Characterization of the Cancer-Associated Meprin Βeta Variants G45R and G89R

Phosphorylation of meprin β controls its cell surface abundance and subsequently diminishes ectodomain shedding

(2021) Fred Armbrust et al.   FASEB JOURNAL

Tethering soluble meprin α in an enzyme complex to the cell surface affects IBD-associated genes

(2019) Florian Peters et al.   FASEB JOURNAL

The cancer associated meprin β variant p.G32R provides an additional activation site and promotes cancer cell invasion

(2019) Henning Schäffler et al.   JOURNAL OF CELL SCIENCE

Regulation of the alternative β-secretase meprin β by ADAM-mediated shedding

(2019) Franka Scharfenberg et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Differences in Shedding of the Interleukin-11 Receptor by the Proteases ADAM9, ADAM10, ADAM17, Meprin α, Meprin β and MT1-MMP

(2019) Sammel et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Role of meprin metalloproteases in metastasis and tumor microenvironment

(2019) Florian Peters et al.   CANCER AND METASTASIS REVIEWS

ADAM17 Activity and IL-6 Trans-Signaling in Inflammation and Cancer

(2019) Schumacher et al.   Cancers

ADAM17 is required for EGF-R–induced intestinal tumors via IL-6 trans-signaling

(2018) Stefanie Schmidt et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Matrix Metalloproteinase Inhibitors in Cancer Therapy: Turning Past Failures Into Future Successes

(2018) Arthur Winer et al.   MOLECULAR CANCER THERAPEUTICS

SWISS-MODEL: homology modelling of protein structures and complexes

(2018) Andrew Waterhouse et al.   NUCLEIC ACIDS RESEARCH

CD99: A Cell Surface Protein with an Oncojanus Role in Tumors

(2018) et al.   Genes

CD99 at the crossroads of physiology and pathology

(2018) Michela Pasello et al.   Journal of Cell Communication and Signaling

Ectodomain shedding of CD99 within highly conserved regions is mediated by the metalloprotease meprin β and promotes transendothelial cell migration

(2017) Tillmann Bedau et al.   FASEB JOURNAL

BioMuta and BioXpress: mutation and expression knowledgebases for cancer biomarker discovery

(2017) Hayley M Dingerdissen et al.   NUCLEIC ACIDS RESEARCH

Cancer-associated mutations in the canonical cleavage site do not influence CD99 shedding by the metalloprotease meprin β but alter cell migration in vitro

(2017) Tillmann Bedau et al.   Oncotarget

Mucus Detachment by Host Metalloprotease Meprin β Requires Shedding of Its Inactive Pro-form, which Is Abrogated by the Pathogenic Protease RgpB

(2017) Rielana Wichert et al.   Cell Reports

Meprin Metalloproteases Generate Biologically Active Soluble Interleukin-6 Receptor to Induce Trans-Signaling

(2017) Philipp Arnold et al.   Scientific Reports

Generation of aggregation prone N-terminally truncated amyloid β peptides by meprin β depends on the sequence specificity at the cleavage site

(2016) Caroline Schönherr et al.   Molecular Neurodegeneration

Cleavage Site Localization Differentially Controls Interleukin-6 Receptor Proteolysis by ADAM10 and ADAM17

(2016) Steffen Riethmueller et al.   Scientific Reports

Metalloprotease meprin β is activated by transmembrane serine protease matriptase-2 at the cell surface thereby enhancing APP shedding

(2015) Felix Jäckle et al.   BIOCHEMICAL JOURNAL

Calcium negatively regulates meprin β activity and attenuates substrate cleavage

(2015) Philipp Arnold et al.   FASEB JOURNAL

The two faces of IL-6 in the tumor microenvironment

(2014) Daniel T. Fisher et al.   SEMINARS IN IMMUNOLOGY

Overexpression of Membrane Proteins in Primary and Metastatic Gastrointestinal Neuroendocrine Tumors

(2013) Jennifer C. Carr et al.   ANNALS OF SURGICAL ONCOLOGY

The metalloproteases meprin α and meprin β: unique enzymes in inflammation, neurodegeneration, cancer and fibrosis

(2013) Claudia Broder et al.   BIOCHEMICAL JOURNAL

Meprinβ, a novel mediator of vascular remodelling underlying pulmonary hypertension

(2013) Valentina Biasin et al.   JOURNAL OF PATHOLOGY

Metalloproteases meprin   and meprin   are C- and N-procollagen proteinases important for collagen assembly and tensile strength

(2013) C. Broder et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The substrate degradome of meprin metalloproteases reveals an unexpected proteolytic link between meprin β and ADAM10

(2012) Tamara Jefferson et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

IL-6 Trans-Signaling via the Soluble IL-6 Receptor: Importance for the Pro-Inflammatory Activities of IL-6

(2012) Stefan Rose-John   International Journal of Biological Sciences

Structural basis for the sheddase function of human meprin   metalloproteinase at the plasma membrane

(2012) J. L. Arolas et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Analyzing the protease web in skin: meprin metalloproteases are activated specifically by KLK4, 5 and 8 vice versa leading to processing of proKLK7 thereby triggering its activation

(2010) Anke Ohler et al.   BIOLOGICAL CHEMISTRY

Processing of Procollagen III by Meprins: New Players in Extracellular Matrix Assembly?

(2010) Daniel Kronenberg et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

The Metalloprotease Meprinβ Processes E-Cadherin and Weakens Intercellular Adhesion

(2008) Maya Huguenin et al.   PLoS One