Analysis of the immune response to sciatic nerve injury identifies efferocytosis as a key mechanism of nerve debridement

Macrophage Metabolism of Apoptotic Cell-Derived Arginine Promotes Continual Efferocytosis and Resolution of Injury

(2020) Arif Yurdagul et al.   Cell Metabolism

Dorsal root ganglion macrophages contribute to both the initiation and persistence of neuropathic pain

(2020) Xiaobing Yu et al.   Nature Communications

Transcription factor c-Maf is a checkpoint that programs macrophages in lung cancer

(2020) Min Liu et al.   JOURNAL OF CLINICAL INVESTIGATION

Injured adult neurons regress to an embryonic transcriptional growth state

(2020) Gunnar H. D. Poplawski et al.   NATURE

Profiling peripheral nerve macrophages reveals two macrophage subsets with distinct localization, transcriptome and response to injury

(2020) Elke Ydens et al.   NATURE NEUROSCIENCE

The clearance of dead cells by efferocytosis

(2020) Emilio Boada-Romero et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Redefining the heterogeneity of peripheral nerve cells in health and autoimmunity

(2020) Jolien Wolbert et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Peripheral nerve resident macrophages share tissue-specific programming and features of activated microglia

(2020) Peter L. Wang et al.   Nature Communications

Phagocytosis of Apoptotic Cells in Resolution of Inflammation

(2020) Ioannis Kourtzelis et al.   Frontiers in Immunology

Coupled scRNA-Seq and Intracellular Protein Activity Reveal an Immunosuppressive Role of TREM2 in Cancer

(2020) Yonatan Katzenelenbogen et al.   CELL

Deacetylation of Miro1 by HDAC6 blocks mitochondrial transport and mediates axon growth inhibition

(2019) Ashley L. Kalinski et al.   JOURNAL OF CELL BIOLOGY

Frontline Science: Blood‐circulating leukocytes fail to infiltrate the spinal cord parenchyma after spared nerve injury

(2019) Rafaela M. Guimarães et al.   JOURNAL OF LEUKOCYTE BIOLOGY

CIITA-Driven MHC Class II Expressing Tumor Cells as Antigen Presenting Cell Performers: Toward the Construction of an Optimal Anti-tumor Vaccine

(2019) Roberto S. Accolla et al.   Frontiers in Immunology

GM-CSF-Dependent Inflammatory Pathways

(2019) John A. Hamilton   Frontiers in Immunology

The Endless Saga of Monocyte Diversity

(2019) Stefania Canè et al.   Frontiers in Immunology

SOAT1 deficiency attenuates atherosclerosis by regulating inflammation and cholesterol transportation via HO-1 pathway

(2018) Nan Wu et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Slingshot: cell lineage and pseudotime inference for single-cell transcriptomics

(2018) Kelly Street et al.   BMC GENOMICS

Lysosomal Cholesterol Hydrolysis Couples Efferocytosis to Anti-Inflammatory Oxysterol ProductionNovelty and Significance

(2018) Manon Viaud et al.   CIRCULATION RESEARCH

Galectin-3 in M2 macrophages plays a protective role in resolution of neuropathology in brain parasitic infection by regulating neutrophil turnover

(2018) Fredice O. Quenum Zangbede et al.   JOURNAL OF NEUROSCIENCE

CD52 glycan binds the proinflammatory B box of HMGB1 to engage the Siglec-10 receptor and suppress human T cell function

(2018) Esther Bandala-Sanchez et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Sarm1/Myd88-5 Regulates Neuronal Intrinsic Immune Response to Traumatic Axonal Injuries

(2018) Qi Wang et al.   Cell Reports

Trauma-Induced Heterotopic Ossification Regulates the Blood-Nerve Barrier

(2018) Zbigniew Gugala et al.   Frontiers in Neurology

Granulocyte-macrophage colony-stimulating factor improves mouse peripheral nerve regeneration following sciatic nerve crush

(2018) André Luis Bombeiro et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Efferocytosis and autoimmune disease

(2018) Mahiru Kawano et al.   INTERNATIONAL IMMUNOLOGY

Activation of Intrinsic Growth State Enhances Host Axonal Regeneration into Neural Progenitor Cell Grafts

(2018) Hiromi Kumamaru et al.   Stem Cell Reports

Inflammasomes in Tissue Damages and Immune Disorders After Trauma

(2018) Perrine Bortolotti et al.   Frontiers in Immunology

Pyroptosis versus necroptosis: similarities, differences, and crosstalk

(2018) Daniel Frank et al.   CELL DEATH AND DIFFERENTIATION

Mesenchymal Precursor Cells in Adult Nerves Contribute to Mammalian Tissue Repair and Regeneration

(2018) Matthew J. Carr et al.   Cell Stem Cell

The physiology of foamy phagocytes in multiple sclerosis

(2018) Elien Grajchen et al.   Acta Neuropathologica Communications

Macrophage biology in the peripheral nervous system after injury

(2018) Richard E. Zigmond et al.   PROGRESS IN NEUROBIOLOGY

CD300 family receptors regulate eosinophil survival, chemotaxis, and effector functions

(2017) Perri Rozenberg et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Neutrophils Are Critical for Myelin Removal in a Peripheral Nerve Injury Model of Wallerian Degeneration

(2017) Jane A. Lindborg et al.   JOURNAL OF NEUROSCIENCE

The Wound Microenvironment Reprograms Schwann Cells to Invasive Mesenchymal-like Cells to Drive Peripheral Nerve Regeneration

(2017) Melanie P. Clements et al.   NEURON

Schwann cells use TAM receptor-mediated phagocytosis in addition to autophagy to clear myelin in a mouse model of nerve injury

(2017) Amanda Brosius Lutz et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Inflammation and metabolism in tissue repair and regeneration

(2017) Sabine A. Eming et al.   SCIENCE

The transcription factor MafB promotes anti-inflammatory M2 polarization and cholesterol efflux in macrophages

(2017) Hwijin Kim   Scientific Reports

Myelin and macrophages in the PNS: An intimate relationship in trauma and disease

(2016) Dennis Klein et al.   BRAIN RESEARCH

Overexpression of the monocyte chemokine CCL2 in dorsal root ganglion neurons causes a conditioning-like increase in neurite outgrowth and does so via a STAT3 dependent mechanism

(2016) Jon P. Niemi et al.   EXPERIMENTAL NEUROLOGY

Clearance of apoptotic neutrophils and resolution of inflammation

(2016) Mallary C. Greenlee-Wacker   IMMUNOLOGICAL REVIEWS

Galectin-3–null mice display defective neutrophil clearance during acute inflammation

(2016) Rachael D Wright et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Progranulin promotes peripheral nerve regeneration and reinnervation: role of notch signaling

(2016) Christine Altmann et al.   Molecular Neurodegeneration

A Systems-Level Analysis of the Peripheral Nerve Intrinsic Axonal Growth Program

(2016) Vijayendran Chandran et al.   NEURON

RBP-J is required for M2 macrophage polarization in response to chitin and mediates expression of a subset of M2 genes

(2016) Julia Foldi et al.   Protein & Cell

Cytokine amplification and macrophage effector functions in aortic inflammation and abdominal aortic aneurysm formation

(2016) Talha Ijaz et al.   Journal of Thoracic Disease

GM-CSF promotes migration of human monocytes across the blood brain barrier

(2015) Daphne Y. S. Vogel et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

A novel and robust conditioning lesion induced by ethidium bromide

(2015) Edmund R. Hollis et al.   EXPERIMENTAL NEUROLOGY

CCL2 Mediates Neuron-Macrophage Interactions to Drive Proregenerative Macrophage Activation Following Preconditioning Injury

(2015) M. J. Kwon et al.   JOURNAL OF NEUROSCIENCE

PPARγ activation following apoptotic cell instillation promotes resolution of lung inflammation and fibrosis via regulation of efferocytosis and proresolving cytokines

(2015) Y-S Yoon et al.   Mucosal Immunology

Injured sensory neuron–derived CSF1 induces microglial proliferation and DAP12-dependent pain

(2015) Zhonghui Guan et al.   NATURE NEUROSCIENCE

Targeting GM-CSF in inflammatory diseases

(2015) Ian P. Wicks et al.   Nature Reviews Rheumatology

The neuroimmunology of degeneration and regeneration in the peripheral nervous system

(2015) A. DeFrancesco-Lisowitz et al.   NEUROSCIENCE

Neuroinflammation triggered by β-glucan/dectin-1 signaling enables CNS axon regeneration

(2015) Katherine T. Baldwin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

GM-CSF reduces expression of chondroitin sulfate proteoglycan (CSPG) core proteins in TGF-β-treated primary astrocytes

(2015) Jung-Kyoung Choi et al.   BMB Reports

iDISCO: A Simple, Rapid Method to Immunolabel Large Tissue Samples for Volume Imaging

(2014) Nicolas Renier et al.   CELL

Novel Roles for Osteopontin and Clusterin in Peripheral Motor and Sensory Axon Regeneration

(2014) M. C. Wright et al.   JOURNAL OF NEUROSCIENCE

Dendritic cell fate is determined by BCL11A

(2014) G. C. Ippolito et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Inflammation in dorsal root ganglia after peripheral nerve injury: Effects of the sympathetic innervation

(2013) Elspeth M. McLachlan et al.   AUTONOMIC NEUROSCIENCE-BASIC & CLINICAL

Resolution of inflammation: an integrated view

(2013) Almudena Ortega-Gómez et al.   EMBO Molecular Medicine

Sphingomyelin and ceramide are physiological ligands for human LMIR3/CD300f, inhibiting FcεRI-mediated mast cell activation

(2013) Kumi Izawa et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Low-density Lipoprotein Receptor-related Protein 1 (LRP1)-dependent Cell Signaling Promotes Axonal Regeneration

(2013) Choya Yoon et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Critical Role for Macrophages Near Axotomized Neuronal Cell Bodies in Stimulating Nerve Regeneration

(2013) J. P. Niemi et al.   JOURNAL OF NEUROSCIENCE

Granulocyte macrophage colony-stimulating factor promotes regeneration of retinal ganglion cells in vitro through a mammalian target of rapamycin-dependent mechanism

(2013) Jacqueline Legacy et al.   JOURNAL OF NEUROSCIENCE RESEARCH

The sva package for removing batch effects and other unwanted variation in high-throughput experiments

(2012) Jeffrey T. Leek et al.   BIOINFORMATICS

LDL receptor-related protein-1 is a sialic-acid-independent receptor for myelin-associated glycoprotein that functions in neurite outgrowth inhibition by MAG and CNS myelin

(2012) Travis L. Stiles et al.   JOURNAL OF CELL SCIENCE

Endoneurial Fibroblast-Like Cells

(2012) Laurence Richard et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

c-Jun Reprograms Schwann Cells of Injured Nerves to Generate a Repair Cell Essential for Regeneration

(2012) Peter J. Arthur-Farraj et al.   NEURON

Macrophage presence is essential for the regeneration of ascending afferent fibres following a conditioning sciatic nerve lesion in adult rats

(2011) Ernesto A Aguilar Salegio et al.   BMC NEUROSCIENCE

Detailed characterization of neuro-immune responses following neuropathic injury in mice

(2011) Cristina Fabiola Kim et al.   BRAIN RESEARCH

Conditioning lesions before or after spinal cord injury recruit broad genetic mechanisms that sustain axonal regeneration: Superiority to camp-mediated effects

(2011) Armin Blesch et al.   EXPERIMENTAL NEUROLOGY

Modulation of Macrophage Efferocytosis in Inflammation

(2011) Darlynn Korns et al.   Frontiers in Immunology

ABCA1 and ABCG1 Protect Against Oxidative Stress–Induced Macrophage Apoptosis During Efferocytosis

(2010) Laurent Yvan-Charvet et al.   CIRCULATION RESEARCH

On the longevity of resident endoneurial macrophages in the peripheral nervous system: a study of physiological macrophage turnover in bone marrow chimeric mice

(2010) Marcus Müller et al.   JOURNAL OF THE PERIPHERAL NERVOUS SYSTEM

Circulating Ly-6C+ myeloid precursors migrate to the CNS and play a pathogenic role during autoimmune demyelinating disease

(2009) I. L. King et al.   BLOOD

The Role of Galectin-3/MAC-2 in the Activation of the Innate-Immune Function of Phagocytosis in Microglia in Injury and Disease

(2009) Shlomo Rotshenker   JOURNAL OF MOLECULAR NEUROSCIENCE

Molecular Basis of the Interactions of the Nogo-66 Receptor and Its Homolog NgR2 with Myelin-Associated Glycoprotein: Development of NgROMNI-Fc, a Novel Antagonist of CNS Myelin Inhibition

(2009) L. A. Robak et al.   JOURNAL OF NEUROSCIENCE

Neuroscience in the era of functional genomics and systems biology

(2009) Daniel H. Geschwind et al.   NATURE

RESPONSES OF THE NERVE CELL BODY TO AXOTOMY

(2009) Peter M. Richardson et al.   NEUROSURGERY

The Structure of the GM-CSF Receptor Complex Reveals a Distinct Mode of Cytokine Receptor Activation

(2008) Guido Hansen et al.   CELL

Nerve injury signaling

(2008) Namiko Abe et al.   CURRENT OPINION IN NEUROBIOLOGY

Interactions between Schwann cells and macrophages in injury and inherited demyelinating disease

(2008) Rudolf Martini et al.   GLIA

Requirement of Myeloid Cells for Axon Regeneration

(2008) B. Barrette et al.   JOURNAL OF NEUROSCIENCE

Another Barrier to Regeneration in the CNS: Activated Macrophages Induce Extensive Retraction of Dystrophic Axons through Direct Physical Interactions

(2008) K. P. Horn et al.   JOURNAL OF NEUROSCIENCE

GM-CSF inhibits glial scar formation and shows long-term protective effect after spinal cord injury

(2008) Xian Huang et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

PirB is a Functional Receptor for Myelin Inhibitors of Axonal Regeneration

(2008) J. K. Atwal et al.   SCIENCE