Topoisomerase I inhibition and peripheral nerve injury induce DNA breaks and ATF3-associated axon regeneration in sensory neurons

The Mechanisms of Peripheral Nerve Preconditioning Injury on Promoting Axonal Regeneration

(2021) Xiaoyan Yang et al.   NEURAL PLASTICITY

Deletion of Topoisomerase 1 in excitatory neurons causes genomic instability and early onset neurodegeneration

(2020) Giulia Fragola et al.   Nature Communications

Chromatin Remodeling and Immediate Early Gene Activation by SLFN11 in Response to Replication Stress

(2020) Junko Murai et al.   Cell Reports

Transcriptional Reprogramming of Distinct Peripheral Sensory Neuron Subtypes after Axonal Injury

(2020) William Renthal et al.   NEURON

Early neuronal accumulation of DNA double strand breaks in Alzheimer’s disease

(2019) Niraj M. Shanbhag et al.   Acta Neuropathologica Communications

Dual Processing of R-Loops and Topoisomerase I Induces Transcription-Dependent DNA Double-Strand Breaks

(2019) Agnese Cristini et al.   Cell Reports

An Intrinsic Epigenetic Barrier for Functional Axon Regeneration

(2017) Yi-Lan Weng et al.   NEURON

Long Neural Genes Harbor Recurrent DNA Break Clusters in Neural Stem/Progenitor Cells

(2016) Pei-Chi Wei et al.   CELL

A Systems-Level Analysis of the Peripheral Nerve Intrinsic Axonal Growth Program

(2016) Vijayendran Chandran et al.   NEURON

Transcription-associated processes cause DNA double-strand breaks and translocations in neural stem/progenitor cells

(2016) Bjoern Schwer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Atf3mutant mice show reduced axon regeneration and impaired regeneration-associated gene induction after peripheral nerve injury

(2016) Manuel Gey et al.   Open Biology

The catalytic topoisomerase II inhibitor dexrazoxane induces DNA breaks, ATF3 and the DNA damage response in cancer cells

(2015) Shiwei Deng et al.   BRITISH JOURNAL OF PHARMACOLOGY

Activity-Induced DNA Breaks Govern the Expression of Neuronal Early-Response Genes

(2015) Ram Madabhushi et al.   CELL

Lack of motor recovery after prolonged denervation of the neuromuscular junction is not due to regenerative failure

(2015) Miyuki Sakuma et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Growth control mechanisms in neuronal regeneration

(2015) Ella Doron-Mandel et al.   FEBS LETTERS

The distinctive cellular responses to DNA strand breaks caused by a DNA topoisomerase I poison in conjunction with DNA replication and RNA transcription

(2015) Ryo Sakasai et al.   GENES & GENETIC SYSTEMS

Overexpression of ATF3 or the combination of ATF3, c-Jun, STAT3 and Smad1 promotes regeneration of the central axon branch of sensory neurons but without synergistic effects

(2015) Nitish D. Fagoe et al.   HUMAN MOLECULAR GENETICS

Overexpression of Sox11 Promotes Corticospinal Tract Regeneration after Spinal Injury While Interfering with Functional Recovery

(2015) Z. Wang et al.   JOURNAL OF NEUROSCIENCE

c-Jun Gene-Modified Schwann Cells: Upregulating Multiple Neurotrophic Factors and Promoting Neurite Outgrowth

(2015) Liangliang Huang et al.   TISSUE ENGINEERING PART A

Transcriptional elongation requires DNA break-induced signalling

(2015) Heeyoun Bunch et al.   Nature Communications

The transcriptional landscape of dorsal root ganglia after sciatic nerve transection

(2015) Shiying Li et al.   Scientific Reports

Cell intrinsic control of axon regeneration

(2014) F. M. Mar et al.   EMBO REPORTS

Improving peripheral nerve regeneration: From molecular mechanisms to potential therapeutic targets

(2014) K. Ming Chan et al.   EXPERIMENTAL NEUROLOGY

Diminished Schwann Cell Repair Responses Underlie Age-Associated Impaired Axonal Regeneration

(2014) Michio W. Painter et al.   NEURON

Injury-Induced HDAC5 Nuclear Export Is Essential for Axon Regeneration

(2013) Yongcheol Cho et al.   CELL

Activity-dependent neuronal signalling and autism spectrum disorder

(2013) Daniel H. Ebert et al.   NATURE

PI3K–GSK3 signalling regulates mammalian axon regeneration by inducing the expression of Smad1

(2013) Saijilafu et al.   Nature Communications

DLK: The “Preconditioning” Signal for Axon Regeneration?

(2012) Paola Nix et al.   NEURON

Role of Transcription Factors in Peripheral Nerve Regeneration

(2012) Smriti Patodia et al.   Frontiers in Molecular Neuroscience

Effect of ionizing radiation in sensory ganglion neurons: organization and dynamics of nuclear compartments of DNA damage/repair and their relationship with transcription and cell cycle

(2011) Iñigo Casafont et al.   ACTA NEUROPATHOLOGICA

The histone acetyltransferase p300 promotes intrinsic axonal regeneration

(2011) Perrine Gaub et al.   BRAIN

The transcription factor Sox11 promotes nerve regeneration through activation of the regeneration-associated gene Sprr1a

(2011) Xiaotang Jing et al.   EXPERIMENTAL NEUROLOGY

Replication stress induces 53BP1-containing OPT domains in G1 cells

(2011) Jeanine A. Harrigan et al.   JOURNAL OF CELL BIOLOGY

Accelerating axonal growth promotes motor recovery after peripheral nerve injury in mice

(2011) Chi Him Eddie Ma et al.   JOURNAL OF CLINICAL INVESTIGATION

A Gene Network Perspective on Axonal Regeneration

(2011) Ronald E. van Kesteren et al.   Frontiers in Molecular Neuroscience

Activating Transcription Factor 3, a Useful Marker for Regenerative Response after Nerve Root Injury

(2011) Hans Lindå et al.   Frontiers in Neurology

HDAC inhibition promotes neuronal outgrowth and counteracts growth cone collapse through CBP/p300 and P/CAF-dependent p53 acetylation

(2010) P Gaub et al.   CELL DEATH AND DIFFERENTIATION

Calcium-induced cleavage of DNA topoisomerase I involves the cytoplasmic-nuclear shuttling of calpain 2

(2010) Shang-Min Chou et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

In Vivo Formation of  -H2AX and 53BP1 DNA Repair Foci in Blood Cells After Radioiodine Therapy of Differentiated Thyroid Cancer

(2010) M. Lassmann et al.   JOURNAL OF NUCLEAR MEDICINE

Targeting Cdk5 Activity in Neuronal Degeneration and Regeneration

(2009) Jyotshnabala Kanungo et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

Ataxia telangiectasia mutated activation by transcription- and topoisomerase I-induced DNA double-strand breaks

(2009) Olivier Sordet et al.   EMBO REPORTS

ATF3 transcription factor and its emerging roles in immunity and cancer

(2009) Matthew R. Thompson et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

KLF Family Members Regulate Intrinsic Axon Regeneration Ability

(2009) D. L. Moore et al.   SCIENCE

A p53-CBP/p300 transcription module is required for GAP-43 expression, axon outgrowth and regeneration

(2008) A Tedeschi et al.   CELL DEATH AND DIFFERENTIATION