Synthesis of Difluoromethyl Pyrazolines and Pyrazoles by [3+2] Cycloaddition Reaction of Difluoroacetohydrazonoyl Bromides with Electron‐deficient Olefins

Pyrazoline analogues: Design, synthesis, and evaluation of anti-osteoporosis activity

(2022) Kriti Sharma et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

New Halogen-Containing Drugs Approved by FDA in 2021: An Overview on Their Syntheses and Pharmaceutical Use

(2022) Davide Benedetto Tiz et al.   MOLECULES

Trifluoromethylated Pyrazoles via Sequential (3 + 2)-Cycloaddition of Fluorinated Nitrile Imines with Chalcones and Solvent-Dependent Deacylative Oxidation Reactions

(2022) Anna Kowalczyk et al.   ORGANIC LETTERS

Synthesis of an Eccentric Electron-Deficient Fluorinated Motif, Tetrafluoro-λ6-sulfanyl gem-Difluorocyclopropenes

(2022) Koki Maruno et al.   ORGANIC LETTERS

Fluorinated Pyrazoles: From Synthesis to Applications

(2021) Pavel K. Mykhailiuk   CHEMICAL REVIEWS

Regioselective Decarboxylative Cycloaddition Route to Fully Substituted 3‐CF 3 ‐Pyrazoles from Nitrilimines and Isoxazolidinediones

(2021) Yu‐Chen Tian et al.   ADVANCED SYNTHESIS & CATALYSIS

Combined 3D-QSAR and docking analysis for the design and synthesis of chalcones as potent and selective monoamine oxidase B inhibitors

(2021) Marco Mellado et al.   BIOORGANIC CHEMISTRY

U.S. FDA Approved Drugs from 2015–June 2020: A Perspective

(2021) Priyadeep Bhutani et al.   JOURNAL OF MEDICINAL CHEMISTRY

Pyrazoles and Pyrazolines as Anti-Inflammatory Agents

(2021) Martha Mantzanidou et al.   MOLECULES

Design, synthesis and evaluation of anticancer activity of new pyrazoline derivatives by down-regulation of VEGF: Molecular docking and apoptosis inducing activity

(2021) Rasha A. Hassan et al.   BIOORGANIC CHEMISTRY

Synthesis of Difluoromethylated Pyrazoles by the [3 + 2] Cycloaddition Reaction of Difluoroacetohydrazonoyl Bromides

(2021) Tongyu Han et al.   JOURNAL OF ORGANIC CHEMISTRY

Contribution of Organofluorine Compounds to Pharmaceuticals

(2020) Munenori Inoue et al.   ACS Omega

Current Contributions of Organofluorine Compounds to the Agrochemical Industry

(2020) Yuta Ogawa et al.   iScience

A straightforward access to 3-trifluoromethyl-1H-indazoles via (3+2)-cycloaddition of arynes with nitrile imines derived from trifluoroacetonitrile

(2020) Anna Kowalczyk et al.   JOURNAL OF FLUORINE CHEMISTRY

[3 + 2] Cycloaddition of para-Quinone Methides with Nitrile Imines: Approach to Spiro-pyrazoline-cyclohexadienones

(2019) Yingpeng Su et al.   JOURNAL OF ORGANIC CHEMISTRY

Synthesis, Crystal Structure, Antifungal Activity, and Docking Study of Difluoromethyl Pyrazole Derivatives

(2019) Li Qiao et al.   JOURNAL OF HETEROCYCLIC CHEMISTRY

Toward Continuous‐Flow Synthesis of Biologically Interesting Pyrazole Derivatives

(2019) Amrita Das et al.   ADVANCED SYNTHESIS & CATALYSIS

Selective fluorometric “Turn-off” sensing for Hg2+ with pyrazoline compound and its application in real water sample analysis

(2019) Ebru Bozkurt et al.   INORGANICA CHIMICA ACTA

Polysubstituted 3-trifluoromethylpyrazoles: regioselective (3 + 2)-cycloaddition of trifluoroacetonitrile imines with enol ethers and functional group transformations

(2018) Greta Utecht et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

A Straightforward Access to Trifluoromethylated Spirobipyrazolines through a Double (3+2)-Cycloaddition of Fluorinated Nitrile Imines with Alkoxyallenes

(2018) Marcin Jasiński et al.   SYNLETT

Synthesis of N -Nitroso CHF2 -Pyrazolines and Their Transformation into CHF2 -Isoxazolines and -Pyrazoles

(2017) Pavlo S. Lebed et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Difluoromethyl Bioisostere: Examining the “Lipophilic Hydrogen Bond Donor” Concept

(2017) Yossi Zafrani et al.   JOURNAL OF MEDICINAL CHEMISTRY

Visible-Light Photocatalytic E to Z Isomerization of Activated Olefins and Its Application for the Syntheses of Coumarins

(2017) Kun Zhan et al.   Catalysts

Next Generation of Fluorine-Containing Pharmaceuticals, Compounds Currently in Phase II–III Clinical Trials of Major Pharmaceutical Companies: New Structural Trends and Therapeutic Areas

(2016) Yu Zhou et al.   CHEMICAL REVIEWS

The unique fluorine effects in organic reactions: recent facts and insights into fluoroalkylations

(2016) Chuanfa Ni et al.   CHEMICAL SOCIETY REVIEWS

Fluoroalkyl-Substituted Diazomethanes and Their Application in a General Synthesis of Pyrazoles and Pyrazolines

(2016) Lucas Mertens et al.   CHEMISTRY-A EUROPEAN JOURNAL

The structural, electro-optical, charge transport and nonlinear optical properties of 2-[(3,5-dimethyl-1-phenyl-1H-pyrazol-4-yl)methylidene]indan-1,3-dione

(2016) Ahmad Irfan et al.   OPTIK

In Situ Generation of Difluoromethyl Diazomethane for [3+2] Cycloadditions with Alkynes

(2015) Pavel K. Mykhailiuk   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Multigram Synthesis of Fluoroalkyl-Substituted Pyrazole-4-carboxylic Acids

(2014) Rustam T. Iminov et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Rings in Drugs

(2014) Richard D. Taylor et al.   JOURNAL OF MEDICINAL CHEMISTRY

Fluorine in Pharmaceutical Industry: Fluorine-Containing Drugs Introduced to the Market in the Last Decade (2001–2011)

(2013) Jiang Wang et al.   CHEMICAL REVIEWS

Phosphotungstic Acid Immobilized on Amine-Grafted Graphene Oxide as Acid/Base Bifunctional Catalyst for One-Pot Tandem Reaction

(2013) Wenfeng Zhang et al.   INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH

Synthesis of diversely fluorinated pyrazoles as novel active agrochemical ingredients

(2012) Florence Giornal et al.   JOURNAL OF FLUORINE CHEMISTRY

Nitrile Imines: Matrix Isolation, IR Spectra, Structures, and Rearrangement to Carbodiimides

(2012) Didier Bégué et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Reaction of a Trifluoromethylated N-Monosubstituted Hydrazone with α,β-Ethenyl Ketones: A Novel Synthesis of Substituted Pyrazolidines and Pyrazolines

(2011) Yongming Wu et al.   SYNTHESIS-STUTTGART

Selective difluoromethylation and monofluoromethylation reactions

(2009) Jinbo Hu et al.   CHEMICAL COMMUNICATIONS

Understanding organofluorine chemistry. An introduction to the C–F bond

(2007) David O'Hagan   CHEMICAL SOCIETY REVIEWS

Fluorine in medicinal chemistry

(2007) Sophie Purser et al.   CHEMICAL SOCIETY REVIEWS