Trifluoromethylated Pyrazoles via Sequential (3 + 2)-Cycloaddition of Fluorinated Nitrile Imines with Chalcones and Solvent-Dependent Deacylative Oxidation Reactions

Fluorinated Pyrazoles: From Synthesis to Applications

(2021) Pavel K. Mykhailiuk   CHEMICAL REVIEWS

α,β-Disubstituted CF3-Enones as a Trifluoromethyl Building Block: Regioselective Preparation of Totally Substituted 3-CF3-Pyrazoles

(2021) Vasiliy M. Muzalevskiy et al.   JOURNAL OF ORGANIC CHEMISTRY

Regioselective Decarboxylative Cycloaddition Route to Fully Substituted 3‐CF 3 ‐Pyrazoles from Nitrilimines and Isoxazolidinediones

(2021) Yu‐Chen Tian et al.   ADVANCED SYNTHESIS & CATALYSIS

Copper-Catalyzed Reductive Ring-Cleavage of Isoxazoles: Synthesis of Fluoroalkylated Enaminones and Application for the Preparation of Celecoxib, Deracoxib, and Mavacoxib

(2021) Chao Wan et al.   JOURNAL OF ORGANIC CHEMISTRY

Synthesis of Difluoromethylated Pyrazoles by the [3 + 2] Cycloaddition Reaction of Difluoroacetohydrazonoyl Bromides

(2021) Tongyu Han et al.   JOURNAL OF ORGANIC CHEMISTRY

Iridium-Catalyzed Silylation of Five-Membered Heteroarenes: High Sterically Derived Selectivity from a Pyridyl-Imidazoline Ligand

(2020) Caleb Karmel et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Deoxofluorination of (Hetero)aromatic Acids

(2020) Serhii Trofymchuk et al.   JOURNAL OF ORGANIC CHEMISTRY

Regioselective Synthesis of 3-Trifluoromethylpyrazole by Coupling of Aldehydes, Sulfonyl Hydrazides, and 2-Bromo-3,3,3-trifluoropropene

(2020) Chuanle Zhu et al.   ORGANIC LETTERS

Cycloaddition of Trifluoroacetaldehyde N-Triftosylhydrazone (TFHZ-Tfs) with Alkynes for Synthesizing 3-Trifluoromethylpyrazoles

(2020) Hongwei Wang et al.   ORGANIC LETTERS

The Huisgen Reaction: Milestones of the 1,3‐Dipolar Cycloaddition

(2020) Martin Breugst et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

2,2,2-Trifluorodiazoethane (CF3CHN2): A Long Journey since 1943

(2020) Pavel K. Mykhailiuk   CHEMICAL REVIEWS

Et 3 N ‐catalyzed cycloaddition reactions of α‐(trifluoromethyl)styrenes with 2,2,2‐trifluorodiazoethane to access bis(trifluoromethyl)‐substituted pyrazolines

(2020) Chunmei Li et al.   CHINESE JOURNAL OF CHEMISTRY

Highly fluorinated 2,3-dihydro-1,3,4-thiadiazole derivatives via [3+2]-cycloadditions of tertiary thioamides with nitrile imines derived from trifluoroacetonitrile

(2020) Greta Utecht-Jarzyńska et al.   JOURNAL OF FLUORINE CHEMISTRY

Use of trifluoroacetaldehyde N-tfsylhydrazone as a trifluorodiazoethane surrogate and its synthetic applications

(2019) Xinyu Zhang et al.   Nature Communications

Development of Cyanopyrazoles as Building Blocks to Fungicide Fluxapyroxad and Analogues

(2019) Yue Zhang et al.   JOURNAL OF ORGANIC CHEMISTRY

Tris(pyrazolyl)borate Cobalt-Catalyzed Hydrogenation of C═O, C═C, and C═N Bonds: An Assistant Role of a Lewis Base

(2019) Yang Lin et al.   ORGANIC LETTERS

Trapping of trifluoroacetonitrile imines with mercaptoacetaldehyde and mercaptocarboxylic acids: An access to fluorinated 1,3,4-thiadiazine derivatives via (3+3)-annulation

(2019) Greta Utecht-Jarzyńska et al.   JOURNAL OF FLUORINE CHEMISTRY

Deacylative Reactions: Synthetic Applications

(2018) Aitor Ortega-Martínez et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Pyrazole synthesis via a cascade Sonogashira coupling/cyclization of N-propargyl sulfonylhydrazones

(2018) Ying Yang et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Polysubstituted 3-trifluoromethylpyrazoles: regioselective (3 + 2)-cycloaddition of trifluoroacetonitrile imines with enol ethers and functional group transformations

(2018) Greta Utecht et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

A radical approach to the copper oxidative addition problem: Trifluoromethylation of bromoarenes

(2018) Chip Le et al.   SCIENCE

Electrophilic Halogenation of Hydrazones of CF3-ynones. Regioselective Synthesis of 4-halo-substituted 3-CF3-pyrazoles

(2018) Vasily Muzalevskiy et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

First (3+2)-Cycloadditions of Thiochalcones as C=S Dipolarophiles: Efficient Synthesis of 1,3,4-Thiadiazoles via Reactions with Fluorinated Nitrile Imines

(2017) Grzegorz Mlostoń et al.   SYNTHESIS-STUTTGART

Direct [3+2]-cycloaddition of electron-deficient alkynes with CF 3 CHN 2 : Regioselective one-pot synthesis of 3-trifluoromethylpyrazoles

(2017) Feng Li et al.   TETRAHEDRON LETTERS

Trifluoromethylated 2,3-dihydro-1,3,4-thiadiazoles via the regioselective [3+2]-cycloadditions of fluorinated nitrile imines with aryl, hetaryl, and ferrocenyl thioketones

(2016) Grzegorz Mlostoń et al.   JOURNAL OF FLUORINE CHEMISTRY

Fluorinated diazoalkanes – a versatile class of reagents for the synthesis of fluorinated compounds

(2016) Lucas Mertens et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Trifluoromethylpyrazoles as anti-inflammatory and antibacterial agents: A review

(2015) Kamalneet Kaur et al.   JOURNAL OF FLUORINE CHEMISTRY

Three-component synthesis of fluorinated pyrazoles from fluoroalkylamines, NaNO2 and electron-deficient alkynes

(2015) Pavel K. Mykhailiuk   ORGANIC & BIOMOLECULAR CHEMISTRY

Synthesis of 3-trifluoromethylpyrazoles via trifluoromethylation/cyclization of α,β-alkynic hydrazones using a hypervalent iodine reagent

(2014) Guojing Ji et al.   CHEMICAL COMMUNICATIONS

Trifluoromethylated Heterocycles

(2014) Andrei Gakh et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Synthesis of Polysubstituted Pyrazoles by a Platinum-Catalyzed Sigmatropic Rearrangement/Cyclization Cascade

(2014) Jia-Jie Wen et al.   ORGANIC LETTERS

Silver-Mediated Cycloaddition of Alkynes with CF3CHN2: Highly Regioselective Synthesis of 3-Trifluoromethylpyrazoles

(2013) Feng Li et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Stereospecific Asymmetric N-Heterocyclic Carbene (NHC)-Catalyzed Redox Synthesis of Trifluoromethyl Dihydropyranones and Mechanistic Insights

(2013) Alyn T. Davies et al.   JOURNAL OF ORGANIC CHEMISTRY

Synthesis of diversely fluorinated pyrazoles as novel active agrochemical ingredients

(2012) Florence Giornal et al.   JOURNAL OF FLUORINE CHEMISTRY

Reaction of a Trifluoromethylated N-Monosubstituted Hydrazone with α,β-Ethenyl Ketones: A Novel Synthesis of Substituted Pyrazolidines and Pyrazolines

(2011) Yongming Wu et al.   SYNTHESIS-STUTTGART