Regioselective Decarboxylative Cycloaddition Route to Fully Substituted 3‐CF 3 ‐Pyrazoles from Nitrilimines and Isoxazolidinediones

Fluorinated Pyrazoles: From Synthesis to Applications

(2021) Pavel K. Mykhailiuk   CHEMICAL REVIEWS

Regioselective Synthesis of 5-Trifluoromethylpyrazoles by [3 + 2] Cycloaddition of Nitrile Imines and 2-Bromo-3,3,3-trifluoropropene

(2021) Hao Zeng et al.   JOURNAL OF ORGANIC CHEMISTRY

Synthesis of Both Mirror Images of 9-Membered CF3-Heterocycles using a Single Antipode of Chiral Ligand under Pd-catalyzed Decarboxylative Ring-expansion with Kinetic Resolution

(2020) Hiroto Uno et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Regioselective Synthesis of 3-Trifluoromethylpyrazole by Coupling of Aldehydes, Sulfonyl Hydrazides, and 2-Bromo-3,3,3-trifluoropropene

(2020) Chuanle Zhu et al.   ORGANIC LETTERS

Cycloaddition of Trifluoroacetaldehyde N-Triftosylhydrazone (TFHZ-Tfs) with Alkynes for Synthesizing 3-Trifluoromethylpyrazoles

(2020) Hongwei Wang et al.   ORGANIC LETTERS

Remote Fluorination and Fluoroalkyl(thiol)ation Reactions

(2020) Ilan Marek et al.   CHEMISTRY-A EUROPEAN JOURNAL

2,2,2-Trifluorodiazoethane (CF3CHN2): A Long Journey since 1943

(2020) Pavel K. Mykhailiuk   CHEMICAL REVIEWS

A straightforward access to 3-trifluoromethyl-1H-indazoles via (3+2)-cycloaddition of arynes with nitrile imines derived from trifluoroacetonitrile

(2020) Anna Kowalczyk et al.   JOURNAL OF FLUORINE CHEMISTRY

Potassium Acetate-Catalyzed Double Decarboxylative Transannulation To Access Highly Functionalized Pyrroles

(2020) Jun-Kuan Li et al.   ORGANIC LETTERS

Difluorodiazoethane (CF2HCHN2): a new reagent for the introduction of the difluoromethyl group

(2019) Pavel Mykhailiuk et al.   CHEMISTRY-A EUROPEAN JOURNAL

Catalytic (3+2) Palladium-Aminoallyl Cycloaddition with Conjugated Dienes

(2019) Barry M. Trost et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Development of Cyanopyrazoles as Building Blocks to Fungicide Fluxapyroxad and Analogues

(2019) Yue Zhang et al.   JOURNAL OF ORGANIC CHEMISTRY

Ex Situ Generation of Difluorodiazoethane (CF2HCHN2): Application in the Regioselective Synthesis of CF2H-Containing Pyrazoles

(2019) Jian-Shu Wang et al.   ORGANIC LETTERS

Silver-catalyzed synthesis of 5-aryl-3-trifluoromethyl pyrazoles

(2019) Yihui Xu et al.   TETRAHEDRON LETTERS

Polysubstituted 3-trifluoromethylpyrazoles: regioselective (3 + 2)-cycloaddition of trifluoroacetonitrile imines with enol ethers and functional group transformations

(2018) Greta Utecht et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Direct Regioselective [3 + 2] Cycloaddition Reactions of Masked Difluorodiazoethane with Electron-Deficient Alkynes and Alkenes: Synthesis of Difluoromethyl-Substituted Pyrazoles

(2018) Jun-Liang Zeng et al.   ORGANIC LETTERS

Selective, Metal-Free Approach to 3- or 5-CF3-Pyrazoles: Solvent Switchable Reaction of CF3-Ynones with Hydrazines

(2017) Vasiliy M. Muzalevskiy et al.   JOURNAL OF ORGANIC CHEMISTRY

Iron-Catalyzed Decarboxylative (4+1) Cycloadditions: Exploiting the Reactivity of Ambident Iron-Stabilized Intermediates

(2016) Qiang Wang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Trifluoromethyl nitrogen heterocycles: synthetic aspects and potential biological targets

(2016) F. Meyer   CHEMICAL COMMUNICATIONS

Fluoroalkyl-Substituted Diazomethanes and Their Application in a General Synthesis of Pyrazoles and Pyrazolines

(2016) Lucas Mertens et al.   CHEMISTRY-A EUROPEAN JOURNAL

Fluorinated diazoalkanes – a versatile class of reagents for the synthesis of fluorinated compounds

(2016) Lucas Mertens et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Bond-shift isomers: the co-existence of allenic and propargylic phenylnitrile imines

(2015) Cláudio M. Nunes et al.   CHEMICAL COMMUNICATIONS

Core-structure-inspired asymmetric addition reactions: enantioselective synthesis of dihydrobenzoxazinone- and dihydroquinazolinone-based anti-HIV agents

(2015) Shen Li et al.   CHEMICAL SOCIETY REVIEWS

Selective Incorporation of Fluorine in Pyrazoles

(2015) Joseph C. Sloop et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Trifluoromethylpyrazoles as anti-inflammatory and antibacterial agents: A review

(2015) Kamalneet Kaur et al.   JOURNAL OF FLUORINE CHEMISTRY

Three-component synthesis of fluorinated pyrazoles from fluoroalkylamines, NaNO2 and electron-deficient alkynes

(2015) Pavel K. Mykhailiuk   ORGANIC & BIOMOLECULAR CHEMISTRY

An efficient route to 3-trifluoromethylpyrazole via cyclization/1,5-H shift and its applications in the synthesis of bioactive compounds

(2015) Yongdong Wang et al.   TETRAHEDRON

Palladium-Catalyzed Asymmetric Decarboxylative Cycloaddition of Vinylethylene Carbonates with Michael Acceptors: Construction of Vicinal Quaternary Stereocenters

(2014) Ajmal Khan et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Synthesis of 3-trifluoromethylpyrazoles via trifluoromethylation/cyclization of α,β-alkynic hydrazones using a hypervalent iodine reagent

(2014) Guojing Ji et al.   CHEMICAL COMMUNICATIONS

Chemoselectivity in 1,3-Dipolar Cycloaddition Reactions of Nitrilimines with Multifunctionalized Dipolarophiles

(2014) Ahmad S. Shawali   CURRENT ORGANIC CHEMISTRY

One-Pot Synthesis of CF3-Substituted Pyrazolines/Pyrazoles from Electron-Deficient Alkenes/Alkynes and CF3CHN2Generated in situ: Optimized Synthesis of Tris(trifluoromethyl)pyrazole

(2014) Evgeniy Y. Slobodyanyuk et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Regioselective Cycloaddition of Trifluorodiazoethane with Electron-Deficient Allenic Esters and Ketones: Access to CF3-Substituted Pyrazolines and Pyrazoles

(2014) Fa-Guang Zhang et al.   ORGANIC LETTERS

Silver-Mediated Cycloaddition of Alkynes with CF3CHN2: Highly Regioselective Synthesis of 3-Trifluoromethylpyrazoles

(2013) Feng Li et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Tamed Arene and Heteroarene Trifluoromethylation

(2012) Tatiana Besset et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Synthesis of diversely fluorinated pyrazoles as novel active agrochemical ingredients

(2012) Florence Giornal et al.   JOURNAL OF FLUORINE CHEMISTRY

From 2000 to Mid-2010: A Fruitful Decade for the Synthesis of Pyrazoles

(2011) Santos Fustero et al.   CHEMICAL REVIEWS

Celecoxib

(2011) Paul L. McCormack   DRUGS

Bioisosteric Replacement of the Pyrazole 5-Aryl Moiety ofN-(Piperidin-1-yl)-5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazole-3-carboxamide (SR141716A). A Novel Series of Alkynylthiophenes as Potent and Selective Cannabinoid-1 Receptor Antagonists

(2008) Shi-Liang Tseng et al.   JOURNAL OF MEDICINAL CHEMISTRY

Improved Regioselectivity in Pyrazole Formation through the Use of Fluorinated Alcohols as Solvents: Synthesis and Biological Activity of Fluorinated Tebufenpyrad Analogs

(2008) Santos Fustero et al.   JOURNAL OF ORGANIC CHEMISTRY

Synthesis of rimonabant regioisomer

(2008) Kotagiri Vijay Kumar et al.   MONATSHEFTE FUR CHEMIE