Synthesis and structure–activity relationships of pyrazole-based inhibitors of meprin α and β
出版年份 2023 全文链接
标题
Synthesis and structure–activity relationships of pyrazole-based inhibitors of meprin α and β
作者
关键词
-
出版物
JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY
Volume 38, Issue 1, Pages -
出版商
Informa UK Limited
发表日期
2023-01-20
DOI
10.1080/14756366.2023.2165648
参考文献
相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。- Helical ultrastructure of the metalloprotease meprin α in complex with a small molecule inhibitor
- (2022) Charles Bayly-Jones et al. Nature Communications
- Discovery and Optimization of Selective Inhibitors of Meprin α (Part II)
- (2021) Chao Wang et al. Pharmaceuticals
- Discovery and Optimization of Selective Inhibitors of Meprin α (Part I)
- (2021) Shurong Hou et al. Pharmaceuticals
- Structure and Dynamics of Meprin β in Complex with a Hydroxamate-Based Inhibitor
- (2021) Miriam Linnert et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Hydroxamic Acid Derivatives: From Synthetic Strategies to Medicinal Chemistry Applications
- (2021) Andrea Citarella et al. ACS Omega
- Identification of Mep1a as a susceptibility gene for atherosclerosis in mice
- (2021) Andrew T. Grainger et al. GENETICS
- Characterization of the Cancer-Associated Meprin Βeta Variants G45R and G89R
- (2021) Antonin Gellrich et al. Frontiers in Molecular Biosciences
- Mep1A enhances TNF‐alpha secretion by mast cells and aggravates abdominal aortic aneurysms
- (2020) Ran Gao et al. BRITISH JOURNAL OF PHARMACOLOGY
- Meprin β cleaves TREM2 and controls its phagocytic activity on macrophages
- (2020) Dennis Kristopher Berner et al. FASEB JOURNAL
- Heteroaromatic Inhibitors of the Astacin Proteinases Meprin α, Meprin β and Ovastacin Discovered by a Scaffold‐Hopping Approach
- (2020) Kathrin Tan et al. ChemMedChem
- Mep1a contributes to Ang II-induced cardiac remodeling by promoting cardiac hypertrophy, fibrosis and inflammation
- (2020) Weipeng Ge et al. JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
- Tethering soluble meprin α in an enzyme complex to the cell surface affects IBD-associated genes
- (2019) Florian Peters et al. FASEB JOURNAL
- Regulation of the alternative β-secretase meprin β by ADAM-mediated shedding
- (2019) Franka Scharfenberg et al. CELLULAR AND MOLECULAR LIFE SCIENCES
- Tertiary-Amine-Based Inhibitors of the Astacin Protease Meprin α
- (2018) Kathrin Tan et al. ChemMedChem
- Structure-Guided Design, Synthesis, and Characterization of Next-Generation Meprin β Inhibitors
- (2018) Daniel Ramsbeck et al. JOURNAL OF MEDICINAL CHEMISTRY
- Role of meprin metalloproteinases in cytokine processing and inflammation
- (2018) Christian Herzog et al. CYTOKINE
- Synthesis and characterization of two new hydroxamic acids derivatives and their metal complexes. An investigation on the keto/enol, E/Z and hydroxamate/hydroximate forms
- (2017) Ekrem Adiguzel et al. JOURNAL OF MOLECULAR STRUCTURE
- Strength and Character of R–X···π Interactions Involving Aromatic Amino Acid Sidechains in Protein-Ligand Complexes Derived from Crystal Structures in the Protein Data Bank
- (2017) Kevin Riley et al. Crystals
- Meprin β contributes to collagen deposition in lung fibrosis
- (2017) V. Biasin et al. Scientific Reports
- Metalloproteases meprin-ɑ (MEP1A) is a prognostic biomarker and promotes proliferation and invasion of colorectal cancer
- (2016) Xiao Wang et al. BMC CANCER
- MEP1A contributes to tumor progression and predicts poor clinical outcome in human hepatocellular carcinoma
- (2016) Han-Yue OuYang et al. HEPATOLOGY
- Generation of aggregation prone N-terminally truncated amyloid β peptides by meprin β depends on the sequence specificity at the cleavage site
- (2016) Caroline Schönherr et al. Molecular Neurodegeneration
- Metalloproteinase meprin α regulates migration and invasion of human hepatocarcinoma cells and is a mediator of the oncoprotein Reptin
- (2016) Osman Breig et al. Oncotarget
- Meprin α and meprin β: Procollagen proteinases in health and disease
- (2015) Johannes Prox et al. MATRIX BIOLOGY
- Expression, purification and initial characterization of human meprin β from Pichia pastoris
- (2015) D. Schlenzig et al. PROTEIN EXPRESSION AND PURIFICATION
- Basement membrane protein nidogen-1 is a target of meprin β in cisplatin nephrotoxicity
- (2015) Christian Herzog et al. TOXICOLOGY LETTERS
- Development of high throughput screening assays and pilot screen for inhibitors of metalloproteases meprin α and β
- (2014) Franck Madoux et al. BIOPOLYMERS
- Is there new hope for therapeutic matrix metalloproteinase inhibition?
- (2014) Roosmarijn E. Vandenbroucke et al. NATURE REVIEWS DRUG DISCOVERY
- The metalloproteases meprin α and meprin β: unique enzymes in inflammation, neurodegeneration, cancer and fibrosis
- (2013) Claudia Broder et al. BIOCHEMICAL JOURNAL
- Meprinβ, a novel mediator of vascular remodelling underlying pulmonary hypertension
- (2013) Valentina Biasin et al. JOURNAL OF PATHOLOGY
- Metalloproteases meprin and meprin are C- and N-procollagen proteinases important for collagen assembly and tensile strength
- (2013) C. Broder et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Missing the target: matrix metalloproteinase antitargets in inflammation and cancer
- (2013) Antoine Dufour et al. TRENDS IN PHARMACOLOGICAL SCIENCES
- Functional and structural insights into astacin metallopeptidases
- (2012) F. Xavier Gomis-Rüth et al. BIOLOGICAL CHEMISTRY
- Meprinα Transactivates the Epidermal Growth Factor Receptor (EGFR) via Ligand Shedding, thereby Enhancing Colorectal Cancer Cell Proliferation and Migration
- (2012) Petra Minder et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- The Metalloprotease Meprin β Generates Amino Terminal-truncated Amyloid β Peptide Species
- (2012) Jessica Bien et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Proteomic Analyses Reveal an Acidic Prime Side Specificity for the Astacin Metalloprotease Family Reflected by Physiological Substrates
- (2011) Christoph Becker-Pauly et al. MOLECULAR & CELLULAR PROTEOMICS
- Enhanced Activity of Meprin-α, a Pro-Migratory and Pro-Angiogenic Protease, in Colorectal Cancer
- (2011) Daniel Lottaz et al. PLoS One
- Balance of meprin A and B in mice affects the progression of experimental inflammatory bowel disease
- (2010) Sanjita Banerjee et al. AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY
- Emerging principles in protease-based drug discovery
- (2010) Marcin Drag et al. NATURE REVIEWS DRUG DISCOVERY
- Prointerleukin-18 Is Activated by Meprin βin Vitroandin Vivoin Intestinal Inflammation
- (2008) Sanjita Banerjee et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Meprins, membrane-bound and secreted astacin metalloproteinases
- (2008) E STERCHI et al. MOLECULAR ASPECTS OF MEDICINE
Find Funding. Review Successful Grants.
Explore over 25,000 new funding opportunities and over 6,000,000 successful grants.
ExploreDiscover Peeref hubs
Discuss science. Find collaborators. Network.
Join a conversation