An activity-dependent determinant of synapse elimination in the mammalian brain

Sensory Experience Engages Microglia to Shape Neural Connectivity through a Non-Phagocytic Mechanism

(2020) Lucas Cheadle et al.   NEURON

Tyrosine phosphorylation of the transmembrane protein SIRPα: Sensing synaptic activity and regulating ectodomain cleavage for synapse maturation

(2018) Sivapratha Nagappan-Chettiar et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Visual Experience-Dependent Expression of Fn14 Is Required for Retinogeniculate Refinement

(2018) Lucas Cheadle et al.   NEURON

Neurons under T Cell Attack Coordinate Phagocyte-Mediated Synaptic Stripping

(2018) Giovanni Di Liberto et al.   CELL

Reduced sensory synaptic excitation impairs motor neuron function via Kv2.1 in spinal muscular atrophy

(2017) Emily V Fletcher et al.   NATURE NEUROSCIENCE

The Metabotropic Glutamate Receptor Subtype 1 Mediates Experience-Dependent Maintenance of Mature Synaptic Connectivity in the Visual Thalamus

(2016) Madoka Narushima et al.   NEURON

Cortical Feedback Regulates Feedforward Retinogeniculate Refinement

(2016) Andrew D. Thompson et al.   NEURON

Three Types of Cortical Layer 5 Neurons That Differ in Brain-wide Connectivity and Function

(2015) Euiseok J. Kim et al.   NEURON

Anterograde C1ql1 Signaling Is Required in Order to Determine and Maintain a Single-Winner Climbing Fiber in the Mouse Cerebellum

(2015) Wataru Kakegawa et al.   NEURON

IL-6 regulation of synaptic function in the CNS

(2015) Donna L. Gruol   NEUROPHARMACOLOGY

A switch from inter-ocular to inter-hemispheric suppression following monocular deprivation in the rat visual cortex

(2014) Marta Pietrasanta et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Synapse elimination and learning rules co-regulated by MHC class I H2-Db

(2014) Hanmi Lee et al.   NATURE

Balanced Interhemispheric Cortical Activity Is Required for Correct Targeting of the Corpus Callosum

(2014) Rodrigo Suárez et al.   NEURON

Important scaffold function of the Janus kinase 2 uncovered by a novel mouse model harboring a Jak2 activation-loop mutation

(2013) E. Keil et al.   BLOOD

Pathogenic rare copy number variants in community-based schizophrenia suggest a potential role for clinical microarrays

(2013) G. Costain et al.   HUMAN MOLECULAR GENETICS

Synapse maturation by activity-dependent ectodomain shedding of SIRPα

(2013) Anna B Toth et al.   NATURE NEUROSCIENCE

Plum, an Immunoglobulin Superfamily Protein, Regulates Axon Pruning by Facilitating TGF-β Signaling

(2013) Xiaomeng M. Yu et al.   NEURON

STAT1 Negatively Regulates Spatial Memory Formation and Mediates the Memory-Impairing Effect of Aβ

(2013) Wei-Lun Hsu et al.   NEUROPSYCHOPHARMACOLOGY

Neuronal gp130 Expression Is Crucial to Prevent Neuronal Loss, Hyperinflammation, and Lethal Course of Murine Toxoplasma Encephalitis

(2012) Ulrike Händel et al.   AMERICAN JOURNAL OF PATHOLOGY

Amyloid-  Induces Hepatic Insulin Resistance In Vivo via JAK2

(2012) Y. Zhang et al.   DIABETES

Suppression of Cytokine Signaling by SOCS3: Characterization of the Mode of Inhibition and the Basis of Its Specificity

(2012) Jeffrey J. Babon et al.   IMMUNITY

The JAK/STAT Pathway Is Involved in Synaptic Plasticity

(2012) Céline S. Nicolas et al.   NEURON

Microglia Sculpt Postnatal Neural Circuits in an Activity and Complement-Dependent Manner

(2012) Dorothy P. Schafer et al.   NEURON

Neuronal Intrinsic Mechanisms of Axon Regeneration

(2011) Kai Liu et al.   Annual Review of Neuroscience

JAKs go nuclear: Emerging role of nuclear JAK1 and JAK2 in gene expression and cell growth

(2011) Fouad A. Zouein et al.   GROWTH FACTORS

Sustained axon regeneration induced by co-deletion of PTEN and SOCS3

(2011) Fang Sun et al.   NATURE

Experience-Dependent Retinogeniculate Synapse Remodeling Is Abnormal in MeCP2-Deficient Mice

(2011) Joao Noutel et al.   NEURON

Multiple Forms of Activity-Dependent Competition Refine Hippocampal Circuits In Vivo

(2011) Masahiro Yasuda et al.   NEURON

The Rho exchange factor Arhgef1 mediates the effects of angiotensin II on vascular tone and blood pressure

(2010) Christophe Guilluy et al.   NATURE MEDICINE

Development, specification, and diversity of callosal projection neurons

(2010) Ryann M. Fame et al.   TRENDS IN NEUROSCIENCES

Synapse elimination in the central nervous system

(2009) Masanobu Kano et al.   CURRENT OPINION IN NEUROBIOLOGY

A robust and high-throughput Cre reporting and characterization system for the whole mouse brain

(2009) Linda Madisen et al.   NATURE NEUROSCIENCE

Classical MHCI Molecules Regulate Retinogeniculate Refinement and Limit Ocular Dominance Plasticity

(2009) Akash Datwani et al.   NEURON

SOCS3 Deletion Promotes Optic Nerve Regeneration In Vivo

(2009) Patrice D. Smith et al.   NEURON

Signal Regulatory Proteins (SIRPS) Are Secreted Presynaptic Organizing Molecules

(2008) Hisashi Umemori et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Vision Triggers an Experience-Dependent Sensitive Period at the Retinogeniculate Synapse

(2008) B. M. Hooks et al.   JOURNAL OF NEUROSCIENCE

Amyloid-β causes memory impairment by disturbing the JAK2/STAT3 axis in hippocampal neurons

(2008) T Chiba et al.   MOLECULAR PSYCHIATRY