Genomic instability caused by Arp2/3 complex inactivation results in micronucleus biogenesis and cellular senescence

Cytoplasmic chromatin fragments—from mechanisms to therapeutic potential

(2021) Karl N Miller et al.   eLife

Induced Arp2/3 Complex Depletion Increases FMNL2/3 Formin Expression and Filopodia Formation

(2021) Vanessa Dimchev et al.   Frontiers in Cell and Developmental Biology

The actin nucleation factors JMY and WHAMM enable a rapid Arp2/3 complex-mediated intrinsic pathway of apoptosis

(2021) Virginia L. King et al.   PLoS Genetics

STING Operation at the ER/Golgi Interface

(2021) Tomohiko Taguchi et al.   Frontiers in Immunology

Mechanisms of Cellular Senescence: Cell Cycle Arrest and Senescence Associated Secretory Phenotype

(2021) Ruchi Kumari et al.   Frontiers in Cell and Developmental Biology

The WAVE complex associates with sites of saddle membrane curvature

(2021) Anne Pipathsouk et al.   JOURNAL OF CELL BIOLOGY

A proteomic atlas of senescence-associated secretomes for aging biomarker development

(2020) Nathan Basisty et al.   PLOS BIOLOGY

The cGAS/STING/TBK1/IRF3 innate immunity pathway maintains chromosomal stability through regulation of p21 levels

(2020) Abdul Basit et al.   EXPERIMENTAL AND MOLECULAR MEDICINE

Molecular mechanisms and cellular functions of cGAS–STING signalling

(2020) Karl-Peter Hopfner et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Therapy-Induced Senescence: An “Old” Friend Becomes the Enemy

(2020) Tareq Saleh et al.   Cancers

Interferon-independent STING signaling promotes resistance to HSV-1 in vivo

(2020) Lívia H. Yamashiro et al.   Nature Communications

The Arp2/3 complex is critical for colonisation of the mouse skin by melanoblasts

(2020) Vassilis Papalazarou et al.   DEVELOPMENT

Cellular senescence in ageing: from mechanisms to therapeutic opportunities

(2020) Raffaella Di Micco et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The multiple mechanisms that regulate p53 activity and cell fate

(2019) Antonina Hafner et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Structural basis of STING binding with and phosphorylation by TBK1

(2019) Conggang Zhang et al.   NATURE

Actin filaments regulate microtubule growth at the centrosome

(2019) Daisuke Inoue et al.   EMBO JOURNAL

Cortical branched actin determines cell cycle progression

(2019) Nicolas Molinie et al.   CELL RESEARCH

Local actin nucleation tunes centrosomal microtubule nucleation during passage through mitosis

(2019) Francesca Farina et al.   EMBO JOURNAL

Spindle-F-actin interactions in mitotic spindles in an intact vertebrate epithelium

(2019) Angela M Kita et al.   MOLECULAR BIOLOGY OF THE CELL

A conserved PLPLRT/SD motif of STING mediates the recruitment and activation of TBK1

(2019) Baoyu Zhao et al.   NATURE

Cellular Senescence: Defining a Path Forward

(2019) Vassilis Gorgoulis et al.   CELL

Cell confinement reveals a branched-actin independent circuit for neutrophil polarity

(2019) Brian R. Graziano et al.   PLOS BIOLOGY

Tight nuclear tethering of cGAS is essential for preventing autoreactivity

(2019) Hannah E Volkman et al.   eLife

F-Actin nucleated on chromosomes coordinates their capture by microtubules in oocyte meiosis

(2018) Mariia Burdyniuk et al.   JOURNAL OF CELL BIOLOGY

The cGAS–cGAMP–STING pathway connects DNA damage to inflammation, senescence, and cancer

(2018) Tuo Li et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Hallmarks of Cellular Senescence

(2018) Alejandra Hernandez-Segura et al.   TRENDS IN CELL BIOLOGY

Spatial regulation of the actin cytoskeleton by HSF-1 during aging

(2018) Ryo Higuchi-Sanabria et al.   MOLECULAR BIOLOGY OF THE CELL

Nuclear F-actin and myosins drive relocalization of heterochromatic breaks

(2018) Christopher P. Caridi et al.   NATURE

Nuclear ARP2/3 drives DNA break clustering for homology-directed repair

(2018) Benjamin R. Schrank et al.   NATURE

cGAS surveillance of micronuclei links genome instability to innate immunity

(2017) Karen J. Mackenzie et al.   NATURE

Cytoplasmic chromatin triggers inflammation in senescence and cancer

(2017) Zhixun Dou et al.   NATURE

Innate immune sensing of cytosolic chromatin fragments through cGAS promotes senescence

(2017) Selene Glück et al.   NATURE CELL BIOLOGY

Actin protects mammalian eggs against chromosome segregation errors

(2017) Binyam Mogessie et al.   SCIENCE

Small molecule inhibition of cGAS reduces interferon expression in primary macrophages from autoimmune mice

(2017) Jessica Vincent et al.   Nature Communications

Dynamics of ARF regulation that control senescence and cancer

(2016) Aram Ko et al.   BMB Reports

p21(WAF1) Mediates Cell-Cycle Inhibition, Relevant to Cancer Suppression and Therapy

(2016) Wafik S. El-Deiry   CANCER RESEARCH

Function and regulation of the Arp2/3 complex during cell migration in diverse environments

(2016) Kristen F Swaney et al.   CURRENT OPINION IN CELL BIOLOGY

Naturally occurring p16Ink4a-positive cells shorten healthy lifespan

(2016) Darren J. Baker et al.   NATURE

Regulation and function of the cGAS–STING pathway of cytosolic DNA sensing

(2016) Qi Chen et al.   NATURE IMMUNOLOGY

Actin and Actin-Binding Proteins

(2016) Thomas D. Pollard   Cold Spring Harbor Perspectives in Biology

Activation of STING requires palmitoylation at the Golgi

(2016) Kojiro Mukai et al.   Nature Communications

Profilin-1 Serves as a Gatekeeper for Actin Assembly by Arp2/3-Dependent and -Independent Pathways

(2015) Jeremy D. Rotty et al.   DEVELOPMENTAL CELL

The Arp2/3 complex has essential roles in vesicle trafficking and transcytosis in the mammalian small intestine

(2015) Kang Zhou et al.   MOLECULAR BIOLOGY OF THE CELL

The centrosome is an actin-organizing centre

(2015) Francesca Farina et al.   NATURE CELL BIOLOGY

Isoform diversity in the Arp2/3 complex determines actin filament dynamics

(2015) Jasmine V. G. Abella et al.   NATURE CELL BIOLOGY

Phosphorylation of innate immune adaptor proteins MAVS, STING, and TRIF induces IRF3 activation

(2015) S. Liu et al.   SCIENCE

DNA damage induces nuclear actin filament assembly by Formin-2 and Spire-1/2 that promotes efficient DNA repair

(2015) Brittany J Belin et al.   eLife

Small Molecule Inhibitor of Formin Homology 2 Domains (SMIFH2) Reveals the Roles of the Formin Family of Proteins in Spindle Assembly and Asymmetric Division in Mouse Oocytes

(2015) Hak-Cheol Kim et al.   PLoS One

HSF-1-mediated cytoskeletal integrity determines thermotolerance and life span

(2014) N. A. Baird et al.   SCIENCE

Small Molecules CK-666 and CK-869 Inhibit Actin-Related Protein 2/3 Complex by Blocking an Activating Conformational Change

(2013) Byron Hetrick et al.   CHEMISTRY & BIOLOGY

Loss of Arp2/3 induces an NF-κB–dependent, nonautonomous effect on chemotactic signaling

(2013) Congying Wu et al.   JOURNAL OF CELL BIOLOGY

Lysosome-mediated processing of chromatin in senescence

(2013) Andre Ivanov et al.   JOURNAL OF CELL BIOLOGY

Disruption of Arp2/3 Results in Asymmetric Structural Plasticity of Dendritic Spines and Progressive Synaptic and Behavioral Abnormalities

(2013) I. H. Kim et al.   JOURNAL OF NEUROSCIENCE

Actin-related protein2/3 complex regulates tight junctions and terminal differentiation to promote epidermal barrier formation

(2013) K. Zhou et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Arp2/3 Is Critical for Lamellipodia and Response to Extracellular Matrix Cues but Is Dispensable for Chemotaxis

(2012) Congying Wu et al.   CELL

The Arp2/3 complex is required for lamellipodia extension and directional fibroblast cell migration

(2012) Praveen Suraneni et al.   JOURNAL OF CELL BIOLOGY

Lamin B1 loss is a senescence-associated biomarker

(2012) Adam Freund et al.   MOLECULAR BIOLOGY OF THE CELL

DNA breaks and chromosome pulverization from errors in mitosis

(2012) Karen Crasta et al.   NATURE

Fiji: an open-source platform for biological-image analysis

(2012) Johannes Schindelin et al.   NATURE METHODS

New insights into the regulation and cellular functions of the ARP2/3 complex

(2012) Jeremy D. Rotty et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

STING Specifies IRF3 Phosphorylation by TBK1 in the Cytosolic DNA Signaling Pathway

(2012) Y. Tanaka et al.   Science Signaling

Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders

(2011) Darren J. Baker et al.   NATURE

Activation of nuclear factor-kappa B signalling promotes cellular senescence

(2011) E Rovillain et al.   ONCOGENE

Generation of Micronuclei during Interphase by Coupling between Cytoplasmic Membrane Blebbing and Nuclear Budding

(2011) Koh-ichi Utani et al.   PLoS One

The Senescence-Associated Secretory Phenotype: The Dark Side of Tumor Suppression

(2010) Jean-Philippe Coppé et al.   Annual Review of Pathology-Mechanisms of Disease

Molecular mechanisms of micronucleus, nucleoplasmic bridge and nuclear bud formation in mammalian and human cells

(2010) M. Fenech et al.   MUTAGENESIS

A nucleator arms race: cellular control of actin assembly

(2010) Kenneth G. Campellone et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Characterization of two classes of small molecule inhibitors of Arp2/3 complex

(2009) B. J. Nolen et al.   NATURE

Oncogene-Induced Senescence Relayed by an Interleukin-Dependent Inflammatory Network

(2008) Thomas Kuilman et al.   CELL

WHAMM Is an Arp2/3 Complex Activator That Binds Microtubules and Functions in ER to Golgi Transport

(2008) Kenneth G. Campellone et al.   CELL

Spindle Positioning in Mouse Oocytes Relies on a Dynamic Meshwork of Actin Filaments

(2008) Jessica Azoury et al.   CURRENT BIOLOGY

The WAVE/SCAR complex promotes polarized cell movements and actin enrichment in epithelia during C. elegans embryogenesis

(2008) Falshruti B. Patel et al.   DEVELOPMENTAL BIOLOGY

Senescence-Associated Secretory Phenotypes Reveal Cell-Nonautonomous Functions of Oncogenic RAS and the p53 Tumor Suppressor

(2008) Jean-Philippe Coppé et al.   PLOS BIOLOGY