Synthesis and structure–activity relationships of pyrazole-based inhibitors of meprin α and β

Helical ultrastructure of the metalloprotease meprin α in complex with a small molecule inhibitor

(2022) Charles Bayly-Jones et al.   Nature Communications

Discovery and Optimization of Selective Inhibitors of Meprin α (Part II)

(2021) Chao Wang et al.   Pharmaceuticals

Discovery and Optimization of Selective Inhibitors of Meprin α (Part I)

(2021) Shurong Hou et al.   Pharmaceuticals

Structure and Dynamics of Meprin β in Complex with a Hydroxamate-Based Inhibitor

(2021) Miriam Linnert et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Hydroxamic Acid Derivatives: From Synthetic Strategies to Medicinal Chemistry Applications

(2021) Andrea Citarella et al.   ACS Omega

Identification of Mep1a as a susceptibility gene for atherosclerosis in mice

(2021) Andrew T. Grainger et al.   GENETICS

Characterization of the Cancer-Associated Meprin Βeta Variants G45R and G89R

(2021) Antonin Gellrich et al.   Frontiers in Molecular Biosciences

Mep1A enhances TNF‐alpha secretion by mast cells and aggravates abdominal aortic aneurysms

(2020) Ran Gao et al.   BRITISH JOURNAL OF PHARMACOLOGY

Meprin β cleaves TREM2 and controls its phagocytic activity on macrophages

(2020) Dennis Kristopher Berner et al.   FASEB JOURNAL

Heteroaromatic Inhibitors of the Astacin Proteinases Meprin α, Meprin β and Ovastacin Discovered by a Scaffold‐Hopping Approach

(2020) Kathrin Tan et al.   ChemMedChem

Mep1a contributes to Ang II-induced cardiac remodeling by promoting cardiac hypertrophy, fibrosis and inflammation

(2020) Weipeng Ge et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Tethering soluble meprin α in an enzyme complex to the cell surface affects IBD-associated genes

(2019) Florian Peters et al.   FASEB JOURNAL

Regulation of the alternative β-secretase meprin β by ADAM-mediated shedding

(2019) Franka Scharfenberg et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Tertiary-Amine-Based Inhibitors of the Astacin Protease Meprin α

(2018) Kathrin Tan et al.   ChemMedChem

Structure-Guided Design, Synthesis, and Characterization of Next-Generation Meprin β Inhibitors

(2018) Daniel Ramsbeck et al.   JOURNAL OF MEDICINAL CHEMISTRY

Role of meprin metalloproteinases in cytokine processing and inflammation

(2018) Christian Herzog et al.   CYTOKINE

Synthesis and characterization of two new hydroxamic acids derivatives and their metal complexes. An investigation on the keto/enol, E/Z and hydroxamate/hydroximate forms

(2017) Ekrem Adiguzel et al.   JOURNAL OF MOLECULAR STRUCTURE

Strength and Character of R–X···π Interactions Involving Aromatic Amino Acid Sidechains in Protein-Ligand Complexes Derived from Crystal Structures in the Protein Data Bank

(2017) Kevin Riley et al.   Crystals

Meprin β contributes to collagen deposition in lung fibrosis

(2017) V. Biasin et al.   Scientific Reports

Metalloproteases meprin-ɑ (MEP1A) is a prognostic biomarker and promotes proliferation and invasion of colorectal cancer

(2016) Xiao Wang et al.   BMC CANCER

MEP1A contributes to tumor progression and predicts poor clinical outcome in human hepatocellular carcinoma

(2016) Han-Yue OuYang et al.   HEPATOLOGY

Generation of aggregation prone N-terminally truncated amyloid β peptides by meprin β depends on the sequence specificity at the cleavage site

(2016) Caroline Schönherr et al.   Molecular Neurodegeneration

Metalloproteinase meprin α regulates migration and invasion of human hepatocarcinoma cells and is a mediator of the oncoprotein Reptin

(2016) Osman Breig et al.   Oncotarget

Meprin α and meprin β: Procollagen proteinases in health and disease

(2015) Johannes Prox et al.   MATRIX BIOLOGY

Expression, purification and initial characterization of human meprin β from Pichia pastoris

(2015) D. Schlenzig et al.   PROTEIN EXPRESSION AND PURIFICATION

Basement membrane protein nidogen-1 is a target of meprin β in cisplatin nephrotoxicity

(2015) Christian Herzog et al.   TOXICOLOGY LETTERS

Development of high throughput screening assays and pilot screen for inhibitors of metalloproteases meprin α and β

(2014) Franck Madoux et al.   BIOPOLYMERS

Is there new hope for therapeutic matrix metalloproteinase inhibition?

(2014) Roosmarijn E. Vandenbroucke et al.   NATURE REVIEWS DRUG DISCOVERY

The metalloproteases meprin α and meprin β: unique enzymes in inflammation, neurodegeneration, cancer and fibrosis

(2013) Claudia Broder et al.   BIOCHEMICAL JOURNAL

Meprinβ, a novel mediator of vascular remodelling underlying pulmonary hypertension

(2013) Valentina Biasin et al.   JOURNAL OF PATHOLOGY

Metalloproteases meprin   and meprin   are C- and N-procollagen proteinases important for collagen assembly and tensile strength

(2013) C. Broder et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Missing the target: matrix metalloproteinase antitargets in inflammation and cancer

(2013) Antoine Dufour et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Functional and structural insights into astacin metallopeptidases

(2012) F. Xavier Gomis-Rüth et al.   BIOLOGICAL CHEMISTRY

Meprinα Transactivates the Epidermal Growth Factor Receptor (EGFR) via Ligand Shedding, thereby Enhancing Colorectal Cancer Cell Proliferation and Migration

(2012) Petra Minder et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Metalloprotease Meprin β Generates Amino Terminal-truncated Amyloid β Peptide Species

(2012) Jessica Bien et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Proteomic Analyses Reveal an Acidic Prime Side Specificity for the Astacin Metalloprotease Family Reflected by Physiological Substrates

(2011) Christoph Becker-Pauly et al.   MOLECULAR & CELLULAR PROTEOMICS

Enhanced Activity of Meprin-α, a Pro-Migratory and Pro-Angiogenic Protease, in Colorectal Cancer

(2011) Daniel Lottaz et al.   PLoS One

Balance of meprin A and B in mice affects the progression of experimental inflammatory bowel disease

(2010) Sanjita Banerjee et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Emerging principles in protease-based drug discovery

(2010) Marcin Drag et al.   NATURE REVIEWS DRUG DISCOVERY

Prointerleukin-18 Is Activated by Meprin βin Vitroandin Vivoin Intestinal Inflammation

(2008) Sanjita Banerjee et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Meprins, membrane-bound and secreted astacin metalloproteinases

(2008) E STERCHI et al.   MOLECULAR ASPECTS OF MEDICINE