Caspase-1 Engages Full-Length Gasdermin D through Two Distinct Interfaces That Mediate Caspase Recruitment and Substrate Cleavage

Title
Caspase-1 Engages Full-Length Gasdermin D through Two Distinct Interfaces That Mediate Caspase Recruitment and Substrate Cleavage
Authors
Keywords
gasdermin D, inflammatory caspases, pyroptosis, inflammasome, crystal structure, active site, exosite, dual site engagement
Journal
IMMUNITY
Volume 53, Issue 1, Pages 106-114.e5
Publisher
Elsevier BV
Online
2020-06-17
DOI
10.1016/j.immuni.2020.06.007

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