse outcomes in these pregnancies.
JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE
(2022)
Article
Obstetrics & Gynecology
A. Zhang, T. T. Stolk, E. Lopriore, L. Sun, T. Duan, D. Oepkes
Summary: This study found that second-trimester abdominal circumference discordant monochorionic twins are at increased risk of adverse perinatal outcomes, including abnormal umbilical artery and ductus venosus flow, low birth weight, birth weight discordance, intrauterine fetal demise, and severe neonatal morbidity. Early and intensified fetal surveillance for these twins is necessary to improve perinatal outcomes.
JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE
(2022)
Article
Multidisciplinary Sciences
Mefkure Eraslan Sahin, Erdem Sahin, Mehmet Mete Kirlangic
Summary: The current study aimed to investigate the relationship between third-trimester persistent maternal hypotension and small for gestational age (SGA) neonates as well as other adverse perinatal outcomes. A large retrospective cohort study was conducted, enrolling 6560 pregnant women who were divided into two groups based on maternal blood pressure: a normotensive group (n: 6290) and a persistent maternal hypotension group (n: 270). The study found no significant association between persistent maternal hypotension and SGA neonates or other adverse perinatal outcomes.
Article
Multidisciplinary Sciences
Stefanie Elisabeth Damhuis, Hester Dorien Kamphof, Anita C. J. Ravelli, Sanne Jehanne Gordijn, Wessel J. Ganzevoort
Summary: This study aimed to evaluate the burden of hypoxia-related adverse perinatal outcomes among (near) term births, reflected in an association with birth weight centiles as a proxy for placental function. The study found that the incidence of hypoxia-related outcomes was highest in fetuses with lowest birth weight centiles but can be identified throughout the entire spectrum. Additional diagnostic modalities that indicate placental dysfunction at (near) term gestation are urgently needed.
Article
Obstetrics & Gynecology
Anna Bonnevier, Karel Marsal, Jana Brodszki, Ann Thuring, Karin Kallen
Summary: In this study, the cerebroplacental ratio (CPR) was found to have better predictive value for predicting small for gestational age (SGA) births compared to its components, the umbilical artery (UA) pulsatility index (PI) and middle cerebral artery (MCA) PI. CPR and MCA PI were equally good at predicting neonatal morbidity, especially in SGA pregnancies, and both were significantly better predictors than UA PI.
ACTA OBSTETRICIA ET GYNECOLOGICA SCANDINAVICA
(2021)
Article
Obstetrics & Gynecology
Adeniyi Kolade Aderoba, Christos Ioannou, Jennifer J. Kurinczuk, Maria A. Quigley, Angelo Cavallaro, Lawrence Impey
Summary: This study aims to investigate the impact of universal late third-trimester ultrasound scan on perinatal mortality, morbidity, and obstetric intervention. The results show that introducing universal ultrasound can reduce perinatal mortality and severe morbidity, although the changes are not statistically significant. Additionally, the detection of low birthweight improves when markers of growth restriction are used, but there is still room for improvement.
BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY
(2023)
Review
Obstetrics & Gynecology
Jose R. Duncan, Claudio Schenone, Sarah G. Obican
Summary: Abnormal UtAD in the third trimester is associated with various perinatal complications, but its prediction accuracy for adverse pregnancy outcomes is limited. Adding maternal characteristics and biochemical markers to prediction models can improve the performance.
CURRENT OPINION IN OBSTETRICS & GYNECOLOGY
(2022)
Article
Obstetrics & Gynecology
Maria Luiza Rozo Bahia, Guillermo Coca Velarde, Fernanda Campos da Silva, Edward Araujo Junior, Renato Augusto Moreira de Sa
Summary: Severe late-onset fetal growth restriction can be diagnosed by estimating fetal weight, abdominal circumference, and amniotic fluid index. A decrease in the middle cerebral artery pulsatility index increases the probability of ICU admission, with the most common complications being intraventricular hemorrhage and necrotizing enterocolitis.
JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE
(2022)
Article
Public, Environmental & Occupational Health
Baptiste Tarasi, Jacques Cornuz, Carole Clair, David Baud
Summary: The study of 20843 pregnant women showed that smoking during pregnancy is associated with various adverse perinatal outcomes, with a dose dependent effect.
Article
Acoustics
J. Rodriguez-Calvo, C. Villalain, P. I. Gomez-Arriaga, M. S. Quezada, I. Herraiz, A. Galindo
Summary: The study aimed to analyze the ability to predict perinatal survival and severe neonatal morbidity in cases of early-onset fetal growth restriction (eoFGR) using maternal variables, ultrasound parameters, and angiogenic markers at the time of diagnosis. The results showed that a model combining estimated fetal weight and maternal serum PlGF accurately predicts perinatal survival in eoFGR cases diagnosed before 28 weeks of gestation.
ULTRASOUND IN OBSTETRICS & GYNECOLOGY
(2023)
Article
Obstetrics & Gynecology
Jennifer E. Powel, Niraj R. Chavan, Emily W. Zantow, Matthew F. Bialko, Lauren G. Farley, Kellen M. Mccormick, Tracy M. Tomlinson
Summary: This study aimed to assess the association between estimated fetal weight and/or abdominal circumference and adverse perinatal outcomes in pregnancies complicated by fetal growth restriction. Data were collected from a cohort of singleton pregnancies and divided into three groups: fetuses that met the consensus criteria for fetal growth restriction, fetuses that failed to meet the consensus criteria but were small for gestational age, and fetuses with birth weights within the normal range. The study found that fetuses with estimated fetal weight and/or abdominal circumference below the 10th percentile, but not meeting the consensus criteria for fetal growth restriction, were not at increased risk of adverse outcomes. The study highlights the importance of using consensus criteria for defining fetal growth restriction to avoid unnecessary interventions and testing.
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2023)
Article
Obstetrics & Gynecology
E. Kalafat, B. Liu, I. Barratt, R. Bhate, A. Papageorghiou, A. Khalil
Summary: This study investigated the perinatal outcomes of dichorionic twin pregnancies complicated by selective fetal growth restriction (sFGR). The umbilical artery Z-scores were found to be associated with both intrauterine death and adverse perinatal outcomes.
BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY
(2023)
Article
Clinical Neurology
Maria Camila Cortes-Albornoz, Camilo Calixto, M. Alejandra Bedoya, Ryne A. Didier, Judy A. Estroff, Camilo Jaimes
Summary: This study characterized the normal fetal brain growth between the 12th and 20th weeks of gestational age. The results showed distinct trajectories for different compartments of the brain, with the fastest growth observed in the supratentorial brain and extra-axial cerebrospinal fluid.
AMERICAN JOURNAL OF NEURORADIOLOGY
(2023)