Synthesis of Difluoromethylated Pyrazoles by the [3 + 2] Cycloaddition Reaction of Difluoroacetohydrazonoyl Bromides
Published 2021 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
Synthesis of Difluoromethylated Pyrazoles by the [3 + 2] Cycloaddition Reaction of Difluoroacetohydrazonoyl Bromides
Authors
Keywords
-
Journal
JOURNAL OF ORGANIC CHEMISTRY
Volume 87, Issue 1, Pages 498-511
Publisher
American Chemical Society (ACS)
Online
2021-12-16
DOI
10.1021/acs.joc.1c02521
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- Facile preparation and conversion of 4,4,4-trifluorobut-2-yn-1-ones to aromatic and heteroaromatic compounds
- (2021) Takashi Yamazaki et al. Beilstein Journal of Organic Chemistry
- Fluorinated Pyrazoles: From Synthesis to Applications
- (2021) Pavel K. Mykhailiuk CHEMICAL REVIEWS
- Regioselective Decarboxylative Cycloaddition Route to Fully Substituted 3‐CF 3 ‐Pyrazoles from Nitrilimines and Isoxazolidinediones
- (2021) Yu‐Chen Tian et al. ADVANCED SYNTHESIS & CATALYSIS
- Contribution of Organofluorine Compounds to Pharmaceuticals
- (2020) Munenori Inoue et al. ACS Omega
- Current Contributions of Organofluorine Compounds to the Agrochemical Industry
- (2020) Yuta Ogawa et al. iScience
- A straightforward access to 3-trifluoromethyl-1H-indazoles via (3+2)-cycloaddition of arynes with nitrile imines derived from trifluoroacetonitrile
- (2020) Anna Kowalczyk et al. JOURNAL OF FLUORINE CHEMISTRY
- Highly Chemo- and Enantioselective Rh-Catalyzed Hydrogenation of β-Sulfonyl-α,β-unsaturated Ketones: Access to Chiral γ-Ketosulfones
- (2020) Gang Liu et al. ORGANIC LETTERS
- Difluorodiazoethane (CF2HCHN2): a new reagent for the introduction of the difluoromethyl group
- (2019) Pavel Mykhailiuk et al. CHEMISTRY-A EUROPEAN JOURNAL
- [3 + 2] Cycloaddition of para-Quinone Methides with Nitrile Imines: Approach to Spiro-pyrazoline-cyclohexadienones
- (2019) Yingpeng Su et al. JOURNAL OF ORGANIC CHEMISTRY
- Trapping of trifluoroacetonitrile imines with mercaptoacetaldehyde and mercaptocarboxylic acids: An access to fluorinated 1,3,4-thiadiazine derivatives via (3+3)-annulation
- (2019) Greta Utecht-Jarzyńska et al. JOURNAL OF FLUORINE CHEMISTRY
- Synthesis, Crystal Structure, Antifungal Activity, and Docking Study of Difluoromethyl Pyrazole Derivatives
- (2019) Li Qiao et al. JOURNAL OF HETEROCYCLIC CHEMISTRY
- Toward Continuous‐Flow Synthesis of Biologically Interesting Pyrazole Derivatives
- (2019) Amrita Das et al. ADVANCED SYNTHESIS & CATALYSIS
- Ex Situ Generation of Difluorodiazoethane (CF2HCHN2): Application in the Regioselective Synthesis of CF2H-Containing Pyrazoles
- (2019) Jian-Shu Wang et al. ORGANIC LETTERS
- Fluorine and Fluorinated Motifs in the Design and Application of Bioisosteres for Drug Design
- (2018) Nicholas A. Meanwell JOURNAL OF MEDICINAL CHEMISTRY
- Polysubstituted 3-trifluoromethylpyrazoles: regioselective (3 + 2)-cycloaddition of trifluoroacetonitrile imines with enol ethers and functional group transformations
- (2018) Greta Utecht et al. ORGANIC & BIOMOLECULAR CHEMISTRY
- Direct Regioselective [3 + 2] Cycloaddition Reactions of Masked Difluorodiazoethane with Electron-Deficient Alkynes and Alkenes: Synthesis of Difluoromethyl-Substituted Pyrazoles
- (2018) Jun-Liang Zeng et al. ORGANIC LETTERS
- Potent Inhibitors of Hepatitis C Virus NS3 Protease: Employment of a Difluoromethyl Group as a Hydrogen-Bond Donor
- (2018) Barbara Zheng et al. ACS Medicinal Chemistry Letters
- 1,1-Diphosphines and divinylphosphines via base catalyzed hydrophosphination
- (2018) N. T. Coles et al. CHEMICAL COMMUNICATIONS
- Carbon-Selective Difluoromethylation of Soft Carbon Nucleophiles with Difluoromethylated Sulfonium Ylide
- (2018) Jiansheng Zhu et al. CHINESE JOURNAL OF CHEMISTRY
- Air- and Light-Stable S-(Difluoromethyl)sulfonium Salts: C-Selective Electrophilic Difluoromethylation of β-Ketoesters and Malonates
- (2018) Sheng-Le Lu et al. ORGANIC LETTERS
- gem-Digold Acetylide Complexes for Catalytic Intermolecular [4 + 2] Cycloaddition: Having Two Gold Centers Is Better for Asymmetric Catalysis
- (2018) Masaki Nanko et al. ORGANIC LETTERS
- Synthesis of N -Nitroso CHF2 -Pyrazolines and Their Transformation into CHF2 -Isoxazolines and -Pyrazoles
- (2017) Pavlo S. Lebed et al. EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
- Synthesis of Celecoxib, Mavacoxib, SC-560, Fluxapyroxad, and Bixafen Enabled by Continuous Flow Reaction Modules
- (2017) Joshua Britton et al. EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
- Expected and unexpected results in reactions of fluorinated nitrile imines with (cyclo)aliphatic thioketones
- (2017) Greta Utecht et al. JOURNAL OF FLUORINE CHEMISTRY
- Difluoromethyl Bioisostere: Examining the “Lipophilic Hydrogen Bond Donor” Concept
- (2017) Yossi Zafrani et al. JOURNAL OF MEDICINAL CHEMISTRY
- Next Generation of Fluorine-Containing Pharmaceuticals, Compounds Currently in Phase II–III Clinical Trials of Major Pharmaceutical Companies: New Structural Trends and Therapeutic Areas
- (2016) Yu Zhou et al. CHEMICAL REVIEWS
- The unique fluorine effects in organic reactions: recent facts and insights into fluoroalkylations
- (2016) Chuanfa Ni et al. CHEMICAL SOCIETY REVIEWS
- Fluoroalkyl-Substituted Diazomethanes and Their Application in a General Synthesis of Pyrazoles and Pyrazolines
- (2016) Lucas Mertens et al. CHEMISTRY-A EUROPEAN JOURNAL
- Synthesis of CF2H-Substituted Pyrazolines by [3+2] Cycloaddition between CF2HCHN2and Electron-Deficient Alkenes
- (2016) Jue Li et al. EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
- Trifluoromethylated 2,3-dihydro-1,3,4-thiadiazoles via the regioselective [3+2]-cycloadditions of fluorinated nitrile imines with aryl, hetaryl, and ferrocenyl thioketones
- (2016) Grzegorz Mlostoń et al. JOURNAL OF FLUORINE CHEMISTRY
- In Situ Generation of Difluoromethyl Diazomethane for [3+2] Cycloadditions with Alkynes
- (2015) Pavel K. Mykhailiuk ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
- Recent Advances of Catalytic Asymmetric 1,3-Dipolar Cycloadditions
- (2015) Takuya Hashimoto et al. CHEMICAL REVIEWS
- Monofluorination of Organic Compounds: 10 Years of Innovation
- (2015) Pier Alexandre Champagne et al. CHEMICAL REVIEWS
- Fluoroalkylative Aryl Migration of Conjugated N-Arylsulfonylated Amides Using Easily Accessible Sodium Di- and Monofluoroalkanesulfinates
- (2015) Zhengbiao He et al. ORGANIC LETTERS
- Rh-catalyzed decarbonylation of conjugated ynones via carbon–alkyne bond activation: reaction scope and mechanistic exploration via DFT calculations
- (2015) Alpay Dermenci et al. Chemical Science
- Good Partnership between Sulfur and Fluorine: Sulfur-Based Fluorination and Fluoroalkylation Reagents for Organic Synthesis
- (2014) Chuanfa Ni et al. CHEMICAL REVIEWS
- Trifluoromethyltrimethylsilane: Nucleophilic Trifluoromethylation and Beyond
- (2014) Xiao Liu et al. CHEMICAL REVIEWS
- Electrophilic Trifluoromethylation by Use of Hypervalent Iodine Reagents
- (2014) Julie Charpentier et al. CHEMICAL REVIEWS
- Multigram Synthesis of Fluoroalkyl-Substituted Pyrazole-4-carboxylic Acids
- (2014) Rustam T. Iminov et al. EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
- Rings in Drugs
- (2014) Richard D. Taylor et al. JOURNAL OF MEDICINAL CHEMISTRY
- Synthesis ofgem-Difluorocyclopropa(e)nes and O-, S-, N-, and P-Difluoromethylated Compounds with TMSCF2Br
- (2013) Lingchun Li et al. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
- Fluorine in Pharmaceutical Industry: Fluorine-Containing Drugs Introduced to the Market in the Last Decade (2001–2011)
- (2013) Jiang Wang et al. CHEMICAL REVIEWS
- Platinum-Catalyzed Hydrosilylations of Internal Alkynes: Harnessing Substituent Effects to Achieve High Regioselectivity
- (2012) Douglas A. Rooke et al. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
- Synthesis of diversely fluorinated pyrazoles as novel active agrochemical ingredients
- (2012) Florence Giornal et al. JOURNAL OF FLUORINE CHEMISTRY
- Nitrile Imines: Matrix Isolation, IR Spectra, Structures, and Rearrangement to Carbodiimides
- (2012) Didier Bégué et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Efficient Difluoromethylation of sp3Carbon Nucleophiles by Bromodifluoromethylation Reagents with Organic Bases
- (2012) Guokai Liu et al. ChemistryOpen
- Cation versus Radical: Studies on the C/O Regioselectivity in Electrophilic Tri-, Di- and Monofluoromethylations of β-Ketoesters
- (2012) Yu-Dong Yang et al. ChemistryOpen
- Asymmetric Construction of Stereogenic Carbon Centers Featuring a Trifluoromethyl Group from Prochiral Trifluoromethylated Substrates
- (2010) Jing Nie et al. CHEMICAL REVIEWS
- Fluorine in health care: Organofluorine containing blockbuster drugs
- (2010) David O’Hagan JOURNAL OF FLUORINE CHEMISTRY
- Difluoromethyl 2-Pyridyl Sulfone: A Newgem-Difluoroolefination Reagent for Aldehydes and Ketones
- (2010) Yanchuan Zhao et al. ORGANIC LETTERS
- N-Tosyl-S-difluoromethyl-S-phenylsulfoximine: A New Difluoromethylation Reagent for S-, N-, and C-Nucleophiles
- (2009) Wei Zhang et al. ORGANIC LETTERS
- Understanding organofluorine chemistry. An introduction to the C–F bond
- (2007) David O'Hagan CHEMICAL SOCIETY REVIEWS
Add your recorded webinar
Do you already have a recorded webinar? Grow your audience and get more views by easily listing your recording on Peeref.
Upload NowCreate your own webinar
Interested in hosting your own webinar? Check the schedule and propose your idea to the Peeref Content Team.
Create Now