Trifluoromethyl nitrogen heterocycles: synthetic aspects and potential biological targets

Pyrrolidinyl PNA with α/β-Dipeptide Backbone: From Development to Applications

(2015) Tirayut Vilaivan   ACCOUNTS OF CHEMICAL RESEARCH

Highly potent and selective pyrazolylpyrimidines as Syk kinase inhibitors

(2015) Jang-Sik Choi et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Selective CB2 receptor agonists. Part 1: The identification of novel ligands through computer-aided drug design (CADD) approaches

(2015) Eugene R. Hickey et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Monofluorination of Organic Compounds: 10 Years of Innovation

(2015) Pier Alexandre Champagne et al.   CHEMICAL REVIEWS

Fluorinated Oligomers and Polymers in Photopolymerization

(2015) Alessandra Vitale et al.   CHEMICAL REVIEWS

Entropic Contribution of Elongation Factor P to Proline Positioning at the Catalytic Center of the Ribosome

(2015) Lili K. Doerfel et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Palladium-Catalyzed Arylation of Fluoroalkylamines

(2015) Andrew T. Brusoe et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Straightforward Synthesis of Novel Enantiopure α-Trifluoromethylated Azetidine 2-Carboxylic Acid and Homoserines

(2015) Nathalie Lensen et al.   ORGANIC LETTERS

Halogen bonding in polymer science: from crystal engineering to functional supramolecular polymers and materials

(2015) Gilles Berger et al.   Polymer Chemistry

Fluorinated conjugated polymers in organic bulk heterojunction photovoltaic solar cells

(2015) Franck Meyer   PROGRESS IN POLYMER SCIENCE

Aziridine Formation with Retention of Configuration from a Pentacoordinated 1,2-Thiazetidine Bearing Two Chiral Centers at the 3- and 4-Positions

(2014) Yuya Daicho et al.   BULLETIN OF THE CHEMICAL SOCIETY OF JAPAN

Advances in Catalytic Enantioselective Fluorination, Mono-, Di-, and Trifluoromethylation, and Trifluoromethylthiolation Reactions

(2014) Xiaoyu Yang et al.   CHEMICAL REVIEWS

Enzymatic Fluorination and Biotechnological Developments of the Fluorinase

(2014) David O’Hagan et al.   CHEMICAL REVIEWS

Recent Advances in the Stereoselective Synthesis of Aziridines

(2014) Leonardo Degennaro et al.   CHEMICAL REVIEWS

Trifluoromethyltrimethylsilane: Nucleophilic Trifluoromethylation and Beyond

(2014) Xiao Liu et al.   CHEMICAL REVIEWS

Electrophilic Trifluoromethylation by Use of Hypervalent Iodine Reagents

(2014) Julie Charpentier et al.   CHEMICAL REVIEWS

19F Magnetic Resonance Imaging (MRI): From Design of Materials to Clinical Applications

(2014) Ilaria Tirotta et al.   CHEMICAL REVIEWS

Selective Synthesis of Functionalized Trifluoromethylated Pyrrolidines, Piperidines, and Azepanes Starting from 1-Tosyl-2-(trifluoromethyl)aziridine

(2014) Jeroen Dolfen et al.   CHEMISTRY-A EUROPEAN JOURNAL

An aza-Michael addition protocol to fluoroalkylated β-amino acid derivatives and enantiopure trifluoromethylated N-heterocycles

(2014) Xing Yang et al.   GREEN CHEMISTRY

Synthesis, Structure, and Thermolysis of Tetracoordinated 1λ4,2-Selenazetidines Bearing Two Chiral Centers at the 3- and 4-Positions

(2014) Yuya Daicho et al.   HETEROATOM CHEMISTRY

Selective Synthesis of cis- and trans-2-(Methyl/phenyl)-3-(trifluoromethyl)aziridines and Their Regio- and Stereospecific Ring Opening

(2014) Matthias Moens et al.   JOURNAL OF ORGANIC CHEMISTRY

Access to novel functionalized trifluoromethyl β-lactams by ring expansion of aziridines

(2014) S. Decamps et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Trisubstituted 2-Trifluoromethyl Pyrrolidines via Catalytic Asymmetric Michael Addition/Reductive Cyclization

(2014) Michael T. Corbett et al.   ORGANIC LETTERS

Intramolecular cyclization of acetylene-containing α-amino carboxylates and α-amino phosphonates: synthesis of α-CF3-substituted dehydroprolines and their P-analogs

(2014) M. A. Zotova et al.   RUSSIAN CHEMICAL BULLETIN

Synthesis of α-CF3 azanorbornene and azetidines by aza Diels–Alder or iodine-mediated cyclizations: application in ROMP and ligand design

(2014) Gilles Berger et al.   TETRAHEDRON LETTERS

Fluorine in Pharmaceutical Industry: Fluorine-Containing Drugs Introduced to the Market in the Last Decade (2001–2011)

(2013) Jiang Wang et al.   CHEMICAL REVIEWS

Nucleophile-Directed Selective Transformation ofcis-1-Tosyl-2-tosyloxymethyl-3-(trifluoromethyl)aziridine into Aziridines, Azetidines, and Benzo-Fused Dithianes, Oxathianes, Dioxanes, and (Thio)morpholines

(2013) Sara Kenis et al.   CHEMISTRY-A EUROPEAN JOURNAL

Construction of Optically Active Quaternary Propargyl Amines by Highly Enantioselective Zinc/BINOL-Catalyzed Alkynylation of Ketoimines

(2013) Gaochao Huang et al.   CHEMISTRY-A EUROPEAN JOURNAL

Highly β-Regioselective Friedel-Crafts Aminoalkylation of Pyrroles with Cyclic Perfluoroalkylated Imines

(2013) Olga I. Shmatova et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Stereoselective Synthesis of Trifluoromethyl Analogues of Polyhydroxypyrrolidines

(2013) Rama K. Khangarot et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Tetrazole-Substituted Five, Six, and Seven-Membered Cyclic Amines Bearing Perfluoroalkyl Groups - Efficient Synthesis by Azido-Ugi Reaction

(2013) Olga I. Shmatova et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Aminoalkylation of Indoles with α-Polyfluoroalkylated Cyclic Imines

(2013) Nikolay E. Shevchenko et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Cycloaddition of N-substituted imines of trifluoropyruvate with diazomethane: Efficient synthesis of 2-(trifluoromethyl)aziridine-2-carboxylates

(2013) Yuliya V. Rassukana et al.   JOURNAL OF FLUORINE CHEMISTRY

Synthesis and Biological Evaluation of 8-Aminomethyltetracycline Derivatives as Novel Antibacterial Agents

(2013) Roger B. Clark et al.   JOURNAL OF MEDICINAL CHEMISTRY

Synthesis of Fluorinated β-Aminophosphonates and γ-Lactams

(2013) Concepción Alonso et al.   JOURNAL OF ORGANIC CHEMISTRY

Friedel–Crafts alkylation of natural amino acid-derived pyrroles with CF3-substituted cyclic imines

(2013) Olga I. Shmatova et al.   MENDELEEV COMMUNICATIONS

Synthesis of 2- and 3-trifluoromethylmorpholines: useful building blocks for drug discovery

(2013) Andriy V. Shcherbatiuk et al.   TETRAHEDRON

4-CF3-ezetimibe analogs: design, synthesis, and biological evaluation of cholesterol absorption inhibitions

(2013) Yingle Liu et al.   TETRAHEDRON LETTERS

Asymmetric synthesis of trifluoromethylated aziridines from CF3-substituted N-tert-butanesulfinyl ketimines

(2013) Yanmei Yang et al.   TETRAHEDRON LETTERS

Identification of a potent and metabolically stable series of fluorinated diphenylpyridylethanamine-based cholesteryl ester transfer protein inhibitors

(2012) Michael M. Miller et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Chiral Brønsted acid-catalyzed diastereo- and enantioselective synthesis of CF3-substituted aziridines

(2012) Zhuo Chai et al.   CHEMICAL COMMUNICATIONS

Synthesis of 1-Alkyl-2-(trifluoromethyl)azetidines and Their Regiospecific Ring Opening toward Diverse α-(Trifluoromethyl)Amines via Intermediate Azetidinium Salts

(2012) Sara Kenis et al.   JOURNAL OF ORGANIC CHEMISTRY

Synthesis and Use of a Trifluoromethylated Azomethine Ylide Precursor

(2012) Gaël Tran et al.   JOURNAL OF ORGANIC CHEMISTRY

Preparation of Trifluoromethyl-Substituted Aziridines with in Situ Generated CF3CHN2

(2012) Stefan A. Künzi et al.   ORGANIC LETTERS

Diastereoselective Synthesis of CF3-Substituted, Epoxide-Fused Heterocycles with β-(Trifluoromethyl)vinylsulfonium Salts

(2012) Sven P. Fritz et al.   ORGANIC LETTERS

Nucleophilic difluoromethylation of CN bonds in heterocycles with difluoromethyl silane reagents

(2012) Weizhou Huang et al.   TETRAHEDRON

Synthesis of fluorinated N-aminoaziridines: access to new CF3-peptidomimetics

(2012) Bertrand Schweitzer-Chaput et al.   TETRAHEDRON

Asymmetric synthesis of β-aryl-β-trifluoromethyl-β-aminoarones via Mannich-type reactions of ketone enolates with chiral aryl CF3-substituted N-tert-butanesulfinyl ketimines

(2012) Yingle Liu et al.   TETRAHEDRON

Organic fluorine compounds: a great opportunity for enhanced materials properties

(2011) Ricarda Berger et al.   CHEMICAL SOCIETY REVIEWS

Fluorinated amino acids: compatibility with native protein structures and effects on protein–protein interactions

(2011) Mario Salwiczek et al.   CHEMICAL SOCIETY REVIEWS

Regioselectivity in the ring opening of non-activated aziridines

(2011) Sonja Stanković et al.   CHEMICAL SOCIETY REVIEWS

The fluorous effect in biomolecular applications

(2011) Massimo Cametti et al.   CHEMICAL SOCIETY REVIEWS

Synthesis of 9-substituted 2,3,4,9-tetrahydro-1H-carbazole derivatives and evaluation of their anti-prion activity in TSE-infected cells

(2011) Tsutomu Kimura et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

(5S)-5-(Trifluoromethyl)pyrrolidin-2-one as a Promising Building Block for Fluoroorganic Chemistry

(2011) Andrii V. Bezdudny et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Preparation and Synthetic Applications of Azetidines

(2011) F. G. West et al.   HETEROCYCLES

Synthesis of CF3-containing α-alkynyl-α-aminophosphonates by Sonogashira cross-coupling reaction

(2011) Maria A. Zotova et al.   JOURNAL OF FLUORINE CHEMISTRY

Synopsis of Some Recent Tactical Application of Bioisosteres in Drug Design

(2011) Nicholas A. Meanwell   JOURNAL OF MEDICINAL CHEMISTRY

Preparation of Optically Pure α-Trifluoromethyl-α-amino Acids fromN-Tosyl-2-trifluoromethyl-2-alkyloxycarbonyl Aziridine

(2011) Toshimasa Katagiri et al.   JOURNAL OF ORGANIC CHEMISTRY

Straightforward synthesis of 1-alkyl-2-(trifluoromethyl)aziridines starting from 1,1,1-trifluoroacetone

(2011) Sara Kenis et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Synthesis of α-CN and α-CF3N-Heterocycles through Tandem Nucleophilic Additions

(2011) Junbin Han et al.   ORGANIC LETTERS

Diastereoselective synthesis of trans-trifluoromethyl-β-lactams and α-alkyl-β-trifluoromethyl-β-amino esters

(2011) Vitaliy Petrik et al.   TETRAHEDRON

Highly diastereoselective synthesis of quaternary α-trifluoromethyl α-amino acids from chiral imines of trifluoropyruvate

(2010) Qiao-Qiao Min et al.   CHEMICAL COMMUNICATIONS

Recent Developments in the Synthesis of Pyrrolidine-Containing Iminosugars

(2010) Bridget L. Stocker et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Reductive Amination/Cyclization of ω-Trifluoromethyl Keto Esters to Trifluoromethylated δ-Amino Alcohols and Lactams

(2010) Wen Wan et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Oxidative desulfurization–fluorination of thioethers. Application for the synthesis of fluorinated nitrogen containing building blocks

(2010) Verena Hugenberg et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Enantiomerically pure 2-aryl(alkyl)-2-trifluoromethylaziridines: synthesis and ring opening with selected O- and N-nucleophiles

(2010) Fabienne Grellepois et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Preparation and Reactions of (β-Trifluoromethyl)vinyl Sulfonium Salt

(2010) Ryoko Maeda et al.   ORGANIC LETTERS

Trifluoromethylation of the amide group

(2010) V. V. Levin et al.   RUSSIAN CHEMICAL BULLETIN

Recent developments in regioselective ring opening of aziridines

(2010) Pengfei Lu   TETRAHEDRON

The reaction of cyclic imines with the Ruppert–Prakash reagent. Facile approach to α-trifluoromethylated nornicotine, anabazine, and homoanabazine

(2010) Nikolay E. Shevchenko et al.   TETRAHEDRON

Aziridine alkaloids as potential therapeutic agents

(2009) Fyaz M.D. Ismail et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Convenient Synthesis ofN-Terminal Tfm-Dipeptides from Unprotected Enantiopure α-Tfm-Proline and α-Tfm-Alanine

(2009) Grégory Chaume et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Fluorinated isatin derivatives. Part 3. New side-chain fluoro-functionalized pyrrolidinyl sulfonyl isatins as potent caspase-3 and -7 inhibitors

(2009) Anil Kumar Podichetty et al.   Future Medicinal Chemistry

Facile synthesis of cyclic α-perfluoroalkyl-α-aminophosphonates

(2009) Irina L. Odinets et al.   JOURNAL OF FLUORINE CHEMISTRY

Azetidines: New Tools for the Synthesis of Nitrogen Heterocycles

(2009) François Couty et al.   SYNLETT

Syntheses and structure–activity relationships of novel 3′-difluoromethyl and 3′-trifluoromethyl-taxoids

(2008) Larissa V. Kuznetsova et al.   JOURNAL OF FLUORINE CHEMISTRY

Concise access to enantiopure (S)- and (R)-α-trifluoromethyl pyroglutamic acids from ethyl trifluoropyruvate-based chiral CF3-oxazolidines (Fox)

(2008) Grégory Chaume et al.   JOURNAL OF FLUORINE CHEMISTRY

Iodocyclization of Chiral CF3-Allylmorpholinones: A Versatile Strategy for the Synthesis of Enantiopure α-Tfm-Prolines and α-Tfm-Dihydroxyprolines

(2008) Caroline Caupène et al.   ORGANIC LETTERS