Local translation in neurons: visualization and function

Late Endosomes Act as mRNA Translation Platforms and Sustain Mitochondria in Axons

(2019) Jean-Michel Cioni et al.   CELL

Subcellular transcriptomes and proteomes of developing axon projections in the cerebral cortex

(2019) Alexandros Poulopoulos et al.   NATURE

Local protein synthesis is a ubiquitous feature of neuronal pre- and postsynaptic compartments

(2019) Anne-Sophie Hafner et al.   SCIENCE

The Neuronal Gene Arc Encodes a Repurposed Retrotransposon Gag Protein that Mediates Intercellular RNA Transfer

(2018) Elissa D. Pastuzyn et al.   CELL

Retrovirus-like Gag Protein Arc1 Binds RNA and Traffics across Synaptic Boutons

(2018) James Ashley et al.   CELL

FUS Phase Separation Is Modulated by a Molecular Chaperone and Methylation of Arginine Cation-π Interactions

(2018) Seema Qamar et al.   CELL

Molecular control of local translation in axon development and maintenance

(2018) Jean-Michel Cioni et al.   CURRENT OPINION IN NEUROBIOLOGY

NMDAR‐dependent Argonaute 2 phosphorylation regulates miRNA activity and dendritic spine plasticity

(2018) Dipen Rajgor et al.   EMBO JOURNAL

Synaptic N6-methyladenosine (m6A) epitranscriptome reveals functional partitioning of localized transcripts

(2018) Daria Merkurjev et al.   NATURE NEUROSCIENCE

Alternative 3′ UTRs Modify the Localization, Regulatory Potential, Stability, and Plasticity of mRNAs in Neuronal Compartments

(2018) Georgi Tushev et al.   NEURON

Rapid Cue-Specific Remodeling of the Nascent Axonal Proteome

(2018) Roberta Cagnetta et al.   NEURON

Rapid, experience-dependent translation of neurogranin enables memory encoding

(2018) Kendrick J. Jones et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Time- and polarity-dependent proteomic changes associated with homeostatic scaling at central synapses

(2018) Christoph T Schanzenbächer et al.   eLife

Local and global influences on protein turnover in neurons and glia

(2018) Aline R Dörrbaum et al.   eLife

Single-molecule analysis of endogenous β-actin mRNA trafficking reveals a mechanism for compartmentalized mRNA localization in axons

(2018) Benita Turner-Bridger et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A New Photocaged Puromycin for an Efficient Labeling of Newly Translated Proteins in Living Neurons

(2018) Isam Elamri et al.   CHEMBIOCHEM

Noncanonical Modulation of the eIF2 Pathway Controls an Increase in Local Translation during Neural Wiring

(2018) Roberta Cagnetta et al.   MOLECULAR CELL

Translating regeneration: Local protein synthesis in the neuronal injury response

(2018) Sandip Koley et al.   NEUROSCIENCE RESEARCH

Alternative 3′ UTRs direct localization of functionally diverse protein isoforms in neuronal compartments

(2018) Camilla Ciolli Mattioli et al.   NUCLEIC ACIDS RESEARCH

Precisely measured protein lifetimes in the mouse brain reveal differences across tissues and subcellular fractions

(2018) Eugenio F. Fornasiero et al.   Nature Communications

Active presynaptic ribosomes in the mammalian brain, and altered transmitter release after protein synthesis inhibition

(2018) Matthew S Scarnati et al.   eLife

The long 3′UTR mRNA of CaMKII is essential for translation-dependent plasticity of spontaneous release in Drosophila melanogaster

(2017) Elena A. Kuklin et al.   JOURNAL OF NEUROSCIENCE

Sonic Hedgehog Guides Axons via Zipcode Binding Protein 1-Mediated Local Translation

(2017) Léa Lepelletier et al.   JOURNAL OF NEUROSCIENCE

Structure-based inhibitors of tau aggregation

(2017) P. M. Seidler et al.   Nature Chemistry

RNA Docking and Local Translation Regulate Site-Specific Axon Remodeling In Vivo

(2017) Hovy Ho-Wai Wong et al.   NEURON

Activity-dependent spatially localized miRNA maturation in neuronal dendrites

(2017) Sivakumar Sambandan et al.   SCIENCE

Activity-Dependent Regulation of Alternative Cleavage and Polyadenylation During Hippocampal Long-Term Potentiation

(2017) Mariana M. Fontes et al.   Scientific Reports

miR-182 Regulates Slit2-Mediated Axon Guidance by Modulating the Local Translation of a Specific mRNA

(2017) Anaïs Bellon et al.   Cell Reports

Intra-axonal Synthesis of SNAP25 Is Required for the Formation of Presynaptic Terminals

(2017) Andreia F.R. Batista et al.   Cell Reports

Single Molecule Translation Imaging Visualizes the Dynamics of Local β-Actin Synthesis in Retinal Axons

(2017) Florian Ströhl et al.   Scientific Reports

Are aberrant phase transitions a driver of cellular aging?

(2016) Simon Alberti et al.   BIOESSAYS

Redefining the Translational Status of 80S Monosomes

(2016) Erin E. Heyer et al.   CELL

Dynamic Axonal Translation in Developing and Mature Visual Circuits

(2016) Toshiaki Shigeoka et al.   CELL

Distal Alternative Last Exons Localize mRNAs to Neural Projections

(2016) J. Matthew Taliaferro et al.   MOLECULAR CELL

The RNA-binding protein SFPQ orchestrates an RNA regulon to promote axon viability

(2016) Katharina E Cosker et al.   NATURE NEUROSCIENCE

Presynaptic Protein Synthesis Is Required for Long-Term Plasticity of GABA Release

(2016) Thomas J. Younts et al.   NEURON

Nascent Proteome Remodeling following Homeostatic Scaling at Hippocampal Synapses

(2016) Christoph T. Schanzenbächer et al.   NEURON

Translation dynamics of single mRNAs in live cells and neurons

(2016) B. Wu et al.   SCIENCE

Update: Mechanisms Underlying N 6 -Methyladenosine Modification of Eukaryotic mRNA

(2016) Yang Wang et al.   TRENDS IN GENETICS

A Dendritic Golgi Satellite between ERGIC and Retromer

(2016) Marina Mikhaylova et al.   Cell Reports

Unconventional secretory processing diversifies neuronal ion channel properties

(2016) Cyril Hanus et al.   eLife

Translating the Genome in Time and Space: Specialized Ribosomes, RNA Regulons, and RNA-Binding Proteins

(2015) Zhen Shi et al.   Annual Review of Cell and Developmental Biology

Single-Molecule Imaging of PSD-95 mRNA Translation in Dendrites and Its Dysregulation in a Mouse Model of Fragile X Syndrome

(2015) M. F. Ifrim et al.   JOURNAL OF NEUROSCIENCE

Direct visualization of newly synthesized target proteins in situ

(2015) Susanne tom Dieck et al.   NATURE METHODS

Dysregulation and restoration of translational homeostasis in fragile X syndrome

(2015) Joel D. Richter et al.   NATURE REVIEWS NEUROSCIENCE

ALS/FTD Mutation-Induced Phase Transition of FUS Liquid Droplets and Reversible Hydrogels into Irreversible Hydrogels Impairs RNP Granule Function

(2015) Tetsuro Murakami et al.   NEURON

Coupled local translation and degradation regulate growth cone collapse

(2015) Alessia Deglincerti et al.   Nature Communications

Neuron-wide RNA transport combines with netrin-mediated local translation to spatially regulate the synaptic proteome

(2015) Sangmok Kim et al.   eLife

Liquid-Liquid Phase Separation in Biology

(2014) Anthony A. Hyman et al.   Annual Review of Cell and Developmental Biology

Axonal Transport: Cargo-Specific Mechanisms of Motility and Regulation

(2014) Sandra Maday et al.   NEURON

Composition of isolated synaptic boutons reveals the amounts of vesicle trafficking proteins

(2014) B. G. Wilhelm et al.   SCIENCE

Phosphorylation of Zipcode Binding Protein 1 Is Required for Brain-Derived Neurotrophic Factor Signaling of Local  -Actin Synthesis and Growth Cone Turning

(2013) Y. Sasaki et al.   JOURNAL OF NEUROSCIENCE

Coupling of NF-protocadherin signaling to axon guidance by cue-induced translation

(2013) Louis C Leung et al.   NATURE NEUROSCIENCE

The Central Dogma Decentralized: New Perspectives on RNA Function and Local Translation in Neurons

(2013) Christine E. Holt et al.   NEURON

Metabolic Turnover of Synaptic Proteins: Kinetics, Interdependencies and Implications for Synaptic Maintenance

(2013) Laurie D. Cohen et al.   PLoS One

Local Translation of Extranuclear Lamin B Promotes Axon Maintenance

(2012) Byung C. Yoon et al.   CELL

Comprehensive Analysis of mRNA Methylation Reveals Enrichment in 3′ UTRs and near Stop Codons

(2012) Kate D. Meyer et al.   CELL

Reprogramming axonal behavior by axon-specific viral transduction

(2012) B A Walker et al.   GENE THERAPY

Nuclear translation visualized by ribosome-bound nascent chain puromycylation

(2012) Alexandre David et al.   JOURNAL OF CELL BIOLOGY

Single-molecule imaging of translational output from individual RNA granules in neurons

(2012) Vedakumar Tatavarty et al.   MOLECULAR BIOLOGY OF THE CELL

Topology of the human and mouse m6A RNA methylomes revealed by m6A-seq

(2012) Dan Dominissini et al.   NATURE

The Local Transcriptome in the Synaptic Neuropil Revealed by Deep Sequencing and High-Resolution Imaging

(2012) Iván J. Cajigas et al.   NEURON

Subcellular Knockout of Importin β1 Perturbs Axonal Retrograde Signaling

(2012) Rotem Ben-Tov Perry et al.   NEURON

Identification of a cis-acting element that localizes mRNA to synapses

(2012) E. J. Meer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Dendritic Branch Is the Preferred Integrative Unit for Protein Synthesis-Dependent LTP

(2011) Arvind Govindarajan et al.   NEURON

Transmembrane Receptor DCC Associates with Protein Synthesis Machinery and Regulates Translation

(2010) Joseph Tcherkezian et al.   CELL

Coordination of size and number of excitatory and inhibitory synapses results in a balanced structural plasticity along mature hippocampal CA1 dendrites during LTP

(2010) Jennifer N. Bourne et al.   HIPPOCAMPUS

Translational Control Mechanisms in Long-lasting Synaptic Plasticity and Memory

(2010) Christos Gkogkas et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Subcellular Profiling Reveals Distinct and Developmentally Regulated Repertoire of Growth Cone mRNAs

(2010) K. H. Zivraj et al.   JOURNAL OF NEUROSCIENCE

In situ visualization and dynamics of newly synthesized proteins in rat hippocampal neurons

(2010) Daniela C Dieterich et al.   NATURE NEUROSCIENCE

An NGF-responsive element targets myo-inositol monophosphatase-1 mRNA to sympathetic neuron axons

(2010) Catia Andreassi et al.   NATURE NEUROSCIENCE

Transcriptome analysis of embryonic and adult sensory axons reveals changes in mRNA repertoire localization

(2010) L. F. Gumy et al.   RNA

Axonal mRNA in Uninjured and Regenerating Cortical Mammalian Axons

(2009) A. M. Taylor et al.   JOURNAL OF NEUROSCIENCE

Synapse- and Stimulus-Specific Local Translation During Long-Term Neuronal Plasticity

(2009) D. O. Wang et al.   SCIENCE

A functional equivalent of endoplasmic reticulum and Golgi in axons for secretion of locally synthesized proteins

(2008) Tanuja T. Merianda et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Secretory Outposts for the Local Processing of Membrane Cargo in Neuronal Dendrites

(2008) Cyril Hanus et al.   TRAFFIC