Caspase-11-mediated tubular epithelial pyroptosis underlies contrast-induced acute kidney injury

The Gasdermin-D pore acts as a conduit for IL-1β secretion in mice

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Roles of Caspases in Necrotic Cell Death

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Pyroptosis

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GSDMD membrane pore formation constitutes the mechanism of pyroptotic cell death

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Pyroptosis triggers pore-induced intracellular traps (PITs) that capture bacteria and lead to their clearance by efferocytosis

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Contrast-Induced Acute Kidney Injury

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GsdmD p30 elicited by caspase-11 during pyroptosis forms pores in membranes

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An endogenous caspase-11 ligand elicits interleukin-1 release from living dendritic cells

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Programmed necrosis in inflammation: Toward identification of the effector molecules

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Canonical Inflammasomes Drive IFN-γ to Prime Caspase-11 in Defense against a Cytosol-Invasive Bacterium

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Pyroptosis: Caspase-11 Unlocks the Gates of Death

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Inflammasomes Coordinate Pyroptosis and Natural Killer Cell Cytotoxicity to Clear Infection by a Ubiquitous Environmental Bacterium

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Caspase target drives pyroptosis

(2015) Petr Broz   NATURE

Caspase-11 cleaves gasdermin D for non-canonical inflammasome signalling

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Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death

(2015) Jianjin Shi et al.   NATURE

Regulated Cell Death in AKI

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Inflammatory caspases are innate immune receptors for intracellular LPS

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Canonical and non-canonical effects of the NLRP3 inflammasome in kidney inflammation and fibrosis

(2013) Georg Lorenz et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

Activating Nrf-2 Signaling Depresses Unilateral Ureteral Obstruction-Evoked Mitochondrial Stress-Related Autophagy, Apoptosis and Pyroptosis in Kidney

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Section 4: Contrast-induced AKI

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The Inflammasomes in Kidney Disease

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Non-canonical inflammasome activation targets caspase-11

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Anti-GBM Glomerulonephritis Involves IL-1 but Is Independent of NLRP3/ASC Inflammasome-Mediated Activation of Caspase-1

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Toll-Like Receptors and Danger Signaling in Kidney Injury

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Radiocontrast-Induced Acute Kidney Injury

(2008) Peter A. McCullough   NEPHRON PHYSIOLOGY