Article
Environmental Sciences
Lan Gao, Jing Chen, Jian Li, An-Qi Cui, Wei-Wei Zhang, Xiu-Liang Li, Jing Wang, Xiao-Yi Zhang, Ye Zhao, Yuan-Hua Chen, Cheng Zhang, Hua Wang, De-Xiang Xu
Summary: The study revealed that ROS-mediated GCN2/eIF2 alpha activation plays a role in the disruption of testicular T synthesis induced by MC-LR, providing a new clue for understanding the mechanism of endocrine disruption caused by MC-LR.
SCIENCE OF THE TOTAL ENVIRONMENT
(2021)
Article
Environmental Sciences
Xueyun Li, Lili Tian, Xinyi Oiao, Lei Ye, Hong Wang, Mengyun Wang, Jianmin Sang, Fuhong Tian, Ren-Shan Ge, Yiyan Wang
Summary: Citrinin, a mycotoxin found in fruits, is toxic to the kidneys, liver, and embryos. This study revealed that citrinin inhibits Leydig cell development in prepubertal male rats, resulting in decreased testosterone levels, increased serum LH and FSH levels, and apoptosis of Leydig cells.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2023)
Article
Environmental Sciences
Xiu-liang Li, Yu-lin Liu, Jia-yu Liu, Yan-yan Zhu, Xin-xin Zhu, Wei-wei Zhang, Jian Li, Ye Zhao, Ling-li Zhao, Cheng Zhang, Hua Wang, De-xiang Xu, Lan Gao
Summary: Our previous study revealed that exposure to 1-Nitropyrene (1-NP) disrupted testicular testosterone synthesis in mice, and in this present research, we found that the ER stress inhibitor 4-phenylbutyric acid (4-PBA) and the PERK kinase inhibitor GSK2606414 were able to recover the ER stress and testosterone synthases reduction caused by 1-NP in TM3 cells. Additionally, the use of the antioxidant N-Acetyl-L-cysteine (NAC) mitigated oxidative stress and attenuated ER stress, especially the PERK-eIF2a signaling activation and downregulation of testosterone synthases in 1-NP-treated TM3 cells. NAC also showed in vitro and in vivo potential for mitigating 1-NP-induced testosterone synthesis.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2023)
Article
Environmental Sciences
Dichao Hu, Lili Tian, Xueyun Li, Yirui Chen, Zheqing Xu, Ren-shan Ge, Yiyan Wang
Summary: This study found that Tetramethyl bisphenol A (TMBPA) inhibits the activity of Leydig cell steroidogenic enzymes and induces ferroptosis, thereby inhibiting testosterone synthesis in late puberty.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2022)
Article
Pharmacology & Pharmacy
Fuhong Tian, Qiyao Li, Lei Shi, Jingjing Li, Mengna Shi, Yang Zhu, Huitao Li, Ren-shan Ge
Summary: BPAF exposure in pregnant rats was found to have adverse effects on fetal Leydig cells and germ cells, leading to male reproductive tract malformation. These effects were mediated by interference with steroidogenic networks, suppression of the antioxidant defense system, reduction of SIRT1 and PGC1 alpha signals, and increased AMPK phosphorylation.
TOXICOLOGY AND APPLIED PHARMACOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Ruben Moreira, Ana D. Martins, Marco G. Alves, Maria de Lourdes Pereira, Pedro F. Oliveira
Summary: Low testosterone levels are a major cause of male infertility, and endocrine-disrupting chemicals such as chromium (Cr) can affect testicular steroidogenesis and male fertility. In particular, Cr(III) picolinate (CrPic(3)) has been found to inhibit enzymes involved in steroidogenesis and impact reactive oxygen species (ROS) levels, testosterone levels, and sperm motility and count. However, further research is needed to fully understand the effects of CrPic(3) on male fertility and ensure its safety for use by men.
Article
Environmental Sciences
Cuimei Li, Linlin Zhang, Tiantian Ma, Lei Gao, Luda Yang, Meina Wu, Zhaoxia Pang, Xiaoyu Wang, Qiyang Yao, Yaoyao Xiao, Lijia Zhao, Wei Liu, Hongcong Zhao, Caixia Wang, Aihua Wang, Yaping Jin, Huatao Chen
Summary: This study demonstrates that BPA disrupts testosterone production by inhibiting NR1D1 signaling in Leydig cells, leading to a decrease in testosterone levels in mice. Additionally, circadian clock genes are also involved in this process.
Review
Biochemistry & Molecular Biology
Ansul Lokdarshi, Albrecht G. von Arnim
Summary: The pan-eukaryotic protein kinase GCN2 regulates mRNA translation in response to external and metabolic conditions. In plants, GCN2 has assumed novel functions, including innate immunity and retrograde signaling. However, there are still unresolved questions regarding the divergence of the GCN2 system in green plants, such as whether GCN2 regulates amino acid biosynthesis and the role of phosphorylation of eIF2 alpha in translation control.
Article
Biochemistry & Molecular Biology
Shuai Lin, Meng-Ying Ye, Qian-Yun Fu, Chao-Lin Pan, Ya-Jie Liu, Li-Ming Zheng, Qiang Hong, Yuan-Hua Chen
Summary: Elevated serum cholic acid (CA) due to gestational cholestasis is associated with fetal growth restriction (FGR). CA induces FGR by causing placental glucocorticoid barrier dysfunction and activating the GCN2/eIF2 alpha pathway via excessive production of reactive oxygen species (ROS). NAC, an inhibitor, can rescue CA-induced FGR by inhibiting the activation of the GCN2/eIF2 alpha pathway and restoring the protein level of 11 beta-Hydroxysteroid dehydrogenase-2 (11 beta-HSD2) in placental trophoblasts.
Article
Andrology
Lili Tian, Xueyun Li, Yiyan Wang, Quanxu Chen, Xiaoheng Li, Ren-Shan Ge, Xingwang Li
Summary: Oncostatin M stimulates the proliferation of immature Leydig cells while inhibiting the function of immature and adult Leydig cells, affecting cell cycle and testosterone synthesis.
Review
Biochemistry & Molecular Biology
Elizabeth Monageng, Ugochukwu Offor, Ndivhuho Beauty Takalani, Kutullo Mohlala, Chinyerum Sylvia Opuwari
Summary: Leydig cells are vital for reproductive health and oxidative stress can cause dysfunction of these cells, leading to male infertility. Medicinal plants have shown potential in improving Leydig cell function and are being considered as alternative treatments for male infertility. This review provides an overview of the impact of oxidative stress on Leydig cells and the effects of various medicinal plant extracts on these cells, including Aspalathus linearis, Camellia sinensis, and Moringa oleifera.
Article
Reproductive Biology
Zhi-Xian Zhao, Ming-Yu Shang, Cheng Long, Xue-Jun Yao, Xiao-Bo Gao, Yong Guo, Xi-Hui Sheng, Xiang-Guo Wang, Kai Xing, Long-Fei Xiao, Xiao-Long Qi
Summary: This study investigated the effects of ALA on testosterone biosynthesis and found that ALA can promote testosterone synthesis by activating the JNK-SF-1 signaling pathway in primary rooster Leydig cells.
Article
Environmental Sciences
Jian Li, Xin Dong, Jia-Yu Liu, Lan Gao, Yi-Chao Huang, Yan Wang, Hua Wang, Wei Wei, De-Xiang Xu
Summary: This study found that exposure to 1-Nitropyrene (1-NP) may partially contribute to placental P4 synthesis inhibition and IUGR through inducing FUNDC1-mediated mitophagy.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Article
Cardiac & Cardiovascular Systems
Angela K. Lucas-Herald, Augusto C. Montezano, Rheure Alves-Lopes, Laura Haddow, Malika Alimussina, Stuart O'Toole, Martyn Flett, Boma Lee, S. Basith Amjad, Mairi Steven, Katriona Brooksbank, Linsay McCallum, Christian Delles, Sandosh Padmanabhan, S. Faisal Ahmed, Rhian M. Touyz
Summary: Hypospadias is associated with vascular dysfunction and may predispose males to cardiovascular diseases. Perturbed Rho kinase- and Nox5/ROS-dependent signaling are involved, highlighting the importance of hypospadias as a risk factor for cardiovascular diseases in males.
EUROPEAN HEART JOURNAL
(2022)
Review
Biochemistry & Molecular Biology
Stefania Fortunato, Cecilia Lasorella, Nunzio Dipierro, Federico Vita, Maria Concetta de Pinto
Summary: The increase in environmental temperature due to global warming has a critical impact on plant growth and productivity. Heat stress can cause damage to biochemical and physiological processes, but plants have defense mechanisms, such as the heat stress response (HSR), which involves a complex network of heat shock factors (HSFs) and heat shock proteins (HSPs). Reactive oxygen species (ROS) can act as signal molecules in HSR, depending on the balance between their production and scavenging. Antioxidants play a critical role in maintaining an optimal redox environment, but the HS-dependent ROS burst triggers redox-dependent signaling cascades in the cell.
Article
Engineering, Chemical
Wenxuan Cui, Robert C. Hale, Yichao Huang, Fengli Zhou, Yan Wu, Xiaolin Liang, Yang Liu, Hongli Tan, Da Chen
Summary: Microplastic pollution is a global concern. This study investigates the sorption of various organic contaminants on HDPE and PVC microplastics under saline conditions. The sorption coefficients varied for different chemicals and microplastics, and were largely influenced by hydrophobicity. Particle size did not significantly affect sorption isotherms but influenced equilibrium time and maximum sorption, likely due to surface area. Biofilms on HDPE microplastics enhanced contaminant sorption capacity. These findings provide new insights into chemical-microplastic interactions in marine environments.
JOURNAL OF MEMBRANE SCIENCE
(2023)
Article
Environmental Sciences
Xu Hong, Yi Zhou, Zhiyuan Zhu, Yuting Li, Zuo Li, Yuheng Zhang, Xinxin Hu, Fuhai Zhu, Yong Wang, Mingliang Fang, Yichao Huang, Tong Shen
Summary: This study demonstrates a significant association between BPA exposure and risk of obesity, as well as elevated levels of IL-17A in human adipose tissue. Animal experiments further confirm that BPA exposure exacerbates weight gain, insulin resistance, and inflammation in adipose tissue. Genetically modified mice with altered IL-17A gene show reversed inflammatory response and improved insulin sensitivity. Mediation analysis in humans suggests that IL-17A plays a mediating role in the association between BPA exposure and obesity risk.
ENVIRONMENT INTERNATIONAL
(2023)
Correction
Engineering, Environmental
Hongli Tan, Liu Yang, Yichao Huang, Lin Tao, Da Chen
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2023)
Article
Environmental Sciences
Kun Peng, Zhao Li, Tian-Rui Gao, Jia Lv, Wen-Jing Wang, Ping Zhan, Wen-Cong Yao, Hui Zhao, Hua Wang, De-Xiang Xu, Yichao Huang, Zhu-Xia Tan
Summary: This study analyzed the urinary metabolites of polycyclic aromatic hydrocarbons (PAH) and their association with chronic obstructive pulmonary disease (COPD). The results showed that the exposure to PAH was linked to increased COPD risk, particularly for certain metabolites such as 1-NAP and 2-NAP. This highlights the need for timely environmental regulation.
ENVIRONMENTAL RESEARCH
(2023)
Editorial Material
Food Science & Technology
Yichao Huang, Di Wu, Hua Wang, Quancai Sun, Yongning Wu
FOOD AND CHEMICAL TOXICOLOGY
(2023)
Article
Nanoscience & Nanotechnology
Mengjing Wang, Qianqian Li, Changzhi Shi, Jia Lv, Youdong Xu, Junjie Yang, Shae Linn Chua, Linran Jia, Huaiwen Chen, Qian Liu, Changjin Huang, Yichao Huang, Jianmin Chen, Mingliang Fang
Summary: The health risks of biodegradable plastics and their effects on the gastrointestinal tract are not well understood. In this study, we found that polylactic acid microplastics generated nanoparticles during gastrointestinal processes. These nanoparticles bioaccumulated in the liver, intestine, and brain of mice, causing intestinal damage and acute inflammation.
NATURE NANOTECHNOLOGY
(2023)
Article
Environmental Sciences
Man Deng, Tianrui Gao, Lin Tao, Weitian Tang, Xinying Wang, Ye Jiang, Mingliang Fang, Yichao Huang
Summary: Assessment of human exposure to mixtures of non-persistent chemicals requires accurate characterization and estimation of preceding exposure levels, and assessment sampling approaches remain disputable. This study used a targeted method to quantify urinary concentrations of 59 common non-persistent chemicals in consecutive spot samples from 11 participants. The results showed that certain chemicals had high reproducibility, while others had low reproducibility, suggesting that different sampling approaches may be needed for different chemicals.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Article
Environmental Sciences
Wen-Jing Wang, Kun Peng, Xue Lu, Yan-Yan Zhu, Zhao Li, Qing-Hua Qian, Ya-Xin Yao, Lin Fu, Yan Wang, Yi-Chao Huang, Hui Zhao, Hua Wang, De -Xiang Xu, Zhu-Xia Tan
Summary: Accumulating evidences show that long-term exposure to atmospheric fine particles and air pollutants increases the risk of COPD. Cadmium (Cd) is an important toxic substance in these pollutants. A mouse model was established to demonstrate that respiratory Cd exposure induces COPD-like lung injury.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Article
Pharmacology & Pharmacy
Xue He, Shi-Min Liang, Hong-Qian Wang, Li Tao, Yan Wang, Cheng Zhang, Yi-Chao Huang, De-Xiang Xu, Xi Chen
Summary: This study aimed to explore the effect of MitoQ on APAP-induced liver injury and its possible mechanisms. The results showed that MitoQ may alleviate APAP-evoked hepatotoxicity by eliminating protein nitration and suppressing hepatic lipid peroxidation (LPO). MitoQ prevents APAP-induced liver injury partially dependent on FSP1 and independent of GPX4.
TOXICOLOGY AND APPLIED PHARMACOLOGY
(2023)
Article
Environmental Sciences
Yuan Zeng, Hui-Min Ma, Qian-Yu Zhang, Lin Tao, Tao Wang, Cong Wan, She-Jun Chen, Bi-Xian Mai
Summary: This study investigated the spatial-temporal variations of polycyclic aromatic compounds (PACs) in fine particulate matter (PM2.5) and their toxicity. The results found that high molecular weight polycyclic aromatic hydrocarbons (MW302 PAHs) played a significant role in reactive oxygen species (ROS) generation, and industrial sources were identified as important contributors to PM2.5 toxicity in the studied city.
ENVIRONMENT INTERNATIONAL
(2023)
Article
Environmental Sciences
Wencong Yao, Jingjing Xu, Weitian Tang, Chang Gao, Lin Tao, Jie Yu, Jia Lv, Hua Wang, Yijun Fan, De-Xiang Xu, Yichao Huang
Summary: Exposure to PFHxS during pregnancy increases fetal death incidence and disrupts placental lipid metabolism, leading to placental dysplasia. These findings provide a basis for understanding the effects of PFHxS on lipid metabolism and underlying mechanisms.
ENVIRONMENT INTERNATIONAL
(2023)
Article
Environmental Sciences
Pan Yang, Lang-Jing Deng, Jin-Ying Xie, Xiao-Jie Li, Xiao-Na Wang, Bin Sun, Tian-Qing Meng, Cheng-Liang Xiong, Yi-Chao Huang, Yi-Xin Wang, An Pan, Da Chen, Yan Yang
Summary: This study examined the potential link between phthalate ester (PAE) exposure and sperm quality in healthy male adults from Hubei Province, China. The results showed that PAE exposure was associated with decreased sperm concentration and count, and this effect may be mediated by changes in sperm mitochondrial DNA copy number.
ENVIRONMENTAL POLLUTION
(2023)
Article
Environmental Sciences
Weigui Ni, Qingping Xue, Shanshan Zhang, Xue Yang, Shiyi Wu, Xingcheng He, Yan Xiao, Wenling Chang, Ying Wen, Yichao Huang, Yi-Xin Wang, Da Chen, Chun-Xia Yang, Xiong-Fei Pan
Summary: This study examined the association between PCBs and mortality risk, and whether diet quality could modify this association. The findings showed that dioxin-like PCBs and non-dioxin-like PCBs were significantly associated with all-cause mortality, and the association was modified by diet quality.
ENVIRONMENTAL RESEARCH
(2023)
Article
Food Science & Technology
Ge Wang, Yichao Huang, Yanpeng Gao, Ge Chen, Leqi Cui, Ye Peng, Quancai Sun
Summary: The aim of this research was to investigate the influence and potential mechanisms of Bisphenol BP (BPBP) on adipogenesis in 3T3-L1 cells. The results showed that low concentrations (0.01 μM) of BPBP promoted cell fat differentiation and triglyceride accumulation. RNA-seq data revealed differentially expressed genes related to adipocyte differentiation and adipogenesis after BPBP treatment, suggesting the activation of PPAR-γ signaling pathway as a key factor. This study provides evidence for the potential obesogenic effect of BPBP and calls for further research on its safety in food products.
CURRENT RESEARCH IN FOOD SCIENCE
(2023)
Article
Environmental Sciences
Fengjiang Sun, Yichao Huang, Hexia Chen, Jialing Huang, Long Zhang, Shuchao Wei, Fangyi Liu, Da Chen, Wei Huang
Summary: This study investigated the effects of BPA, BPF, and BPAF exposure on hepatotoxicity in mice fed with high-fat diets. The results showed that these alternatives caused liver damage and disrupted fatty acid and lipid metabolism. The study highlights the adverse effects of BPA alternatives, contributing to the consideration of their safe use.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)