Gasdermins and pyroptosis in the kidney

Streptococcal pyrogenic exotoxin B cleaves GSDMA and triggers pyroptosis

(2022) Wanyan Deng et al.   NATURE

Structure of the NLRP3 decamer bound to the cytokine release inhibitor CRID3

(2022) Inga V. Hochheiser et al.   NATURE

Bacterial gasdermins reveal an ancient mechanism of cell death

(2022) Alex G. Johnson et al.   SCIENCE

Epithelial Gasdermin D shapes the host-microbial interface by driving mucus layer formation

(2022) Jian Zhang et al.   Science Immunology

No longer married to inflammasome signaling: the diverse interacting pathways leading to pyroptotic cell death

(2022) Ashley Weir et al.   BIOCHEMICAL JOURNAL

Group A Streptococcus induces GSDMA-dependent pyroptosis in keratinocytes

(2022) Doris L. LaRock et al.   NATURE

Role of Pyroptosis in Inflammatory Bowel Disease (IBD): From Gasdermins to DAMPs

(2022) Shuxia Zhang et al.   Frontiers in Pharmacology

Pyroptosis in inflammation-related respiratory disease

(2022) Yuanyu Feng et al.   JOURNAL OF PHYSIOLOGY AND BIOCHEMISTRY

Single-cell analysis highlights differences in druggable pathways underlying adaptive or fibrotic kidney regeneration

(2022) Michael S. Balzer et al.   Nature Communications

Gasdermin D–mediated release of IL-33 from senescent hepatic stellate cells promotes obesity-associated hepatocellular carcinoma

(2022) Ryota Yamagishi et al.   Science Immunology

Gasdermin D-deficient mice are hypersensitive to acute kidney injury

(2022) Wulf Tonnus et al.   Cell Death & Disease

NLRP3 inflammasome: A potential therapeutic target to minimize renal ischemia/reperfusion injury during transplantation

(2022) Xiaochen Su et al.   TRANSPLANT IMMUNOLOGY

NINJ1 mediates plasma membrane rupture during lytic cell death

(2021) Nobuhiko Kayagaki et al.   NATURE

The distribution of cellular turnover in the human body

(2021) Ron Sender et al.   NATURE MEDICINE

GSDME-mediated pyroptosis promotes inflammation and fibrosis in obstructive nephropathy

(2021) Yinshuang Li et al.   CELL DEATH AND DIFFERENTIATION

Type 1 interferon aggravates lipopolysaccharide-induced sepsis through upregulating Caspase-11 and Gasdermin D

(2021) Yan Wang et al.   JOURNAL OF PHYSIOLOGY AND BIOCHEMISTRY

Channelling inflammation: gasdermins in physiology and disease

(2021) Xing Liu et al.   NATURE REVIEWS DRUG DISCOVERY

Caspase 3/GSDME-dependent pyroptosis contributes to chemotherapy drug-induced nephrotoxicity

(2021) Xiujin Shen et al.   Cell Death & Disease

Gasdermin E deficiency attenuates acute kidney injury by inhibiting pyroptosis and inflammation

(2021) Weiwei Xia et al.   Cell Death & Disease

Inhibition of NLRP3 inflammasome ameliorates podocyte damage by suppressing lipid accumulation in diabetic nephropathy

(2021) Ming Wu et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Gasdermin E permits interleukin-1 beta release in distinct sublytic and pyroptotic phases

(2021) Bowen Zhou et al.   Cell Reports

VX‐765 ameliorates renal injury and fibrosis in diabetes by regulating caspase‐1‐mediated pyroptosis and inflammation

(2021) Si Wen et al.   Journal of Diabetes Investigation

Gasdermin-E-mediated pyroptosis participates in the pathogenesis of Crohn’s disease by promoting intestinal inflammation

(2021) Gao Tan et al.   Cell Reports

Gasdermin D and Beyond – Gasdermin-mediated Pyroptosis in Bacterial Infections

(2021) Lee M. Booty et al.   JOURNAL OF MOLECULAR BIOLOGY

Molecular mechanisms and functions of pyroptosis in inflammation and antitumor immunity

(2021) Junwei Hou et al.   MOLECULAR CELL

Dying cells fan the flames of inflammation

(2021) Kim Newton et al.   SCIENCE

Structural Mechanism for GSDMD Targeting by Autoprocessed Caspases in Pyroptosis

(2020) Kun Wang et al.   CELL

Gasdermin E–mediated target cell pyroptosis by CAR T cells triggers cytokine release syndrome

(2020) Yuying Liu et al.   Science Immunology

RIPK3 collaborates with GSDMD to drive tissue injury in lethal polymicrobial sepsis

(2020) Hui Chen et al.   CELL DEATH AND DIFFERENTIATION

Gasdermin E suppresses tumour growth by activating anti-tumour immunity

(2020) Zhibin Zhang et al.   NATURE

FDA-approved disulfiram inhibits pyroptosis by blocking gasdermin D pore formation

(2020) Jun Jacob Hu et al.   NATURE IMMUNOLOGY

Granzyme A from cytotoxic lymphocytes cleaves GSDMB to trigger pyroptosis in target cells

(2020) Zhiwei Zhou et al.   SCIENCE

N-GSDMD trafficking to neutrophil organelles facilitates IL-1β release independently of plasma membrane pores and pyroptosis

(2020) Mausita Karmakar et al.   Nature Communications

Caspase-1 Engages Full-Length Gasdermin D through Two Distinct Interfaces That Mediate Caspase Recruitment and Substrate Cleavage

(2020) Zhonghua Liu et al.   IMMUNITY

Genetic analyses identify GSDMB associated with asthma severity, exacerbations, and antiviral pathways

(2020) Xingnan Li et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Extended subsite profiling of the pyroptosis effector protein gasdermin D reveals a region recognized by inflammatory caspase-11

(2020) Betsaida Bibo-Verdugo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cell profiling of mouse acute kidney injury reveals conserved cellular responses to injury

(2020) Yuhei Kirita et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The NLRP3 inhibitor Mcc950 attenuates acute allograft damage in rat kidney transplants

(2020) Xun-feng Zou et al.   TRANSPLANT IMMUNOLOGY

PD-L1-mediated gasdermin C expression switches apoptosis to pyroptosis in cancer cells and facilitates tumour necrosis

(2020) Junwei Hou et al.   NATURE CELL BIOLOGY

Phase 3 Trial of Interleukin-1 Trap Rilonacept in Recurrent Pericarditis

(2020) Allan L. Klein et al.   NEW ENGLAND JOURNAL OF MEDICINE

Extrinsic and intrinsic apoptosis activate pannexin‐1 to drive NLRP3 inflammasome assembly

(2019) Kaiwen W Chen et al.   EMBO JOURNAL

Crystal Structures of the Full-Length Murine and Human Gasdermin D Reveal Mechanisms of Autoinhibition, Lipid Binding, and Oligomerization

(2019) Zhonghua Liu et al.   IMMUNITY

The cleavage of gasdermin D by caspase-11 promotes tubular epithelial cell pyroptosis and urinary IL-18 excretion in acute kidney injury

(2019) Naijun Miao et al.   KIDNEY INTERNATIONAL

Pejvakin-mediated pexophagy protects auditory hair cells against noise-induced damage

(2019) Jean Defourny et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

IRF2 transcriptionally induces GSDMD expression for pyroptosis

(2019) Nobuhiko Kayagaki et al.   Science Signaling

Gasdermin pores permeabilize mitochondria to augment caspase-3 activation during apoptosis and inflammasome activation

(2019) Corey Rogers et al.   Nature Communications

Cathepsin G Inhibition by Serpinb1 and Serpinb6 Prevents Programmed Necrosis in Neutrophils and Monocytes and Reduces GSDMD-Driven Inflammation

(2019) Sabrina Sofia Burgener et al.   Cell Reports

Acute kidney injury

(2019) Claudio Ronco et al.   LANCET

Mechanism of membrane pore formation by human gasdermin‐D

(2018) Estefania Mulvihill et al.   EMBO JOURNAL

The Gasdermin-D pore acts as a conduit for IL-1β secretion in mice

(2018) Rosalie Heilig et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

The Pore-Forming Protein Gasdermin D Regulates Interleukin-1 Secretion from Living Macrophages

(2018) Charles L. Evavold et al.   IMMUNITY

Effectiveness and safety of anakinra in gout patients with stage 4–5 chronic kidney disease or kidney transplantation: A multicentre, retrospective study

(2018) Clotilde Loustau et al.   JOINT BONE SPINE

Extensive peptide and natural protein substrate screens reveal that mouse caspase-11 has much narrower substrate specificity than caspase-1

(2018) Monica L. Gonzalez Ramirez et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Renal immune surveillance and dipeptidase-1 contribute to contrast-induced acute kidney injury

(2018) Arthur Lau et al.   JOURNAL OF CLINICAL INVESTIGATION

Inhibition of Interleukin-1β by Canakinumab and Cardiovascular Outcomes in Patients With Chronic Kidney Disease

(2018) Paul M Ridker et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Macrophage Uptake of Necrotic Cell DNA Activates the AIM2 Inflammasome to Regulate a Proinflammatory Phenotype in CKD

(2018) Takanori Komada et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Targeting the NLRP3 inflammasome in inflammatory diseases

(2018) Matthew S. J. Mangan et al.   NATURE REVIEWS DRUG DISCOVERY

Caspase-1 inhibition prevents glial inflammasome activation and pyroptosis in models of multiple sclerosis

(2018) Brienne A. McKenzie et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Further evidence for “gain-of-function” mechanism of DFNA5 related hearing loss

(2018) Hongyang Wang et al.   Scientific Reports

Gasdermin D Exerts Anti-inflammatory Effects by Promoting Neutrophil Death

(2018) Hiroto Kambara et al.   Cell Reports

Cryo-EM structure of the gasdermin A3 membrane pore

(2018) Jianbin Ruan et al.   NATURE

Caspase-11-mediated tubular epithelial pyroptosis underlies contrast-induced acute kidney injury

(2018) Zhen Zhang et al.   Cell Death & Disease

Pharmacological inhibition of the NLRP3 inflammasome reduces blood pressure, renal damage, and dysfunction in salt-sensitive hypertension

(2018) Shalini M Krishnan et al.   CARDIOVASCULAR RESEARCH

Comparative Analysis and Refinement of Human PSC-Derived Kidney Organoid Differentiation with Single-Cell Transcriptomics

(2018) Haojia Wu et al.   Cell Stem Cell

Advantages of Single-Nucleus over Single-Cell RNA Sequencing of Adult Kidney: Rare Cell Types and Novel Cell States Revealed in Fibrosis

(2018) Haojia Wu et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Caspase-8 induces cleavage of gasdermin D to elicit pyroptosis during Yersinia infection

(2018) Joseph Sarhan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Pathogen blockade of TAK1 triggers caspase-8–dependent cleavage of gasdermin D and cell death

(2018) Pontus Orning et al.   SCIENCE

ESCRT-dependent membrane repair negatively regulates pyroptosis downstream of GSDMD activation

(2018) Sebastian Rühl et al.   SCIENCE

Shiga Toxin/Lipopolysaccharide Activates Caspase-4 and Gasdermin D to Trigger Mitochondrial Reactive Oxygen Species Upstream of the NLRP3 Inflammasome

(2018) Jaye M. Platnich et al.   Cell Reports

Identification of a selective and direct NLRP3 inhibitor to treat inflammatory disorders

(2017) Hua Jiang et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Chronic Kidney Disease

(2017) Angela C Webster et al.   LANCET

Chemotherapy drugs induce pyroptosis through caspase-3 cleavage of a gasdermin

(2017) Yupeng Wang et al.   NATURE

Transgenic expression of human APOL1 risk variants in podocytes induces kidney disease in mice

(2017) Pazit Beckerman et al.   NATURE MEDICINE

Anakinra reduces blood pressure and renal fibrosis in one kidney/DOCA/salt-induced hypertension

(2017) Yeong Hann Ling et al.   PHARMACOLOGICAL RESEARCH

Autoimmune disease variants regulateGSDMBgene expression in human immune cells and whole blood

(2017) Yang Hu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Gene polymorphism linked to increased asthma and IBD risk alters gasdermin-B structure, a sulfatide and phosphoinositide binding protein

(2017) Kinlin L. Chao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cleavage of DFNA5 by caspase-3 during apoptosis mediates progression to secondary necrotic/pyroptotic cell death

(2017) Corey Rogers et al.   Nature Communications

Infiltration of M1, but not M2, macrophages is impaired after unilateral ureter obstruction in Nrf2-deficient mice

(2017) Yuji Sogawa et al.   Scientific Reports

Inflammasome Complexes: Emerging Mechanisms and Effector Functions

(2016) Vijay A.K. Rathinam et al.   CELL

NLRP3 regulates a non-canonical platform for caspase-8 activation during epithelial cell apoptosis

(2016) H Chung et al.   CELL DEATH AND DIFFERENTIATION

Pyroptosis is driven by non-selective gasdermin-D pore and its morphology is different from MLKL channel-mediated necroptosis

(2016) Xin Chen et al.   CELL RESEARCH

GSDMD membrane pore formation constitutes the mechanism of pyroptotic cell death

(2016) Lorenzo Sborgi et al.   EMBO JOURNAL

An NLRP3-specific inflammasome inhibitor attenuates crystal-induced kidney fibrosis in mice

(2016) Isis Ludwig-Portugall et al.   KIDNEY INTERNATIONAL

Pore-forming activity and structural autoinhibition of the gasdermin family

(2016) Jingjin Ding et al.   NATURE

Inflammasome-activated gasdermin D causes pyroptosis by forming membrane pores

(2016) Xing Liu et al.   NATURE

GsdmD p30 elicited by caspase-11 during pyroptosis forms pores in membranes

(2016) Robin A. Aglietti et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

GSDMB induces an asthma phenotype characterized by increased airway responsiveness and remodeling without lung inflammation

(2016) Sudipta Das et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

An endogenous caspase-11 ligand elicits interleukin-1 release from living dendritic cells

(2016) Ivan Zanoni et al.   SCIENCE

Gasdermin C Is Upregulated by Inactivation of Transforming Growth Factor β Receptor Type II in the Presence of Mutated Apc, Promoting Colorectal Cancer Proliferation

(2016) Masashi Miguchi et al.   PLoS One

Hypervulnerability to Sound Exposure through Impaired Adaptive Proliferation of Peroxisomes

(2015) Sedigheh Delmaghani et al.   CELL

BAY 11-7082 ameliorates diabetic nephropathy by attenuating hyperglycemia-mediated oxidative stress and renal inflammation via NF-κB pathway

(2015) Sambasiva Rao Kolati et al.   ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY

Caspase-11 activates a canonical NLRP3 inflammasome by promoting K+efflux

(2015) Sebastian Rühl et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Caspase-11 cleaves gasdermin D for non-canonical inflammasome signalling

(2015) Nobuhiko Kayagaki et al.   NATURE

Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death

(2015) Jianjin Shi et al.   NATURE

Phagocytosis of apoptotic cells in homeostasis

(2015) Sanja Arandjelovic et al.   NATURE IMMUNOLOGY

A small-molecule inhibitor of the NLRP3 inflammasome for the treatment of inflammatory diseases

(2015) Rebecca C Coll et al.   NATURE MEDICINE

Innate immunity in diabetes and diabetic nephropathy

(2015) Jun Wada et al.   Nature Reviews Nephrology

Genetic Polymorphisms in Inflammasome-Dependent Innate Immunity among Pediatric Patients with Severe Renal Parenchymal Infections

(2015) Chi-Hui Cheng et al.   PLoS One

The inflammasome and lupus

(2014) J. Michelle Kahlenberg et al.   CURRENT OPINION IN RHEUMATOLOGY

Acute Kidney Injury and Chronic Kidney Disease as Interconnected Syndromes

(2014) Lakhmir S. Chawla et al.   NEW ENGLAND JOURNAL OF MEDICINE

AIM2 and NLRP3 inflammasomes activate both apoptotic and pyroptotic death pathways via ASC

(2013) V Sagulenko et al.   CELL DEATH AND DIFFERENTIATION

Bay11-7082 attenuates murine lupus nephritis via inhibiting NLRP3 inflammasome and NF-κB activation

(2013) Jijun Zhao et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Proapoptotic Chemotherapeutic Drugs Induce Noncanonical Processing and Release of IL-1  via Caspase-8 in Dendritic Cells

(2013) C. Antonopoulos et al.   JOURNAL OF IMMUNOLOGY

Noncanonical Inflammasome Activation by Intracellular LPS Independent of TLR4

(2013) N. Kayagaki et al.   SCIENCE

Mixed Lineage Kinase Domain-like Protein Mediates Necrosis Signaling Downstream of RIP3 Kinase

(2012) Liming Sun et al.   CELL

AIM2/ASC triggers caspase-8-dependent apoptosis in Francisella-infected caspase-1-deficient macrophages

(2012) R Pierini et al.   CELL DEATH AND DIFFERENTIATION

Calcium oxalate crystals induce renal inflammation by NLRP3-mediated IL-1β secretion

(2012) Shrikant R. Mulay et al.   JOURNAL OF CLINICAL INVESTIGATION

Cutting Edge: FAS (CD95) Mediates Noncanonical IL-1  and IL-18 Maturation via Caspase-8 in an RIP3-Independent Manner

(2012) L. Bossaller et al.   JOURNAL OF IMMUNOLOGY

Dectin-1 is an extracellular pathogen sensor for the induction and processing of IL-1β via a noncanonical caspase-8 inflammasome

(2012) Sonja I Gringhuis et al.   NATURE IMMUNOLOGY

Treating inflammation by blocking interleukin-1 in a broad spectrum of diseases

(2012) Charles A. Dinarello et al.   NATURE REVIEWS DRUG DISCOVERY

Programmed Cell Death in Animal Development and Disease

(2011) Yaron Fuchs et al.   CELL

Non-canonical inflammasome activation targets caspase-11

(2011) Nobuhiko Kayagaki et al.   NATURE

Secondary necrosis: The natural outcome of the complete apoptotic program

(2010) Manuel T. Silva   FEBS LETTERS

Anti-inflammatory Compounds Parthenolide and Bay 11-7082 Are Direct Inhibitors of the Inflammasome

(2010) Christine Juliana et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The NLRP3 Inflammasome Promotes Renal Inflammation and Contributes to CKD

(2010) A. Vilaysane et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Caspase-1-induced pyroptosis is an innate immune effector mechanism against intracellular bacteria

(2010) Edward A Miao et al.   NATURE IMMUNOLOGY

Necrotic cells trigger a sterile inflammatory response through the Nlrp3 inflammasome

(2009) S. S. Iyer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Methylation of the DFNA5 increases risk of lymph node metastasis in human breast cancer

(2008) Myoung Sook Kim et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Distinctive expression and function of fourGSDMfamily genes (GSDMA-D) in normal and malignant upper gastrointestinal epithelium

(2008) Norihisa Saeki et al.   GENES CHROMOSOMES & CANCER

Stimulation of Toll-like receptor 3 and 4 induces interleukin-1β maturation by caspase-8

(2008) Jonathan Maelfait et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Aberrant promoter methylation and tumor suppressive activity of the DFNA5 gene in colorectal carcinoma

(2008) M S Kim et al.   ONCOGENE

Differential expression and localisation of gasdermin-like (GSDML), a novel member of the cancer-associated GSDMDC protein family, in neoplastic and non-neoplastic gastric, hepatic, and colon tissues

(2007) Stacy Carl-McGrath et al.   PATHOLOGY