Microcystin-LR inhibits testosterone synthesis via reactive oxygen species-mediated GCN2/eIF2α pathway in mouse testes

Light Activates the Translational Regulatory Kinase GCN2 via Reactive Oxygen Species Emanating from the Chloroplast

(2020) Ansul Lokdarshi et al.   PLANT CELL

The endoplasmic reticulum stress and related signal pathway mediated the glyphosate-induced testosterone synthesis inhibition in TM3 cells

(2020) Yongpeng Xia et al.   ENVIRONMENTAL POLLUTION

Reactive oxygen species-mediated cellular genotoxic stress is involved in 1-nitropyrene-induced trophoblast cycle arrest and fetal growth restriction

(2020) Bo Wang et al.   ENVIRONMENTAL POLLUTION

Distinct mitochondrial defects trigger the integrated stress response depending on the metabolic state of the cell

(2020) Eran Mick et al.   eLife

Long-term 1-nitropyrene exposure induces endoplasmic reticulum stress and inhibits steroidogenesis in mice testes

(2020) Jian Li et al.   CHEMOSPHERE

Assessment of diagnostic biomarkers of liver injury in the setting of microcystin-LR (MC-LR) hepatotoxicity

(2020) Robin C. Su et al.   CHEMOSPHERE

Oxidized-LDL inhibits testosterone biosynthesis by affecting mitochondrial function and the p38 MAPK/COX-2 signaling pathway in Leydig cells

(2020) Jun Jing et al.   Cell Death & Disease

Environmental exposure to cadmium impairs fetal growth and placental angiogenesis via GCN-2-mediated mitochondrial stress

(2020) Yong-Wei Xiong et al.   JOURNAL OF HAZARDOUS MATERIALS

Gossypol Induces Disruption of Spermatogenesis and Steroidogenesis in Male Mice

(2019) Whasun Lim et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Microcystin-LR disturbs testicular development of giant freshwater prawn Macrobrachium rosenbergii

(2019) Yingying Zhang et al.   CHEMOSPHERE

Aconitine inhibits androgen synthesis enzymes by rat immature Leydig cells via down-regulating androgen synthetic enzyme expression in vitro

(2019) Yiluan Wang et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Epigenetic modification of H3K4 and oxidative stress are involved in MC‐LR‐induced apoptosis in testicular cells of SD rats

(2019) Le Yuan et al.   ENVIRONMENTAL TOXICOLOGY

High ecological and human health risks from microcystins in vegetable fields in southern China

(2019) Lei Xiang et al.   ENVIRONMENT INTERNATIONAL

Seasonal variation and potential risk assessment of microcystins in the sediments of Lake Taihu, China

(2019) Qingju Xue et al.   ENVIRONMENTAL POLLUTION

Microcystin-leucine arginine mediates apoptosis and engulfment of Leydig cell by testicular macrophages resulting in reduced serum testosterone levels

(2018) Yabing Chen et al.   AQUATIC TOXICOLOGY

UPRmt regulation and output: a stress response mediated by mitochondrial-nuclear communication

(2018) Andrew Melber et al.   CELL RESEARCH

Chronic exposure of nanomolar MC-LR caused oxidative stress and inflammatory responses in HepG2 cells

(2018) Junguo Ma et al.   CHEMOSPHERE

Bioaccumulation of microcystin congeners in soil-plant system and human health risk assessment: A field study from Lake Taihu region of China

(2018) Qing Cao et al.   ENVIRONMENTAL POLLUTION

Microcystin-LR reduces the synthesis of gonadotropin-releasing hormone by activating multiple signaling pathways resulting in decrease of testosterone in mice

(2018) Jie Ding et al.   SCIENCE OF THE TOTAL ENVIRONMENT

Role of eIF2α Kinases in Translational Control and Adaptation to Cellular Stress

(2018) Ronald C. Wek   Cold Spring Harbor Perspectives in Biology

Inhibition of GCN2 sensitizes ASNS-low cancer cells to asparaginase by disrupting the amino acid response

(2018) Akito Nakamura et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Occurrence and toxicity of microcystin congeners other than MC-LR and MC-RR: A review

(2018) Leticia Díez-Quijada et al.   FOOD AND CHEMICAL TOXICOLOGY

Hepatotoxicity and immunotoxicity of MC-LR on silver carp

(2018) Xiaoyu Li et al.   ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY

Microcystin-leucine arginine exhibits immunomodulatory roles in testicular cells resulting in orchitis

(2017) Yabing Chen et al.   ENVIRONMENTAL POLLUTION

Serum microcystin levels positively linked with risk of hepatocellular carcinoma: A case-control study in southwest China

(2017) Chuanfen Zheng et al.   HEPATOLOGY

Activation of Gcn2 in response to different stresses

(2017) Silje Anda et al.   PLoS One

Life-cycle exposure to microcystin-LR interferes with the reproductive endocrine system of male zebrafish

(2016) Yujing Su et al.   AQUATIC TOXICOLOGY

Microcystin-LR bioaccumulation and depuration kinetics in lettuce and arugula: Human health risk assessment

(2016) Micheline Kézia Cordeiro-Araújo et al.   SCIENCE OF THE TOTAL ENVIRONMENT

Activation of GCN2 kinase by ribosome stalling links translation elongation with translation initiation

(2016) Ryuta Ishimura et al.   eLife

Comparison of response indices to toxic microcystin-LR in blood of mice

(2013) Xianing Huang et al.   CHEMOSPHERE

Microcystin-LR induces autophagy and apoptosis in rat Sertoli cells in vitro

(2013) Yu Chen et al.   TOXICON

The toxic effects of microcystin-LR on rat spermatogonia in vitro

(2012) Yuan Zhou et al.   TOXICOLOGY LETTERS

Protective Coupling of Mitochondrial Function and Protein Synthesis via the eIF2α Kinase GCN-2

(2012) Brooke M. Baker et al.   PLoS Genetics

The Molecular Biology, Biochemistry, and Physiology of Human Steroidogenesis and Its Disorders

(2011) Walter L. Miller et al.   ENDOCRINE REVIEWS

Benzo[ a ]pyrene Reduces Testosterone Production in Rat Leydig Cells via a Direct Disturbance of Testicular Steroidogenic Machinery

(2011) Jin-Yong Chung et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

Decline of sperm quality and testicular function in male mice during chronic low-dose exposure to microcystin-LR

(2011) Yu Chen et al.   REPRODUCTIVE TOXICOLOGY

Microcystin (-LR) affects hormones level of male mice by damaging hypothalamic-pituitary system

(2011) Xueting Wang et al.   TOXICON

Investigation of Microcystin Congener–Dependent Uptake into Primary Murine Neurons

(2010) Daniel Feurstein et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

Pubertal cadmium exposure impairs testicular development and spermatogenesis via disrupting testicular testosterone synthesis in adult mice

(2009) Yan-Li Ji et al.   REPRODUCTIVE TOXICOLOGY