Article
Biochemistry & Molecular Biology
Ansul Lokdarshi, Albrecht G. von Arnim, Teressa K. Akuoko
Summary: The protein kinase GCN2 and its phosphorylation target eIF2 alpha play a key role in the plant's integrated stress response, regulating translation under stressful conditions. Recent studies show that GCN2 in Arabidopsis is controlled by reactive oxygen species from the chloroplast under various abiotic stresses like excess light.
PLANT SIGNALING & BEHAVIOR
(2022)
Article
Endocrinology & Metabolism
Julie Brossaud, Clementine Bosch-Bouju, Nathalie Marissal-Arvy, Marie-Neige Campas-Lebecque, Jean-Christophe Helbling, Scott P. Webster, Brian R. Walker, Xavier Fioramonti, Guillaume Ferreira, Pascal Barat, Jean-Benoit Corcuff, Marie-Pierre Moisan
Summary: Diabetes can affect the cognitive abilities of children although vascular disorders have not yet appeared. Dysregulation of the hypothalamus-pituitary-adrenal axis due to variations in glucose levels and relative insulin deficiency in treated type 1 diabetes can indirectly impact brain function. Inhibiting the activity of 11 beta-hydroxysteroid dehydrogenase 1 (11 beta-HSD1) can prevent memory deficits in diabetic juvenile rats.
Article
Biochemistry & Molecular Biology
Sisi Wu, Na Chen, Xia Tong, Xu Xu, Qihui Chen, Fan Wang
Summary: This study aimed to investigate the protective mechanism of selenium (Se) against cadmium (Cd)-induced placental glucocorticoid barrier damage and fetal growth restriction (FGR). The results showed that Se can enhance the function of the placental barrier by upregulating the transcription factor Sp1, thereby alleviating Cd-induced FGR.
JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Hanwen Li, Sihan Hu, Runze Wu, Hongyou Zhou, Kai Zhang, Ke Li, Wenzheng Lin, Qin Shi, Hao Chen, Shan Lv
Summary: This study demonstrated that 11 beta-HSD1 plays a significant role in facilitating osteoclasts formation and maturation through the Hippo signaling pathway. Knock-in mice with high expression of 11 beta-HSD1 showed a significant decrease in bone volume, while specific knock-out in osteoclasts provided protection to the skeleton. In vitro experiments confirmed that high expression of 11 beta-HSD1 promoted osteoclast formation and maturation.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2023)
Article
Cell Biology
Elise P. Gomez-Sanchez, Celso E. Gomez-Sanchez
Summary: This review provides a brief overview of the discovery and elucidation of three cloned 11 beta-hydroxysteroid dehydrogenase enzymes in humans, as well as their role in regulating metabolism and immune cell differentiation. Additionally, it discusses pathological examples associated with disruptions in the functions of these enzymes.
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2021)
Article
Multidisciplinary Sciences
Nantia Othonos, Riccardo Pofi, Anastasia Arvaniti, Sarah White, Ilaria Bonaventura, Nikolaos Nikolaou, Ahmad Moolla, Thomas Marjot, Roland H. Stimson, Andre P. van Beek, Martijn van Faassen, Andrea M. Isidori, Elizabeth Bateman, Ross Sadler, Fredrik Karpe, Paul M. Stewart, Craig Webster, Joanne Duffy, Richard Eastell, Fatma Gossiel, Thomas Cornfield, Leanne Hodson, K. Jane Escott, Andrew Whittaker, Ufuk Kirik, Ruth L. Coleman, Charles A. B. Scott, Joanne E. Milton, Olorunsola Agbaje, Rury R. Holman, Jeremy W. Tomlinson
Summary: The study suggests that inhibiting 11 beta-hydroxysteroid dehydrogenase type 1 (11 beta-HSD1) with AZD4017 could mitigate the adverse effects of glucocorticoids while preserving their anti-inflammatory actions. Co-treatment of AZD4017 with prednisolone shows potential in limiting the adverse effects of glucocorticoids.
NATURE COMMUNICATIONS
(2023)
Article
Chemistry, Multidisciplinary
Zhi-Neng You, Ke Zhou, Yu Han, Bing-Yi Yang, Qi Chen, Jiang Pan, Xiao-Long Qian, Chun-Xiu Li, Jian-He Xu
Summary: This study presents a highly atom-economic, self-sufficient hydride-shuttling cascade that concurrently obtains two pharmaceutically important building blocks, demonstrating the potential of cofactors in bio-oxidation.
Article
Endocrinology & Metabolism
Israel Hernandez-Bustamante, Yanina Santander-Plantamura, Dulce Mata-Espinosa, Andres Reyes-Chaparro, Estela I. Bini, Ivan Torre-Villalvazo, Armando R. Tovar, Jorge Barrios-Payan, Brenda Marquina-Castillo, Rogelio Hernandez-Pando, Andrea Carranza
Summary: Metabolic syndrome is the precursor of type 2 diabetes mellitus, and tuberculosis is a global threat and a major cause of morbi-mortality in developing countries. People with type 2 diabetes mellitus are more susceptible to Mycobacterium tuberculosis infection. Our study found that DHEA can directly inhibit the growth of Mycobacterium tuberculosis, and in silico docking analysis and molecular dynamic simulation studies supported this conclusion.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Chien-An Chen, Jer-Ming Chang, Hung-Chun Chen, Eddy-Essen Chang
Summary: Podocyte migration, a key factor in the development of proteinuria and glomerulonephropathy, is influenced by the interaction between Transforming growth factor-beta 1 (TGF beta 1), endoplasmic reticulum (ER) stress, and reactive oxygen species (ROS). This study reveals that TGF-beta 1-induced ER stress leads to the generation of intracellular ROS and subsequent expression of integrin-beta 3, ultimately promoting podocyte migration.
JOURNAL OF BIOCHEMISTRY
(2022)
Article
Developmental Biology
Johanna R. Jahnke, Enrique Teran, Francisca Murgueitio, Holger Cabrera, Amanda L. Thompson
Summary: Maternal distress may influence the functioning of HSD11B2 gene, which in turn affects infant HPA axis development. Maternal HPA axis dysregulation is linked to lower placental HSD11B2 expression, leading to exaggerated cortisol reactivity in infants.
Article
Multidisciplinary Sciences
Xiuting He, Jing Wu, Wenli Hou, Jie Li, Hongqin Xu
Summary: This study investigated the association between multiple single nucleotide polymorphisms (SNPs) in the HSD11B1 gene and the progression of liver cirrhosis (LC) and hepatocellular carcinoma (HCC). The rs932335 variant of HSD11B1 was found to be significantly associated with the progression of LC, but not with HCC.
Article
Pharmacology & Pharmacy
Shiro Heitaku, Tomohiko Sasase, Tomohiro Sotani, Mimi Maki, Sohei Katsumi, Sumiaki Fukuda, Hiroyuki Goto, Hiroshi Yamamoto, Jun Nishiu
Summary: The selective 11 beta-HSD1 inhibitor JTT-654 can alleviate insulin resistance and hyperglycemia in cortisone-treated rats and non-obese type 2 diabetic GK rats, enhancing insulin response in adipose tissue and liver. These findings suggest that JTT-654 improves insulin resistance and non-obese type 2 diabetes by inhibiting adipose tissue and liver 11 beta-HSD1.
BIOLOGICAL & PHARMACEUTICAL BULLETIN
(2023)
Article
Endocrinology & Metabolism
Jesse S. Krause, Jonathan H. Perez, Angus M. A. Reid, Jeffrey Cheah, Valerie Bishop, John C. Wingfield, Simone L. Meddle
Summary: The study found that in captive male white-crowned sparrows undergoing acute stress, restraint stress handling increased mRNA expression of CBG in the liver and hypothalamus, while decreasing GnIH expression. However, there were no changes in MR, GR, 11 beta HSD1, and 11 beta HSD2 mRNA expression in the brain, pituitary gland, and liver.
GENERAL AND COMPARATIVE ENDOCRINOLOGY
(2021)
Article
Medicine, General & Internal
Alice G. Vassiliou, Dimitra A. Vassiliadi, Chrysi Keskinidou, Edison Jahaj, Efi Botoula, Stylianos Tsagarakis, Anastasia Kotanidou, Ioanna Dimopoulou
Summary: This study aimed to evaluate the expression of MR and HSD11B isozymes in peripheral polymorphonuclear cells (PMNs) in critically ill patients. The results showed that MR expression was consistently lower in critically ill patients compared to healthy controls throughout the study period. In addition, HSD11B1 expression was also lower, while HSD11B2 expression was higher. These findings suggest diminished availability of local endogenous cortisol and glucocorticoid resistance in critically ill patients.
CLINICAL MEDICINE & RESEARCH
(2023)
Review
Physiology
David Pearce, Anna D. Manis, Viatcheslav Nesterov, Christoph Korbmacher
Summary: Regulated Na+ transport in the distal nephron is crucial for fluid and electrolyte homeostasis, controlling the levels and concentrations of various ions. Recent research has provided a clearer understanding of the transporters involved in moving Na+ in the distal nephron and their relationships with other ions, as well as the roles of signaling systems and components. Emerging evidence suggests that local K+ concentrations are involved in the reciprocal regulation of NCC and ENaC activity, adjusting renal K+ secretion in response to dietary intake.
PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY
(2022)