Obeticholic Acid Protects against Gestational Cholestasis-Induced Fetal Intrauterine Growth Restriction in Mice

Magnesium sulphate can alleviate oxidative stress and reduce inflammatory cytokines in rat placenta of intrahepatic cholestasis of pregnancy model

(2018) Fei Han et al.   ARCHIVES OF GYNECOLOGY AND OBSTETRICS

Protective Effects of Hydrogen Sulfide Against Cigarette Smoke Exposure-Induced Placental Oxidative Damage by Alleviating Redox Imbalance via Nrf2 Pathway in Rats

(2018) Fusheng Zhao et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

The ileum-liver Farnesoid X Receptor signaling axis mediates the compensatory mechanism of 17α-ethynylestradiol-induced cholestasis via increasing hepatic biosynthesis of chenodeoxycholic acids in rats

(2018) Fan Zhang et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Farnesoid X receptor agonist obeticholic acid inhibits renal inflammation and oxidative stress during lipopolysaccharide-induced acute kidney injury

(2018) Jin-Bo Zhu et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Bile acid-induced apoptosis and bile acid synthesis are reduced by over-expression of Augmenter of Liver Regeneration (ALR) in a STAT3-dependent mechanism

(2018) Sara Ibrahim et al.   EXPERIMENTAL CELL RESEARCH

Biliary bile acids in hepatobiliary injury – What is the link?

(2017) Peter Fickert et al.   JOURNAL OF HEPATOLOGY

Perinatal outcomes associated with intrahepatic cholestasis of pregnancy

(2017) Christina Annette Herrera et al.   Journal of Maternal-Fetal & Neonatal Medicine

Bile acid levels and risk of adverse perinatal outcomes in intrahepatic cholestasis of pregnancy: A meta-analysis

(2017) Donghua Cui et al.   JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH

Resveratrol mitigates trophoblast and endothelial dysfunction partly via activation of nuclear factor erythroid 2-related factor-2

(2017) Seshini Gurusinghe et al.   PLACENTA

Maternal di-(2-ethylhexyl) phthalate exposure during pregnancy causes fetal growth restriction in a stage-specific but gender-independent manner

(2017) Ru Shen et al.   REPRODUCTIVE TOXICOLOGY

Possible Involvement of Nitric Oxide in Enhanced Liver Injury and Fibrogenesis during Cholestasis in Cytoglobin-deficient Mice

(2017) Tuong Thi Van Thuy et al.   Scientific Reports

Farnesoid X receptor activation protects the kidney from ischemia-reperfusion damage

(2017) Zhibo Gai et al.   Scientific Reports

INTERGROWTH-21st vs customized birthweight standards for identification of perinatal mortality and morbidity

(2016) Ngaire H. Anderson et al.   AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY

Endocrine and metabolic diurnal rhythms in young adult men born small vs appropriate for gestational age

(2016) Charlotte Brøns et al.   EUROPEAN JOURNAL OF ENDOCRINOLOGY

Protective role of biliverdin against bile acid-induced oxidative stress in liver cells

(2016) Ester Gonzalez-Sanchez et al.   FREE RADICAL BIOLOGY AND MEDICINE

Obeticholic Acid Protects against Lipopolysaccharide-Induced Fetal Death and Intrauterine Growth Restriction through Its Anti-Inflammatory Activity

(2016) Yuan-Hua Chen et al.   JOURNAL OF IMMUNOLOGY

The effects of Nrf2 deletion on placental morphology and exchange capacity in the mouse

(2016) Nisreen Kweider et al.   Journal of Maternal-Fetal & Neonatal Medicine

A Placebo-Controlled Trial of Obeticholic Acid in Primary Biliary Cholangitis

(2016) Frederik Nevens et al.   NEW ENGLAND JOURNAL OF MEDICINE

Liver Cholesterol Overload Aggravates Obstructive Cholestasis by Inducing Oxidative Stress and Premature Death in Mice

(2016) Natalia Nuño-Lámbarri et al.   Oxidative Medicine and Cellular Longevity

Severe intrahepatic cholestasis of pregnancy is a risk factor for preeclampsia in singleton and twin pregnancies

(2015) Yael Raz et al.   AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY

Intrahepatic cholestasis of pregnancy: observational study of the treatment with low-dose ursodeoxycholic acid

(2015) Titta Joutsiniemi et al.   BMC GASTROENTEROLOGY

Increased ubiquitination and reduced plasma membrane trafficking of placental amino acid transporter SNAT-2 in human IUGR

(2015) Y.-Y. Chen et al.   CLINICAL SCIENCE

Intrahepatic cholestasis of pregnancy and cancer, immune-mediated and cardiovascular diseases: A population-based cohort study

(2015) Elisabeth A. Wikström Shemer et al.   JOURNAL OF HEPATOLOGY

Farnesoid X nuclear receptor ligand obeticholic acid for non-cirrhotic, non-alcoholic steatohepatitis (FLINT): a multicentre, randomised, placebo-controlled trial

(2015) Brent A Neuschwander-Tetri et al.   LANCET

Agonist of farnesoid X receptor protects against bile acid induced damage and oxidative stress in mouse placenta – A study on maternal cholestasis model

(2015) W.-B. Wu et al.   PLACENTA

Pregnancy course in patients with intrahepatic cholestasis of pregnancy treated with very low doses of ursodeoxycholic acid

(2015) Monika Grymowicz et al.   SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY

Maternal bile acid transporter deficiency promotes neonatal demise

(2015) Yuanyuan Zhang et al.   Nature Communications

Vitamin D3 inhibits lipopolysaccharide-induced placental inflammation through reinforcing interaction between vitamin D receptor and nuclear factor kappa B p65 subunit

(2015) Yuan-Hua Chen et al.   Scientific Reports

The Metabolic Profile of Intrahepatic Cholestasis of Pregnancy Is Associated With Impaired Glucose Tolerance, Dyslipidemia, and Increased Fetal Growth

(2014) Marcus G. Martineau et al.   DIABETES CARE

Intrahepatic cholestasis of pregnancy is associated with an increased risk of gestational diabetes

(2014) Marcus Martineau et al.   European Journal of Obstetrics & Gynecology and Reproductive Biology

Inflammation in rat pregnancy inhibits spiral artery remodeling leading to fetal growth restriction and features of preeclampsia

(2014) Tiziana Cotechini et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The Nrf2 regulatory network provides an interface between redox and intermediary metabolism

(2014) John D. Hayes et al.   TRENDS IN BIOCHEMICAL SCIENCES

Down-regulation of placental mTOR, insulin/IGF-I signaling, and nutrient transporters in response to maternal nutrient restriction in the baboon

(2013) Jovita V. Kavitha et al.   FASEB JOURNAL

Regulation of Nrf2—an update

(2013) Suryakant K. Niture et al.   FREE RADICAL BIOLOGY AND MEDICINE

Maternal cholestasis during pregnancy programs metabolic disease in offspring

(2013) Georgia Papacleovoulou et al.   JOURNAL OF CLINICAL INVESTIGATION

NADPH Oxidases, Reactive Oxygen Species, and the Kidney: Friend and Foe

(2013) M. Sedeek et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Cardiovascular programming in children born small for gestational age and relationship with prenatal signs of severity

(2012) Fatima Crispi et al.   AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY

Stereological assessment of placental morphology in intrahepatic cholestasis of pregnancy

(2012) E. Wikström Shemer et al.   PLACENTA

Peroxiredoxin 1 and its role in cell signaling

(2011) Carola A. Neumann et al.   CELL CYCLE

Characterisation of the nuclear receptors FXR, PXR and CAR in normal and cholestatic placenta

(2011) V.L. Geenes et al.   PLACENTA

A placental phenotype for intrahepatic cholestasis of pregnancy

(2011) V.L. Geenes et al.   PLACENTA

Liver disease in pregnancy

(2010) Deepak Joshi et al.   LANCET

Intrahepatic cholestasis of pregnancy

(2009) Victoria Geenes et al.   WORLD JOURNAL OF GASTROENTEROLOGY

Molecular pathogenesis of intrahepatic cholestasis of pregnancy

(2008) Marco Arrese et al.   EXPERT REVIEWS IN MOLECULAR MEDICINE