Driving axon regeneration by orchestrating neuronal and non-neuronal innate immune responses via the IFNγ-cGAS-STING axis

Why Has the Ability to Regenerate Following CNS Injury Been Repeatedly Lost Over the Course of Evolution?

(2022) Seth Blackshaw   Frontiers in Neuroscience

STING controls nociception via type I interferon signalling in sensory neurons

(2021) Christopher R. Donnelly et al.   NATURE

An activity-dependent determinant of synapse elimination in the mammalian brain

(2021) Masahiro Yasuda et al.   NEURON

Topoisomerase I inhibition and peripheral nerve injury induce DNA breaks and ATF3-associated axon regeneration in sensory neurons

(2021) Yung-Chih Cheng et al.   Cell Reports

An active vesicle priming machinery suppresses axon regeneration upon adult CNS injury

(2021) Brett J. Hilton et al.   NEURON

Transfer of cGAMP into Bystander Cells via LRRC8 Volume-Regulated Anion Channels Augments STING-Mediated Interferon Responses and Anti-viral Immunity

(2020) Chun Zhou et al.   IMMUNITY

CNTF-STAT3-IL-6 Axis Mediates Neuroinflammatory Cascade across Schwann Cell-Neuron-Microglia

(2020) Zhongsheng Hu et al.   Cell Reports

A new neutrophil subset promotes CNS neuron survival and axon regeneration

(2020) Andrew R. Sas et al.   NATURE IMMUNOLOGY

Interferon-γ signaling in human iPSC–derived neurons recapitulates neurodevelopmental disorder phenotypes

(2020) Katherine Warre-Cornish et al.   Science Advances

Analysis of the immune response to sciatic nerve injury identifies efferocytosis as a key mechanism of nerve debridement

(2020) Ashley L Kalinski et al.   eLife

cGAS in action: Expanding roles in immunity and inflammation

(2019) Andrea Ablasser et al.   SCIENCE

A protein-interaction network of interferon-stimulated genes extends the innate immune system landscape

(2019) Philipp Hubel et al.   NATURE IMMUNOLOGY

Local translation in neurons: visualization and function

(2019) Christine E. Holt et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Thrombospondin-1 Mediates Axon Regeneration in Retinal Ganglion Cells

(2019) Eric R. Bray et al.   NEURON

Interferon-Stimulated Genes: What Do They All Do?

(2019) John W. Schoggins   Annual Review of Virology

The Struggle to Make CNS Axons Regenerate: Why Has It Been so Difficult?

(2019) James W. Fawcett   NEUROCHEMICAL RESEARCH

PTPN1/2-mediated dephosphorylation of MITA/STING promotes its 20S proteasomal degradation and attenuates innate antiviral response

(2019) Tian Xia et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Epigenomic signatures underpin the axonal regenerative ability of dorsal root ganglia sensory neurons

(2019) Ilaria Palmisano et al.   NATURE NEUROSCIENCE

Rewiring Neuronal Glycerolipid Metabolism Determines the Extent of Axon Regeneration

(2019) Chao Yang et al.   NEURON

Single-Cell Profiles of Retinal Ganglion Cells Differing in Resilience to Injury Reveal Neuroprotective Genes

(2019) Nicholas M. Tran et al.   NEURON

Intrinsic Immunity Shapes Viral Resistance of Stem Cells

(2018) Xianfang Wu et al.   CELL

The cGAS–cGAMP–STING pathway connects DNA damage to inflammation, senescence, and cancer

(2018) Tuo Li et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Intrinsic mechanisms of neuronal axon regeneration

(2018) Marcus Mahar et al.   NATURE REVIEWS NEUROSCIENCE

Epitranscriptomic m 6 A Regulation of Axon Regeneration in the Adult Mammalian Nervous System

(2018) Yi-Lan Weng et al.   NEURON

Sarm1/Myd88-5 Regulates Neuronal Intrinsic Immune Response to Traumatic Axonal Injuries

(2018) Qi Wang et al.   Cell Reports

Interferons in Traumatic Brain and Spinal Cord Injury: Current Evidence for Translational Application

(2018) Francesco Roselli et al.   Frontiers in Neurology

Compartmentalized Signaling in Neurons: From Cell Biology to Neuroscience

(2017) Marco Terenzio et al.   NEURON

Expanding Axonal Transcriptome Brings New Functions for Axonally Synthesized Proteins in Health and Disease

(2017) Amar N. Kar et al.   NEUROSCIENTIST

Drugging the Undruggable: Therapeutic Potential of Targeting Protein Tyrosine Phosphatases

(2016) Zhong-Yin Zhang   ACCOUNTS OF CHEMICAL RESEARCH

Restoration of Visual Function by Enhancing Conduction in Regenerated Axons

(2016) Fengfeng Bei et al.   CELL

The multicellular complexity of peripheral nerve regeneration

(2016) Anne-Laure Cattin et al.   CURRENT OPINION IN NEUROBIOLOGY

Mapping a multiplexed zoo of mRNA expression

(2016) Harry M. T. Choi et al.   DEVELOPMENT

Inhibition of Low Molecular Weight Protein Tyrosine Phosphatase by an Induced-Fit Mechanism

(2016) Rongjun He et al.   JOURNAL OF MEDICINAL CHEMISTRY

Unexpected role of interferon-γ in regulating neuronal connectivity and social behaviour

(2016) Anthony J. Filiano et al.   NATURE

A Systems-Level Analysis of the Peripheral Nerve Intrinsic Axonal Growth Program

(2016) Vijayendran Chandran et al.   NEURON

The Calcium Channel Subunit Alpha2delta2 Suppresses Axon Regeneration in the Adult CNS

(2016) Andrea Tedeschi et al.   NEURON

Intrinsic Control of Axon Regeneration

(2016) Zhigang He et al.   NEURON

Two Modes of the Axonal Interferon Response Limit Alphaherpesvirus Neuroinvasion

(2016) Ren Song et al.   mBio

Positive feedback regulation of type I interferon by the interferon-stimulated gene STING

(2015) F. Ma et al.   EMBO REPORTS

An in vitro assay to study induction of the regenerative state in sensory neurons

(2015) E. Frey et al.   EXPERIMENTAL NEUROLOGY

Positive Feedback Regulation of Type I IFN Production by the IFN-Inducible DNA Sensor cGAS

(2015) Feng Ma et al.   JOURNAL OF IMMUNOLOGY

Injured adult retinal axons with Pten and Socs3 co-deletion reform active synapses with suprachiasmatic neurons

(2015) Songshan Li et al.   NEUROBIOLOGY OF DISEASE

Subtype-Specific Regeneration of Retinal Ganglion Cells following Axotomy: Effects of Osteopontin and mTOR Signaling

(2015) Xin Duan et al.   NEURON

Neuroinflammation triggered by β-glucan/dectin-1 signaling enables CNS axon regeneration

(2015) Katherine T. Baldwin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Interferon-Stimulated Genes: A Complex Web of Host Defenses

(2014) William M. Schneider et al.   Annual Review of Immunology

CRISPR-Cas9 Knockin Mice for Genome Editing and Cancer Modeling

(2014) Randall J. Platt et al.   CELL

Therapeutic Potential of Targeting the Oncogenic SHP2 Phosphatase

(2014) Li-Fan Zeng et al.   JOURNAL OF MEDICINAL CHEMISTRY

In vivo interrogation of gene function in the mammalian brain using CRISPR-Cas9

(2014) Lukasz Swiech et al.   NATURE BIOTECHNOLOGY

Full-length RNA-seq from single cells using Smart-seq2

(2014) Simone Picelli et al.   Nature Protocols

Central Nervous System Regenerative Failure: Role of Oligodendrocytes, Astrocytes, and Microglia

(2014) Jerry Silver et al.   Cold Spring Harbor Perspectives in Biology

Hydroxyindole Carboxylic Acid-Based Inhibitors for Receptor-Type Protein Tyrosine Protein Phosphatase Beta

(2013) Li-Fan Zeng et al.   ANTIOXIDANTS & REDOX SIGNALING

Identifying the Initiating Events of Anti-Listeria Responses Using Mice with Conditional Loss of IFN-  Receptor Subunit 1 (IFNGR1)

(2013) S. H. Lee et al.   JOURNAL OF IMMUNOLOGY

A Potent and Selective Small-Molecule Inhibitor for the Lymphoid-Specific Tyrosine Phosphatase (LYP), a Target Associated with Autoimmune Diseases

(2013) Yantao He et al.   JOURNAL OF MEDICINAL CHEMISTRY

Pan-viral specificity of IFN-induced genes reveals new roles for cGAS in innate immunity

(2013) John W. Schoggins et al.   NATURE

PI3K–GSK3 signalling regulates mammalian axon regeneration by inducing the expression of Smad1

(2013) Saijilafu et al.   Nature Communications

STAR: ultrafast universal RNA-seq aligner

(2012) Alexander Dobin et al.   BIOINFORMATICS

Axonal transcription factors signal retrogradely in lesioned peripheral nerve

(2012) Keren Ben-Yaakov et al.   EMBO JOURNAL

A Highly Selective and Potent PTP-MEG2 Inhibitor with Therapeutic Potential for Type 2 Diabetes

(2012) Sheng Zhang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Dual Leucine Zipper Kinase Is Required for Retrograde Injury Signaling and Axonal Regeneration

(2012) Jung Eun Shin et al.   NEURON

Inflammation and axon regeneration

(2011) Larry I. Benowitz et al.   CURRENT OPINION IN NEUROLOGY

MPYS Is Required for IFN Response Factor 3 Activation and Type I IFN Production in the Response of Cultured Phagocytes to Bacterial Second Messengers Cyclic-di-AMP and Cyclic-di-GMP

(2011) L. Jin et al.   JOURNAL OF IMMUNOLOGY

Leukocyte Common Antigen-Related Phosphatase Is a Functional Receptor for Chondroitin Sulfate Proteoglycan Axon Growth Inhibitors

(2011) D. Fisher et al.   JOURNAL OF NEUROSCIENCE

Temporal Control of Gene Deletion in Sensory Ganglia Using a Tamoxifen-Inducible Advillin-CreERT2 Recombinase Mouse

(2011) Joanne Lau et al.   Molecular Pain

Sustained axon regeneration induced by co-deletion of PTEN and SOCS3

(2011) Fang Sun et al.   NATURE

Leptin Action on GABAergic Neurons Prevents Obesity and Reduces Inhibitory Tone to POMC Neurons

(2011) Linh Vong et al.   NEURON

PTEN deletion enhances the regenerative ability of adult corticospinal neurons

(2010) Kai Liu et al.   NATURE NEUROSCIENCE

Muscle inactivation of mTOR causes metabolic and dystrophin defects leading to severe myopathy

(2009) Valérie Risson et al.   JOURNAL OF CELL BIOLOGY

Acquisition of a Potent and Selective TC-PTP Inhibitor via a Stepwise Fluorophore-Tagged Combinatorial Synthesis and Screening Strategy

(2009) Sheng Zhang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Inner Limiting Membrane Barriers to AAV-mediated Retinal Transduction From the Vitreous

(2009) Deniz Dalkara et al.   MOLECULAR THERAPY

A robust and high-throughput Cre reporting and characterization system for the whole mouse brain

(2009) Linda Madisen et al.   NATURE NEUROSCIENCE

SOCS3 Deletion Promotes Optic Nerve Regeneration In Vivo

(2009) Patrice D. Smith et al.   NEURON

PTP  Is a Receptor for Chondroitin Sulfate Proteoglycan, an Inhibitor of Neural Regeneration

(2009) Y. Shen et al.   SCIENCE

Promoting Axon Regeneration in the Adult CNS by Modulation of the PTEN/mTOR Pathway

(2008) K. K. Park et al.   SCIENCE