Trifluoromethylated 4,5-Dihydro-1,2,4-triazin-6(1H)-ones via (3+3)-Annulation of Nitrile Imines with α-Amino Esters

Quadruple Functionalized Pyrazole Pharmacophores via One‐pot Regioselective [3 + 2] Cycloaddition of Fluorinated Nitrile Imines and Dicyanoalkenes

(2022) Yin Zhou et al.   Chemistry-An Asian Journal

New Halogen-Containing Drugs Approved by FDA in 2021: An Overview on Their Syntheses and Pharmaceutical Use

(2022) Davide Benedetto Tiz et al.   MOLECULES

Trifluoromethylated Pyrazoles via Sequential (3 + 2)-Cycloaddition of Fluorinated Nitrile Imines with Chalcones and Solvent-Dependent Deacylative Oxidation Reactions

(2022) Anna Kowalczyk et al.   ORGANIC LETTERS

An overview of nitrile imine based [3+2] cycloadditions over half a decade

(2022) Ani Deepthi et al.   TETRAHEDRON

Synthesis and Selected Transformations of 2-Unsubstituted Imidazole N-Oxides Using a Ball-Milling Mechanochemical Approach

(2022) Grzegorz Mlostoń et al.   Catalysts

Fluorinated Materials as Positive Electrodes for Li- and Na-Ion Batteries

(2022) Kévin Lemoine et al.   CHEMICAL REVIEWS

Regioselective Synthesis of 3‐Trifluoromethyl 4‐Subtituted Pyrazoles by [3+2] Cycloaddition of Trifluoroacetonitrile Imines and Nitroalkenes

(2022) Ke‐Hu Wang et al.   Asian Journal of Organic Chemistry

Base-Promoted (3 + 2) Cycloaddition of Trifluoroacetohydrazonoyl Chlorides with Imidates En Route to Trifluoromethyl-1,2,4-Triazoles

(2022) Yue Zhang et al.   JOURNAL OF ORGANIC CHEMISTRY

Synthesis of Fluorinated and Fluoroalkylated Heterocycles Containing at Least One Sulfur Atom via Cycloaddition Reactions

(2022) Grzegorz Mlostoń et al.   Materials

Synthesis of Difluoromethyl Pyrazolines and Pyrazoles by [3+2] Cycloaddition Reaction of Difluoroacetohydrazonoyl Bromides with Electron‐deficient Olefins

(2022) Yuanyuan Ren et al.   Asian Journal of Organic Chemistry

4,5-Dihydro-1,2,4-triazin-6(1H)-ones (microreview)

(2022) Anna Kowalczyk et al.   Chemistry of Heterocyclic Compounds

Fluorinated and Non-Fluorinated 1,4-Diarylpyrazoles via MnO2-Mediated Mechanochemical Deacylative Oxidation of 5-Acylpyrazolines

(2022) Greta Utecht-Jarzyńska et al.   MOLECULES

Regioselective Decarboxylative Cycloaddition Route to Fully Substituted 3‐CF 3 ‐Pyrazoles from Nitrilimines and Isoxazolidinediones

(2021) Yu‐Chen Tian et al.   ADVANCED SYNTHESIS & CATALYSIS

A straightforward conversion of 1,4-quinones into polycyclic pyrazoles via [3 + 2]-cycloaddition with fluorinated nitrile imines

(2021) Greta Utecht-Jarzyńska et al.   Beilstein Journal of Organic Chemistry

Recent Advances in Fluorinated Graphene from Synthesis to Applications: Critical Review on Functional Chemistry and Structure Engineering

(2021) Xinyu Chen et al.   ADVANCED MATERIALS

Biological Utility of Fluorinated Compounds: from Materials Design to Molecular Imaging, Therapeutics and Environmental Remediation

(2021) Cheng Zhang et al.   CHEMICAL REVIEWS

Trifluorodiazoethane: A versatile building block to access trifluoromethylated heterocycles

(2021) Anuj Kumar et al.   JOURNAL OF HETEROCYCLIC CHEMISTRY

Synthesis of Difluoromethylated Pyrazoles by the [3 + 2] Cycloaddition Reaction of Difluoroacetohydrazonoyl Bromides

(2021) Tongyu Han et al.   JOURNAL OF ORGANIC CHEMISTRY

Direct Mechanocatalysis –  Using Milling Balls as Catalysts

(2020) Wilm Pickhardt et al.   CHEMISTRY-A EUROPEAN JOURNAL

2,2,2-Trifluorodiazoethane (CF3CHN2): A Long Journey since 1943

(2020) Pavel K. Mykhailiuk   CHEMICAL REVIEWS

Current Contributions of Organofluorine Compounds to the Agrochemical Industry

(2020) Yuta Ogawa et al.   iScience

A straightforward access to 3-trifluoromethyl-1H-indazoles via (3+2)-cycloaddition of arynes with nitrile imines derived from trifluoroacetonitrile

(2020) Anna Kowalczyk et al.   JOURNAL OF FLUORINE CHEMISTRY

Highly fluorinated 2,3-dihydro-1,3,4-thiadiazole derivatives via [3+2]-cycloadditions of tertiary thioamides with nitrile imines derived from trifluoroacetonitrile

(2020) Greta Utecht-Jarzyńska et al.   JOURNAL OF FLUORINE CHEMISTRY

Trifluoromethyl–containing 1,2,4-triazines. Synthesis on the base of perfluorobiacetyl and reactions with thiosemicarbazide and thiourea

(2019) L.V. Saloutina et al.   JOURNAL OF FLUORINE CHEMISTRY

Design, synthesis and screening of 1, 2, 4-triazinone derivatives as potential antitumor agents with apoptosis inducing activity on MCF-7 breast cancer cell line

(2018) Islam Zaki et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Polysubstituted 3-trifluoromethylpyrazoles: regioselective (3 + 2)-cycloaddition of trifluoroacetonitrile imines with enol ethers and functional group transformations

(2018) Greta Utecht et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

A Straightforward Access to Trifluoromethylated Spirobipyrazolines through a Double (3+2)-Cycloaddition of Fluorinated Nitrile Imines with Alkoxyallenes

(2018) Marcin Jasiński et al.   SYNLETT

Mechanochemistry as an emerging tool for molecular synthesis: what can it offer?

(2018) Joseph L. Howard et al.   Chemical Science

An overview on the recent developments of 1,2,4-triazine derivatives as anticancer compounds

(2017) Stella Cascioferro et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Expected and unexpected results in reactions of fluorinated nitrile imines with (cyclo)aliphatic thioketones

(2017) Greta Utecht et al.   JOURNAL OF FLUORINE CHEMISTRY

First (3+2)-Cycloadditions of Thiochalcones as C=S Dipolarophiles: Efficient Synthesis of 1,3,4-Thiadiazoles via Reactions with Fluorinated Nitrile Imines

(2017) Grzegorz Mlostoń et al.   SYNTHESIS-STUTTGART

Discovery of anti-cancer activity for benzo[1,2,4]triazin-7-ones: Very strong correlation to pleurotin and thioredoxin reductase inhibition

(2016) Martin Sweeney et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Trifluoromethyl nitrogen heterocycles: synthetic aspects and potential biological targets

(2016) F. Meyer   CHEMICAL COMMUNICATIONS

Trifluoromethylated 2,3-dihydro-1,3,4-thiadiazoles via the regioselective [3+2]-cycloadditions of fluorinated nitrile imines with aryl, hetaryl, and ferrocenyl thioketones

(2016) Grzegorz Mlostoń et al.   JOURNAL OF FLUORINE CHEMISTRY

Synthesis and Biological Activity of Fused Heteropolycyclic Systems Containing an Indole Moiety

(2015) Mahmoud A. Amin et al.   CURRENT ORGANIC SYNTHESIS

Tautomeric equilibrium in trifluoroacetaldehyde arylhydrazones

(2015) Agata Wojciechowska et al.   TETRAHEDRON

Trifluoromethylated Heterocycles

(2014) Andrei Gakh et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

1,2,4-Triazine Analogs as Novel Class of Therapeutic Agents

(2014) Rajeev Kumar et al.   MINI-REVIEWS IN MEDICINAL CHEMISTRY

Fluorine Substituted 1,2,4-Triazinones as Potential Anti-HIV-1 and CDK2 Inhibitors

(2014) Mohammed S. I. Makki et al.   Journal of Chemistry

Fluorine in Pharmaceutical Industry: Fluorine-Containing Drugs Introduced to the Market in the Last Decade (2001–2011)

(2013) Jiang Wang et al.   CHEMICAL REVIEWS

Synthesis of novel 1-[(1-ethoxymethylene)amino]imidazol-5(4H)-ones and 1,2,4-triazin-6(5H)-ones from optically active α-aminocarboxylic acid hydrazides

(2013) Agnieszka Kudelko et al.   TETRAHEDRON LETTERS

Synthesis of Spiroheterocycles Containing Thiadiazole Thiadiazine and Triazine Moieties from Nitrilimines

(2011) Hany M. M. Dalloul   PHOSPHORUS SULFUR AND SILICON AND THE RELATED ELEMENTS

Synthesis and characterization of novel 1,2,4-triazine derivatives with antiproliferative activity

(2010) Fabian Krauth et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Understanding organofluorine chemistry. An introduction to the C–F bond

(2007) David O'Hagan   CHEMICAL SOCIETY REVIEWS

Fluorine in medicinal chemistry

(2007) Sophie Purser et al.   CHEMICAL SOCIETY REVIEWS