4.8 Article

Pregnancy-Associated Liver Diseases

Journal

GASTROENTEROLOGY
Volume 163, Issue 1, Pages 97-+

Publisher

W B SAUNDERS CO-ELSEVIER INC
DOI: 10.1053/j.gastro.2022.01.060

Keywords

Hyperemesis Gravidarum; Intrahepatic Cholestasis of Pregnancy; Acute Fatty Liver of Pregnancy; Preeclampsia; HELLP Syndrome; Maternal Health; Gestational Liver Disease

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Liver disorders unique to pregnancy are important due to their significant impact on maternal and fetal/neonatal morbidity and mortality. Prompt diagnosis and multidisciplinary care are crucial to minimize risks for pregnant women and their babies.
The liver disorders unique to pregnancy include hyperemesis gravidarum, intrahepatic cholestasis of pregnancy, acute fatty liver of pregnancy, and preeclampsia-associated hepatic impairment, specifically hemolysis, elevated liver enzymes, and low platelet count syndrome (HELLP). Their importance lies in the significant maternal and fetal/ neonatal morbidity and mortality. Expeditious diagnosis and clinical evaluation is critical to ensure timely, appropriate care and minimize risks to the pregnant woman and her fetus/baby. A multidisciplinary approach is essential, including midwives, maternal-fetal-medicine specialists, anesthetists, neonatologists, and hepatologists.

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